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A Retrospective Study of Pulmonary Actinomycosis in a Single Institution in China

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Chinese Medical Journal 2015年第12期128卷 1607-1610页

作者： Xue-Feng Sun Peng Wang hong-Rui Liu ju-hong shi Department of Respiratory Medicine Peking Union Medical College Hospital Beijing 100730 China Department of Clinical Microbiology Peking Union Medical College Hospital Beijing 100730 China Department of Pathology Peking Union Medical College Hospital Beijing 100730 China

Background：Actinomycosis is a rare indolent infectious disease caused by *** pulmonary actinomycosis is thought to be more prevalent in developing countries,data from developing countries are *** study was to reveal the current situation of pulmonary actinomycosis in developing countries and the difference from that in developed ***：Patients fulfilling the inclusion criteria for pulmonary actinomycosis from Peking Union Medical College Hospital in China between January 2003 and December 2014 were retrospectively *** characteristics,clinical symptoms,underlying diseases,diagnostic methods,pulmonary function test results,chest computed tomography （CT） tests,fluoro-2-deoxy-D-glucose positron emission tomography （FDG-PET） tests,initial diagnosis,treatment and prognosis were retrieved from medical records and ***：Twenty-six patients were included in this study （mean age 52.0 ＋ 13.1 years）.The ratio of male to female was 1.17：*** common clinical symptoms were cough （15/26）,sputum （12/26） and hemoptysis （12/26）.Chest CT findings presented as masses （13/26）,nodules （10/26） and infiltrates （3/26）.FDG-PET had an increased standardized uptake value and 4/6 patients were misdiagnosed as *** kinds of antibiotics were used in the treatment of pulmonary actonomycosis and all got favorable *** patients receiving complete resection of the lesion were cured without postoperative use of ***：Pulmonary actinomycosis is a rare disease even in developing countries,and both misdiagnosis and missed diagnosis are ***-PET seems useless in the differential diagnosis,and complete resection of the pulmonary lesion without postoperative antibiotic therapy might be enough to achieve cure.

关键词： Actinomycosis Computed Tomography Lung Misdiagnosis Treatment

Pathological and High Resolution CT Findings in Churg-Strauss Syndrome

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Chinese Medical Sciences Journal 2011年第1期26卷 1-8页

作者： Rui-e Feng Wen-bing Xu ju-hong shi Artin Mahmoudi Wen-bing MU Wen-jie Zheng Yuan-jue Zhu hong-rui Liu Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China Department of Pulmonary Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China Department of Pulmonary and Critical Care Medicine United Family Hospitals and Clinics-Beijing Beijing 100016 China Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China Department of Rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China

Objective To investigate the Churg-Strauss syndrome （CSS） associated lung involvement, concentrating on clinical characteristics, pathological findings of tung involvements, response to treatment, and prognosis. Methods We retrospectively analyzed the characters of the clinical manifestations, thin-section CT and pathological findings of CSS. The study involved 16 patients. Clinical data were obtained by chart review All patients underwent transbronchial lung biopsy （TBLB）. Six of them underwent surgical lung biopsy as well. Results The patients included 7 men and 9 women, aged from 14 to 61 years （median, 47.5 years）. Extrathoracic organs involved included nervous system （7/16） and skin （5/16）. Respiratory symptoms included cough （12/16）, exertional dyspnea （11/16）, hemoptysis （4/16）, and chest pain （3/16）. CT findings included bilateral ground-glass opacities （12 / 16）, bilateral patchy opacities （12 / 16）, and centrilobular nodules （6/16）. The pathological findings of TBLB demonstrated increased eosinophils （3/16）, vasculitis （3/16）, and interstitial pneumonia （16/16）. The pathological fmdings of surgical lung biopsy of 6 cases showed necrotizing vasculitis in 4 cases, capillaries in 5, eosinophilic pneumonia in 3, granulomas in 2, and airway abnormalities in 3. All patients improved in symptoms after therapy during the study period （range, 3 to 51 months; median, 15 months）. Conclusions Asthma may be present in CSS patient when there is bronchial involvement. Grotmd-glass opacities and consolidation seen on high-resolution CT reflect the presence of eosinophilic pneumonia, vasculitis, and pulmonary alveolar hemorrhage. TBLB has significant limitations for the diagnosis of CSS. Early diagnosis and therapy can result in satisfactory prognosis.

关键词： vasculitis asthma Churg-Strauss syndrome granulomatosis hypereosinophilia

Clinical Features and Prognosis in 21 Patients with Extrinsic Allergic Alveolitis

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Chinese Medical Sciences Journal 2009年第4期24卷 202-207页

作者： Ping Wang Zuo-jun Xu Wen-bing Xu ju-hong shi Xin-lun Tian Rui-e Feng Yuan-jue Zhu Department of Respiratory Medicine Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To assess the spectrum of causes, clinical features, differences between disease phases, and prognosis of extrinsic allergic alveolitis （EAA）. Methods Patients with EAA diagnosed at Peking Union Medical College Hospital from August 1983 to May 2007 were analyzed retrospectively. Their medical records were examined to gather clinical, laboratorial, radiological, and histopathological data. Patients were divided to three phases （acute, subacute, and chronic） according to clinical presentations. Follow-up data regarding treatment response, subsequent radio- logical and pulmonary function studies, and clinical outcomes were collected. Results A total of 21 cases were enrolled. Among them, 11 were subacute, 10 were chronic. The most common exposure was pet birds （6 cases, 28.6%）. The primary abnormality of pulmonary function was restriction and/or reduction in diffusing capacity （12 cases, 63.2%）. The most common findings on high-resolution computed tomography （HRCT） were ground-glass opacities （13 cases, 68.4%） and centri- lobular nodules （8 cases, 42.1%）. Airway obstruction in pulmonary function test, emphysema, hmg cysts, and fibrosis on HRCT were more frequently seen in chronic than in subacute patients, though the differences were not statistically significant. Bronchoalveolar lavage fluid （BALF） showed lymphocytosis. The total＇cell count and the percentage of neutrophils were significantly higher in subacute than in chronic patients （P〈0.05）. Nonnecrotizing granulomas were seen in 8 （47.1%） cases. Improvement or normalization in symptoms, radiography, and pulmonary function test after treatment were seen in all 18 patients with avail- able follow-up data. Five patients recurred. Conclusions The characteristic abnormalities of pulmonary function, findings on HRCT, and pa- thology are essential for all phases of EAA, and the atypical manifestations such as obstruction and fibrosis can also be present frequently, particularly in chronic cases. Differentia

关键词： extrinsic allergic alveolitis bronchoalveolar lavage fluid radiography histopathology prognosis

rypes of Organ Involvement in Patients with Immunoglobulin G4-related Disease

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Chinese Medical Journal 2016年第13期129卷 1525-1532页

作者： Yu Chen Ji-Zhi Zhao Rui-E Feng ju-hong shi Xue-Mei Li Yun-Yun Fei Yang shi Wen Zhang Feng-Chun Zhang Department of Rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100032 China Department of Stomatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Respiratory Peking Union Medical College Hospitar Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Rheumatology Traditional Chinese Medicine Hospital Capital Medical University Beijing 100010 China

Background： lmmunoglobulin G4-related disease （IgG4-RD） is a newly recognized systemic disease that can involve multiple organs and various clinical phenotypes. The purpose of this study was to analyze different types of organ involvement in IgG4-RD patients in China. Methods： We conducted a prospective cohort study on IgG4-RD patients to analyze the clinical manifestations and rare features oflgG4-RD. Patients were grouped into different types according to organ involvement regarding organ number and organ site. The constituent ratio in different types was also analyzed. Results： A total of 200 IgG4-RD patients, with a male：female ratio of 2.08：1, were grouped into different types, Cases having involvement of two or three organs were the most common whereas the fewest number of patients had multi-organ （≥4） involvement. Serum IgG4 and lgE levels, IgG4/IgG ratio, and percentage of eosinophils increased as the number of involved organs increased. In addition, constituent ratio analysis revealed that patients with salivary gland/lacrimal gland swelling, who also constituted the largest number of IgG4-RD patients, had higher serum IgG4 concentrations and IgG4/IgG values, had higher percentage of Eos, and were more likely to have had a history of allergies relative to patients with internal organ involvement. Conclusions： The characteristic feature of IgG4-RD is multiple organ involvement with various clinical manifestations and different types. Although serum IgG4 levels increased with the number of involved organs, serum IgG4 levels were higher for those patients with salivary gland/lacrimal gland swelling compared with those with internal organ involvement. Thus, valuable clues to the differential diagnosis of IgG4-RD could be obtained by examining the clinical patterns of organ involvement,

关键词： Immunoglobulin G4 lmmunoglobulin G4-related Disease Organ Involvement Prospective Cohort

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu hong-Wei Li Jian-hong shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling shi Quan-hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

应用中文版15条目重症肌无力生存质量量表对重症肌无力患者生存质量的调查

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北京大学学报（医学版） 2018年第3期50卷 514-520页

作者：苗晓慧连志云刘举陈虹西石紫燕周红雨杨蓉四川大学华西医院神经内科成都610041

目的:调查四川大学华西医院重症肌无力患者生存质量现状,并探讨其影响因素。方法:采用中文版15条目重症肌无力生存质量量表(myasthenia gravis quality of life-15,MGQOL-15)对四川大学华西医院符合标准的168例重症肌无力患者进行调查,... 详细信息

目的:调查四川大学华西医院重症肌无力患者生存质量现状,并探讨其影响因素。方法:采用中文版15条目重症肌无力生存质量量表(myasthenia gravis quality of life-15,MGQOL-15)对四川大学华西医院符合标准的168例重症肌无力患者进行调查,并收集患者的一般资料和临床资料,包括性别、年龄、体重指数(body mass index,BMI)、婚姻状况、文化程度、工作状况、MG分型(Osserman分型)、MG严重程度(myasthenia gravis composite,MGC)得分、是否伴随其他免疫疾病、病程、每月门诊复诊次数、每月疾病花费/收入比、过去1个月症状出现次数等。结果:168例重症肌无力患者,MGQOL-15总得分为(17.67±12.78)分,其中得分最高的前三条目为"工作能力和工作状态受影响、出现下降"(1.661分),"用眼有困难"和"对重症肌无力感到无奈"。单因素分析显示,重症肌无力患者疾病严重程度MGC得分(F=19.353,P<0.001)、每月疾病花费/收入比(F=5.831,P<0.001)、过去1个月症状出现次数不同(F=9.128,P<0.001),患者MGQOL-15得分差异具有统计学意义;多元线性回归分析显示患者疾病严重程度得分(β=0.743,P<0.001)、每月疾病花费/收入比(β=3.347,P<0.001)、过去1个月症状出现次数(β=2.216,P<0.003)是患者MGQOL-15得分的影响因素。结论:MGQOL-15有助于临床医护人员对重症肌无力患者生存质量及影响因素进行判断。重症肌无力患者疾病严重程度、每月疾病花费/收入比和过去1个月症状出现次数是患者生存质量的重要影响因素,医护人员应重视MG患者疾病严重程度和过去1个月症状出现次数等指标评估。

关键词：重症肌无力生存质量 15条目重症肌无力生存质量量表

Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang jue Tang Mansheng Chu Quan shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

针对性干预措施对新生儿医院感染预防效果分析

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中华医院感染学杂志 2017年第7期27卷 1627-1630页

作者：王秀菊王红娟时文玲张玉娟吴玉梅滨州医学院附属医院健康管理部山东滨州256603 滨州医学院附属医院新生儿与新生儿重症科山东滨州256603

目的探讨针对性干预措施对新生儿医院感染预防效果,为临床治疗提供参考依据。方法选取2014年1月-2015年12月医院儿科病房住院的3 234例新生儿为研究对象,根据入院时间分为两组,对照组为2014年住院的新生儿1 540例,实施常规医院感染干预... 详细信息

目的探讨针对性干预措施对新生儿医院感染预防效果,为临床治疗提供参考依据。方法选取2014年1月-2015年12月医院儿科病房住院的3 234例新生儿为研究对象,根据入院时间分为两组,对照组为2014年住院的新生儿1 540例,实施常规医院感染干预措施,观察组为2015年住院的新生儿1 694例,实施针对性医院感染干预措施,比较两组患者临床指标。结果对照组发生医院感染75例,感染率为4.87%,显著高于观察组2.54%,两组比较,观察组医院感染率显著降低,差异有统计学意义(P<0.05);两组新生儿感染部位以导管相关性感染为主,观察组占23.26%,对照组占24.00%;对照组培养分离出42株病原菌,观察组培养分离出35株病原菌,两组病原菌均以大肠埃希菌为主,对照组大肠埃希菌12株占30.95%,观察组大肠埃希菌10株占28.57%;经logistic多因素分析显示,新生儿年龄、体质量、早产、存在侵入性操作、抗菌药物应用均为新生儿发生医院感染的独立危险因素(P<0.05)。结论新生儿发生医院感染的危险因素较多,针对性医院感染干预措施可有效降低新生儿医院感染发生率,医院应对医护人员的工作加强管理,以防控医院感染的发生。

关键词：新生儿医院感染针对性干预措施预防效果