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Evaluation of the intracellular lipid-lowering effect of polyphenols extract from highland barley in HepG2 cells

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Food Science and Human Wellness 2024年第1期13卷 454-461页

作者： Yijun Yao Zhifang Li Bowen Qin Xingrong ju Lifeng Wang College of Food Science and Engineering/Collaborative Innovation Centre for Modern Grain Circulation and Safety Nanjing University of Finance and EconomicsNanjing 210023China

Active ingredients from highland barley have received considerable attention as natural products for developing treatments and dietary supplements against *** practical application,the research of food combinations is more significant than a specific food *** study investigated the lipid-lowering effect of highland barley polyphenols via lipase assay in vitro and HepG2 cells induced by oleic acid(OA).Five indexes,triglyceride(TG),total cholesterol(T-CHO),low density lipoprotein-cholesterol(LDL-C),aspartate aminotransferase(AST),and alanine aminotransferase(ALT),were used to evaluate the lipidlowering effect of highland barley *** also preliminary studied the lipid-lowering mechanism by Realtime fluorescent quantitative polymerase chain reaction(q PCR).The results indicated that highland barley extract contains many components with lipid-lowering effects,such as hyperoside and *** vitro,the lipase assay showed an 18.4%lipase inhibition rate when the additive contents of highland barley extract were 100μg/m *** intracellular lipid-lowering effect of highland barley extract was examined using 0.25 mmol/L OA-induced HepG2 *** results showed that intracellular TG,LDL-C,and T-CHO content decreased by 34.4%,51.2%,and 18.4%,*** and AST decreased by 51.6%and 20.7%compared with the untreated hyperlipidemic HepG2 cells.q PCR results showed that highland barley polyphenols could up-regulation the expression of lipid metabolism-related genes such as PPARγand Fabp4.

关键词： Highland barley Polyphenols extract Lipid-lowering effect HepG2 cells

七氟醚对新生大鼠下丘脑-垂体-肾上腺皮质轴发育的影响

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临床麻醉学杂志 2017年第10期33卷 1021-1024页

作者：邹菊刘彦谭思杰南华大学医学院寄生虫学教研室湖南省衡阳市421001 南华大学医学院组织学与胚胎学教研室湖南省衡阳市421001

目的研究新生期七氟醚暴露对下丘脑-垂体-肾上腺皮质(hypothalamic-pituitary-adrenal,HPA)轴发育及功能的影响。方法新生雄性SD大鼠54只,6日龄,随机分为三组:对照组(C组)、七氟醚组(S组)和布美他尼+七氟醚组(BS组),每组18只。C组:吸入1... 详细信息

目的研究新生期七氟醚暴露对下丘脑-垂体-肾上腺皮质(hypothalamic-pituitary-adrenal,HPA)轴发育及功能的影响。方法新生雄性SD大鼠54只,6日龄,随机分为三组:对照组(C组)、七氟醚组(S组)和布美他尼+七氟醚组(BS组),每组18只。C组:吸入100%氧气6h;S组:吸入2.1%七氟醚6h;BS组:吸入2.1%七氟醚6h,在麻醉前30min和麻醉后3h注射布美他尼。6h后,每组随机选取6只处死收集血清,采用ELISA法测定皮质酮浓度;各组剩余大鼠于第60天行高架十字迷宫测试,第65天行束缚应激30 min,并在应激前后取尾静脉血,采用ELISA法测定血清皮质酮浓度。结果麻醉后S组血清皮质酮浓度明显高于C组(P<0.01);BS组血清皮质酮浓度明显低于S组(P<0.01)。S组进入开放臂次数明显少于C组(P<0.05),开放臂停留时间明显短于C组(P<0.05),应激前后血清皮质酮浓度明显高于C组(P<0.05或P<0.01);BS组进入开放臂次数明显多于S组,开放臂停留时间明显长于S组(P<0.05),应激前后血清皮质酮浓度明显低于S组(P<0.05)。结论新生期七氟醚麻醉可导致HPA轴功能亢进,其机制与GABAA受体相关。

关键词：七氟醚下丘脑-垂体-肾上腺皮质轴布美他尼应激

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

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Genes & Diseases 2024年第2期11卷 597-613页

作者： Yu Zhang Xinliang Gu Yang Li Yuejiao Huang Shaoqing ju Medical School of Nantong University Nantong UniversityNantongJiangsu 226001China Department of Laboratory Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China Department of Medical Oncology Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China

With the development of sequencing technology,transfer RNA(tRNA)-derived small RNAs(tsRNAs)have received extensive attention as a new type of small noncoding *** on the differences in the cleavage sites of nucleases on tRNAs,tsRNAs can be divided into two categories,tRNA halves(tiRNAs)and tRNA-derived fragments(tRFs),each with specific subcellular ***,the biogenesis of tsRNAs is tissue-specific and can be regulated by tRNA *** this review,we first elaborated on the classification and biogenesis of *** summarizing the latest mechanisms of tsRNAs,including transcriptional gene silencing,post-transcriptional gene silencing,nascent RNA silencing,translation regulation,rRNA regulation,and reverse transcription regulation,we explored the representative biological functions of tsRNAs in ***,this review summarized the clinical value of tsRNAs in cancers,thus providing theoretical support for their potential as novel biomarkers and therapeutic targets.

关键词： Biogenesis Biological function Cancer Mechanism Therapeutic strategy tsRNAs

Extracellular vesicles for neural regeneration after spinal cord injury

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Neural Regeneration Research 2024年第3期19卷 491-492页

作者： Young-ju Lim Wook-Tae Park Gun Woo Lee Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaeguKorea

What is spinal cord injury:Spinal cord injury(SCI)is the damage to the structure of the bundles of cells and nerves that communicate signals from the brain to the body and *** pathology of SCI includes both primary and secondary injuries(Morales et al.,2016).Physical forces such as compression,shearing,contusion,and tearing are major causes of primary injury in *** are two main processes in primary injury:acute and *** acute phase includes traumatic disruption of axons and hemorrhage of the blood vessels around the spinal *** injury to the vessels can lead to increased edema within the neural and cord tissues,susceptibility to infiltration by microglia and astrocytes,excitotoxicity,and ***,disruption of the blood-spinal cord barrier results in the release of inflammatory cytokines from specific cells and vessels.

关键词： acute injuries nerves

Multi-scale analyses of phase transformation mechanisms and hardness in linear friction welded Ti17(a+β)/Ti17(β)dissimilar titanium alloy joint

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Chinese Journal of Aeronautics 2024年第1期37卷 312-324页

作者： Zhenguo GUO Tiejun MA Xiawei YANG ju LI Wenya LI Achilles VAIRIS State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesNorthwestern Polytechnical UniversityXi’an 710072China Aeronautical Key Laboratory for Welding and Joining Technologies AVIC Manufacturing Technology InstituteBeijing 100024China Mechanical Engineering Department University of West AtticaAthens 12241Greece

The Ti17(a+β)-Ti17(β)dual alloy-dual property blisk produced using Linear Friction Welding(LFW)is considered as high-performance component in advanced ***,up to now,microstructure evolution and relationship between microstructure and micro mechanical properties of LFWed Ti17(a+β)/Ti17(β)dissimilar joint have not been thoroughly *** this work,complex analyses of the phase transformation mechanisms of the joint are conducted,and phase transformations in individual zones are correlated to their microhardness and *** reveal that a dissolution occurs under high temperatures encountered during LFW,which reduces microhardness of the joint to that of Ti17(a+β)and Ti17(β).In ThermoMechanically Affected Zone of Ti17(a+β)(TMAZ-(a+β))side joint,a large number of nanocrystalline a phases form with different *** microstructure strengthens significantly by fine grains which balances partial softening effect of a dissolution,and increases nanohardness of a phase and microhardness of TMAZ-(a+β).Superlattice metastableβphase precipitates from metastableβin Weld Zone(WZ)during quick cooling following welding,because of short-range diffusion migration of solute atoms,especiallyβstabilizing elements Mo and *** precipitation of the superlattice metastableβphase results in precipitation strengthening,which in turn increases nanohardness of metastableβand microhardness in WZ.

关键词： Linear friction welding Ti17 titanium alloy Phase transformation Microhardness Nanohardness

Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

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Chinese Journal of Natural Medicines 2024年第7期22卷 599-607页

作者： HONG Geum-Lan KIM Kyung-Hyun CHO Sung-Pil LEE Hui-ju KIM Yae-Ji juNG ju-Young Department of Veterinary Medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Korea Department of Anatomy College of MedicineKonyang UniversityDaejeon 35365Korea

Panax ginseng(***.)has been traditionally employed in Korea and China to alleviate fatigue and digestive *** particular,Korean red ginseng(KRG),derived from streamed and dried ***,is known for its anti-aging and anti-inflammatory ***,its effects on benign prostatic hyperplasia(BPH),a representative aging-related disease,and the underlying mechanisms remain *** study aims to elucidate the therapeutic effects of KRG on BPH,with a particular focus on mitochondrial dynamics,including fission and fusion *** effects of KRG on cell proliferation,apoptosis,and mitochondrial dynamics and morphology were evaluated in a rat model of testosterone propionate(TP)-induced BPH and TP-treated LNCaP cells,with mdivi-1 as a *** results revealed that KRG treatment reduced the levels of androgen receptors(AR)and prostate-specific antigens in the BPH *** inhibited cell proliferation by downregulating cyclin D and proliferating cell nuclear antigen(PCNA)levels,and it promoted apoptosis by increasing the ratio of B-cell lymphoma protein 2(Bcl-2)-associated X protein(Bax)to Bcl-2 ***,KRG treatment enhanced the phosphorylation of dynamin-related protein 1(DRP-1,serine 637)compared with that in the BPH group,which inhibited mitochondrial fission and led to mitochondrial *** modulation of mitochondrial dynamics was associated with decreased cell proliferation and increased *** dysregulating AR signaling and inhibiting mitochondrial fission through enhanced DRP-1(ser637)phosphorylation,KRG effectively reduced cell proliferation and induced *** findings suggest that KRG’s regulation of mitochondrial dynamics offers a promising clinical approach for the treatment of BPH.

关键词： Androgen Benign prostatic hyperplasia Fission Korean red ginseng Mitochondria

Synthesis,structure,and luminescence properties of melilite Dy^(3+):Lu_(x)CaLa_(0.98-x)Ga_(3)O_(7) phosphors for use in yellow light-emitting devices

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Journal of Rare Earths 2024年第8期42卷 1489-1495,I0003页

作者： Yunyun Liu Chuanxin Huang Meng Wang Xihu Wang Yan Wang ju Gao School of Opto-Electronic Engineering Zaozhuang UniversityZaozhuang277160China Key Laboratory of Functional Materials and Devices for Informatics of Anhui Educational Institutions Department of PhysicsFuyang Normal UniversityFuyang236037China Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002.China

Dy^(3+) and Lu^(3+) co-doped CaLaGa_(3)O_(7) phosphors were prepared via high-temperature solid-phase *** electronic structures of LuxCaLa_(0.98-x)Ga_(3)O_(7) were investigated by the first-principles *** influence of Lu^(3+) on yellow light emission was studied using X-ray diffraction(XRD)and photoluminescence(PL) *** XRD results indicate that compared to Dy^(3+):CaLaGa_(3)O_(7),the cell parameters of Dy^(3+):LuCaLaGa_(3)O_(7) tend to decrease,which is due to the smaller radius of Lu^(3+).When pumped by blue GaN laser diode(LD),the emission peaks of phosphors with different Lu^(3+)doping concentrations in the visible region are similar,with the strongest peak at 574 nm in the yellow light region,which is sensitive to human *** optimal doping concentration of Lu^(3+) is confirmed to be1 at%,when all emission spectra and measured fluorescence lifetimes are taken into ***,the optimal phosphor composition Dy^(3+):Lu_(x)CaLa_(0.98-x)Ga_(3)O_(7)(x=0.01) has an internal quantum efficiency(IQE) of 46.94% and an external quantum efficiency(EQE) of 15.19%.Most notably,the prepared phosphor demonstrates excellent thermal stability and a high activation energy(0.203 eV).In addition,the International Illumination Commission color coordinates of the Dy^(3+):LuxCaLa_(0.98-x)Ga_(3)O_(7) phosphors are in the yellow light *** above analysis indicates that the Dy^(3+):LuxCaLa_(0.98-x)Ga_(3)O_(7)(x=0.001)phosphor has promising application prospects in yellow light-emitting devices.

关键词： Dy^(3+):Lu_(x)CaLa_(0.98-x)Ga_(3)O_(7)phosphors Yellow emission Structure characteristics Luminescent properties Rare earths

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当代中国社会管理研究的主要视角及发展趋势

南昌大学学报（人文社会科学版） 2015年第5期46卷 71-77页

作者：乔小明谭菊华云南师范大学学报编辑部云南昆明650092 江西师范大学招生就业处江西南昌330022

社会管理问题是国内研究的热点问题,虽然研究成果众多,但大致可以归纳到5个视角之下进行讨论。通过这种分类研究有助于更好地理解社会管理理论,创新社会管理实践。当代社会管理研究的问题主要在于理论研究脱离社会实际,部分西方理论脱... 详细信息

社会管理问题是国内研究的热点问题,虽然研究成果众多,但大致可以归纳到5个视角之下进行讨论。通过这种分类研究有助于更好地理解社会管理理论,创新社会管理实践。当代社会管理研究的问题主要在于理论研究脱离社会实际,部分西方理论脱离中国国情等3个方面。未来对社会管理问题的研究要注重4个方面的有机结合,探索建立适合中国国情的社会管理体系。

关键词：当代中国社会管理研究视角发展趋势

Constraining the Earth-mass Primordial Black Hole Mergers Model of the Non-repeating FRBs Using the First CHIME/FRB Catalog

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Research in Astronomy and Astrophysics 2024年第9期24卷 76-82页

作者： Min Meng Qiu-ju Huang Can-Min Deng Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

In this paper,we upgrade the constraints for the Earth-mass primordial black hole mergers model based on the first Canadian Hydrogen Intensity Mapping Experiment(CHIME)/fast radio burst(FRB)*** the null hypothesis that the observed non-repeating FRBs originate from Earth-mass primordial black hole mergers,we find that how the charges were distributed in the primordial black hole population is well described by a double powerlaw function with typical charge value of law function with typical charge value of q_(c)/10^(-5)=1.60_(-0.28)^(+0.28),where the power-law index α_(1)=2.33_(-0.18)^(+0.15) for q

关键词： black hole physics (stars:)gamma ray burst:general (cosmology:)dark matter