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Visualizing Aβdeposits in live young AD model mice with a simple red/near-infrared-fluorescent AIEgen

Science China Chemistry 2022年第2期65卷 339-352页

作者： Yipu Wang Dong mei Xinyi Zhang Da-Hui Qu ju mei Key Laboratory for Advanced Materials Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistryJoint International Research Laboratory for Precision Chemistry and Molecular EngineeringInstitute of Fine ChemicalsSchool of Chemistry&Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China Clinical Research Center Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

Precise and early detection ofβ-amyloid(Aβ)deposits in situ and in real time is pivotal to the diagnosis and early intervention of Alzheimer’s disease(AD).Optical imaging stands out to be a promising technique for such a task;however,it still remains a big challenge,due to the lack of high-performance imaging contrast *** by poor blood-brain barrier(BBB)penetrability,short-wavelength excitation and emission,as well as the aggregation-caused quenching effect,the widely used goldstandard probes cannot be used for early in-vivo imaging of Aβ***,we integrate the Aβdeposits-favored geometry,amphiphilic and zwitterionic molecular structure,extended D-π-A electronic structure,and 3 D conformation into one molecule,facilely establishing a simple and economic imaging contrast agent that enjoys high specificity and affinity to Aβdeposits,good BBB penetrability,bright red/near-infrared fluorescence,low interference from autofluorescence,aggregation-induced emission(AIE)feature,high signal-to-noise ratio(SNR),and high ***-vitro,ex-vivo,and in-vivo experiments with different strains of mice indicate that AIE-CNPy-AD holds the universality to Aβdeposits ***,AIE-CNPy-AD is even able to precisely trace the small and sparsely-distributed Aβdeposits in AD model mice as young as 4-month-old APP/PS1 mice,the youngest having Aβ***,the present probe could clearly reveal the increase and enlargement of Aβdeposits as the mice ***,AIE-CNPy-AD might be an ideal alternative for early AD diagnosis and highly reliable monitoring of AD progression.

关键词： Aβdeposits AIE Alzheimer’s disease(AD) red/NIR fluorescence in-vivo imaging diagnosis

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Most recent advances on enzyme-activatable optical probes for bioimaging

Aggregate

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Aggregate 2021年第2期2卷 28-61页

作者： ju mei He Tian Key Laboratory for Advanced Materials Feringa Nobel Prize Scientist Joint Research CenterInstitute of Fine ChemicalsJoint International Research Laboratory for Precision Chemistry and Molecular EngineeringSchool of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghaiChina

Enzymes are essential biological elements that play vital roles in many key cellular events and physiological *** dysregulation of enzyme activity broadly occurs in a large number of diseases ranging from inflammation to neurodegenerative disorders to *** imaging allows accurate and noninvasive visualization of biological analytes/physiological processes of interest closely linked to human health at different *** various imaging modalities,optical imaging stands out benefited from its high sensitivity,excellent spatiotemporal resolution,real-time mode,and facile *** optical probes specifically activatable by disease-relevant enzymes have sprung *** comparison to the“always-on”counterparts,the“off-on”imaging probes activated by enzymes hold great promise for precise diagnosis of diseases at early stage with high target-to-background ratio,dramatically improved specificity,and significantly enhanced ***,the most recent advances in optical probes activatable by enzymes for biosensing and bioimaging are briefly reviewed emphasizing their molecular design,working mechanism,and biomedical ***,some important prospects and the current challenges to fully implement the potential of enzyme-activatable probes for precise and efficient theranostics in life science are also pointed out to hopefully arouse new insights into the development of new generation of theranostics.

关键词： aggregation-induced emission bioimaging chemiluminescence enzyme-activatable near-infrared fluorescence photoacoustic theranostics

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Investigation and analysis of negative emotion in patients with diabetic retinopathy after vitrectomy

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World Journal of Psychiatry 2024年第10期14卷 1513-1520页

作者： Zhi-Heng ju mei-ju Wang Department of Ophthalmology The Third People’s Hospital of ChangzhouChangzhou 213001Jiangsu ProvinceChina

BACKGROUND As the incidence of diabetes continues to increase,the number of patients with diabetic retinopathy(DR)also increases each *** undergoing vitrectomy for DR,patients often experience negative emotional problems that negatively affect their *** To investigate negative feelings in patients with DR after vitrectomy and to explore related influencing *** A total of 146 individuals with DR who were accepted for treatment at The Third People’s Hospital of Changzhou from May 2021 to April 2023 were recruited to participate in this *** patients underwent *** self-rating anxiety scale(SAS)and self-rating depression scale(SDS)were used to assess the degree of anxiety and depression 2-3 days after the *** participants were divided into a healthy control group and a negative emotion *** patients’general demographic characteristics and blood glucose levels were *** regression analysis was used to analyze the factors influencing negative feelings ***’s correlation coefficient was used to analyze the association between SAS scores,SDS scores,and blood glucose *** The control group included 85 *** negative emotion group comprised 40 participants with anxiety,13 with depression,and eight with *** regression showed that being female(OR=3.090,95%CI:1.217-7.847),a family per capita monthly income of<5000 yuan(OR=0.337,95%CI:0.165-0.668),and a longer duration of diabetes(OR=2.068,95%CI:1.817-3.744)were risk factors for negative emotions in patients with DR after vitrectomy(P<0.05).The concentrations of fasting plasma glucose(FPG),2-hour postprandial glucose(2hPG),and glycated hemoglobin(HbA1c)in the negative emotion group exceeded those in the control group(P<0.05).SAS scores were positively associated with FPG(r=0.422),2hPG(r=0.334),and HbA1c(r=0.362;P<0.05).SDS scores were positively correlated with FPG(r=0.218)and 2hPG(r=0.218;P<0.05).CONCLUSION S

关键词： Diabetic retinopathy Vitrectomy Anxiety Depression Blood glucose levels Risk factors

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传统文化融入小学语文低段识字写字教学的途径探究

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黑龙江教师发展学院学报 2025年第1期44卷 117-120页

作者：施洋格肖菊梅湖州师范学院教师教育学院浙江湖州313000 吴兴区爱山小学教育集团浙江湖州313000

小学语文低段识字写字教学中蕴含着丰富的传统文化。将传统文化融入日常汉字教学,可以让学生筑牢文化自信根基,促进学生认知发展,让教师摆脱机械教学。但受历史与现实因素影响,识字写字教学目标偏应试,易忽视背后文化价值;教学过程重效... 详细信息

小学语文低段识字写字教学中蕴含着丰富的传统文化。将传统文化融入日常汉字教学,可以让学生筑牢文化自信根基,促进学生认知发展,让教师摆脱机械教学。但受历史与现实因素影响,识字写字教学目标偏应试,易忽视背后文化价值;教学过程重效率轻体验,师资素养待提升;偏重符号化教学,欠缺字理探究。为了更好地传承传统文化,提高学生识字写字兴趣,可以采取以下途径,即教师要转变观念,强化汉字文化教学;创设文化情境,增强学生学习体验;深研教材,提升教师文化教学敏感度;运用字理教学,提升学生理解深度,以期全面提升学生的文化素养和识字能力。

关键词：传统文化小学语文识字写字教学

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Uniform Invariance Principle of Discontinuous Systems with Parameter Variation

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Acta Mathematicae Applicatae Sinica 2013年第4期29卷 717-724页

作者： ju-mei WEI Rui MA Xiao-wu MU School of Mathematics and Statistics Zhengzhou University

An extension of the invariance principle for a class of discontinuous righthand sides systems with parameter variation in the Filippov sense is proposed. This extension allows the derivative of an auxiliary function V, also called a Lyapunov-like function, along the solutions of the discontinuous system to be positive on some sets. The uniform estimates of attractors and basin of attractions with respect to parameters are also obtained. To this end, we use locally Lipschitz continuous and regular Lyapunov functions, as well as Filippov theory. The obtained results settled in the general context of differential inclusions, and through a uniform version of the LaSalle invariance principle. An illustrative example shows the potential of the theoretical results in providing information on the asymptotic behavior of discontinuous systems.

关键词： invariance principle Lyapunov functions discontinuous systems

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Research progress on tin-based anode materials for sodium ion batteries

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Rare Metals 2020年第9期39卷 1005-1018页

作者： ju-mei Liang Li-juan Zhang De-Ge XiLi Jing Kang Beijing Key Laboratory for Green Catalysis and Separation College of Environmental and Energy EngineeringCenter of Excellence for Environmental Safety and Biological EffectsBeijing University of TechnologyBeijing 100124China

Sodium ion batteries(SIBs)is considered as a promising alternative to the widely used lithium ion batteries in view of the abundant resources and uniform distribution of sodium on the ***,due to the lack of suitable anode and cathode materials,especially the anode materials with excellent performance,its practical application is *** recent years,lots of attentions are devoted to developing new electrode materials with high sodium storage capacity and long *** a large number of anode material libraries,tin-based materials with alloying reaction mechanism show great potential for application in high-energy SIBs due to their high theoretical specific *** this paper,detailed and comprehensive research progress on tin-based anodes(including tin metal,tin alloy as well as its compounds)in recent years is *** efforts to improve the electrochemical properties of tin-based anode materials are ***,the challenges and prospects of these anode materials are also proposed in this review.

关键词： Tin-based material Anode Sodium ion battery Electrochemical performance

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The Synthesis and Characterization of High Molecular Weight Poly(phenylene sulfide/ether)

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Chinese Chemical Letters 2006年第10期17卷 1373-1376页

作者： Ai Qun GU mei ju XIE Zi Li YU Institute of Materials Science ＆ Technology Analytical ＆ Testing Center Sichuan University Chengdu 610064

Poly（phenylene sulfide/ether）（PPSE） was synthesized from 4,4＇-dihydroxydiphenyl sulfide and 4,4＇-dichlorodiphenyl sulfide in solution by nucleophilic substitution reaction. The resulting polymer was characterized by viscosity measurement, elemental analysis, FT-IR, ^1H NMR, X-ray diffraction and thermal analysis. The results showed that the viscosities of the resulting polymer were above 0.68 dL/g, and the linear chain structure of product was confirmed. PPSE had the same reflex indices as poly（p-phenylene sulfide）, an orthorhombic crystalline with unit cell a=0.853, b=0.562, c=1.026nm. The melting temperature, glass transition temperature and initial decomposition temperature were found to be 228℃, 85℃ and 325℃, respectively. The product was soluble in common organic solvents such as NMP, N, N＇-dimethylformamide, N, N＇-dimethylacetamide and 1,2-dichloroethane.

关键词： Poly(phenylene sulfide/ether) (PPSE) synthesis characterization.

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Effectiveness and longevity of amendments to a cadmium-contaminated soil

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Journal of Integrative Agriculture 2020年第4期19卷 1097-1104页

作者： ZHAO Rui Lv Yi-zhong MA Yi-bing LI ju-mei College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193P.R.China Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081P.R.China

The effectiveness and longevity of amendments will influence the reduction in cadmium(Cd) bioavailability by in situ remediation techniques. Different amendments, including red mud(RM), corn straw(CS), rape straw(RS), and their combinations with zinc(Zn) fertilizer, were evaluated based on a long-term field experiment. It was found that all amendments decreased the concentration of available-Cd(EDTA-Cd and Exch-Cd) in soil and also reduced the Cd content(%) in plants. The amendments were still effective after eight years, although the effect did decline over time. The reduction of plant Cd content was 83.5% for red mud plus rape straw(RMRS), 65.3% for red mud plus corn straw(RMCS), 50.9% for RS, 54.0% for RM, and 37.3% for CS in the first few years. The reduction in plant Cd content was still 17.2% for RMRS after eight years, and RMRS was found to be the most effective treatment for decreasing Cd bioavailability. This study also explained that why the reduction in plant Cd content declined over time is the change of available Cd content in soil over time, which is important for guiding agricultural practice. It was concluded that RM, CS, RS, and their combinations with Zn fertilizer as effective amendments can have a profound and lasting positive impact on Cd-contaminated soils.

关键词： cadmium(Cd) amendment bioavailability Cd reduction

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Using nutritional assessment to predict gender-specific risks of sarcopenia among the elderly receiving health check-up in Taipei

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Journal of Geriatric Cardiology 2016年第3期13卷 261-266页

作者： Ya-Hui HUANG Yi-Fen LIN mei-ju CHEN Food and Nutrition Department Heping Fuyou Branch of Taipei City Hospital Taiwan China Department of Family Medicine Heping Fuyou Branch of Taipei City Hospital Taiwan China College of Healthcare Administration and Management National Taipei University of Nursing and Health Science Taiwan China

Quality of life for the elderly in an ageing society is receiving more attention than ever. After age 40, muscle mass loses at the rate of 3% to 8% every 10 years. More- over, the decline intensifies after 60 years old. Although many people do not experience changes in total body weight, their muscle mass is slowly replaced by body fat. Decreased muscle mass means lower muscle strength, which affects physical functioning. As a result, daily activities become con- strained, risks of fall and bone fracture elevated,

关键词： Gender Mini-nutritional assessment Sarcopenia

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Synthesis and Crystal Structure of 3,3'-Dimethyl-dibenzo-18-crown-6

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Chinese Journal of Structural Chemistry 2006年第6期25卷 757-760页

作者： NIU mei-ju DOU Jian-Min WANG Da-Qi LI Da-Cheng Department of Chemistry Liaocheng University Liaocheng 252059 China

3,3′-Dimethyl-dibenzo-18-crown-6 was synthesized and characterized by elemental analysis, FT-IR, ^1H NMR, UV, MS spectra and X-ray single-crystal diffraction. It belongs to orthorhombic, space group Pna21 with a = 8.0790（18）, b = 16.780（4）, c = 15.222（3） .A, Z= 4, V= 2063.6（8） A3 Dc = 1.250 g/cm^3,μ = 0.090 mm^-1, F（000） = 832, R = 0.0474 and wR = 0.1103. According to structural analysis, the title compound possesses a boat-like configuration.

关键词： crown ether 3,3'-dimethyl-dibenzo-18-crown-6 synthesis crystal structure

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