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妊娠合并乙肝病毒感染患者血清DNMT1、TIM-3与HBV-DNA病毒载量和妊娠结局的关系分析

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现代生物医学进展 2024年第4期24卷 656-660,728页

作者：李倩睿唐娟张永男丁祎张觅孙丽洲南京医科大学第一附属医院产科江苏南京210000 南京市第二医院妇产科江苏南京210037 南京市第二医院检验科江苏南京210037

目的:探讨妊娠合并乙肝病毒(HBV)感染患者血清脱氧核糖核酸甲基转移酶1(DNMT1)、T细胞免疫球蛋白粘蛋白-3(TIM-3)与乙型肝炎病毒-脱氧核糖核酸(HBV-DNA)病毒载量和妊娠结局的关系。方法:选取2021年1月~2022年1月南京医科大学第一附属医... 详细信息

目的:探讨妊娠合并乙肝病毒(HBV)感染患者血清脱氧核糖核酸甲基转移酶1(DNMT1)、T细胞免疫球蛋白粘蛋白-3(TIM-3)与乙型肝炎病毒-脱氧核糖核酸(HBV-DNA)病毒载量和妊娠结局的关系。方法:选取2021年1月~2022年1月南京医科大学第一附属医院收治的186例妊娠合并HBV感染患者为HBV感染组,根据HBV-DNA病毒载量分为阳性组56例和阴性组130例,根据妊娠结局分为结局不良组和结局良好组,另选取同期于南京医科大学第一附属医院进行孕检的150名健康孕妇为对照组。采用酶联免疫吸附法检测血清DNMT1、TIM-3水平。比较HBV感染组与对照组、阳性组与阴性组血清DNMT1、TIM-3水平。采用单因素及多因素Logistic回归分析妊娠合并HBV感染患者妊娠结局不良的影响因素,受试者工作特征(ROC)曲线分析血清DNMT1、TIM-3水平对妊娠合并HBV感染患者妊娠结局不良的预测价值。结果:与对照组比较,HBV感染组血清DNMT1、TIM-3水平升高(P34.94 ng/mL、TIM-3>18.96 pg/mL为妊娠合并HBV感染患者妊娠结局不良的独立危险因素(P<0.05)。ROC曲线分析显示,血清DNMT1、TIM-3水平单独和联合检测预测妊娠合并HBV感染患者妊娠结局不良的曲线下面积分别为0.798、0.791、0.870。结论:妊娠合并HBV感染患者血清DNMT1、TIM-3水平升高与HBV-DNA病毒载量阳性和妊娠结局不良密切相关,血清DNMT1、TIM-3水平联合对妊娠合并HBV感染患者妊娠结局预测价值良好。

关键词：妊娠乙肝病毒感染 DNMT1 TIM-3 HBV-DNA 妊娠结局

Dual stimulus responsive borosilicate glass(BSG)scaffolds promote diabetic alveolar bone defectsrepair by modulating macrophage phenotype

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Bioactive Materials 2023年第8期26卷 231-248页

作者： Pengfei Tian Limin Zhao jua.Kim Xian Li Chunyu Liu Xu Cui Tao Liang Yunbo Du Xiehui Chen Haobo Pan Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055PR China Shenzhen Longhua District Central Hospital Shenzhen518000PR China Shenzhen Healthemes Biotechnology Co.Ltd Shenzhen518102PR China

The regeneration of alveolar bone is still clinical challenge,particularly accompanied with diabetes,causing metabolic disorder with a protracted low-grade inflammatory *** a result,the anticipated loading of biomaterials is highly suspicious in spontaneous modulation of cells function,which is mostly disturbed by constant *** this study,we developed glucose and hydrogen peroxide dual-responsive borosilicate glass(BSG)scaffolds loaded with epigallocatechin gallate(EGCG)to synergistically modulate the abnormal inflammation of diabetic alveolar bone *** was found that the release of EGCG by BSG could directly regulate the shift of macrophages from M1 to the M2 phenotype by promoting autophagy and lessening the inhibition of autophagic ***,EGCG can also indirectly regulate the polarization phenotype of macrophages by reducing the activation of NF-κb in stem cells and restoring its immunoregulatory ***,the addition of EGCG to BSG scaffold in diabetes allows for a more striking modulation of the macrophage phenotype in a timely *** altered macrophage phenotype reduces local inflammation and thus increases the ability to repair diabetic alveolar bone,showing promise for the treatment of alveolar defect in diabetic patients.

关键词： Borosilicate Epigallocatechin gallate(EGCG) Alveolar bone Autophagy Mitochondria Macrophage immunomodulatory Diabetes

Properties of Excitons Bound to Neutral Donors in GaAs-AlxGa1-xAs Quantum-Well Wires

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Communications in Theoretical Physics 2006年第5期45卷 945-949页

作者： DI Bing LIU Jian-jua College of Physics Hebei Normal University Shijiazhuang 050010 China

In the effective-mass approximation, using a simple two-parameter wave function and a one-dimensional （ID） equivalent potential model, we calculate variationally the binding energy of an exciton bound to a neutral donor （D^0, X） in finite GaAs-AIxGa1-xAs quantum well wires （QWWs）. At the wire width of 25 A, the binding energy has a peak value, which is also at the position of the peak of the exciton binding energy, and the center-of-mass wave functions of excitons reaches the most centralized distribution. In addition, the changing tendency of the average interparticle distance as the wire width is reverse to that of the binding energy.

关键词： quantum-well wires excitons bound to a neutral donor binding energy

Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects

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生物活性材料(英文) 2023年第5期23卷 101-117页

作者： Shuaijie Li Liyan Zhang Chunyu Liu jua.Kim Kun Su Tingli Chen Limin Zhao Xiaomei Lu Hao Zhang Yinglin Cui Xu Cui Feng Yuan Haobo Pan Department of Orthopedics Tongji HospitalSchool of MedicineTongji UniversityShanghai200065China Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of ScienceShenzhen518055China Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education and Tianjin College of BiotechnologyTianjin University of Science and Technology300457China Shenzhen Longhua District Central Hospital/the Affiliated Central Hospital of Shenzhen Longhua District Guangdong Medical UniversityShenzhen518110China Department of Orthopedics Shanxi Bethune HospitalTaiyuan030032China Shenzhen Key Laboratory of Marine Biomaterials Shenzhen Institute of Advanced TechnologyChinese Academy of ScienceShenzhen518055China

Injectable bone biomaterials like bone cement should be designed and fabricated with certain biological criteria,which include:1)recruitment and polarization of the macrophages from M1(pro-inflammatory)to M2(anti-inflammatory)phenotype,2)enhance vascularization,and 3)activate osteogenic differentiation of bone marrow-derived stem cells to promote bone *** far,no injectable biomaterials could spontaneously regulate the entire bone healing process that involves inflammation,angiogenesis,and ***,in this study,we designed bone cement comprised of strontium and copper-incorporated borosilicate glass(Sr/Cu-BSG)in the liquid phase of chitosan to modulate bone *** vitro studies showed that the controlled release of Sr and Cu ions up-regulated anti-inflammatory genes(IL-1Ra and TGF-β1)while down-regulating pro-inflammatory genes(IL-1βand IL-6)in macrophages at 3 *** and Cu ions also increased the expressions of angiogenic genes(VEGF and bFGF)in HUVECs at 5 days and osteogenic genes(Runx-2,OCN,and OPN)in hBMSCs at 7,14,and 21 days.5Sr3Cu-BSG bone cement exhibited the best anti-inflammatory,angiogenic,and osteogenic properties among the bone cement groups with different Sr and Cu ***-term and long-term implantation of Sr/Cu-BSGs in femoral condylar bone defects of rats and rabbits confirmed the in vitro results,where the degradation rate of Sr/Cu-BSG matched the bone healing *** to in vitro,the 5Sr3Cu-BSG group also showed the highest bone formation in *** physical and chemical properties,along with its bone repairing ability,make the Sr/Cu-BSG bone cement a good candidate biomaterial for treating bone defects.

关键词： Borosilicate glass bone cement Immunomodulation Angiogenesis Osteogenesis

Theoretical Investigation on QSAR of(2-Methyl-3-biphenylyl)methanol Analogs as PD-L1 Inhibitor

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Chinese Journal of Chemical Physics 2020年第4期33卷 459-467,I0001,I0002页

作者： Abdulla Al Mamun Zheng Mei Ling Qiu Xue-hai jua Key Laboratory of Soft Chemistry and Functional Materials of MOE School of Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China Jiangsu Institute of Nuclear Medicine Key Laboratory of Nuclear MedicineMinistry of HealthWuxi 214063China

Cancer is one of the most serious issues in human *** programmed cell death protein 1 and programmed death ligand-1(PD-L1)pathway is one of the great innovations in the last few years,a few numbers of inhibitors can be able to block it.(2-Methyl-3-biphenylyl)methanol derivative is one of ***,the quantitative structure-activity relationship(QSAR)established twenty(2-methyl-3-biphenylyl)methanol derivatives as the programmed death ligand-1 *** functional theory at the B3LPY/6-31+G(d,p)level was employed to study the chemical structure and properties of the chosen *** occupied molecular orbital energy EHOMO,lowest unoccupied molecular orbital energy ELUMO,total energy ET,dipole moment DM,absolute hardnessη,absolute electronegativityχ,softness S,electrophilicityω,energy gap?E,etc.,were observed and *** component analysis(PCA),multiple linear regression(MLR)and multiple nonlinear regression(MNLR)analysis were carried out to establish the *** proposed quantitative models and interpreted outcomes of the compounds were based on statistical *** results of MLR and MNLR exhibited the coefficient R^2 was 0.661 and 0.758,***-one-out cross-validation,r_m^2 metric,r_m^2 test,and"Golbraikh&Tropsha’s criteria"analyses were applied for the validation of MLR and MNLR,which indicate two models are statistically significant and well stable with data variation in the external validation towards *** obtained results showed that the MNLR model predicts the bioactivity more accurately than MLR,and it may be helpful and supporting for evaluation of the biological activity of PD-L1 inhibitors.

关键词： Quantitative structure-activity relationship 2-Methyl-3-biphenylyl methanol derivatives Programmed death ligand-1 inhibitor Density functional theory

认罪认罚从宽制度与检察官在刑事诉讼中的主导地位

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法学评论 2020年第3期38卷 1-11页

作者：贾宇浙江省人民检察院

作为一项重大诉讼制度改革,富含中国特色的认罪认罚从宽制度被正式确立,影响意义深远。检察机关在该项制度中扮演着国家追诉的执行者、案件移转的过滤者、诉讼程序的分流者、合法权益的保障者、诉讼活动的监督者五重角色,检察官在刑事... 详细信息

作为一项重大诉讼制度改革,富含中国特色的认罪认罚从宽制度被正式确立,影响意义深远。检察机关在该项制度中扮演着国家追诉的执行者、案件移转的过滤者、诉讼程序的分流者、合法权益的保障者、诉讼活动的监督者五重角色,检察官在刑事诉讼中的主导地位愈发凸显。新时代刑事检察工作应以此为契机,加快更新检察办案理念,深入推进捕诉一体改革,着力提升量刑建议质量,积极推动科技与办案融合,持续优化诉讼监督格局,切实做优刑事检察法律监督体系和法律监督能力现代化建设。

关键词：认罪认罚从宽制度捕诉一体角色定位检察主导刑事检察

抗美援朝运动时期的社会动员:历史动因、动员方式与现实启示

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延边大学学报（社会科学版） 2023年第4期56卷 49-57,142页

作者：吕健计娟沈阳航空航天大学马克思主义学院沈阳110136

抗美援朝运动时期开展的社会动员,创造了一个总体性动员中国人民精神与实践能量的政治社会时刻。广大民众在中国共产党的带领下以实际行动为抗美援朝战争的胜利提供了精神支撑和物质支持。新时代,社会动员也是凝聚社会力量和赢得民众支... 详细信息

抗美援朝运动时期开展的社会动员,创造了一个总体性动员中国人民精神与实践能量的政治社会时刻。广大民众在中国共产党的带领下以实际行动为抗美援朝战争的胜利提供了精神支撑和物质支持。新时代,社会动员也是凝聚社会力量和赢得民众支持的方式和手段。深入研究抗美援朝运动时期社会动员的历史背景,回溯历史动因,可从其动员方式中获得现实启示:坚持和加强党的全面领导是动员工作取得成功的根本保障;充分依靠人民群众主体力量是动员顺利开展的基础支撑;开展宣传教育工作是社会动员取得成效的重要手段。

关键词：抗美援朝运动社会动员中国共产党的领导人民群众主体力量宣传教育

Roadheader rear support system modeling and mechanical-hydraulic coupling system co-simulation research

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Roadheader rear support system modeling and mechanical-hydra...

PD-1、FOXP3和CSF-1R蛋白表达对霍奇金淋巴瘤患者预后的影响

第一届液压技术与矿山装备国际学术会议

作者： ZHAO Li-jua.ZHAO Xin Liaoning Technology University

In order to estimate the stability of the roadheader rear support system,took the heavy cantilever roadheader of a coal company as the research object,rigid-flex coupled dynamic model of its rear support system was established based on Pro/E,ADAMS and *** hydraulic control system model of rear support was researched in *** two models built the mechanical-hydraulic coupling *** the mechanical dynamic simulation results and verified the reliability of hydraulic system when the co-simulation of rear support was made.

关键词： rear support ADAMS EASY5 co-simulation

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中国实验血液学杂志 2018年第5期26卷 1372-1377页

作者：黎晓鹃何龙济南市第三人民医院肿瘤血液科山东济南250132

目的:研究集落刺激因子1受体(CSF-1R)、叉头转录因子3(FOXP3)和程序性死亡1(PD-1)蛋白表达对霍奇金淋巴瘤患者预后的影响。方法:记录本院收治的54例霍奇金淋巴瘤患者的临床特征资料和治疗方案。采集患者标本,采用免疫组织化学染色法检... 详细信息

目的:研究集落刺激因子1受体(CSF-1R)、叉头转录因子3(FOXP3)和程序性死亡1(PD-1)蛋白表达对霍奇金淋巴瘤患者预后的影响。方法:记录本院收治的54例霍奇金淋巴瘤患者的临床特征资料和治疗方案。采集患者标本,采用免疫组织化学染色法检测微环境相关的预后因子CSF-1R、FOXP3及PD-1蛋白表达,同时通过原位杂交技术检测EB病毒及其小编码的mRNA(EBER);探讨CSF-1R、FOXP3及PD-1 3种蛋白表达与霍奇金淋巴瘤患者预后的关系,并采用单因素分析和多因素分析(Cox比例风险模型)研究影响霍奇金淋巴瘤患者预后的相关因素。结果:54例霍奇金淋巴瘤患者中,CSF-1R^+22例(40. 74%),FOXP3高表达28例(51. 85%),PD-1^+9例(16. 67%)。单因素分析结果发现,国际预后指数(IPI)评分、EBER和FOXP3蛋白表达是霍奇金淋巴瘤患者无进展生存(PFS)的影响因素(均P <0. 05);临床分期(Ann Arbor分期)、IPI评分、EBER、CSF-1R和FOXP3蛋白表达是患者总生存(OS)的影响因素(均P <0. 05)。多因素分析(Cox比例风险模型)结果发现,EBER状态是霍奇金淋巴瘤患者PFS、OS的影响因素(P <0. 05); FOXP3蛋白表达是患者PFS的影响因素(P <0. 05); Ann Arbor分期、CSF-1R蛋白表达均是患者OS的影响因素(均P <0. 05)。结论:CSF-1R、FOXP3与霍奇金淋巴瘤患者的预后有密切联系,可为该病的靶向治疗提供一定的依据。

关键词：集落刺激因子1受体叉头转录因子3 程序性死亡1 霍奇金淋巴瘤