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Investigation into the structures and physicochemical properties of multi-component crystals of voriconazole

Chinese Chemical Letters 2023年第6期34卷 504-511页

作者： Hong-mei Yu Bao-Xi Zhang Wen-Hui Xing mei-ju liu Feng-Feng Wang Ning-Bo Gong Li Zhang Yang Lu Guan-Hua Du Beijing Key Laboratory of Polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China National Institutes for Food and Drug Control Beijing 102629China Beijing City Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Voriconazole(VZL)is a second-generation and broad-spectrum triazole against fungal *** a BCS(biopharmaceutics classification system)class II compound,the poor aqueous solubility has limited its bioavailability and clinical *** to overcome this disadvantage,a cocrystallization strategy based on crystal engineering principles has resulted in five new multi-component crystals of VZL with maleic acid,L-tartaric,protocatechuic,gallic,and 3,5-dinitrobenzoic *** analysis revealed that the hydroxyl/carboxylic acid···triazole N_(3)hydrogen bonding interaction appears as a main supramolecular heterosynthon in the VZL multi-component crystals with organic *** VZL molecule has a flexible conformation in each of the five multi-component *** newly synthesized multi-component crystals showed impressive solubility improvement compared to that of the raw material of *** electrostatic potential surfaces(MEPS)analysis based on density functional(DFT)calculations revealed that hydrogen bond interactions in cocrystals mainly involved pairwise interactions in the global maxima and minima sites,but this rule is not always *** study indicates the potential of cocrystals to improve the solubility and dissolution rate of VZL.

关键词： Multi-component crystal Voriconazole Solubility Dissolution Stability

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay liu Young-ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

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Neuroglobin promotes neurite outgrowth via differential binding to PTEN and Akt

Neuroglobin promotes neurite outgrowth via differential bind...

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中国神经科学学会第十届全国学术会议

作者： Li Li Qian-Rong liu Xiri-Xin Xiong ju-mei liu Xiao-Jing Lai Yong Chen Feng Pan Shang-Bin Yu Albert Cheung Hoi Yu Xiao-Qian Chen School of Basic Medicine Tongji Medical College Key Laboratory of Neurological Diseases Ministry of EducationHubei Provincial Key Laboratory of Neurological Diseases Huazhong University of Science and Technology School of Basic Medical Sciences Health Science Center Neuroscience Research Institute Key Laboratory for Neuroscience Ministry of Education KeyLaboratory for Neuroscience Ministry of Public Health Peking University

Neuroglobin,the third mammalian globin with a hexa-coordinated heme,exists predominantly in neurons of *** plays an important role in neuronal death upon ischemia and oxidative *** physiological function of neuroglobin remains ***,we report a novel function of neuroglobin in neurite ***-down neuroglobin exhibited a prominent neurite-deficient phenotype in mouse neuroblastoma N2a *** neuroglobin prevented neurite outgrowth while ectopic expression of neuroglobin but not homologous cytoglobin promoted neurite outgrowth of N2a cells upon serum *** primary cultured rat cerebral cortical neurons,neuroglobin was up-regulated and preferentially distributed in neurites during neuronal *** of neuroglobin but not cytoglobin in cultured cortical neurons promoted axonal outgrowth while knocking-down of neuroglobin retarded axonal *** overexpression suppressed phosphatase and tensin homolog（PTEN） but increased Akt phosphorylation during neurite *** fluorescence complementation and glutathione S-transferase pull-down assays revealed mat neuroglobin and various mutants（E53Q,E118Q,K119N,H64A,H64L,Y44D） bound with Akt and PTEN *** E53Q mutant showed a prominent reduced PTEN-binding but increased Akt-binding,resulting in decreased p-PTEN,increased p-Akt and increased neurite *** together,we demonstrate a critical role of neuroglobin in neuritogenesis or development via interacting with PTEN and Akt differentially to activate PI3K/Akt pathway,providing potential therapeutic applications of neuroglobin for axonopathy in neurological diseases.

关键词： Ngb neuron axon regeneration PI3K/Akt

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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao mei Tian Jian Wang Fengtao liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-Qiang Jiao Ming Li Xi Chen mei-Ze Xu Tian Ding Xiao-Ping Gong Zhuo-mei Li Xue-Yuan liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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民营医院绩效工资分配中存在的问题与管理对策探讨

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中国卫生产业 2020年第31期17卷 57-59页

作者：居留妹王妍艺扬州洪泉医院人力资源部江苏扬州225200

建立符合民营医院行业特点的、科学合理的绩效工资分配制度,是当前民营医院医疗改革工作亟待解决的问题。该文以扬州洪泉医院为例,对民营医院绩效工资分配问题进行研究,阐述绩效工资的基本含义与分配原则,指出绩效工资分配可以调动医务... 详细信息

建立符合民营医院行业特点的、科学合理的绩效工资分配制度,是当前民营医院医疗改革工作亟待解决的问题。该文以扬州洪泉医院为例,对民营医院绩效工资分配问题进行研究,阐述绩效工资的基本含义与分配原则,指出绩效工资分配可以调动医务人员积极性,有利于医院新技术提升与长期稳定发展。分析民营医院各临床科室主任自行决定奖金分配所导致的问题,并以此为据制定并实施改革措施,重新规定了科主任的奖金发放方法,以及科主任兼医疗组长的奖金分配等,在保护科主任权益的同时,也增加了年轻工作人员的绩效,实现了人才引得进、留得住、用得好,有利于提升医院效益,打造特色品牌,促进长期发展。

关键词：民营医院绩效工资工资分配问题管理对策

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Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang Jia-Qian ju Jing-Cai liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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用SPSS建立岳阳名优黄茶的产量预测模型

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茶叶通讯 2017年第2期44卷 20-24页

作者：覃鸿郑露黄菊梅刘学洞庭湖气候中心湖南岳阳414000 岳阳市气象局湖南岳阳414000 岳阳市农业委员会湖南岳阳414000 华容县气象局湖南华容414200

利用湖南省汨罗市2003~2014年期间上年12月上旬至下年5月下旬的逐日气象观测资料及岳阳县黄沙街茶叶示范场2004~2014年名优茶产量资料,在计算上运用界面友好的SPSS软件,采用逐步回归方法,对名优黄茶产量与气象条件之间的关系进行分析研... 详细信息

利用湖南省汨罗市2003~2014年期间上年12月上旬至下年5月下旬的逐日气象观测资料及岳阳县黄沙街茶叶示范场2004~2014年名优茶产量资料,在计算上运用界面友好的SPSS软件,采用逐步回归方法,对名优黄茶产量与气象条件之间的关系进行分析研究。结果表明:名优茶产量与气象条件之间有着密切的关系,与2月平均风速、1月上旬平均相对湿度、1月中旬平均最高气温等3个气候因子显著相关,逐步回归后建立的春茶产量预测的数学模型,平均预报精确度达到95%,检验效果良好。

关键词： SPSS 黄茶产量预测模型气候因子

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三甲基硅重氮甲烷衍生化-气相色谱法测定水果蔬菜中乙烯利的残留

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农药学学报 2018年第4期20卷 495-499页

作者：陈克云王艳丽沈祥震鞠香胡梅刘艳明祝建华山东省食品药品检验研究院

针对水果蔬菜中乙烯利的残留,建立了三甲基硅重氮甲烷衍生化-气相色谱的分析方法。样品用V（甲醇）：V（盐酸）=9：1的溶液提取,无水乙醚萃取,三甲基硅重氮甲烷衍生化15 min,采用气相色谱-质谱法定性,气相色谱仪-火焰光度检测器（GC-FP... 详细信息

针对水果蔬菜中乙烯利的残留,建立了三甲基硅重氮甲烷衍生化-气相色谱的分析方法。样品用V（甲醇）：V（盐酸）=9：1的溶液提取,无水乙醚萃取,三甲基硅重氮甲烷衍生化15 min,采用气相色谱-质谱法定性,气相色谱仪-火焰光度检测器（GC-FPD）检测,外标法定量。结果显示：在0.01～2 mg/L范围内,乙烯利的质量浓度与其对应的峰面积间线性关系良好,相关系数大于0.999 6;此方法检出限为0.01 mg/kg,定量限为0.03 mg/kg;在辣椒、番茄、香蕉、苹果和梨的空白果蔬样品中分别添加0.01、0.1和1 mg/kg 3个水平下,回收率为93%～102%,相对标准偏差为4.2%～7.3%。该方法准确度和灵敏度高,抗干扰能力强,能准确并快速测定出水果、蔬菜中乙烯利的残留量。

关键词：三甲基硅重氮甲烷衍生化气相色谱水果蔬菜乙烯利残留

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双歧杆菌四联活菌片对类风湿关节炎患者TNF-α和脂联素水平的影响

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泰山医学院学报 2017年第7期38卷 761-764页

作者：高举梅刘毅刘冰孔祥慧胡海建临沂市中心医院风湿免疫科山东临沂276400

目的探讨肠道微生态制剂对类风湿关节炎患者TNF-α和脂联素水平的影响。方法 2015年1月—2017年1月收治类风湿关节炎患者100例,随机分为对照组和观察组各50例,两组患者均给予非甾体抗炎药、甲氨蝶呤、来氟米特等药物控制病情。在上述常... 详细信息

目的探讨肠道微生态制剂对类风湿关节炎患者TNF-α和脂联素水平的影响。方法 2015年1月—2017年1月收治类风湿关节炎患者100例,随机分为对照组和观察组各50例,两组患者均给予非甾体抗炎药、甲氨蝶呤、来氟米特等药物控制病情。在上述常规治疗方案的基础上,观察组患者给予双歧杆菌四联活菌片,剂量为每日3次,每次3片,共观察12周,对两组患者治疗前后的临床症状和实验室检查进行评价和比较,对疗效和安全性进行观察和分析。结果观察12周后,两组患者晨僵、压痛关节数、肿胀关节数、握力、病评、医评、DAS28评分、血沉、CRP、TNF-α、脂联素水平均有好转,差异有统计学意义(P<0.05);与未加用双歧杆菌四联活菌片的对照组相比,50例采用双歧杆菌四联活菌片治疗的观察组患者临床症状和实验室指标好转更加明显(P<0.05)。结论肠道微生态制剂益生菌补充治疗可以减轻类风湿关节炎的临床症状,改善炎症指标,起到控制病情作用。

关键词：类风湿关节炎脂联素 TNF-α 双歧杆菌四联活菌片

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