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Barley Protein LFBEP-C1 from Lactiplantibacillus plantarum dy-1 Fermented Barley Extracts by Inhibiting Lipid Accumulation in a Caenorhabditis elegans Model

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Biomedical and Environmental Sciences 2024年第4期37卷 377-386页

作者： ZHANG Jia Yan LIU Meng Ting LIU Yu Hao DENG Huan bai juan XIE Jian Hua XIAO Xiang School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047JiangxiChina

Objective This study aimed to investigate the lipid-lowering activity of LFBEP-C1 in high glucose-fed Caenorhabditis elegans(***).Methods In this study,the fermented barley protein LFBEP-C1 was prepared and tested for its potential anti-obesity effects on *** worms were fed Escherichia coli OP50(*** OP50),glucose,and different concentrations of *** size,lifespan,movement,triglyceride content,and gene expression were *** results were analyzed using ANOVA and Tukey's multiple comparison *** Compared with the model group,the head-swing frequency of *** in the group of LFBEP-C1 at 20μg/mL increased by 33.88%,and the body-bending frequency increased by 27.09%.This indicated that LFBEP-C1 improved the locomotive ability of *** average lifespan of *** reached 13.55 days,and the body length and width of the *** decreased after LFBEP-C1 ***,LFBEP-C1 reduced the content of lipid accumulation and triglyceride *** expression levels of sbp-1,daf-2,and mdt-15 significantly decreased,while those of daf-16,tph-1,mod-1,and ser-4 significantly increased after LFBEP-C1 *** in these genes explain the signaling pathways that regulate lipid *** LFBEP-C1 significantly reduced lipid deposition in *** fed a high-glucose diet and alleviated the adverse effects of a high-glucose diet on the development,lifespan,and exercise behavior of *** addition,LFBEP-C1 regulated lipid metabolism mainly by mediating the expression of genes in the sterol regulatory element-binding protein,insulin,and 5-hydroxytryptamine signaling pathways.

关键词： LFBEP-C1 Fermentation Protein Caenorhabditis elegans Lipid accumulation Signaling pathway

Network Pharmacology and Experimental Study of MomordicineⅠand MomordicineⅡfrom Bitter Melon Saponins in Inhibiting Fat Accumulation

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Biomedical and Environmental Sciences 2024年第5期37卷 526-530页

作者： HUANG Shi Ting LI Shang Yuan LI Xin Yu ZHU Ying ZHU Lin ZHANG Jia Yan ZHAO Yan Sheng DAGLIA Maria XIAO Xiang bai juan School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Department of Pharmacy University of Napoli FedericoⅡVia D.Montesano 4980131 NaplesItaly International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013JiangsuChina

Bitter melon(Momordica Charania L.),a member of the Cucurbitaceae family,is widely distributed across tropical and subtropical ***,an important functional component of bitter melon,has been proven to exert hypoglycemic effects similarly to insulin,and also possesses lipid-lowering properties inhibiting preadipocyte differentiation and fat synthesis^([1]).

关键词： melon Momordica subtropical

Influences of Lactiplantibacillus plantarum and Saccharomyces cerevisiae fermentation on the nutritional components,flavor property and lipid-lowering effect of highland barley

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未来食品学报(英文) 2024年第3期4卷 258-266页

作者： juan bai Linzhao He Jinfu Zhang Xiangyue Gu Beiqi Wu Anlin Wang Ying Zhu Jiayan Zhang Yansheng Zhao Jie Yuan Xiang Xiao School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China

Highland barley is a well-known cereal in Qinghai-Tibet Plateau area with high nutritional value,which has been reported to be a health-promoting grain for the obesity and the *** by certain microbiota can improve the flavor property and nutritional *** the present study,Lactiplantibacillus plantarum and Saccharomyces cerevisiae were singly or jointly applied to ferment highland barley,and the profile of volatile substances and lipid-lowering effects of the respective extracts were *** indicated that either *** or *** or co-fermentation could consume the polysaccharides of highland barley to provide energy,and dramatically increase the contents of total protein and *** chromatography-mass spectrometry(GC-MS)analysis revealed that the presence of *** was critical for production of the pleasant flavors,especially for the ethyl ester substances including hexadecanoic acid ethyl,hexanoic acid ethyl ester and so ***,we found that fermented highland barley extracts by *** exhibited stronger lipid-lowering effects in Caenorhabditis elegans than that by ***,while the co-fermentation not only emitted pleasant odors but also exerted high hypolipidemic *** all,co-fermentation by *** and *** was proposed to be a promising processing to improve the flavor and functional properties of highland barley.

关键词： Highland barley Lactiplantibacillus plantarum Saccharomyces cerevisiae Fermentation Flavor property Lipid-lowering

挤压膨化鹿茸菇-大麦复合粉的理化特性、胃肠消化和酵解特性

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食品科学 2024年第13期45卷 198-209页

作者：丁怡炜范松涛白娟顾耀军肖香江苏大学食品与生物工程学院江苏镇江202013 江苏江南生物科技有限公司江苏镇江212300

通过挤压膨化制备大麦粉(BF)、鹿茸菇-大麦复合粉(DLR)、鹿茸菇副产物-大麦复合粉(DBY),分析添加鹿茸菇组分对产品理化特性和营养功能的影响。结果表明,DLR和DBY的淀粉糊化程度明显降低。采用标准化INFOGEST 2.0方法模拟胃肠消化发现,DB... 详细信息

通过挤压膨化制备大麦粉(BF)、鹿茸菇-大麦复合粉(DLR)、鹿茸菇副产物-大麦复合粉(DBY),分析添加鹿茸菇组分对产品理化特性和营养功能的影响。结果表明,DLR和DBY的淀粉糊化程度明显降低。采用标准化INFOGEST 2.0方法模拟胃肠消化发现,DBY组因鹿茸菇副产物富含可溶性膳食纤维,其抗氧化能力显著高于BF和DLR组(P0.5,P<0.05)。综上,添加鹿茸菇组分有效改善复合大麦粉产品品质和功能特性,且DBY具有更好的抗氧化活性和肠道菌群调节作用,研究结果可为开发鹿茸菇-大麦膨化产品提供理论支持。

关键词：挤压膨化大麦鹿茸菇体外消化酵解肠道微生物

Progress in MXene-based catalysts for oxygen evolution reaction

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Electron 2024年第1期2卷 48-67页

作者： Jieli Chen Xiaohong Gao Jing Li Zhenye Kang juan bai Tianjiao Wang Yuliang Yuan Chenghang You Yu Chen Bao Yu Xia Xinlong Tian School of Marine Science and Engineering Hainan Provincial Key Lab of Fine ChemistrySchool of Chemistry and Chemical EngineeringHainan UniversityHaikouChina School of Chemistry and Physics Queensland University of TechnologyBrisbaneQueenslandAustralia Key Laboratory of Macromolecular Science of Shaanxi Province School of Materials Science and EngineeringShaanxi Normal UniversityXi'anChina School of Chemistry and Chemical Engineering State Key Laboratory of Materials Processing and Die&Mould TechnologyKey Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education)Hubei Key Laboratory of Material Chemistry and Service FailureWuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology(HUST)WuhanChina

Electrochemical water splitting for hydrogen generation is considered one of the most promising strategies for reducing the use of fossil fuels and storing renewable electricity in hydrogen ***,the anodic oxygen evolution process remains a bottleneck due to the remarkably high overpotential of about 300 mV to achieve a current density of 10 mA cm^(−2).The key to solving this dilemma is the development of highly efficient catalysts with minimized overpotential,long-term stability,and low *** a new 2D material,MXene has emerged as an intriguing material for future energy conversion technology due to its benefits,including superior conductivity,excellent hydrophilic properties,high surface area,versatile chemical composition,and ease of processing,which make it a potential constituent of the oxygen evolution catalyst *** review aims to summarize and discuss the recent development of oxygen evolution catalysts using MXene as a component,emphasizing the synthesis and synergistic effect of MXene-based composite *** on the discussions summarized in this review,we also provide future research directions regarding electronic interaction,stability,and structural evolution of MXene-based oxygen evolution *** believe that a broader and deeper research in this area could accelerate the discovery of efficient catalysts for electrochemical oxygen evolution.

关键词： MXene-based catalysts oxygen evolution reaction water splitting

高职院校生产性实训基地“三全育人”创新实践研究——以杨凌职业技术学院旅游与管理学院旅苑创咖实训室为例

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黑龙江教师发展学院学报 2024年第4期43卷 101-104页

作者：白娟利杨凌职业技术学院陕西咸阳712100

在高职院校开展“三全育人”工作,需要构建全方位、全过程、全员参与的实践育人机制。当前高职院校通过构建生产实训性基地,进一步提升了高职院校实践育人的能力。基于此,以杨凌职业技术学院旅游与管理学院旅苑创咖实训室为例,分析当前... 详细信息

在高职院校开展“三全育人”工作,需要构建全方位、全过程、全员参与的实践育人机制。当前高职院校通过构建生产实训性基地,进一步提升了高职院校实践育人的能力。基于此,以杨凌职业技术学院旅游与管理学院旅苑创咖实训室为例,分析当前我国高职院校生产性实训基地建设过程中面临的挑战,并提出高职院校生产性实训基地“三全育人”创新实践策略,以期进一步强化人才培养评价机制,优化生产性实训基地师资队伍,促进高职院校生产性实训基地“三全育人”创新实践能力的提升。

关键词：高职院校生产性实训基地 “三全育人” 创新实践

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桑叶蜜炙工艺优化研究

文山学院学报 2024年第2期37卷 8-13页

作者：白华白娟张雪涛安徽中医药科学院亳州中医药研究所安徽亳州236800 亳州职业技术学院安徽亳州236800 安徽医学高等专科学校安徽合肥230061 安徽省医学科学研究院安徽合肥230061

目的:桑叶蜜炙工艺的优选。方法:以黄酮类化合物:芦丁、绿原酸、紫云英苷、异槲皮苷,槲皮素的含量为指标,通过正交试验以及高效液相色谱法,对桑叶的蜜炙方法进行系统研究。结果:桑叶蜜炙工艺的优选方案是:药材与熟蜜的重量比为5∶1,闷... 详细信息

目的:桑叶蜜炙工艺的优选。方法:以黄酮类化合物:芦丁、绿原酸、紫云英苷、异槲皮苷,槲皮素的含量为指标,通过正交试验以及高效液相色谱法,对桑叶的蜜炙方法进行系统研究。结果:桑叶蜜炙工艺的优选方案是:药材与熟蜜的重量比为5∶1,闷润时间为20 min,用武火(900W)炒制3 min时,黄酮类化合物的含量最高。结论:本次实验中桑叶与蜜的重量比、闷润时间、炒制火候、炒制时间等因素对桑叶的蜜炙影响较大,利用正交试验结合高效液相色谱法有助于有效准确地测出桑叶蜜炙后黄酮类化合物的含量,为今后桑叶的蜜炙工艺提供参考。

关键词：蜜炙桑叶正交试验高效液相色谱法黄酮类化合物

lncRNA NEAT1促进miR-451a表达抑制AngⅡ诱导的高血压致血管重构

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微循环学杂志 2024年第1期34卷 6-13页

作者：江蓉谢娣白娟电子科技大学医学院附属绵阳医院绵阳市中心医院绵阳621000

目的:探究长链非编码RNA(lncRNA)-核富集丰度转录物1(NEAT1)调控微小RNA-451a(miR-451a)对血管紧张素Ⅱ(AngⅡ)诱导的高血压致血管重构的影响。方法:将C57BL/6小鼠随机分作control组、model组、shRNA组、sh-NEAT1组、sh-NEAT1+inhibitor NC组、sh-NEAT1+miR-451a inhibitor组,15只/组;除control组外其余小鼠皮下埋入AngⅡ微量泵建立高血压模型,并于2周后尾静脉分别注射相应剂量shRNA、sh-NEAT1、inhibitor NC及miR-451a inhibitor慢病毒液,control组及model组注射等剂量PBS。检测小鼠血压;qRT-PCR检测胸主动脉组织lncRNA NEAT1及miR-451a表达;HE染色及Masson染色分别观察胸主动脉组织病理学及胶原纤维分布情况;免疫组化法观察胸主动脉组织Ki-67的表达;Western blot检测胸主动脉组织I型胶原蛋白(Col1)、Ⅲ型胶原蛋白(Col3)表达;双荧光素酶报告基因实验验证lncRNA NEAT1与miR-451a的靶向关系。结果:与control组比,model组小鼠收缩压(SBP)、胸主动脉组织lncRNA NEAT1表达、中膜厚度(MT)/主动脉管腔内径(LD)、胶原沉积、Ki-67阳性表达、Col1、Col3蛋白表达显著增加,miR-451a表达显著减少(P<0.05);与shRNA组相比,sh-NEAT1组SBP、lncRNA NEAT1表达、MT/LD、胶原沉积、Ki-67阳性表达、Col1、Col3蛋白表达显著降低,miR-451a表达显著增加(P<0.05);与sh-NEAT1+inhibitor NC组相比,sh-NEAT1+miR-451a inhibitor组SBP、MT/LD、胶原沉积、Ki-67阳性表达、Col1、Col3蛋白表达显著增加(P<0.05),miR-451a表达显著减少(P<0.05),lncRNA NEAT1表达无明显变化(P<0.05);lncRNA NEAT1与miR-451a间存在靶向关系。结论:lncRNA NEAT1沉默对AngⅡ所致高血压大鼠血管重构的改善可能与其促进miR-451a表达有关。

关键词： lncRNA NEAT1 微小RNA-451a 高血压血管重构血管紧张素Ⅱ

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尿素水解反应器疏水系统优化改造

节能 2024年第7期43卷 54-56页

作者：鲍磊林百娟内蒙古润达能源管理服务有限公司内蒙古鄂尔多斯017000 华能电力热力销售有限责任公司内蒙古呼和浩特010051

某电厂在尿素水解制氨方法中,蒸汽进入尿素水解器做功后产生大量带有热量的疏水,但不能回收利用,存在热量利用率低、企业成本高等问题。将尿素水解反应器原有的疏水系统进行改造,利用疏水对尿素储罐进行加热,以及利用疏水向尿素溶解罐... 详细信息

某电厂在尿素水解制氨方法中,蒸汽进入尿素水解器做功后产生大量带有热量的疏水,但不能回收利用,存在热量利用率低、企业成本高等问题。将尿素水解反应器原有的疏水系统进行改造,利用疏水对尿素储罐进行加热,以及利用疏水向尿素溶解罐提供溶质和热量。经过对疏水系统的改造,企业获得良好的经济收益,避免对疏水的浪费,节约了水资源。

关键词：尿素水解疏水经济运行