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Repurposing ibrutinib:therapeutic effects and implications for translational approaches in Alzheimer’s disease

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Neural Regeneration Research 2023年第10期18卷 2194-2195页

作者： hyun-ju lee Hyang-Sook Hoe Department of Neural Development and Disease Korea Brain Research Institute(KBRI)DaeguSouth Korea Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science&TechnologyDaegu 42988South Korea

Alzheimer’s disease(AD)is the most prevalent neurodegenerative disease,and the number of patients with AD is estimated to double by 2060(Alzheimer’s Association,2022).The AD mortality rate has increased by 145%over the last decade,the largest increase among the ten leading causes of death in the US(Alzheimer’s Association,2022).

关键词： Alzheimer mortality therapeutic

The photodynamic therapy on Streptococcus mutans biofilms using erythrosine and dental halogen curing unit

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International Journal of Oral Science 2012年第4期4卷 196-201页

作者： Young-Ho lee Ho-Won Park ju-hyun lee hyun-Woo Seo Si-Young lee Department of Pediatric Dentistry Graduate SchoolCollege of DentistryGangneung-Wonju National University Department of Pediatric Dentistry College of DentistryGangneung-Wonju National University Department of Microbiology and Immunology College of DentistryGangneung-Wonju National University

The purpose of our study was to evaluate the effect of photodynamic therapy （PDT）, using erythrosine as a photosensitizing agent and a dental halogen curing unit as a light source, on Streptococcus mutans in a biofilm phase. The S. mutans biofilms were formed in a 24-well cell culture cluster. Test groups consisted of biofilms divided into four groups： group 1： no photosensitizer or light irradiation treatment （control group）; group 2： photosensitizer treatment alone; group 3： light irradiation alone; group 4： photosensitizer treatment and light irradiation. After treatments, the numbers of colony-forming unit （CFU） were counted and samples were examined by confocal laser scanning fluorescence microscopy （CLSM）. Only group 4 （combined treatment） resulted in significant increases in cell death, with rates of 75% and 55% after 8 h of incubation, and 74% and 42% at 12 h, for biofilms formed in brain-heart infusion （BHI） broth supplemented with 0% or O. 1% sucrose, respectively. Therefore, PDT of S. mutans biofilms using a combination of erythrosine and a dental halogen curing unit, both widely used in dental clinics, resulted in a significant increase in cell death. The PDT effects are decreased in biofilms that form in the presence of sucrose.

关键词： biofilms dental halogen curing unit erythrosine photodynamic therapy Streptococcus mutans

Measuring the spatial and social characteristics of the architectural plans of aged care facilities

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Frontiers of Architectural Research 2017年第4期6卷 431-441页

作者： ju hyun lee Michael J. Ostwaid hyunsoo lee School of Architecture and Built Environment The University of Newcastle Callaghan NSW 2308 Australia Department of Interior Architecture and Built Environment Yonsei University Seoul 03722 Republic of Korea

This paper presents a method that combines visibility graph and isovist analyses to investigate the spatia[ and social properties of architectural plans for aged care facilities. The potential of the combined method is examined by measuring the properties of three sets of plans for residential aged care facilities. The first set is a pair of hypothetical, idealized plans, which allegedly reflect the ＂best practice＂ in the industry. The second set comprises a pair of plans for recent Australian designs, and the third set is a pair of plans for South Korean facilities. Results of the computational anatysis of these six plans suggest that social and cultural factors may shape the design of aged care settings and partially explain their international differences. The application of this methodological approach contributes to the understanding of the relation- ship between spaces and their cultural and social properties in the design of aged care facitities.

关键词： Visibitity graph anaty-sis (VGA) Space Syntax Aged care facility Isovist property Sociocutturalcharacteristics

Nanoparticle Targeting with Antibodies in the Central Nervous System

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Biomedical Engineering Frontiers 2023年第1期4卷 159-176页

作者： ju hyun lee Dana V.Chapman W.Mark Saltzman Department of Biomedical Engineering Yale UniversityNew HavenCTUSA

Treatments for disease in the central nervous system(CNS)are limited because of difficulties in agent penetration through the blood-brain barrier,achieving optimal dosing,and mitigating off-target *** prospect of precision medicine in CNS treatment suggests an opportunity for therapeutic nanotechnology,which offers tunability and adaptability to address specific diseases as well as targetability when combined with antibodies(Abs).Here,we review the strategies to attach Abs to nanoparticles(NPs),including conventional approaches of chemisorption and physisorption as well as attempts to combine irreversible Ab immobilization with controlled *** also summarize trends that have been observed through studies of systemically delivered Ab–NP conjugates in ***,we discuss the future outlook for Ab–NPs to deliver therapeutics into the CNS.

关键词： agent irreversible particle

Examining control,centrality and flexibility in Palladio’s villa plans using space syntax measurements

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Frontiers of Architectural Research 2021年第3期10卷 467-482页

作者： Michael J.Dawes Michael J.Ostwald ju hyun lee UNSW Built Environment The University of New South WalesSydneyNSW 2052Australia

Andrea Palladio’s Renaissance villas are amongst the most famous and widely studied examples of domestic architecture ever *** majority of past research about Palladio’s architecture employed historical,mathematical and computational methods to analyse their complex proportional systems and *** contrast,this paper examines three of Palladio’s arguments about his villas plans which relate to their spatial properties and topological ***,this paper uses a computational method e the justified plan graph(JPG)e to test two arguments about the location and significance of the primary salon on the plan,and a third about the extent to which the rooms in Palladio’s plans are,as he claims,flexible enough to contain alternative *** ten of Palladio’s piano nobile(main floor)plans from I Quattro Libri Dell’Architettura as cases,this paper develops mathematical data to test three hypotheses framed around Palladio’s plans and theories.

关键词： Andrea palladio Palladian villa Renaissance architecture Space syntax justified plan graph(JPG)

Identification of novel HLA-A 0201-restricted epitopes from anterior gradient-2 as a tumor-associated antigen against colorectal cancer

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Cellular & Molecular Immunology 2012年第2期9卷 175-183页

作者： hyun ju lee Cheol Yi Hong Chun-Ji Jin Mi-hyun Kim Youn-Kyung lee Thanh-Nhan Nguyen-Pham hyunah lee Byoung Chul Park Ik-Joo Chung Hyeoung-Joon Kim Je-jung lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun Hospital Hwasun Jeollanamdo Korea Department of Hematology-Oncology Chonnam National University Gwangju Korea VaxcelI-Bio Therapeutics Hwasun Jeollanamdo Korea Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Korea Research Institute of Bioscience and Biotechnology （KRIBB） Daejeon Korea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Gwangiu Korea

Anterior gradient-2 （AGR2） promotes tumor growth, cell migration and cellular transformation and its enhanced expression is almost completely restricted to malignant tissues, thus making AGR2 an interesting target for the development of immunotherapeutic strategies. We investigated whether the AGR2 molecule comprises human leukocyte antigen （HLA）-A 0201-binding epitopes recognized by human cytotoxic T lymphocytes （CTLs）, which could be targeted in dendritic cell （DC）-based cancer immunotherapy against colorectal cancer （CRC）. We reviewed the sequence of AGR2 for peptides that could potentially bind to HLA-A 0201 with the aid of a computer-based program. Five candidate peptides with different binding scores were synthesized and tested. These peptides were then assessed for their immunogenicity to elicit specific immune responses mediated by CTLs in vitro by means of enzyme-linked immunospot assays and CTL assays. AGR2 was highly expressed in several CRC cell lines, including DK01, DLD1, KM 12C, HCT-8 and HT-29. DCs pulsed with AGR2-P2 （aa 11-19; LLVALSYTL） or AGR2-P4 （aa 127-135; RIMFVDPSL） generated potent CTLs that could lyse T2 cells pulsed with AGR2-P2 or AGR2-P4 and HLA-A0201＋ AGR2-positive CRC cell lines in a strong dose-dependent and HLA-A 0201-restricted manner. In conclusion, these novel epitopes derived from AGR2 protein may be attractive candidates for DC-based immunotherapy for CRC.

关键词： AGR2 colorectal cancer dendritic cell tumor-associated antigen

Transient involuntary movement disorder after spinal anesthesia: A case report

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World Journal of Clinical Cases 2021年第26期9卷 7917-7922页

作者： Giyoung Yun Eunsoo Kim Wangseok Do Young-Hoon jung hyun-ju lee Yesul Kim Department of Anesthesia and Pain Medicine Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Anesthesia and Pain Medicine Pusan National UniversitySchool of MedicineYangsan 50612South Korea

BACKGROUND Spinal anesthesia is commonly used for various *** many complications occur after induction of spinal anesthesia,involuntary movement is an extremely rare *** SUMMARY Herein,we report the case of a 54-year-old healthy male patient who experienced involuntary movements after intrathecal injection of local *** patient had undergone metal implant removal surgery in both the lower extremities;7 h after intrathecal hyperbaric bupivacaine administration,involuntary raising of the left leg began to occur every 2 *** the movement disorder appeared,the patient was conscious and *** other specific symptoms were noted in the physical examination conducted immediately after the involuntary leg raising started;moreover,the patient's motor and sensory assessments were *** symptom gradually *** hours after the symptom first occurred,its frequency decreased to approximately once every three *** days postoperatively,the symptoms had completely disappeared without *** Anesthesiologists should be aware that movement disorders can occur after spinal anesthesia and be able to identify the cause,such as electrolyte imbalance or epilepsy,since immediate action may be required for ***,it is crucial to know that involuntary movement that develop following spinal anesthesia is mostly self-limiting and may not require additional costly examinations.

关键词： Movement disorder Spinal anesthesia Bupivacaine Dexmedetomidine Case report

Effect of gadolinium incorporation on optical characteristics of YNbO_4:Eu^(3+) phosphors for lamp applications

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Journal of Rare Earths 2012年第3期30卷 205-209页

作者： Sung Hwan Choi G. Anoop Dong Wook Suh Kyung Pil Kim hyun ju lee Jae Soo Yoo Display Materials Laboratory School of Chemical Engineering and Materials Science Chung-Ang University

Eu3＋-doped （Y,Gd）NbO4 phosphor was synthesized by solid-state reaction for possible application in cold cathode fluorescent lamps. A broad absorption band with peak maximum at 272 nm was observed which was due to the charge transfer between Eu3＋ ions and neighboring oxygen anions. A deep red emission at the peak wavelength of 612 nm was observed which could be attributed to the 5D0→7F2 transition in Eu3＋ ions. The highest luminance for Y1-x-yGdyNbO4：Eux3＋ under 254 nm excitation was achieved at Eu3＋ concentration of 18 mol.% （x=0.18） and Gd3＋ concentration of 8.2 mol.% （y=0.082）. The luminance of Y0.738Gd0.082NbO4：Eu3＋0.18 was higher than that of a typical commercial phosphor Y2O3：Eu3＋ and the CIE chromaticity coordinate was （0.6490, 0.3506）, which was deeper than that of Y2O3：Eu3＋. The particle size of the synthesized phosphors was controlled by the NaCl flux and particle size as high as 8 μm with uniform size distribution of particles was obtained.

关键词： YNbO4:Eu oxide phosphors rare earths

Combined Insights from Leachate Structure and Microstructure Characteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies

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Rice science 2024年第4期31卷 475-488,I0035,I0036页

作者： Mingyo HA Hyo-Young JEONG ju Hun lee hyun-jung CHUNG Division of Food and Nutrition Chonnam National UniversityGwangju 61186South Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841South Korea Division of Food Science&Culinary Arts Shinhan UniversityGyeonggi 11644South Korea

Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample had the highest total solids and amylopectin amount in the leachate. The amylopectin amount in the leachate differed significantly based on the targeted water content. Morphological characterization revealed that the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural hardness of the AEC_58% sample was much higher than that of the other samples. The PSC_63% sample had the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leachate. Sensory characterization showed that the PSC_63% sample had the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leachate and textural and sensory characteristics of reheated convenience rice among the different processing technologies.

关键词： reheated convenience rice starch structure leachate multi-scale structure eating quality processing technology