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Research in Astronomy and Astrophysics 2024年第9期24卷 76-82页

作者： Min Meng qiu-ju Huang Can-Min Deng Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

In this paper,we upgrade the constraints for the Earth-mass primordial black hole mergers model based on the first Canadian Hydrogen Intensity Mapping Experiment(CHIME)/fast radio burst(FRB)*** the null hypothesis that the observed non-repeating FRBs originate from Earth-mass primordial black hole mergers,we find that how the charges were distributed in the primordial black hole population is well described by a double powerlaw function with typical charge value of law function with typical charge value of q_(c)/10^(-5)=1.60_(-0.28)^(+0.28),where the power-law index α_(1)=2.33_(-0.18)^(+0.15) for q

关键词： black hole physics (stars:)gamma ray burst:general (cosmology:)dark matter

Hydrogen production from hydrolysis of NaBH_(4) solution over Co-Fe-B@g-C_(3)N_(4)/NF thin film catalyst

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Rare Metals 2024年第6期43卷 2648-2659页

作者： Yan Wang Jia-Xin Ma Jian Ren Di Zhang Feng-Yan Xu Ke Zhang Zhong-qiu Cao qiu-ju Sun Guo-De Li Shi-Wei Wu Hong-Hui Chen College of Chemistry and Chemical Engineering Shenyang Normal UniversityShenyang 110034China Experimental Center Shenyang Normal UniversityShenyang 110034China Hunan Shande Energy Storage New Materials Research Institute Limited Company Changde 415000China

In this study,the double loaded Co-Fe-B@g-C_(3)N_(4)/NF(NF:Ni foam)thin film catalysts were prepared for the first time via chemical deposition method at room *** optimizing the reducing agent concentration to 0.9 mol·L^(-1),the as-obtained Co-Fe-B@g-C_(3)N_(4)/NF exhibited the twisted ribbon structure with more distinct three-dimensional hierarchy and the smaller particle size,showing the good catalytic property for the hydrolysis of NaBH_(4)*** H_(2)generation rate of Co-Fe-B@g-C_(3)N_(4)/NF and binary Co-B@g-C_(3)N_(4)/NF under visible light irradiation surpassed the value under natural *** apparent activation energy of Co-Fe-B@g-C_(3)N_(4)/NF(45.0 kJ·mol^(-1))under visible light irradiation was obviously reduced when compared with the natural condition(48.4 kJ·mol^(-1))and binary Co-B@g-C_(3)N_(4)/NF(60.6 kJ·mol^(-1))under visible light ***,the catalytic performance of the optimized Co-Fe-B@g-C_(3)N_(4)/NF thin film catalyst was superior to most of the reported non-noble metal and even noble metal ***,it illustrated that the catalytic H_(2)production performance of Co-Fe-B@g-C_(3)N_(4)/NF thin film was distinctly improved after the introduction of light and multicomponent recombination.

关键词： Sodium borohydride Co-Fe-B@g-C_(3)N_(4)/NF catalyst Chemical deposition Hydrogen production

Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern

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Life Metabolism 2024年第1期3卷 21-36页

作者： Shuo Wang Lingling Zhang Jingyu Zhao Meijuan Bai Yijun Lin Qianqian Chu jue Gong ju qiu Yan Chen CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

The monocarboxylate transporter 1(MCT1),encoded by gene Slc16a1,is a proton-coupled transporter for lactate and other monocar***1-mediated lactate transport was recently found to regulate various biological ***,how MCT1 and lactate in the intestine modulate the physiology and pathophysiology of the body is *** this study,we generated a mouse model with specific deletion of Slc16a1 in the intestinal epithelium(Slc16a1IKO mice)and investigated the functions of MCT1 in the *** fed a high-fat diet,Slc16a1IKO male mice had improvement in glucose tolerance and insulin sensitivity,while Slc16a1IKO female mice only had increased *** of intestinal MCT1 in male mice was associated with downregulation of pro-inflammatory pathways,together with decreased circulating levels of inflammatory cytokines including tumor necrosis factor alpha(TNFα)and C-C motif chemokine ligand 2(CCL2).Lactate had a stimulatory effect on pro-inflammatory macrophages in *** number of intestinal macrophages was reduced in Slc16a1IKO male mice in *** deletion of Slc16a1 in male mice reduced interstitial lactate level in the *** addition,treatment of male mice with estrogen lowered interstitial lactate level in the intestine and abolished the difference in glucose homeostasis between Slc16a1IKO and wild-type *** of intestinal MCT1 also blocked the transport of lactate and short-chain fatty acids from the intestine to the portal *** effect of Slc16a1 deletion on glucose homeostasis in male mice was partly mediated by alterations in gut *** conclusion,our work reveals that intestinal MCT1 regulates glucose homeostasis in a sex-dependent manner.

关键词： MCT1 intestine lactate short-chain fatty acids insulin resistance obesity

丹酚酸B对香烟烟雾提取物诱导的支气管上皮细胞凋亡的影响

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中国临床药理学杂志 2024年第6期40卷 825-829页

作者：胡秋芳吕秋菊乐山职业技术学院基础医学教研室四川乐山614000 乐山市人民医院内分泌科四川乐山614000

目的研究丹酚酸B对香烟烟雾提取物(CSE)诱导的支气管上皮细胞凋亡的影响及机制。方法将人支气管上皮细胞16HBE分成对照组、模型组(香烟烟雾提取物诱导)、实验低剂量组(烟雾诱导+11μmol·L^(-1)丹酚酸B处理)、实验中剂量组(烟雾诱导+22... 详细信息

目的研究丹酚酸B对香烟烟雾提取物(CSE)诱导的支气管上皮细胞凋亡的影响及机制。方法将人支气管上皮细胞16HBE分成对照组、模型组(香烟烟雾提取物诱导)、实验低剂量组(烟雾诱导+11μmol·L^(-1)丹酚酸B处理)、实验中剂量组(烟雾诱导+22μmol·L^(-1)丹酚酸B处理)、实验高剂量组(烟雾诱导+44μmol·L^(-1)丹酚酸B处理)、实验高剂量+Compound C组(烟雾诱导+44μmol·L^(-1)丹酚酸B+AMPK信号通路抑制剂Compound C处理)。用细胞计数试剂盒-8(CCK-8)实验检测细胞增殖情况,以蛋白质印迹法检测磷酸化腺苷—磷酸活化蛋白激酶(p-AMPK)、CCAAT/增强子结合蛋白同源蛋白(CHOP)、活化转录因子4(ATF4)蛋白表达,用PI单染法检测细胞周期,用Annexin V-FITC/PI双染法检测细胞凋亡情况,用分光光度法检测胱天蛋白酶-3(caspase-3)活性。结果对照组、模型组、实验低剂量组、实验中剂量组、实验高剂量组、实验高剂量+Compound C组的细胞增殖活性(OD值)分别为0.86±0.07、0.38±0.03、0.45±0.03、0.54±0.04、0.68±0.03和0.42±0.04,支气管上皮细胞中p-AMPK/AMPK蛋白表达量比值分别为0.41±0.03、0.13±0.03、0.20±0.02、0.28±0.04、0.36±0.04和0.22±0.02,G0/G1期细胞比例分别为(54.40±5.84)%、(82.93±4.50)%、(75.45±4.73)%、(67.41±2.70)%、(59.15±3.73)%和(69.80±6.59)%,细胞凋亡率分别为(3.21±0.49)%、(24.90±3.35)%、(20.56±1.73)%、(13.55±1.68)%、(9.20±1.07)%和(18.04±1.79)%;实验低剂量组、实验中剂量组、实验高剂量组与模型组相比,在统计学上差异均有统计学意义(均P<0.05);实验高剂量+Compound C组与实验高剂量组相比,在统计学上差异均有统计学意义(均P<0.05)。结论丹酚酸B通过激活AMPK信号通路影响内质网应激,减少香烟烟雾提取物诱导的支气管上皮细胞凋亡。

关键词：丹酚酸B 腺苷一磷酸活化蛋白激酶信号内质网应激支气管上皮细胞细胞周期阻滞

Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： Luo-Xi XIAO Zi-Yu WANG Jiang-Tao LI Hai-Mei WANG Yi-Ming HAO Pan ZHOU Yu-Lin HUANG qiu-ju DENG Yong-Chen HAO Na YANG Li-Zhen HAN Zhao YANG Ping-Ping JIA Yue QI Jing LIU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

太阳辐射减轻哮喘机制研究取得新突破——UVB辐射通过降低2型天然淋巴细胞功能发挥抗哮喘作用

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中国科学：生命科学 2024年第4期54卷 766-768页

作者：姬晓娟邱菊中国科学院大学中国科学院上海营养与健康研究所中国科学院肿瘤与微环境重点实验室上海200031

自然环境中太阳紫外线(solar ultraviolet,UV)的辐射普遍存在,人类常不可避免地暴露于UV辐射下.尽管太阳辐射促进维生素D的体内合成,与此同时引起的DNA、蛋白质和脂质损伤可能诱发细胞死亡、突变、光老化和癌症等有害后果[1].UV辐射诱... 详细信息

自然环境中太阳紫外线(solar ultraviolet,UV)的辐射普遍存在,人类常不可避免地暴露于UV辐射下.尽管太阳辐射促进维生素D的体内合成,与此同时引起的DNA、蛋白质和脂质损伤可能诱发细胞死亡、突变、光老化和癌症等有害后果[1].UV辐射诱导表皮屏障损伤,产生和释放顺式尿酸、血小板活化因子、肿瘤坏死因子等免疫调节因子,激活下游信号通路.

关键词：血小板活化因子免疫调节因子太阳紫外线肿瘤坏死因子 UV辐射维生素D 光老化细胞死亡

Tissue inhibitor of metalloproteinase-3 expression affects clinicopathological features and prognosis of aflatoxin B1-related hepatocellular carcinoma

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World Journal of Hepatology 2024年第8期16卷 1131-1144页

作者： qiu-ju Liang Qin-Qin Long Feng-Qin Tian Qun-Ying Su Xiao-Ying Zhu Xi-Dai Long Clinicopathological Diagnosis and Research Center The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Tumor Pathology Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education InstitutesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND The dysregulation of tissue inhibitor of metalloproteinase-3(TIMP3)was positively correlated with the progression of hepatocellular carcinoma(HCC).However,it is not clear whether TIMP3 expression is associated with the clinico-pathological features and prognosis of aflatoxin B1(AFB1)-related HCC(AHCC).A retrospective study,including 182 patients with AHCC,was conducted to explore the link between TIMP3 expression in cancerous tissues and the clinico-pathological characteristics and prognosis of ***3 expression was detected by immunohistochemistry and its effects on the clinicopathological features and prognosis of AHCC were evaluated by Kaplan-Meier survival analysis and Cox regression survival *** ratio,hazard ratio(HR),median overall survival time(MST),median tumor recurrence-free survival time(MRT),and corresponding 95%confidential interval(CI)was calculated to RESULTS Kaplan-Meier survival analysis showed that compared with high TIMP3 expression,low TIMP3 expression in tumor tissues significantly decreased the MST(36.00 mo vs 18.00 mo)and MRT(32.00 mo vs 16 mo)of patients with *** Cox regression survival analysis further proved that decreased expression of TIMP3 increased the risk of death(HR=2.85,95%CI:2.04-4.00)and tumor recurrence(HR=2.26,95%CI:1.57-3.26).Furthermore,decreased expression of TIMP3 protein in tissues with AHCC was significantly correlated with tumor clinicopatho-logical features,such as tumor size,tumor grade and stage,tumor microvessel density,and tumor blood ***,TIMP3 protein expression was also negatively associated with amount of AFB1-DNA adducts in tumor *** These findings indicate that the dysregulation of TIMP3 expression is related to AHCC biological behaviors and affects tumor outcome,suggesting that TIMP3 may act as a prognostic biomarker for AHCC.

关键词： Tissue inhibitor of metalloproteinase-3 expression Aflatoxin B1 Hepatocellular carcinoma Clinicopathological feature Prognosis

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五音戏中的地域文化书写与内涵阐释

哈尔滨学院学报 2024年第5期45卷 108-112页

作者：邱菊淄博师范高等专科学校山东淄博255130

五音戏,原名“肘鼓子”,是鲁中地区地方戏曲形式之一。它产生于章丘青野一带,流行于济南、淄博等地,距今约四百年的历史。五音戏的唱腔婉转,极具民间口头文学特点,素有“北方越剧”之称,2006年被列为第一批国家级非物质文化遗产。五音... 详细信息

五音戏,原名“肘鼓子”,是鲁中地区地方戏曲形式之一。它产生于章丘青野一带,流行于济南、淄博等地,距今约四百年的历史。五音戏的唱腔婉转,极具民间口头文学特点,素有“北方越剧”之称,2006年被列为第一批国家级非物质文化遗产。五音戏能够在鲁中大地生根、发芽并且传承下去,不仅在于它独到的艺术特色,还在于它与当地文化紧密结合,充分展现了当地百姓的精神品质、日常生活以及当地社会的历史文化、社会的发展与变化等,这也是五音戏地域文化的充分体现。

关键词：雅俗共赏虚实相生五音戏地域文化

Clinical characteristics of sudden hearing loss during pregnancy

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 165-172页

作者： Xiao-Nan Wu Hong-Yang Wang Xiao-Long Zhang Guo-Hui Chen Jing Guan Yun Gao Da-Yong Wang qiu-ju Wang Senior Department of Otolaryngology-Head&Neck Surgery The Sixth Medical Center of PLA General HospitalChinese PLA Medical SchoolBeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina

Objective:The objective of this study was to explore the clinical characteristics and management of sudden hearing loss(HL)during pregnancy,thus better guiding the clinical ***:The clinical and follow-up data of 17 patients(17 ears)with sudden HL during pregnancy were analyzed retrospectively(the observe group).Twelve nonpregnant female patients(12 ears)with sudden HL of similar clinical characteristics were selected as the control *** prognosis of the two groups was *** the patients were followed up after delivery,and two of them were readmitted to the hospital 1–2 months after ***:The observe group had better improvement in hearing and a higher response rate compared to the control *** pure tone hearing and speech recognition rate of patients could still be improved after the readmitted treatment,and the hearing could partially recover spontaneously during *** laboratory indicators that affect the inflammatory response and coagulation pathway were significantly different between the two ***:The hearing condition of sudden HL during pregnancy is severe,and the prognosis of these patients is better than nonpregnant patients of similar clinical *** treatment is still effective,and some patients showed self-healing with time during *** inflammatory response and coagulation function may affect the hearing of patients through a metabolic pathway.

关键词： management pregnancy prognosis sudden hearing loss

基于耳石微化学的珠江水系日本鳗鲡洄游特征研究

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水生生物学报 2024年第10期48卷 1758-1765页

作者：贾秋菊帅方敏李捷上海海洋大学海洋生物资源与管理学院上海201306 中国水产科学研究院珠江水产研究所广州510380 国家渔业资源环境广州观测实验站广州510380 农业农村部外来入侵水生生物防控重点实验室广州510380 广东省水产动物免疫与绿色养殖重点实验室广州510380

为了解珠江水系日本鳗鲡(Anguilla japonica)洄游生态特征,有效保护鳗鲡野生种群,采集了柳州、合山、武宣、桂平、梧州等11个淡水生境以及珠海1个河口生境共155尾日本鳗鲡,利用电子探针微区分析仪测定耳石中的Sr、Ca元素比值,对耳石微化... 详细信息

为了解珠江水系日本鳗鲡(Anguilla japonica)洄游生态特征,有效保护鳗鲡野生种群,采集了柳州、合山、武宣、桂平、梧州等11个淡水生境以及珠海1个河口生境共155尾日本鳗鲡,利用电子探针微区分析仪测定耳石中的Sr、Ca元素比值,对耳石微化学Sr/Ca进行分析,结果发现珠江水系日本鳗鲡具有“海水–淡水”、“海水–河口–淡水”、“海水–河口–海水–河口–淡水”、“海水–河口–淡水–河口–淡水”等多种洄游模式。但总体而言,最终都会洄游到淡水中育肥。这说明珠江水系的日本鳗鲡具有适应不同栖息地和盐度的能力,在不同水域之间表现出灵活的洄游策略,同时也说明了淡水栖息地保护的重要性。

关键词：降河洄游耳石微化学 Sr/Ca 珠江日本鳗鲡

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