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Deep learning in hepatocellular carcinoma:Current status and future perspectives

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World Journal of Hepatology 2021年第12期13卷 2039-2051页

作者： Joseph C Ahn Touseef Ahmad Qureshi Amit G Singal Debiao Li ju-dong yang Gastroenterology and Hepatology Mayo ClinicRochesterMN 55904United States Biomedical Imaging Research Institute Cedars-Sinai Medical CenterLos AngelesCA 90048United States Internal Medicine University of Texas Southwestern Medical CenterDallasTX 75390United States Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCA 90048United States

Hepatocellular carcinoma(HCC)is among the leading causes of cancer incidence and *** decades of research and development of new treatment options,the overall outcomes of patients with HCC continue to remain *** are areas of unmet need in risk prediction,early diagnosis,accurate prognostication,and individualized treatments for patients with *** years have seen an explosive growth in the application of artificial intelligence(AI)technology in medical research,with the field of HCC being no *** the various AI-based machine learning algorithms,deep learning algorithms are considered state-of-the-art techniques for handling and processing complex multimodal data ranging from routine clinical variables to high-resolution medical *** article will provide a comprehensive review of the recently published studies that have applied deep learning for risk prediction,diagnosis,prognostication,and treatment planning for patients with HCC.

关键词： Hepatocellular carcinoma Artificial intelligence Deep learning

Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 751-756页

作者： Yee Hui Yeo Xinyuan He Fan Lv Yunyu Zhao Yi Liu ju dong yang Jian Zu Fanpu Ji Mindie H.Nguyen Division of General Internal Medicine Cedars-Sinai Medical CenterLos AngelesCaliforniaUSA Department of Infectious Diseases the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina School of Mathematics and Sta-tistics Xi’an Jiaotong UniversityXi’anShaanxiChina Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCAUSA National&Local Joint Engineering Research Center of Biodiagnosis and Biotherapy the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and Hepa-tology Stanford University Medical CenterPalo AltoCaliforniaUSA Department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCaliforniaUSA

Immunocompromised status and interrupted routine care may render patients with cirrhosis vulnerable to the coronavi-rus disease 2019(COVID-19)pandemic.A nationwide data-set that includes more than 99%of the decedents in the *** April 2012 and September 2021 was *** age-standardized mortality during the pandemic were esti-mated according to prepandemic mortality rates,stratified by *** deaths were determined by estimating the difference between observed and projected mortality rates.A temporal trend analysis of observed mortality rates was also performed in 0.83 million decedents with cirrhosis between April 2012 and September 2021 was *** an increasing trend of cirrhosis-related mortality before the pandemic,with a semiannual percentage change(SAPC)of 0.54%[95%confidence interval(CI):(0.0-1.0%),p=0.036],a precipitous increase with seasonal variation occurred dur-ing the pandemic(SAPC 5.35,95%CI:1.9-8.9,p=0.005).Significantly increased mortality rates were observed in those with alcohol-associated liver disease(ALD),with a SAPC of 8.44(95%CI:4.3-12.8,p=0.001)during the ***-cause mortality of nonalcoholic fatty liver disease rose stead-ily across the entire study period with a SAPC of 6.79(95%CI:6.3-7.3,p<0.001).The decreasing trend of HCV-related mortality was reversed during the pandemic,while there was no significant change in HBV-related *** there was significant increase in COVID-19-related deaths,more than 55%of the excess deaths were the indirect impact of the *** observed an alarming increase in cirrhosis-related deaths during the pandemic especially for ALD,with evidence in both direct and indirect *** findings have implications on formulating policies for patients with cirrhosis.

关键词： Cirrhosis mortality Alcohol-associated liver disease Epidemiology Nonalcoholic fatty liver disease COVID-19

Hepatocellular carcinoma surveillance:current practice and future directions

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Hepatoma Research 2022年第1期8卷 157-168页

作者： Joseph CAhn Yi-Te Lee Vatche GAgopian Yazhen Zhu Sungyong You Hsian-Rong Tseng ju dong yang Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905USA California NanoSystems Institute Crump Institute for Molecular ImagingUniversity of CaliforniaLos AngelesCA 90095USA Department of Molecular and Medical Pharmacology University of CaliforniaLos AngelesCA 90095USA Department of Surgery University of CaliforniaLos AngelesCA 90095USA Jonsson Comprehensive Cancer Center University of CaliforniaLos AngelesCA 90048USA Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical CenterLos AngelesCA 90048USA Departments of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048USA Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCA 90048USA Comprehensive Transplant Center Cedars-Sinai Medical Center Los AngelesCA 90048USA

Hepatocellular carcinoma(HCC)is among the leading causes of cancer incidence and mortality *** of individuals with cirrhosis or other conditions that confer a high risk of HCC development is essential for early detection and improved overall *** ultrasonography with or without alpha-fetoprotein is widely recommended as the standard method for HCC surveillance,but it has limited sensitivity in early disease and may be inadequate in certain *** review article will provide a comprehensive overview of the current landscape of HCC surveillance,including the rationale and indications for HCC surveillance,standard methods for HCC surveillance,and their strengths/*** surveillance methods such as the role of cross-sectional imaging,emerging circulating biomarkers,as well as the problem of under-utilization of HCC surveillance and surveillance-related harms will also be discussed in this review.

关键词： Hepatocellular carcinoma surveillance cirrhosis hepatitis B virus alpha-fetoprotein liquid biopsy under-utilization

Current impact of viral hepatitis on liver cancer development: The challenge remains

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World Journal of Gastroenterology 2021年第24期27卷 3556-3567页

作者： Ângelo Zambam de Mattos Jose D Debes Andre Boonstra ju-dong yang Domingo C Balderramo Giovana D P Sartori Angelo Alves de Mattos Department of Gastroenterology and Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Brazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90050-170Brazil Department of Medicine Division of Gastroenterology and Infectious DiseasesUniversity of MinnesotaMinneapolisMN 55455United States Department of Gastroenterology and Hepatology Erasmus Medical CenterRotterdam NL-3015Netherlands Division of Digestive and Liver Diseases Department of MedicineCedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Gastroenterology Hospital Privado Universitario de CórdobaCórdoba 5016Argentina Department of Medicine Instituto Universitario de Ciencias Biomédicas de CórdobaCórdoba 5016Argentina Department of Internal Medicine Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Brazil

Chronic infections due to hepatitis B and hepatitis C viruses are responsible for most cases of hepatocellular carcinoma(HCC)worldwide,and this association is likely to remain during the next ***,viral hepatitis-related HCC imposes an important burden on public health in terms of disability-adjusted life *** order to reduce such a burden,some major challenges must be *** vaccination against hepatitis B virus,especially in the neonatal period,is probably the most relevant primary preventive measure against the development of ***,considering the large adult population already infected with hepatitis B and C viruses,it is also imperative to identify these individuals to ensure their access to *** hepatitis B and C currently have highly effective therapies,which are able to diminish the risk of development of liver ***,it is essential for individuals at high-risk of HCC to be included in surveillance programs,so that tumors are detected at an early *** with hepatitis B or C and advanced liver fibrosis or cirrhosis benefit from being followed in a surveillance *** hepatitis B virus is oncogenic and capable of leading to liver cancer even in individuals with early stages of liver fibrosis,other high-risk groups of patients with hepatitis B are also candidates for *** effort is required concerning these strategies in order to decrease the incidence and the mortality of viral hepatitis-related HCC.

关键词： Hepatitis B virus Hepatitis C virus Hepatocellular carcinoma Epidemiology Vaccination Surveillance

Metformin does not improve survival in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第42期20卷 15750-15755页

作者： Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck ju dong yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine Division of Gastroenterology McGill University Health Centre Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Thai Red Cross Society Division of Biomedical Statistics and Informatics Mayo Clinic College of Medicine

AIM: To assess whether metformin, which has a chemopreventive effect in chronic liver disease, has any chemotherapeutic effect in hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Metformin Diabetes Survival Liver disease Lactic acidosis

Hepatic sinusoidal obstruction syndrome due to tacrolimus in a liver-transplantation recipient

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Gastroenterology Report 2021年第5期9卷 485-487,I0003页

作者： Shuang-Nan Zhou Dan-Ni Feng Ning Zhang Yan-Ling Sun Yong-Wu Li Xia Zhou ju dong yang Zhen-Wen Liu Hong-Ling Liu Liver Transplantation Center Fifth Medical Center of Chinese PLA General HospitalBeijingP.R.China Department of Integrated TCM&Western Medicine Fifth Medical Center of Chinese PLA General HospitalBeijingP.R.China Department of Radiology Fifth Medical Center of Chinese PLA General HospitalBeijingP.R.China Division of Digestive and Liver Diseases Department of MedicineCedars Sinai Medical CenterLos AngelesCAUSA Samuel Oschin Comprehensive Cancer Institute Cedars Sinai Medical CenterLos AngelesCAUSA Comprehensive Transplant Center Cedars Sinai Medical CenterLos AngelesCAUSA

Introduction Hepatic sinusoidal obstruction syndrome(HSOS)is a hepatic vascular disease characterized by injury of the endothelial cells in the sinusoidal hepatic and interlobular veins,intra-hepatic congestion,liver dysfunction,and portal hypertension[1].In Western countries,HSOS is often associated with myeloablative regimens used for hematopoietic stem-cell transplantation,while,in China,it is often associated with oral intake of Gynura segetum plants that contain pyrrolidine alkaloids[2].In addition,new-onset HSOS after solid-organ transplantation has received increasing attention[3-8].

关键词：肝移植术后他克莫司肝窦

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热力学计算模拟对月球镁质岩套源区的约束

矿物岩石地球化学通报 2021年第5期40卷 1154-1165页

作者：鞠东阳杜蔚李瑞庞润连中国科学院地球化学研究所矿床地球化学国家重点实验室贵阳550081 中国科学院大学北京100049 中国科学院比较行星学卓越创新中心合肥230026

镁质岩套是月球上最重要的岩石之一。通常认为该类岩石的母岩浆来自月幔翻转引起的深部物质的减压熔融或者月壳底部的混合杂化。但是,这两类模型分别面对无法重现样品中橄榄石的Cr_(2)O_(3)含量过低等地球化学特征,也无法解释镁质岩套... 详细信息

镁质岩套是月球上最重要的岩石之一。通常认为该类岩石的母岩浆来自月幔翻转引起的深部物质的减压熔融或者月壳底部的混合杂化。但是,这两类模型分别面对无法重现样品中橄榄石的Cr_(2)O_(3)含量过低等地球化学特征,也无法解释镁质岩套与其他月球样品年龄重合的问题。本文采用热力学计算方法,通过改变源区物质组成、熔融程度、熔融方式及结晶方式等参数,对两种模型进行了一系列的正演研究。结果表明,月球的镁质岩套有多种成因:月幔物质减压熔融形成的熔体通过平衡结晶可以形成镁质岩套,并满足样品中橄榄石Cr_(2)O_(3)含量的制约;减压熔融模型可以解释某些月球样品年龄的重合,但是成分较为单一,而混合杂化模型形成的镁质岩套成分范围较广。

关键词：热力学计算镁质岩套减压熔融混合杂化月壳年龄

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei dong Fei Luan juanjuan yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan junling Lü Chunchi Zhang dong Liang Lei yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array