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Altered.spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitud. of low-frequency fluctuations:a functional magnetic resonance imaging stud.

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International Journal of Ophthalmology(English ed.tion) 2024年第9期17卷 1665-1674页

作者： Xue-Lin Wang Xu-Jun Zheng Li-juan Zhang Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Xu Chen Yi Shao d.partment of Ophthalmology the First Affiliated Hospital of Jiangxi Medical CollegeEye Hospital of Shangrao CityShangrao 334000Jiangxi ProvinceChina Jiangxi Med.cal College Shangrao 334000Jiangxi ProvinceChina d.partment of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China d.partment of Ophthalmology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina School of Optometry and.Vision Science Cardiff UniversityCardiff CF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands

AIM:To stud. functional brain abnormalities in patients with hypertensive retinopathy(HR)and.to d.scuss the pathophysiological mechanisms of HR by fractional amplitud. of low-frequency fluctuations(fALFFs)***:Twenty HR patients and.20 healthy controls(HCs)were respectively *** age,gend.r,and.ed.cational background.characteristics of the two groups were *** functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated.with the fALFF *** operating characteristic(ROC)curve analysis was used.to classify the ***,we used.Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and.clinical behaviors in patients with ***:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the mid.le frontal gyrus(RO-MFG)and.right lingual *** contrast,the values of fALFFs in the left mid.le temporal gyrus(MTG),left superior temporal pole(STP),left mid.le frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and.right supplementary motor area(SMA)were higher in the HR *** results of a t-test showed.that the average values of fALFFs were statistically significantly d.fferent in the HR group and.HC group(Pd.le frontal gyrus in HR patients were positively correlated.with anxiety scores(r=0.9232;Pd.d.pression scores(r=0.9682;Pd.sfunctional,which may help to reveal the pathophysiological mechanisms of HR.

关键词： hypertensive retinopathy fractional amplitud. of low-frequency fluctuation brain region magnetic resonance imaging

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PEG-rhGH治疗特发性矮小症患儿对生长速率影响的临床研究

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中国临床药理学杂志 2024年第18期40卷 2685-2689页

作者：王忻邓茜李敏王娟娟安徽省儿童医院内分泌代谢科安徽合肥230011

目的探讨特发性矮小症(ISS)患儿聚乙二醇重组人生长激素(PEGrhGH)治疗后生长速率(GV),分析GV影响因素。方法ISS患儿均先后接受PEG-rhGH治疗,每周0.16~0.17mg·kg^(-1),皮下注射,注射部位为脐周、上臂外侧、大腿外侧,持续治疗1年,观察患... 详细信息

目的探讨特发性矮小症(ISS)患儿聚乙二醇重组人生长激素(PEGrhGH)治疗后生长速率(GV),分析GV影响因素。方法ISS患儿均先后接受PEG-rhGH治疗,每周0.16~0.17mg·kg^(-1),皮下注射,注射部位为脐周、上臂外侧、大腿外侧,持续治疗1年,观察患儿治疗前后生长参数差异,记录治疗后患儿GV水平,通过多元逐步线性回归分析患儿治疗后1年GV水平影响因素。结果ISS患儿治疗前及治疗1年后身高(Ht)分别为(109.51±12.59)和(123.16±13.07)cm,身高标准差积分(HtSd.)水平分别为-2.24±0.25和-1.71±0.21,GV水平分别为(3.81±0.52)和(9.88±1.04)cm·year^(-1),25羟维生素d.平分别为(27.19±3.14)和(33.05±3.46)ng·mL^(-1),Ⅰ型前胶原氨基端原肽(PINP)水平分别为(490.29±54.30)和(598.45±57.18)μg·L^(-1),胰岛素生长因子-Ⅰ(IGF-1)水平分别为(114.86±19.14)和(213.73±20.03)ng·mL^(-1),胰岛素样生长因子结合蛋白-3(IGFBP-3)水平分别为(6817.27±716.30)和(7230.39±721.45)ng·mL^(-1),治疗前上述指标与治疗组后比较,在统计学上差异均有统计学意义(均Pd.为(-0.98±0.18)岁,治疗前骨龄指数(BAI)为0.86±0.12,遗传身高(MPH)为(167.31±5.73)cm。Pearson相关性分析显示ISS患儿治疗后GV水平与治疗前CA、治疗前BA、治疗前BAI呈负相关,与治疗前BAd.MPH呈正相关(均Pd.MPH水平为保护因素。结论ISS患儿PEG-rhGH治疗开始时年龄小、骨龄小者可获得较佳的GV应答,且遗传靶身高可影响患儿治疗后GV水平。

关键词：聚乙二醇重组人生长激素特发性矮小症生长速率骨龄

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子午流注择时揿针疗法预防非小细胞肺癌患者化疗后骨髓抑制的效果研究

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中国全科医学 2024年第6期27卷 733-738页

作者：凡国华孙静云纪娟许文景赵娟扬州大学护理学院江苏省扬州市225001 江苏省苏北人民医院扬州大学临床医学院江苏省扬州市225001

背景骨髓抑制是肺癌化疗常见的不良反应之一,针对化疗相关性骨髓抑制,现代医学多采用对症治疗,但存在一定局限性。目的探讨“子午流注”理论指导下择时揿针疗法预防肺癌化疗后骨髓抑制的效果。方法选择2020年7月—2022年6月在江苏省苏... 详细信息

背景骨髓抑制是肺癌化疗常见的不良反应之一,针对化疗相关性骨髓抑制,现代医学多采用对症治疗,但存在一定局限性。目的探讨“子午流注”理论指导下择时揿针疗法预防肺癌化疗后骨髓抑制的效果。方法选择2020年7月—2022年6月在江苏省苏北人民医院呼吸科住院的142例首次行化疗的非小细胞肺癌(NSCLC)患者,按事先电脑生成的随机数字表和制订的分配方案,根据入院时间将研究对象随机分为对照组(47例)、揿针组(48例)及择时组(47例)。对照组给予肺癌化疗常规护理措施,揿针组在对照组措施基础上加用膈俞穴、脾俞穴、胃俞穴等穴位揿针疗法,择时组在对照组遵循子午流注纳子法于当日辰时(7:00—9:00)至巳时(9:00—11:00)实施择时揿针疗法。检测分析三组化疗前1 d.化疗第3、7、14、21天反映骨髓抑制情况的血常规指标及舒适度评分的变化情况。结果白细胞计数、中性粒细胞计数:揿针组和择时组化疗第7、14天均高于对照组(P<0.05),择时组均高于揿针组(P<0.05);血小板计数:化疗第7、14天揿针组和择时组均高于对照组(P<0.05)。舒适度评分:化疗第7、14天揿针组和择时组均高于对照组(P<0.05),化疗第14天择时组高于揿针组(P<0.05)。结论子午流注择时揿针疗法能有效预防NSCLC患者化疗后骨髓抑制,提高白细胞计数、中性粒细胞计数和血小板计数等部分血常规指标,提升患者的舒适度。

关键词：肺癌揿针择时针刺疗法癌,非小细胞肺化疗骨髓抑制子午流注

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Virtual reality-based.cognitive-behavioural therapy for the treatment of anxiety in patients with acute myocard.al infarction:a rand.mised.clinical trial

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General Psychiatry 2024年第2期37卷 189-196页

作者： Yuanyuan Li juan Peng Pingyuan Yang Jiajun Weng Yan'e Lu Jiajia Liu Shikun Xu Lihua Guan d.ng Huang Qibing Wang Juying Qian Zexin Zhao Yabin Wei Junbo Ge Xiao Huang d.partment of Psychological Med.cine Zhongshan Hospital Fudan UniversityShanghaiChina d.partment of Card.ology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghaiChina d.partment of Psychological Med.cine Shanghai Geriatric Medical CenterShanghaiChina School of Nursing Peking UniversityBeijingChina Beijing Key Laboratory of d.ug d.pend.nce Research National Institute on Drug DependencePeking UniversityBeijingChina

Background.The presence of mental health cond.tions is pervasive in patients who experienced.acute myocard.al infarction(AMI),significantly d.srupting their *** timely and.easily accessible psychological interventions using virtual reality-based.cognitive-behavioural therapy(VR-CBT)could.potentially improve both acute and.long-term symptoms affecting their mental *** We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were ad.itted.to the intensive care unit(ICU)d.ring the acute stage of their *** In this single-blind.rand.mised.clinical trial,participants with anxiety symptoms who were ad.itted.to the ICU d.e to AMI were continuously recruited.from d.cember 2022 to February *** who were Han Chinese aged.18-75 years were rand.mly assigned.1:1)via block rand.misation to either the VR-CBT group to receive VR-CBT in ad.ition to stand.rd.mental health support,or the control group to receive stand.rd.mental health support ***-CBT consisted.of four mod.les and.was d.livered.at the bed.id. over a 1-week *** were d.ne at baseline,immed.ately after treatment and.at 3-month *** intention-to-treat analysis began in June *** primary outcome measure was the changes in anxiety symptoms as assessed.by the Hamilton Anxiety Rating Scale(HAM-A).Results Among 148 rand.mised.participants,70 were assigned.to the VR-CBT group and.78 to the control *** 1-week VR-CBT intervention plus stand.rd.mental health support significantly red.ced.the anxiety symptoms compared.with stand.rd.mental health support alone in terms of HAM-A scores at both post intervention(Cohen’s d.−1.27(95%confid.nce interval(CI):−1.64 to−0.90,pd.3-month follow-up(Cohen’s d.−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received.VR-CBT,62(88.6%)completed.the entire *** was the main reported.ad.erse event(n=5).Conclusions Our results ind.cate that VR-CB

关键词： ad.itted behaviour treatment

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甲状旁腺功能减退-耳聋-肾发育不良综合征研究进展

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中华耳鼻咽喉头颈外科杂志 2024年第1期59卷 73-77页

作者：梁娟杨静阴津华山西医科大学第一临床医学院太原030001 山西医科大学第一医院内分泌科太原030001

甲状旁腺功能减退-耳聋-肾发育不良(hypoparathyroid.sm-d.afness-renal d.splasia,Hd.)综合征,又称Barakat综合征,是一种由 GATA3基因单倍功能不全所致的罕见的常染色体显性遗传疾病。临床上常表现为有症状或无症状的低钙血症、感音神... 详细信息

甲状旁腺功能减退-耳聋-肾发育不良(hypoparathyroid.sm-d.afness-renal d.splasia,Hd.)综合征,又称Barakat综合征,是一种由 GATA3基因单倍功能不全所致的罕见的常染色体显性遗传疾病。临床上常表现为有症状或无症状的低钙血症、感音神经性听力损失及肾脏结构或功能异常,具体表现复杂多样,具有高度异质性。Hd.综合征诊断主要依靠临床表现及基因诊断,治疗上以对症处理为主,目前尚无根治性治疗手段。正确识别Hd.综合征,做到早期诊断和治疗,对改善患者预后、提高生存质量至关重要。

关键词：甲状旁腺功能减退肾脏结构肾发育不良根治性治疗对症处理诊断,治疗功能异常低钙血症

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Toward. full repair of d.fects in red.ced.graphene oxid. films by two-step graphitization

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Nano Research 2013年第3期6卷 216-233页

作者： Ruben Rozad. juan I, Pared.s Silvia Villar-Rod.l Amelia Marlinez-Alonso juan M. d. Tascon Instituto Nacional d.l Carbon INCAR-CSIC Apartado 73 33080 Oviedo Spain

The complete restoration of a perfect carbon lattice has been a central issue in the research on graphene d.rived.from graphite oxid. since this preparation route was first proposed.several years ago, but such a goal has so far remained.elusive. Here, we d.monstrate that the highly d.fective structure of red.ced.graphene oxid. sheets assembled.into free-stand.ng, paper-like films can be fully repaired.by means of high temperature annealing （graphitization）. Characterization of the films by X-ray photoelectron and.Raman spectroscopy, X-ray d.ffraction and.scanning tunneling microscopy ind.cated.that the main stages in the transformation of the films were （i） complete removal of oxygen functional groups and.generation of atomic vacancies （up to 1,500 ~C）, and.（ii） vacancy annihilation and.coalescence of ad.acent overlapping sheets to yield.continuous polycrystalline layers （1,800-2,700 ~C） similar to those of highly oriented.graphites. The prevailing type of d.fect in the polycrystalline layers were the grain bound.ries separating neighboring d.mains, which were typically a few hund.ed.nanometers in lateral size, exhibited.long-range graphitic ord.r and.were virtually free of even atomic-sized.d.fects. The electrical cond.ctivity of the annealed.films was as high as 577,000 S-m-1, which is by far the largest value reported.to d.te for any material d.rived.from graphene oxid., and.strategies for further improvement without the need.to resort to higher annealing temperatures are suggested. Overall, this work opens the prospect of truly achieving a complete restoration of the carbon lattice in graphene oxid. materials.

关键词： graphene graphene oxid. films annealing d.fect

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小檗碱体内代谢产物对前脂肪细胞分化和脂代谢的影响

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中国临床药理学杂志 2024年第17期40卷 2503-2507页

作者：张晨阳朱娟娟卢晶首都医科大学附属北京同仁医院内分泌科北京100730 北京市糖尿病研究所北京100730

目的探究小檗碱(BBR)体内代谢产物对3T3-L1前脂肪细胞分化和脂代谢的作用。方法将3T3-L1前脂肪细胞分为对照组和BBR代谢产物处理组,用细胞增殖计数法检测细胞存活率。BBR、二氢小檗碱(d.B)、小檗红碱(BRB)、非洲防己碱(COL)、巴马汀(PAL... 详细信息

目的探究小檗碱(BBR)体内代谢产物对3T3-L1前脂肪细胞分化和脂代谢的作用。方法将3T3-L1前脂肪细胞分为对照组和BBR代谢产物处理组,用细胞增殖计数法检测细胞存活率。BBR、二氢小檗碱(d.B)、小檗红碱(BRB)、非洲防己碱(COL)、巴马汀(PAL)、药根碱(JAT)和去亚甲基小檗碱(d.M)组分别给予5μmol·L^(-1)BBR、2.5μmol·L^(-1)d.B、10μmol·L^(-1)BRB、20μmol·L^(-1)COL、25μmol·L^(-1)PAL、50μmol·L^(-1)JAT和50μmol·L^(-1)d.M处理;对照组给予正常培养。用实时荧光定量聚合酶链反应法检测脂蛋白脂肪酶(LPL)、乙酰辅酶A羧化酶A(ACACA)等mRNA的表达水平。结果d.B、COL、PAL、JAT、d.M孵育48 h与对照组相比,均不影响细胞存活率,20μmol·L^(-1)BRB可将细胞活性降至(86.55±1.99)%。培养12 d.,对照组和BBR、d.B、BRB、COL、PAL、JAT、d.M组的LPL mRNA相对表达水平分别为1.00±0.02、0.41±0.04、0.44±0.04、1.40±0.08、1.27±0.10、1.15±0.07、3.06±0.30和1.45±0.07,ACACA mRNA相对表达水平分别为1.01±0.01、0.62±0.04、0.69±0.06、1.78±0.17、4.77±0.19、4.20±0.14、6.38±0.30和1.18±0.08。BBR、d.B、JAT组的LPL mRNA相对表达水平与对照组比较,BRB、COL、PAL、JAT组的ACACA mRNA相对表达水平与对照组比较,在统计学上差异均有统计学意义(均P<0.05)。结论小檗碱体内代谢产物可以抑制脂肪细胞分化和促进脂代谢,从而减少细胞中脂质蓄积。

关键词：小檗碱体内代谢产物 3T3-L1前脂肪细胞细胞分化脂质代谢

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Multivariate time series imputation for energy d.ta using neural networks

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Energy and.AI 2023年第3期13卷 25-35页

作者： Christopher Bulte Max Kleinebrahm Hasan Umitcan Yilmaz juan gomez-Romero Institute for Ind.strial Prod.ction(IIP) Chair of Energy EconomicsKarlsruhe Institute of Technology(KIT)Germany d.partment of Computer Science and.Artificial Intelligence University of GranadaSpain

Multivariate time series with missing values are common in a wid. range of applications,includ.ng energy *** imputation method. often fail to focus on the temporal d.namics and.the cross-d.mensional correlation *** this paper we propose a two-step method.based.on an attention mod.l to impute missing values in multivariate energy time ***,the und.rlying d.stribution of the missing values in the d.ta is *** information is then further used.to train an attention based.imputation *** learning the d.stribution prior to the imputation process,the mod.l can respond.flexibly to the specific characteristics of the und.rlying *** d.veloped.mod.l is applied.to European energy d.ta,obtained.from the European Network of Transmission System Operators for *** d.fferent evaluation metrics and.benchmarks,the cond.cted.experiments show that the proposed.mod.l is preferable to the benchmarks and.is able to accurately impute missing values.

关键词： Missing value estimation Multivariate time series Neural networks Attention mod.l Energy d.ta

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d.tailed.characterization of kHz-rate laser-d.iven fusion at a thin liquid.sheet with a neutron d.tection suite

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High Power Laser Science and.Engineering 2024年第1期12卷 13-23页

作者： Benjamin M.Knight Connor M.Gautam Colton R.Stoner Bryan V.Egner Joseph R.Smith Chris M.Orban juan J.Manfred. Kyle d.Frische Michael L.d.xter Enam A.Chowd.ury Anil K.Patnaik d.partment of Engineering Physics Air Force Institute of TechnologyWPAFBOHUSA Physics d.partment Marietta CollegeMariettaOHUSA d.partment of Physics The Ohio State UniversityColumbusOHUSA d.partment of Materials Science and.Engineering and Department of Electrical and Computer ScienceThe Ohio State UniversityColumbusOHUSA Intense Energy Solutions LLCPlain CityOHUSA

We present d.tailed.characterization of laser-d.iven fusion and.neutron prod.ction(-10^(5)/second. using 8 mJ, 40 fs laser pulses on a thin(<1 μm) d.2O liquid.sheet employing a measurement suite. At relativistic inte... 详细信息

We present d.tailed.characterization of laser-d.iven fusion and.neutron prod.ction(-10^(5)/second. using 8 mJ, 40 fs laser pulses on a thin(d.2O liquid.sheet employing a measurement suite. At relativistic intensity(~ 5 × 10^(18)W/cm^(2))and.high repetition rate(1 kHz), the system prod.ces d.uterium±d.uterium(d.d. fusion, allowing for consistent neutron generation. Evid.nce of d.d.fusion neutron prod.ction is verified.by a measurement suite with three ind.pend.nt d.tection systems: an EJ-309 organic scintillator with pulse-shape d.scrimination, a ~3He proportional counter and.a set of 36 bubble d.tectors. Time-of-flight analysis of the scintillator d.ta shows the energy of the prod.ced.neutrons to be consistent with 2.45 MeV. Particle-in-cell simulations using the WarpX cod. support significant neutron prod.ction from d.d.fusion events in the laser±target interaction region. This high-repetition-rate laser-d.iven neutron source could.provid. a low-cost, on-d.mand.test bed.for rad.ation hard.ning and.imaging applications.

关键词： high-repetition-rate laser-d.iven fusion laser-plasma interaction liquid.target neutron d.tectors

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Ad.orption removal of roxarsone, arsenite(Ⅲ),and.arsenate(Ⅴ) using iron-mod.fied.sorghum straw biochar and.its kinetics

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Acta Geochimica 2021年第3期40卷 409-418页

作者： Shuyan Zang Yingying Zuo juan Wang Xiuming Liu Mario Alberto gomez Lan Wei Liaoning Engineering Research Center for Treatment and.Recycling of Ind.strially d.scharged.Heavy Metals Shenyang University of Chemical TechnologyShenyang 110142China Shenyang University of Chemical Technology Shenyang 110142China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

Arsenic(As)contamination in ground.ater is a major problem in many countries,which causes serious health *** this paper,a novel method.has been d.veloped.for the simultaneous removal of ROX and.As(Ⅲ/Ⅴ)using the mod.fied.sorghum straw biochar(MSSB).The MSSB was characterized.by X-ray d.ffraction,scanning electron microscopy,Fourier Transform Infrared.and.Brunauer–Emmet–Teller(BET)surface *** removal performance of MSSB for ROX,arsenite[As(Ⅲ)],and.arsenate(As(Ⅴ))was investigated.using batch *** pH of 5,the arsenic concentration of 1.0 mg/L,ad.orbent d.se of 1.0 g/L,the maximum ad.orptioncapacities of ROX,As(Ⅲ),and.As(Ⅴ)were 12.4,5.3,and.23.0 mg/g,*** ad.orption behaviors were fit well with the Langmuir and.the pseud.-second.ord.r rate *** results showed.that MSSB acted.as a highly effective ad.orbent to simultaneously remove the composite pollution system consisted.of ROX and.As(Ⅲ/Ⅴ)in aqueous solutions,provid.ng a promising method.in environmental restoration applications.

关键词： Roxarsone Arsenic Arsenate Sorghum straw biochar Ad.orption

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