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Exosomes:the next-generation therapeutic platform for ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing yang Jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： Fan yang Zhaoyang MA Xingming GUO Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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结直肠癌肝转移的危险因素分析

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中华消化外科杂志 2008年第4期7卷 287-289页

作者：颜登国张汝一鞠冬阳甄运寰姬清华贵阳医学院附属医院肛肠外科 550004

目的探讨影响结直肠癌肝转移的危险因素。方法回顾性分析1989年1月至2004年12月收治的1341例结直肠癌患者的临床资料。结果1341例结直肠癌患者中有肝转移者155例，发生率为11．56％。性别、原发肿瘤部位和大小、区域淋巴结转移、肠壁浸... 详细信息

目的探讨影响结直肠癌肝转移的危险因素。方法回顾性分析1989年1月至2004年12月收治的1341例结直肠癌患者的临床资料。结果1341例结直肠癌患者中有肝转移者155例，发生率为11．56％。性别、原发肿瘤部位和大小、区域淋巴结转移、肠壁浸润层次、邻近脏器侵犯、合并症和腹腔种植影响肝转移（X^2=6．517，10．208，11．173，42．160，80．731，6．593，3．887，14．352，P〈0．05）。logistic回归分析显示，性别、区域淋巴结转移、肠壁浸润层次、合并症和原发肿瘤部位与结直肠癌肝转移有关（b=0．655，-0．488，1．355，-0．752，0．273，P〈0．05）。结论男性、有区域淋巴结转移、肿瘤侵犯浆膜外组织的结直肠癌患者更容易发生肝转移；结肠癌较直肠癌更容易发生肝转移；有合并症的患者发生肝转移的几率小。

关键词：结肠肿瘤直肠肿瘤肝转移危险因素

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Microstructure evolution and thermal physical properties of CuCr alloy after high pressure treatment

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Rare Metals 2014年第3期33卷 293-298页

作者： Yu-Quan Ma Hong-ju Lin dong-dong SongMechanical and Electrical Engineering College Hebei Normal University of Science and Technology

The thermal diffusion coefficient, thermal conductivity, and thermal expansion coefficient of CuCr alloy prepared by infiltration were measured by thermal constant tester and dilatometer before and after high pressure heat treatment, at the same time, the effect of high pressure treatment on the thermal physical properties of CuCr alloy was discussed by the analysis of its microstructure. The experimental results show that high pressure heat treatment can increase the thermal diffusion coefficient and thermal conductivity of CuCr alloy, but it changes slightly in the pressure range of 1-6 GPa. As for thermal expansion coefficient, when the temperature is higher than 130 °C, it is obviously higher than that of the alloy without high pressure treatment after 1 GPa pressure treatment, and the higher the temperature is, the larger their differences are.

关键词： CuCr alloy High pressure treatment Thermaldiffusion coefficient Thermal conductivity Thermalexpansion coefficient

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Sex differences in aging and injured brain

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Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson Yuan yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Prediction of preferential fluid flow in porous structures based on topological network models: Algorithm and experimental validation

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Science China(Technological Sciences) 2018年第8期61卷 1217-1227页

作者： ju yang LIU Peng ZHANG dongShuang dong JiaBin RANJITH P.G. CHANG Chun State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology School of Mechanics and Civil Engineering China University of Mining & Technology School of Resources and Safety Engineering China University of Mining & Technology Institute of Mechanics Chinese Academy of Science Department of Civil Engineering Monash University

The understanding and prediction of preferential fluid flow in porous media have attracted considerable attention in various engineering fields because of the implications of such flows in leading to a non-equilibrium fluid flow in the subsurface. In this study, a novel algorithm is proposed to predict preferential flow paths based on the topologically equivalent network of a porous structure and the flow resistance of flow paths. The equivalent flow network was constructed using Poiseuille's law and the maximal inscribed sphere algorithm. The flow resistance of each path was then determined based on Darcy's law. It was determined that fluid tends to follow paths with lower flow resistance. A computer program was developed and applied to an actual porous structure. To validate the algorithm and program, we tested and recorded two-dimensional(2 D) water flow using an ablated Perspex sheet featuring the same porous structure investigated using the analytical calculations. The results show that the measured preferential flow paths are consistent with the predictions.

关键词： preferential flow porous structure topological networks flow resistance Darcy's law experimental validation

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Calibration of Camera with Large Field-of-View Based on Flexible Planar Target

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Journal of Harbin Institute of Technology(New Series) 2013年第4期20卷 14-20页

作者： ju Huo Wen-Bo dong Ning yang Wu-Kang Lin Dept.of Electrical Engineering Harbin Institute of Technology Control and Simulation Center Harbin Institute of Technology

For high precision calibration of camera with large field-of-view,massive calibration points will be needed if traditional methods are selected,which makes the calibration complex and *** order to solve this problem,a calibration method based on flexible planar target is *** this method,distortion factor is firstly acquired by the invariance of cross ratio,and existing feature points are adjusted with the distortion ***,a large number of points that will be used for the calibration are constructed with the adjusted feature ***,Tsai method is modified so as to reduce the complexity of calibration,which makes the process *** simulation and real experiments show that the method proposed in this paper is simple,linear,accurate and robust,and the precision of this method is close to that of Tsai method using abundant *** method can satisfy the requirement of high precision calibration for camera with large field-of-view.

关键词： large field-of-view calibration distortion factor flexible planar target linear two-step method

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Elastic Low-Energy Electron Collisions with Methanethiol

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Chinese Journal of Chemical Physics 2015年第6期28卷 -页

作者： Ke-dong Wang ju Meng Institute of Theoretical and Computational Chemistry Key Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 ChinaSchool of Physics and Electronical Engineering Henan Normal University Xinxiang 453007 China School of Physics and Electronical Engineering Henan Normal University Xinxiang 453007 China

We report ab initio scattering calculations results of electron-methanethiol collisions using R-matrix approach within the static-exchange and static-exchange-polarization approximations. The calculated elastic integral cross sections are in agreement with the experimental data. Two shape resonances of 2A′ symmetry located at 4.06 and 8.32 eV are detected within static-exchange-polarization model. For this dipole molecule, Born-closure procedure was used to account for the higher partial waves (l>4) for the convergence of the cross section. The effective collision frequencies over a wide electron temperature range (200–30000 K) are calculated using the data of the momentum-transfer cross section.

关键词： Elastic integral cross sections Differential cross section Shape resonance

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