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Five-year major clinical outcomes between first-generation ana second- generation drug-eluting stents in acute myocardial infarction patients underwent percutaneous coronary intervention

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Journal of Geriatric Cardiology 2018年第8期15卷 523-533页

作者： Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun ju yeol baek Woong Gil Choi Tae Soo Kang Ji Hoon Ahn Sang-Ho Park Ahmed Mashaly Jin Oh Na Cheol Ung Choi Hong Euy Lim Eung ju Kim Chang Gyu Park Hong Seog Seo Dong Joo Oh Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuneheon South Korea Cardiovascular Center Korea University Guro Hospital Seoul South Korea Department of Medicine Korea University Graduate School Seoul South Korea Cardiovascular Center Cheong Ju St. Mary hospital Cheong Ju Chung Buk South Korea SCardiology Department Konkuk University Chungju Hospital Chungju South Korea Department of Internal Medicine Cardiovascular Division Dankook University Hospital Cheonan South Korea Department of Cardiology Soonchunhyang University Gumi Hospital G-umi South Korea Cardiology Department Soonchunhyang University Cheonan Hospital Cheonan South Korea

Background There were limited data comparing the major clinical outcomes between first-generation （1G）-drug eluting stentts （DES） and second-generation （2G）-DES in patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI） during very long follow-up periods. We thought to investigate the comparative efficacy and safety of 2G-DES compared with 1G-DES in AMI patients during 5-year follow-up periods. Method A total of 1016 eligible AMI patients who underwent PCI with 1G-DES [paclitaxel-, sirolimus-, 1G-zotarolimus-eluting stent （endeavor~ or endeavor sprintS）, n = 554] or 2G-DES [2G-zotarolimus （endeavor resolute~）- or everolimus-eluting stent, n = 462] were enrolled. The primary endpoint was the occurrence of major adverse cardiac events （MACE） defined as total death, non-fatal myocardial infarction （MI）, target lesion revascularization （TLR）, target vessel revascularization （TVR）, non-target vessel revascularization （Non-TVR） and the secondary endpoint was stem thrombosis （ST） at 5 years. Results Two propensity score-ma- tched （PSM） groups （232 pairs, n = 464, C-statistic = 0.802） were generated. During the 5-year follow-up period, the cumulative incidence of TLR [hazard ratio （HR）： 3.133; 95% confidence interval （CI）： 1.539-6.376; P = 0.002], TVR （HR： 3.144; 95% CI： 1.59645.192; P = 0.001） and total revascularization rate （FIR： 1.874; 95% CI： 1.086-3.140; P = 0.023） were significantly higher in 1G-DES compared with 2G-DES after PSM. However, the incidence of total death, non-fatal MI and ST were similar between the two groups. Conclusion In this single-center and all-comers registry, 2G-DES＇s superiorities for TLR, TVP, and total revascularization in AMI patients suggested during 5-year clinical follow-up periods.

关键词： Acute myocardial infarction Clinical outcomes Drug-eluting stem

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Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention

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Journal of Geriatric Cardiology 2019年第8期16卷 639-647页

作者： Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim ju yeol baek Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park Hong Seog Seo Division of Cardiology Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea Department of Cardiology Soonchunhyang University College of MedicineSeoulSouth Korea Cardiovascular Center Korea University Guro HospitalSeoulSouth Korea Department of Medicine Korea University Graduate SchoolSeoulSouth Korea Cardiovascular Center Seoul St. Mary’s Hospitalthe Catholic University of KoreaSeoulSouth Korea Cardiology Department Konkuk University Chungju HospitalChungjuSouth Korea Department of Internal Medicine Cardiovascular DivisionDankook University HospitalCheonanSouth Korea Department of Cardiology Soonchunhyang University Gumi HospitalGumiSouth Korea Cardiology Department Soonchunhyang University Cheonan HospitalCheonanSouth Korea Division of Cardiology Department of Internal MedicineCardiovascular CenterNowon Eulji Medical CenterEulji UniversitySeoulSouth Korea

Background There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. Results After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. Conclusions In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years.

关键词： Chronic total occlusion Drug-eluting stent Outcomes

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Metabolic relationships between marine red algae and algae‑associated bacteria

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Marine Life Science & Technology 2024年第2期6卷 298-314页

作者： Kyung Hyun Kim Jeong Min Kim ju Hye baek Sang Eun Jeong Hocheol Kim Hwan Su Yoon Che Ok Jeon Department of Biological Sciences and Biotechnology Hannam UniversityDaejon 34054Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon 16419Republic of Korea

Mutualistic interactions between marine phototrophs and associated bacteria are an important strategy for their success-ful survival in the ocean,but little is known about their metabolic ***,bacterial communities in the algal sphere(AS)and bulk solution(BS)of nine marine red algal cultures were analyzed,and Roseibium and Phycisphaera were identified significantly more abundantly in AS than in *** metabolic features of Roseibium RMAR6-6(isolated and genome-sequenced),Phycisphaera MAG 12(obtained by metagenomic sequencing),and a marine red alga,Porphyridium purpureum CCMP1328(from GenBank),were analyzed ***6-6 has the genetic capability to fix nitrogen and produce B vitamins(B1,B2,B5,B6,B9,and B12),bacterioferritin,dimethylsulfoniopropionate(DMSP),and phenylacetate that may enhance algal growth,whereas MAG 12 may have a limited metabolic capability,not producing vitamins B9 and B12,DMSP,phenylacetate,and siderophores,but with the ability to produce bacitracin,possibly modulating algal *** CCMP1328 lacks the genetic capability to fix nitrogen and produce vitamin B12,DMSP,phenylacetate,and *** was shown that the nitrogen-fixing ability of RMAR6-6 promoted the growth of ***-pureum,and DMSP reduced the oxidative stress of *** metabolic interactions between strain RMAR6-6 and *** CCMP1328 were also investigated by the transcriptomic analyses of their monoculture and *** together,potential metabolic relationships between Roseibium and *** were *** study provides a bet-ter understanding of the metabolic relationships between marine algae and algae-associated bacteria for successful growth.

关键词： Metabolic relationship Marine red algae Symbiotic bacteria Roseibium Phycisphaera Porphyridium

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An Embedded Consensus ADMM Distribution Algorithm Based on Outer Approximation for Improved Robust State Estimation of Networked

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1217-1226页

作者： Zifeng Zhang Yuntao ju State Grid Information&Telecommunication Group Co. Ltd.Beijing BranchBejingChina School of Electrical and Control Engineering North China University of TechnologyBeijingChina

Networked microgrids(NMGs)are critical in theaccommodation of distributed renewable ***,theexisting centralized state estimation(SE)cannot meet the demandsof NMGs in distributed energy *** currentestimator is also not robust against bad *** study introducesthe concepts of relative error to construct an improvedrobust SE(IRSE)optimization model with mixed-integer nonlinearprogramming(MINLP)that overcomes the disadvantage ofinaccurate results derived from different measurements whenthe same tolerance range is considered in the robust SE(RSE).To improve the computation efficiency of the IRSE optimizationmodel,the number of binary variables is reduced based on theprojection statistics and normalized residual methods,which effectivelyavoid the problem of slow convergence or divergenceof the algorithm caused by too many integer ***,an embedded consensus alternating direction of multiplier method(ADMM)distribution algorithm based on outer approximation(OA)is proposed to solve the IRSE optimization *** algorithm can accurately detect bad data and obtain SE resultsthat communicate only the boundary coupling informationwith *** tests show that the proposed algorithmeffectively detects bad data,obtains more accurate SE results,and ensures the protection of private information in all microgrids.

关键词： Distributed optimization alternating direction of multiplier methods(ADMM) robust state estimation(RSE) mixed-integer nonlinear programming(MINLP) networked microgrid(NMG)

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Markovian Quadratic BSDEs with an Unbounded Sub-quadratic Growth

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 441-462页

作者： Jingnan ju Shanjian TANG Shanghai Center for Mathematical Sciences Fudan UniversityShanghai 200433China Department of Finance and Control Sciences School of Mathematical SciencesFudan UniversityShanghai 200433China

This paper is devoted to the solvability of Markovian quadratic backward stochastic differential equations(BSDEs for short)with bounded terminal *** generator is allowed to have an unbounded sub-quadratic growth in the second unknown variable *** existence and uniqueness results are given to these *** an application,an existence result is given to a system of coupled forward-backward stochastic differential equations with measurable coefficients.

关键词： Markovian BSDE Quadratic growth Unbounded sub-quadratic term coeficients Coupled FBSDE

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The combined application of stem cells and three-dimensional bioprinting scaffolds for the repair of spinal cord injury

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Neural Regeneration Research 2024年第8期19卷 1751-1758页

作者： Dingyue ju Chuanming Dong Department of Anatomy Medical College of Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

Spinal cord injury is considered one of the most difficult injuries to repair and has one of the worst prognoses for injuries to the nervous *** surgery,the poor regenerative capacity of nerve cells and the generation of new scars can make it very difficult for the impaired nervous system to restore its neural *** treatments can only alleviate secondary injuries but cannot fundamentally repair the spinal ***,there is a critical need to develop new treatments to promote functional repair after spinal cord *** recent years,there have been seve ral developments in the use of stem cell therapy for the treatment of spinal cord *** significant developments in the field of tissue engineering,three-dimensional bioprinting technology has become a hot research topic due to its ability to accurately print complex *** led to the loading of three-dimensional bioprinting scaffolds which provided precise cell *** three-dimensional bioprinting scaffolds co uld repair damaged neural circuits and had the potential to repair the damaged spinal *** this review,we discuss the mechanisms underlying simple stem cell therapy,the application of different types of stem cells for the treatment of spinal cord injury,and the different manufa cturing methods for three-dimensional bioprinting *** particular,we focus on the development of three-dimensional bioprinting scaffolds for the treatment of spinal cord injury.

关键词： biomaterials embryonic stem cells induced pluripotent stem cells mesenchymal stem cells nerve regeneration spinal cord injury stem cell therapy stem cells three-dimensional bioprinting

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The symmetric space,strong isotropy irreducibility and equigeodesic properties

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Science China Mathematics 2024年第1期67卷 129-148页

作者： Ming Xu ju Tan School of Mathematical Sciences Capital Normal UniversityBeijing 100048China School of Microelectronics and Data Science Anhui University of TechnologyMa'anshan 243032China

A smooth curve on a homogeneous manifold G/H is called a Riemannian equigeodesic if it is a homogeneous geodesic for any G-invariant Riemannian *** homogeneous manifold G/H is called Riemannian equigeodesic,if for any x∈G/H and any nonzero y∈Tx(G/H),there exists a Riemannian equigeodesic c(t) with c(0)=x and ■(0)=*** two notions can be naturally transferred to the Finsler setting,which provides the definitions for Finsler equigeodesics and Finsler equigeodesic *** prove two classification theorems for Riemannian equigeodesic spaces and Finsler equigeodesic spaces,***,a homogeneous manifold G/H with a connected simply connected quasi compact G and a connected H is Riemannian equigeodesic if and only if it can be decomposed as a product of Euclidean factors and compact strongly isotropy irreducible ***,a homogeneous manifold G/H with a compact semisimple G is Finsler equigeodesic if and only if it can be locally decomposed as a product,in which each factor is Spin(7)/G2,G2/SU (3) or a symmetric space of compact *** results imply that the symmetric space and the strongly isotropy irreducible space of compact type can be interpreted by equigeodesic *** an application,we classify the homogeneous manifold G/H with a compact semisimple G such that all the G-invariant Finsler metrics on G/H are *** suggests a new project in homogeneous Finsler geometry,i.e.,to systematically study the homogeneous manifold G/H on which all the G-invariant Finsler metrics satisfy a certain geometric property.

关键词： equigeodesic equigeodesic space flag manifold orbit type stratification symmetric space strongly isotropy irreducible space

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Novel fabrication techniques for ultra-thin silicon based flexible electronics

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International Journal of Extreme Manufacturing 2024年第4期6卷 116-149页

作者： ju Young Lee Jeong Eun ju Chanwoo Lee Sang Min Won Ki jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea YU-Korea Institute of Science and Technology(KIST)Institute Yonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Flexible electronics offer a multitude of advantages,such as flexibility,lightweight property,portability,and high *** unique properties allow for seamless applications to curved and soft surfaces,leading to extensive utilization across a wide range of fields in consumer *** applications,for example,span integrated circuits,solar cells,batteries,wearable devices,bio-implants,soft robotics,and biomimetic ***,flexible electronic devices have been developed using a variety of materials such as organic,carbon-based,and inorganic semiconducting ***(Si)owing to its mature fabrication process,excellent electrical,optical,thermal properties,and cost efficiency,remains a compelling material choice for flexible ***,the research on ultra-thin Si in the context of flexible electronics is studied rigorously *** thinning of Si is crucially important for flexible electronics as it reduces its bending stiffness and the resultant bending strain,thereby enhancing flexibility while preserving its exceptional *** review provides a comprehensive overview of the recent efforts in the fabrication techniques for forming ultra-thin Si using top-down and bottom-up approaches and explores their utilization in flexible electronics and their applications.

关键词： flexible electronics silicon fabrication technique top-down approach bottom-up approach

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Boron-10 stimulated helium production and accelerated radiation displacements for rapid development of fusion structural materials

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Journal of Materiomics 2024年第2期10卷 377-385页

作者： Yunsong jung ju Li Department of Nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA Korea Institute of Fusion Energy Daejeon34133Republic of Korea

Boron doping,combined with neutron capture in fission reactors,has been used to simulate the helium effect on fusion structural ***,inhomogeneous helium bubble formation was often observed due to boron segregation to grain *** excess radiation displacements due to^(10)B(n,α)^(7)Li reaction,the high-energy lithium and helium ions,also were not accounted for,which can significantly accelerate the displacements-per-atom(dpa)accumulation alongside helium production(appm).Hereby an isotopically pure^(10)B doping approach is proposed to simulate the extreme envi-ronment inside fusion reactors with a high He appm-to-dpa ratio of about 10,which is about 10^(2)×larger than in fission *** modeling showed that~13%of total radiation displacement was induced by^(10)B(n,α)^(7)Li in the case of 1000 appm^(10)B doped Fe samples,which becomes even greater with increasing^(10)B *** homogenous radiation damage and helium generation are pre-dicted for grain sizes less than 1 mm,even if the boron partially formed precipitates or segregates on grain *** studies with various^(10)B doping(and^(235)U-codoping)levels in research reactors showed the estimated helium generation and radiation damage would significantly mimic fusion conditions and greatly expedite fusion materials testing,from many years down to months.

关键词： Fusion power reactor Helium transmutation He appm-to-dpa ratio Boron-10 doping Accelerated materials testing

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Design of multifunctional polymeric binders in silicon anodes for lithium‐ion batteries

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Carbon Energy 2024年第4期6卷 140-163页

作者： Masytha Nuzula Ramdhiny ju‐Won Jeon Department of Chemistry Kookmin UniversitySeoulRepublic of Korea Correspondence

Silicon(Si)is a promising anode material for lithium‐ion batteries(LIBs)owing to its tremendously high theoretical storage capacity(4200 mAh g−1),which has the potential to elevate the energy of ***,Si anodes exhibit severe volume change during lithiation/delithiation processes,resulting in anode pulverization and delamination with detrimental growth of solid electrolyte interface *** a result,the cycling stability of Si anodes is insufficient for commercialization in *** binders can play critical roles in Si anodes by affecting their cycling stability,although they occupy a small portion of the *** review introduces crucial factors influencing polymeric binders'properties and the electrochemical performance of Si *** particular,we emphasize the structure–property relationships of binders in the context of molecular design strategy,functional groups,types of interactions,and functionalities of ***,binders with additional functionalities,such as electrical conductivity and self‐healability,are extensively discussed,with an emphasis on the binder design principle.

关键词： conductivity lithium‐ion batteries molecular interactions polymeric binders self‐healability Si anodes

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