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COVID-19 and Indirect Liver Injury:A Narrative Synthesis of the Evidence

Journal of Clinical and Translational Hepatology 2021年第5期9卷 760-768页

作者： Francisco Idalsoaga Gustavo Ayares juan Pablo Arab Luis antonio Díaz Departamento de Gastroenterología Escuela de MedicinaPontificia Universidad Católica de ChileSantiagoChile Centro de Envejecimiento y Regeneración(CARE) Facultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiagoChile

The liver is frequently affected by severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2)*** most common manifestations are mildly elevated alanine aminotransferase and aspartate aminotransferase,with a prevalence of 16-53%among *** with severe coronavirus disease 2019(COVID-19)seem to have higher rates of acute liver dysfunction,and the presence of abnormal liver tests at admission signifies a higher risk of severe disease during *** with chronic liver diseases also have a higher risk of severe disease and mortality(mainly seen in patients with metabolic-associated fatty liver disease).Several pathways of damage have been proposed in the liver involvement of COVID-19 patients;although,the end-cause is most likely *** liver tests have been attributed to the expression of angiotensin-converting enzyme 2 receptors in SARS-CoV-2 *** enzyme is expressed widely in cholangiocytes and less in *** factors attributed to liver damage include drug-induced liver injury,uncontrolled release of proinflammatory molecules(“cytokine storm”),pneumonia-associated hypoxia,and direct damage by the *** steatosis,vascular thrombosis,fibrosis,and inflammatory features(including Kupffer cell hyperplasia)are the most common liver histopathological findings in deceased COVID-19 patients,suggesting important indirect mechanisms of liver *** this translational medicinebased narrative review,we summarize the current data on the possible indirect mechanisms involved in liver damage due to COVID-19,the histopathological findings,and the impact of these mechanisms in patients with chronic liver disease.

关键词： COVID-19 SARS-CoV-2 Liver hepatitis Liver injury Novel coronavirus

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Hybrid Security Assessment Methodology for Web Applications

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Computer Modeling in Engineering & Sciences 2021年第1期126卷 89-124页

作者： Roddy A.Correa juan Ramon Bermejo Higuera Javier Bermejo Higuera juan antonio SiciliaMontalvo Manuel Sanchez Rubio A.Alberto Magrenan Universidad Tecnica Particular de Loja San Cayetano AltoLojaEcuador Escuela Superior de Ingenieria y Tecnologia Universidad Internacional de La RiojaLogrono26006Spain Universidad de la Rioja Logrono26006Spain

This study presents a methodology to evaluate and prevent security vulnerabilities issues for web *** analysis process is based on the use of techniques and tools that allow to perform security assessments of white box and black box,to carry out the security validation of a web application in an agile and precise *** objective of the methodology is to take advantage of the synergies of semi-automatic static and dynamic security analysis tools and manual *** one of the phases contemplated in the methodology is supported by security analysis tools of different degrees of coverage,so that the results generated in one phase are used as feed for the following phases in order to get an optimized global security analysis *** methodology can be used as part of other more general methodologies that do not cover how to use static and dynamic analysis tools in the implementation and testing phases of a Secure Software Development Life Cycle(SSDLC).A practical application of the methodology to analyze the security of a real web application demonstrates its effectiveness by obtaining a better optimized vulnerability detection result against the true and false positive *** analysis with manual checking is used to audit the results,24.6 per cent of security vulnerabilities reported by the static analysis has been checked and it allows to study which vulnerabilities can be directly exploited *** phase is very important because it permits that each reported vulnerability can be checked by a dynamic second tool to confirm whether a vulnerability is true or false positive and it allows to study which vulnerabilities can be directly exploited *** analysis finds six(6)additional critical *** control analysis finds other five(5)important vulnerabilities such as Insufficient Protected Passwords or Weak Password Policy and Excessive Authentication Attacks,two vulnerabilities that permit brute force at

关键词： Web applications security vulnerability weakness security analysis white box black box interactive application security testing static application security testing dynamic application security testing

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Record-high near-band-edge optical nonlinearities and two-level model correction of poled polymers by spectroscopic electromodulation and ellipsometry

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Science China Chemistry 2022年第3期65卷 584-593页

作者： Taili Liu Di Zhang Md Rashedul Huqe Wen Wang juan antonio Zapien Sai-Wing Tsang Jingdong Luo Shenzhen Research Institute City University of Hong KongShenzhen 518057China Department of Chemistry City University of Hong KongHong Kong SARChina Department of Materials Science and Engineering City University of Hong KongHong Kong SARChina Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong SARChina

The determination of nonlinearities near the band edge of organic and polymeric electro-optic(EO)materials is important from the viewpoint of molecular nonlinear optics(NLO)and photonic device *** on transmission-mode Stark effect electromodulation(EM)spectroscopy,we study the electric-field-induced changes in optical absorption and refraction of newly developed EO polymers from the visible to near-infrared(NIR)wavelengths and report record-high near-band-edge complex EO effects from poled thin *** ofΔn andΔk up to 10^(-3) and 10^(-2) are found at an applied electric field of 2.0×10^(5)-3.0×10^(5)V/*** study of linear optical properties of poled films by spectroscopic ellipsometry shows large polinginduced birefringence and a nearly two-fold increase in the extinction coefficients at the extraordinary *** the Kramers-Kronig analysis,we obtained the real and imaginary second-order nonlinear coefficients up to~3,500 and~5,600 pm/V,respectively,which are believed to be the highest NLO coefficients of poled polymers through the resonance *** approach goes beyond the previous works,applicable only to several discrete wavelengths,to a full-spectral analysis with independent verification of slab waveguide *** considering both the electroabsorption and electrorefraction effects,our study overcomes the limitation of the classic qualitative two-level model and provides a quantitative understanding of near-resonance optical nonlinearities of organic EO *** can inspire the exploration of high-speed,absorptive,or phase-shifting light-modulators using EO polymers for on-chip applications.

关键词： poled polymers electroabsorption electro-optic effect second-order nonlinear susceptibilities

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Integral Representation Formulas Related to the Lamé–Navier System

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Acta Mathematica Sinica,English Series 2020年第12期36卷 1341-1356页

作者： Ricardo ABREU-BLAYA juan BORY-REYES Marcos antonio-HERRERA-PELáEZ José María SIGARRETA-ALMIRA Facultad de Matemáticas Universidad Autónoma de GuerreroGuerreroMéxico Instituto Politécnico Nacional SEPI-ESIME-ZAC CD-MXMéxico

The paper provides integral representations for solutions to a certain first order partial differential equation natural arising in the factorization of the Lamé–Navier system with the help of Clifford analysis *** representations look like in spirit to the Borel–Pompeiu and Cauchy integral formulas both in three and higher dimensional setting.

关键词： Lamésystem Clifford analysis Dirac operator

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Effect of Organo-Modified Nanosepiolite on Fire Behaviors and Mechanical Performance of Polypropylene Composites

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中国化学:英文版 2015年第2期33卷 285-291页

作者： Junhao Zhang Sergio de juan antonio Esteban-Cubillo Julio Santarén De-Yi Wang Madrid Institute for Advanced Studies of Materials(IMDEA-Materials) C/Eric Kandel2Getafe(Madrid)28906Spain Tolsa S.A.R.&D.Department Carretera de Madrid a Rivas Jarama3528031 MadridSpain

The objective of the study was to investigate the effect of the organo-modified nanosepiolite(ONSep)on improving the fire safety of polypropylene(PP).The composites based on PP,flame retardant master batch(MB-FR,25 wt%PP+50 wt%decabromodiphenyl ether(DBDPE)+25%antimony trioxide(ATO))and ONSep were prepared via melt *** results of the limiting oxygen index(LOI)and vertical burning rating(UL-94)test indicated that PP/40 wt%MB composites had no rating with seriously dripping phenomenon,while the LOI value was only ***,as 4 wt%ONSep was added in PP/40 wt%MB composites,the composites achieved UL94 V-0 rating and the LOI value was *** comparison,PP/50 wt%MB composites could not reach the V-0 rating *** TGA results revealed that the addition of ONSep enhanced the thermal stability of the PP/MB-FR *** cone calorimeter results indicated that the heat release rate,average mass loss rate,smoke production rate and smoke temperature of the PP/40 wt%MB-FR/4 wt%ONSep composites decreased in comparison with those of PP/40 wt%MB-FR ***,the Young modulus and impact strength were also much better improved with the increase of ONSep ***,the synergistic flame retardancy of ONSep in PP/MB-FR matrix significantly containing a halogen based flame retardant(DBDPE)significantly improved the fire safety and mechanical properties of the composites,and allowed to decrease the total amount of brominated fire retardants.

关键词： nanosepiolite polypropylene flame retardancy heat release rate

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Combinatorial Method with Static Analysis for Source Code Security in Web Applications

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Computer Modeling in Engineering & Sciences 2021年第11期129卷 541-565页

作者： juan Ramon Bermejo Higuera Javier Bermejo Higuera juan antonio Sicilia Montalvo Tomas Sureda Riera Christopher I.Argyros A.Alberto Magrenan Escuela Superior de Ingenierıa y Tecnologıa Universidad Internacional de La RiojaLogronoLa Rioja26006Spain Computer Science Department University of AlcalaMadrid28801Spain Department of Computing and Technology Cameron UniversityLawton73505OklahomaUSA Universidad de la Rioja LogronoLa Rioja26006Spain

Security weaknesses in web applications deployed in cloud architectures can seriously affect its data confidentiality and *** construction of the procedure utilized in the static analysis tools of source code security differs and therefore each tool finds a different number of each weakness type for which it is *** utilize the possible synergies different static analysis tools may process,this work uses a new method to combine several source codes aiming to investigate how to increase the performance of security weakness detection while reducing the number of false ***,five static analysis tools will be combined with the designed method to study their behavior using an updated benchmark for OWASP Top Ten Security Weaknesses(OWASP TTSW).The method selects specific metrics to rank the tools for different criticality levels of web applications considering different weights in the *** findings show that simply including more tools in a combination is not synonymous with better results;it depends on the specific tools included in the combination due to their different designs and techniques.

关键词： Weakness benchmark security testing analysis comparative methodology tools combination web application

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Hepatocellular carcinoma in non-alcoholic fatty liver disease from a clinical and public health perspective

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 755-758页

作者： Luis antonio Díaz Marco Arrese juan Pablo Arab Departamento de Gastroenterología Escuela de MedicinaPontificia Universidad Católica de ChileSantiagoChile Division of Gastroenterology Department of MedicineSchulich School of MedicineWestern University&London Health Sciences CentreLondonONCanada Alimentiv LondonONCanada

Non-alcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver disease in the western world(1).Currently,the global prevalence of NAFLD is estimated at 30%and is notably higher in South America and the Middle East(1).NAFLD prevalence has been rising during the last decades,and cases of decompensated NAFLD cirrhosis could increase by 168%in 2030(Figure 1A)(2).These trends are probably explained by several factors including the decrease in viral hepatitis incidence and the increasing prevalence of obesity and type 2 diabetes mellitus(T2DM)among the general population(2).

关键词： prevalence NAFLD liver

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Effect of aging on behaviour of mesenchymal stem cells

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World Journal of Stem Cells 2019年第6期11卷 337-346页

作者： juan antonio Fafián-Labora Miriam Morente-López María C Arufe Grupo de Terapia Celular y Medicina Regenerativa Departamento de Fisioterapia Ciencias Biomédicas y MedicinaUniversidade da Coru?a

Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called “mesenchymal stem cells” or “mesenchymal stromal cells (MSCs)”, contributes directly to the homeostatic maintenance of their organs;hence, their senescence could be very deleterious for human bodily functions. MSCs are easily isolated and amenable their expansion in vitro because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many in vivo animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MSCs, some hints may be derived from the study of cellular behaviour in vivo and in vitro, autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSC senescence over the last three years.

关键词： Mesenchymal stem cells Aging Autophagy Mitochondrial stress Extracellular vesicles

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Evanescence:Time in Modern Plastic Art

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Fudan Journal of the Humanities and Social Sciences 2020年第4期13卷 535-558页

作者： juan antonio Roche Carcel Angel Enrique Carretero Pasin University of Alicante AlicanteSpain University of Santiago de Compostela Santiago de CompostelaSpain

The Article follows the trail of Max Weber's comprehensive sociology and uses the hermeneutic and iconological analysis methods applied to significant contemporary plastic art works(painting and sculpture)which are representative of modern and late modern *** from these theoretical and methodological bases,it pursues three specific objectives:(a)to analyze the construction of Time in plastic art,(b)to verify how this theme has evolved in artistic practices from the first modernity to the second and(c)to verify the way in which the complementary visual language the conceptual of contemporary sociological *** this regard,our paper provides evidence that the selected works prioritize a kind of temporality determined by the logic of capitalist industrial *** likewise becomes obvious that time—focused on an accelerated and instantaneous omnipresent—lacks both an origin and a telos\it has neither a past nor a future and,in parallel,a gap has opened between the time of natural life and the artificial one,as well as between space and time,which is only transiently bridged at the imaginary level of ***,the experience of time has been emptied,in such a way that the latter has lost some of its solidity and让s sense of permanence,while the contingent,the fleeting and the ephemeral now occupy in its place.

关键词： Evanescent time Plastic art Iconological analysis Social hermeneutic Social sciences

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Systematic Approach for Web Protection Runtime Tools’Effectiveness Analysis

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 579-599页

作者： Tomás Sureda Riera juan Ramón Bermejo Higuera Javier Bermejo Higuera juan antonio Sicilia Montalvo José Javier Martínez Herráiz Computer Science Department University of AlcaláMadrid28801Spain Escuela Superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLogrono26006Spain

Web applications represent one of the principal vehicles by which attackers gain access to an organization’s network or ***,different approaches to protect web applications have been proposed to *** them,the two major approaches are Web Application Firewalls(WAF)and Runtime Application Self Protection(RASP).It is,thus,essential to understand the differences and relative effectiveness of both these approaches for effective decisionmaking regarding the security of web *** we present a comparative study between WAF and RASP simulated settings,with the aim to compare their effectiveness and efficiency against different categories of *** this,we used computation of different metrics and sorted their results using F-Score *** found that RASP tools scored better than WAF *** this study,we also developed a new experimental methodology for the objective evaluation ofweb protection tools since,to the best of our knowledge,nomethod specifically evaluates web protection tools.

关键词： Web Application Firewall(WAF) Runtime Application Self Protection(RASP) F-Score web attacks experimental methodology

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