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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller won-Kyu ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal won-Ha Lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri H.juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第01期 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-ju Kim Wangyun won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

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Prediction accuracy of reservoir break flood simulation model using finite volume method and UAV

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International Journal of Agricultural and Biological Engineering 2020年第6期13卷 7-15页

作者： jeongbae jeon won Choi Spatial Information Research Institute Korea Land and Geospatial Infomatix CorporationKorea Land and Geospatial Infomatix CorporationJeollabuk-doSouth Korea Department of Rural Systems Engineering Global Smart Farm Convergence MajorResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826South Korea

Methods for producing high-resolution digital topographic maps using an unmanned aerial vehicle(UAV),and 3D fluid dynamics simulation to estimate the flooded areas caused by a collapsed reservoir,were proposed in this *** UAV flight path for photographing damaged areas was divided into two sections considering the drone flight time and overlapping range of the images in the x-and *** metadata taken by the drone were transferred into world coordinates by tracking the key features of the photographs of nearby areas using a 3D rotation *** point cloud data with a 3D space were extracted from the registered images,and a digital surface map(DSM)was produced using a point cloud classification geometric mapping *** amend the serious elevation errors caused by natural or artificial obstacles,a kriging interpolation method was used to reproduce the DSM.A transient computational simulation that considers both the complex geometric topology and hydrodynamic energy of flowing water was conducted using FLOW-3D software to deal with an renormalization group(RNG)turbulence *** flooded areas calculated through visual reading using images taken by the UAV were compared with the 3D simulation results for *** flooded areas estimated through the simulation were approximately 18.3%larger than those found by visual *** flows were mainly observed in obstacles or curved areas of the stream,and the differences in the water depth could be further ***,the villagers confirmed that the flooded areas were much greater than what was seen through the visual ***,the combination of UAV surveying and the 3D simulation method based on the RNG turbulence model is recommended to accurately estimate flooded areas,and it will support an administrative policy aimed at minimizing the economic costs of damage caused by future reservoir collapses.

关键词： reservoir failure flooded area finite volume method unmanned aerial vehicle photogrammetric survey digital surface model

Progress and challenges for replacing n-methyl-2-pyrrolidone/polyvinylidene fluoride slurry formulations in lithium-ion battery cathodes

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Progress in Natural Science:Materials International 2024年第1期34卷 194-206页

作者： Sung Cik Mun Yeong Hoon jeon Jong Ho won Battery Materials Research Center LG Chem Department of Energy Engineering Dankook University

With electric vehicles, energy storage systems, and portable electronic devices becoming increasingly popular, the demand for lithium-ion batteries has surged considerably. In the lithium-ion battery industry, n-methyl-2-pyrrolidone(NMP) is widely used as the solvent for cathode slurry, and polyvinylidene fluoride(PVDF) is used as the cathode binder. However, because of the harmful effect of NMP on the environment and human health, the use of NMP and PVDF for lithium-ion batteries will be highly regulated in the future. Therefore, developing eco-friendly alternatives is crucial for formulating systems using new solvents and binders. Despite numerous efforts, these alternatives have not been widely adopted across the lithium-ion battery industry. It is due to their limited ability to compete on price or performance to replace the traditional NMP/PVDF slurry formulations. This review investigates developments in the search for new solvents and binders that can be used in cathode slurry compositions. The new systems can potentially decrease energy consumption and manufacturing costs associated with NMP recovery, energy-intensive drying processes, and material expenses. We discuss key factors and technical challenges from earlier studies and compare them with the current, optimized formulations based on NMP and PVDF.

关键词： Lithium-ion battery Eco-friendly alternative Slurry formulation Chemical regulation Binder performance

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra jeon Changmin Shin Sun-Young Kwon Sojin Shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

IWTW:A Framework for IoWT Cyber Threat Analysis

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Computer Modeling in Engineering & Sciences 2024年第11期141卷 1575-1622页

作者： GyuHyun jeon Hojun Jin ju Hyeon Lee Seungho jeon jung Taek Seo Department of Information Security Gachon UniversitySeongnam13120Republic of Korea Department of Computer Engineering(Smart Security) Gachon UniversitySeongnam13120Republic of Korea

The Internet of Wearable Things(IoWT)or Wearable Internet of Things(WIoT)is a new paradigm that combines IoT and wearable *** in IoT technology have enabled the miniaturization of sensors embedded in wearable devices and the ability to communicate data and access real-time information over low-power mobile *** devices are highly interdependent with mobile ***,due to their limited processing power and bandwidth,IoWT devices are vulnerable to cyberattacks due to their low level of *** modeling and frameworks for analyzing cyber threats against existing IoT or low-power protocols have been actively *** threat analysis framework used in existing studies was limited to specific protocols and did not target IoWT *** addition,In the literature surveyed to date,no cyber threat analysis framework is targeting ***,the threat model presented in the existing research on cyber threat analysis and modeling for IoWT is specialized for specific *** addition,because it does not present standardized attack tactics and techniques,there is a limitation in that it is difficult to identify attacks *** this paper,we propose an Internet of Wearable Things threat analysis frameWork(IWTW)framework that can derive security threats through systematic analysis of IoWT attack cases and possible security threats and perform cyber threat analysis based on *** methodology for developing the IWTW framework consists of three steps:Analysis,Standardization,and *** attack cases and potential security threats are analyzed in the analysis *** the standardization stage,attack tactics and techniques derived from the analysis of attack cases and potential security threats are standardized,resulting in 3 attack categories,18 attack tactics,and 68 attack *** the compilation stage,standardized security threats are combined to develop the IWTW framework *** present four case st

关键词： Internet of wearable things wearable device threat framework security threat

cAMP/PKA pathway and mitochondrial protection in oxidative stress-induced optic nerve head astrocytes

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Neural Regeneration Research 2021年第1期16卷 108-109页

作者： Keun-Young Kim won-Kyu ju National Center for Microscopy and Imaging Research and Department of Neurosciences University of California San DiegoLa JollaCAUSA Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA

Oxidative stress and cyclic adenosine 3′,5′-monophosphate(cAMP)/protein kinase A(PKA)pathway in the optic nerve head astrocytes:Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and *** the widely appreciated disease relevance of structural and functional abnormalities of astrocyte in the optic nerve head(ONH)that is associated with retinal ganglion cell(RGC)axon degeneration,the molecular mechanisms underlying astrocyte dysfunction in glaucomatous ONH degeneration are poorly *** stress is strongly linked to glaucoma pathogenesis,and astrocytes are the responsible cell type that is mostly related to oxidative stress and glaucomatous ONH degeneration.

关键词： oxidative stress degeneration