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Resistance development,cross-resistance,and fitness costs associated with Aphis gossypii resistance towards sulfoxaflor and acetamiprid in different geographical regions

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Journal of Integrative Agriculture 2024年第7期23卷 2332-2345页

作者： Wei Wang Renfu Zhang Haiyang Liu Ruifeng Ding Qiushi Huang ju Yao Gemei Liang Key Laboratory of Integrated Pest Management on Crop in Northwestern Oasis of Ministry of Agriculture and Rural Affairs Institute of Plant ProtectionXinjiang Academy of Agricultural SciencesUrumqi 830091China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China

Aphis gossypii has become increasingly difficult to manage due to its strong insecticide *** the laboratory,we established sulfoxaflor-resistant and acetamiprid-resistant strains in two *** populations with different basal insecticide resistance levels,and evaluated the effects of basal insecticide resistance on the resistance development and cross-resistance,as well as differences in *** the same selection pressure,Yarkant ***(with low basal insecticide resistance)evolved resistance to sulfoxaflor and acetamiprid more quickly than Jinghe ***(with high basal insecticide resistance),and the evolution of *** resistance to sulfoxaflor developed faster than acetamiprid in both Yarkant and Jinghe,Xingjiang,*** sulfoxaflor-resistant strains selected from Yarkant and Jinghe developed significant cross-resistance to acetamiprid,imidacloprid,thiamethoxam and pymetrozine;while the acetamiprid-resistant strains developed significant cross-resistance to sulfoxaflor,imidacloprid,thiamethoxam,pymetrozine,and *** relative fitness of *** decreased as the resistance to sulfoxaflor and acetamiprid *** relative fitness levels of the sulfoxaflor-resistant strains(Yarkant-SulR and Jinghe-SulR)were lower than those of the acetamipridresistant strains(Yarkant-AceR and Jinghe-AceR).In addition,the relative fitness levels of sulfoxaflor-and acetamiprid-resistant strains were lower in Jinghe than in *** summary,basal insecticide resistance of *** and insecticide type affected the evolution of resistance to insecticides in ***,as well as cross-resistance to other *** sulfoxaflor-and acetamiprid-resistant *** strains had obvious fitness *** results of this work will contribute to the insecticide resistance management and integrated management of ***.

关键词： Aphis gossypii sulfoxaflor acetamiprid cross-resistance fitness costs different sensitivities

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Measuring drug similarity using drug–drug interactions

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Quantitative Biology 2024年第2期12卷 164-172页

作者： Ji Lv Guixia Liu Yuan ju Houhou Huang Ying Sun College of Computer Science and Technology Jilin UniversityChangchunChina Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin UniversityChangchunChina Sichuan University Library Sichuan UniversityChengduChina College of Chemistry Jilin UniversityChangchunChina Department of Respiratory Medicine The First Hospital of Jilin UniversityChangchunChina

Combination therapy is a promising approach to address the challenge of antimicrobial resistance,and computational models have been proposed for predicting drug–drug *** existing models rely on drug similarity measures based on characteristics such as chemical structure and the mechanism of *** this study,we focus on the network structure itself and propose a drug similarity measure based on drug–drug interaction *** explore the potential applications of this measure by combining it with unsupervised learning and semi-supervised learning *** unsupervised learning,drugs can be grouped based on their interactions,leading to almost monochromatic group–group *** addition,drugs within the same group tend to have similar mechanisms of action(MoA).In semi-supervised learning,the similarity measure can be utilized to construct affinity matrices,enabling the prediction of unknown drug–drug *** method exceeds existing approaches in terms of ***,our experiments demonstrate the effectiveness and practicability of the proposed similarity *** the one hand,when combined with clustering algorithms,it can be used for functional annotation of compounds with unknown *** the other hand,when combined with semi-supervised graph learning,it enables the prediction of unknown drug–drug interactions.

关键词： drug similarity drug–drug interactions drug combinations synergy effect clustering semi-supervised learning

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Study on the Relationship between AMPK/UCP2 Pathway and Mitochondrial Dysfunction in Granulosa Cells of Polycystic Ovay Syndrome

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Chinese Journal of Biomedical Engineering(English Edition) 2024年第1期33卷 1-8页

作者： ZHANG ju-shun HE Bin-bin WEN Shi-di Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian 364000China

Objective:To investigate the changes of the AMP-activated protein kinase(AMPK)/uncoupling protein 2(UCP2)(AMPK/UCP2)pathway in ovarian granulosa cells with PCOS and its relationship with mitochondrial ***:PCOS mouse models and normally fed mice,ovarian granulosa cells from the two mice were extracted,and the protein expression levels of AMPKα,p-AMPKαand UCP2 were detected by western *** ROS and ATP content of granulosa cells were determined by colorimetric and chemiluminescence immunoassays to assess mitochondrial *** correlation analysis was used to determine the correlation between AMPK/UCP2 pathway-related proteins,ROS and ***:P-AMPKα/GAPDH(0.12±0.09),AMPKα/GAPDH(0.35±0.40),P-AMPKα/AMPKα(0.56±0.33)and ATP(0.36±0.04)pmol/mg in PCOS model mice were lower than those in non-POCS groups,while UCP2/GAPDH(1.18±0.28)and ROS(48810.92±4498.08)were lower than those in non-POCS *** fluorescence intensity of DCF was higher than that of the non-POCS group(P<0.05).AMPK was positively correlated with ATP and negatively correlated with ***2 was positively correlated with ROS and negatively correlated with ***:There are abnormal changes such as decreased AMPK expression and increased UCP2 expression in ovarian granulosa cells of PCOS,and AMPK is positively and negatively correlated with mitochondrial function indexes ATP and ROS,while UCP2 is the opposite,suggesting that the imbalance in the expression and activity of AMPK/UCP2 pathway in PCOS may be one of the molecular mechanisms leading to mitochondrial *** of AMPK/UCP2 pathway activity may be a potential therapeutic target to ameliorate PCOS-related mitochondrial dysfunction.

关键词： polycystic ovary syndrome AMP-activated protein kinase(AMPK) uncoupling protein 2(UCP2) mitochondrial dysfunction granule cells

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Effect of Menopausal Hormone Replacement Therapy on Cytokine Patterns in a Perimenopausal Mouse Model Established by the Ovarian Castration Method

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Chinese Journal of Biomedical Engineering(English Edition) 2024年第1期33卷 40-48页

作者： HE Bin-bin ZHANG ju-shun WANG Jin-yong Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian 364000China

Objective: To investigate the effect of perimenopausal hormone replacement therapy(HRT) on cytokine patterns in a perimenopausal mouse model established by ovarian castration. Methods: The mice were divided into natural menopause group,ovariectomy group and HRT group, with 15 mice in each group, and the estrous cycle, estrous frequency and menopausal time of the mice were determined by vaginal cytology,and the estrous cycle, estrous frequency and menopausal time were compared among the three groups. The serum levels of estradiol(E2) and progesterone(P4) in each group were detected by double-antibody sandwich ELISA, and the levels of interferon gamma(IFN-γ), interleukin-2(IL-2), IL-4 and IL-10 in the spleen γ tissues of mice were detected by ELISA. Results: The time of menopause(53.07±3.99) d in the HRT group was between that of the natural menopause group(80.80±3.26) d and that of the ovariectomy group(16.27±4.35) d, with a statistically significant difference in the two-by-two comparison of the three groups(P<0.05). The levels of serum E2(694.4±128.3) ng/L and P4(14.2 ±6.0) ng/L in the HRT therapy group are between those of the ovariectomy group and the natural menopause group, with statistically significant differences between the groups(P<0.05). The levels of IL-2(30.9±5.3) pg/ml, IL-4(9.4±1.6) pg/ml, IL-10(19.7±3.1) pg/ml, IFN-γ(22.0±3.7) pg/ml in the HRT group were all between those of natural menopause group and ovariectomy group. The Th1/Th2 ratio in the ovariectomy group was 7.55±1.57, higher than that in the natural menopause group(1.53±0.48) and HRT group(2.38 ±0.44), with statistically significant differences(P<0.05). Conclusion:Menopausal HRT can partially correct the imbalance of Th1/Th2 cytokines, which is able to provide an experimental basis for the regulation of menopause-related immune imbalance by HRT.

关键词： menopause hormone replacement therapy(HRT) ovariectomy mouse model cytokine pattern

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Evidence-Based Dampness-Heat ZHENG(Syndrome) in Cancer: Current Progress toward Establishing Relevant Animal Model with Pancreatic Tumor

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Chinese Journal of Integrative Medicine 2024年第1期30卷 85-95页

作者： JIAO ju-ying CHENG Chien-shan CAO Zhang-qi CHEN Lian-yu CHEN Zhen Department of Integrative Oncology Fudan University Shanghai Cancer CenterShanghai(200032)China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai(200032)China

Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is increasingly becoming accepted by both patients and healthcare workers alike. Chinese medicine characterized by its unique diagnostic and treatment system is the most widely applied complementary and alternative medicine. It emphasizes symptoms and ZHENG(syndrome)-based treatment combined with contemporary disease diagnosis and further stratifies patients into individualized medicine subgroups. As a representative cancer with the highest degree of malignancy, pancreatic cancer is traditionally classified into the "amassment and accumulation". Emerging perspectives define the core pathogenesis of pancreatic cancer as "dampness-heat" and the respective treatment "clearing heat and resolving dampness" has been demonstrated to prolong survival in pancreatic cancer patients, as has been observed in many other cancers. This clinical advantage encourages an exploration of the essence of dampness-heat ZHENG(DHZ) in cancer and investigation into underlying mechanisms of action of herbal formulations against dampness-heat. However, at present, there is a lack of understanding of the molecular characteristics of DHZ in cancer and no standardized and widely accepted animal model to study this core syndrome in vivo. The shortage of animal models limits the ability to uncover the antitumor mechanisms of herbal medicines and to assess the safety profile of the natural products derived from them. This review summarizes the current research on DHZ in cancer in terms of the clinical aspects, molecular landscape, and animal models. This study aims to provide comprehensive insight that can be used for the establishment of a future standardized ZHENG-based cancer animal model.

关键词： cancer Chinese medicine syndrome ZHENG dampness-heat syndrome animal model pancreatic tumor evaluation methods

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Seismic response and correlation analysis of a pile-supported wharf to near-fault pulse-like ground motions

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 883-897页

作者： Wang Jianfeng Su Lei Xie Libo Ling Xianzhang ju Peng School of Civil Engineering Qingdao University of TechnologyQingdao 266500China School of Civil Engineering Harbin Institute of TechnologyHarbin 150006China No.2 Engineering Company Ltd.of CCCC First Harbor Engineering Company Ltd Qingdao 266071China

Earthquake investigations have shown that near-fault pulse-like(NF-P)ground motions have unique characteristics compared to near-fault non-pulse-like(NF-NP)and far-field(FF)ground *** is necessary to study the seismic response of pile-supported wharf(PSW)structures under NF-P ground *** this study,a three-dimensional finite element numerical model is created to simulate a *** imparting three types of ground motion,the engineering demand parameters(EDPs)of PSW under NF-P ground motions were analyzed and compared,in which EDPs are the maximum displacement and bending moment of the *** intensity measures(IMs)were selected to characterize the properties of ground *** correlation between IMs and EDPs was *** results show that the piles present larger displacement and bending moment under NF-P ground motions compared to NF-NP and FF ground *** of the IMs have a high correlation with EDPs under NF-P ground motions,and these IMs are more applicable to FF ground *** correlation coefficients between EDPs and IMs under three types of ground motion were obtained,which will provide a valuable reference for the seismic design of PSWs.

关键词： pile-supported wharf correlation analysis near-fault pulse-like ground motion intensity measure seismic response

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IHMP:an improved hierarchical motion planner for mobile manipulator in static environment

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The Journal of China Universities of Posts and Telecommunications 2024年第3期31卷 56-71页

作者： Wang Binpeng Huang Houqin Xu Fangzhou ju Dianyuan Li Zeqiang Feng Chao School of Electrical Engineering and Automation Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Jinan Engineering Laboratory of Human-Machine Intelligent Cooperation Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China International School for Optoelectronic Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China

Mobile manipulators are used in a variety of fields because of their flexibility and *** path planning capability of the mobile manipulator is one of the important indicators to evaluate the performance of the manipulator,but it is greatly challenged in the face of maps with narrow *** address the problem,an improved hierarchical motion planner(IHMP)is proposed,which consists of a two-dimensional(2D)path planner for the mobile base,and a three-dimensional(3D)trajectory planner for the on-board ***,a hybrid sampling strategy is proposed,which can reduce invalid nodes of the generated probabilistic *** test is used to locate the narrow channel areas,and a Gaussian sampler is deployed in these areas and the ***,a random sampler is deployed in the rest *** planner for on-board manipulator is to generate a collision-free and safe trajectory in the narrow channel with collaboration of the 2D path *** experimental results show that IHMP is effective for mobile manipulator motion planning in complex static environments,especially in narrow channel.

关键词： static environment mobile manipulator motion planner improved hierarchical motion planner(IHMP)

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Effect of Ti_(p) Content on the Work Hardening and Softening Behavior of Mg-Zn-Ca Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 551-560页

作者： Jin-Kai Zhang Cui-ju Wang Yi-Dan Fan Chao Xu Kai-Bo Nie Kun-Kun Deng Shanxi Key Laboratory of Advanced Magnesium-Based Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

The Ti_(p)/ZX60 composites with different Ti_(p) contents were prepared by semi-solid stirring *** extrusion,the microstructure,work hardening and softening behavior of the Ti_(p)/ZX60 composites were analyzed compared with the ZX60(Mg-6Zn-0.2Ca)*** results showed that the addition of Ti_(p) could not only promote the nucleation of dynamic recrystallized(DRXed)grains,but also be propitious to the refinement of DRXed *** increasing Ti_(p) content,the size of DRXed grains decreased accompanied with increasing volume fraction of DRXed *** the Ti_(p) content increased to 15 vol.%,the average size and volume fraction of DRXed grains reached to~0.32μm and 93.2%,***,both the strength and elongation were improved by the addition of Ti_(p).With increasing content of Ti_(p),a substantial increase in the strength was achieved with little change in the ***,the elongation decreased sharply when the Ti_(p) content further increased to 15 vol.%.The addition of Ti_(p) led to an increase in the work hardening rate,which gradually increased with increasing Ti_(p) ***,the softening rate did not demonstrate the same tendency with increasing Ti_(p) *** the conventional ceramic particles,the Ti_(p) can be deformed in coordination with the matrix alloy,which imparted a higher softening rate to the matrix *** though the softening rate improved as the Ti_(p) content increased from 5 to 10 vol.%,it dropped deeply as the Ti_(p) content increased to 15 vol.%owing to the fracture of Ti_(p) during extrusion.

关键词： Titanium particle content Particle reinforced magnesium matrix composites Work hardening Softening behavior Mechanical properties

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End-to-End Paired Ambisonic-Binaural Audio Rendering

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 502-513页

作者： Yin Zhu Qiuqiang Kong junjie Shi Shilei Liu Xuzhou Ye ju-Chiang Wang Hongming Shan junping Zhang Shanghai Key Laboratory of Intelligent Information Processing School of Computer ScienceFudan UniversityShanghai 200433China Beijing ByteDance Technology Co.Ltd. Shanghai 201102China. Chinese University of Hong Kong Hong KongChina IEEE Institute of Science and Technology for Brain-Inspired Intelligence and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433 Shanghai Center for Brain Science and Brain-Inspired Technology Shanghai 200031China

Binaural rendering is of great interest to virtual reality and immersive media. Although humans can naturally use their two ears to perceive the spatial information contained in sounds, it is a challenging task for machines to achieve binaural rendering since the description of a sound field often requires multiple channels and even the metadata of the sound sources. In addition, the perceived sound varies from person to person even in the same sound field. Previous methods generally rely on individual-dependent head-related transferred function(HRTF)datasets and optimization algorithms that act on HRTFs. In practical applications, there are two major drawbacks to existing methods. The first is a high personalization cost, as traditional methods achieve personalized needs by measuring HRTFs. The second is insufficient accuracy because the optimization goal of traditional methods is to retain another part of information that is more important in perception at the cost of discarding a part of the information. Therefore, it is desirable to develop novel techniques to achieve personalization and accuracy at a low cost. To this end, we focus on the binaural rendering of ambisonic and propose 1) channel-shared encoder and channel-compared attention integrated into neural networks and 2) a loss function quantifying interaural level differences to deal with spatial information. To verify the proposed method, we collect and release the first paired ambisonic-binaural dataset and introduce three metrics to evaluate the content information and spatial information accuracy of the end-to-end methods. Extensive experimental results on the collected dataset demonstrate the superior performance of the proposed method and the shortcomings of previous methods.

关键词： Ambisonic attention binaural rendering neural network

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Flexible incidence angle scanning surface plasmon resonance microscopy for morphology detection with enhanced contrast

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Photonics Research 2024年第6期12卷 1213-1221页

作者： LINGKE WANG JINGYU MI SHUQI WANG WENRUI LI ju TANG JIAWEI ZHANG JIWEI ZHANG JIANLIN ZHAO Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710129China

Surface plasmon resonance microscopy(SPRM)has been massively applied for near-field optical measurement,sensing,and imaging because of its high detection sensitivity,nondestructive,noninvasive,wide-field,and label-free imaging ***,the transverse propagation characteristic of the surface plasmon wave generated during surface plasmon resonance(SPR)leads to notable“tail”patterns in the SPR image,which severely deteriorates the image ***,we propose an incidence angle scanning method in SPRM to obtain a resonance angle image with exceptional contrast that significantly mitigates the adverse effects of“tail”*** resonance angle image provides the complete morphology of the analyzed samples and enables two-dimensional quantification,which is incapable in conventional *** effectiveness of the method was experimentally verified using photoresist square samples with different sizes and two-dimensional materials with various geometric *** edges of samples were fully reconstructed and a maximum fivefold increase in the image contrast has been *** method offers a convenient way to enhance the SPRM imaging capabilities with low cost and stable performance,which greatly expands the applications of SPRM in label-free detection,imaging,and quantification.

关键词： angle resonance surface

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