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Prevention of Physiological Impairments from Whole Body Vibration by Conditioning with 4F ApoA-I Mimetic

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Journal of Health Science 2014年第9期2卷 441-452页

作者： Ji-Geng Yan lin-ling Zhang Michael Agresti Yuhui Yan Ammar Matloob Hani S. Matloub Kirkwood A. Pritchard jr. Research Lab of Department of Plastic and Reconstructive Surgery Medical College of Wisconsin 8701 Watertown Plank RoadMilwaukee Wisconsin 53226 USA Research Lab of Department of Pediatric Surgery Children 's Hospital of Wisconsin 9000 West Wisconsin Avenue WauwatosaWisconsin 53226 USA

Is physical fatigue one of the major causes of motor vehicle accidents？ Our study results challenged this traditional belief, and indicated that motor vehicle induced whole body vibration （WBV） is the actual cause. In this study, rats were subjected to simulated WBV. After 2 weeks all rats were evaluated by multiple physiological tests. Results indicated that WBV for short periods impaired the animal＇s mental judgment capabilities as well as sensory and motor functions. The primary reason for this is that WBV caused vasoconstriction, which decreased the cerebral blood flow as shown by Doppler imaging. This reduction in blood flow impaired the animal＇s ability to run a maze. Nerve functions were affected as well. This was shown by a reduction in nerve conduction velocity （NCV）. An increase in tail flick and Von Frey withdrawal times showed sensory deficits. Grip strength was also reduced. 4F （human apolipoprotein A-I molecule mimetic） conditioning has shown preventive effects against WBV injury as indicated by the above functional tests. This animal model simulated the most common motor vehicle travel vibration and validated the biological cause and mechanism of physiological impairment from WBV, which can be translated into a practical application for motor vehicle accident prevention.

关键词： Vibration injury neural impairment 4F (human apolipoprotein A-I molecule mimetic) prevention of motor vehicleaccidents.

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不同约束模型的两自由度振动系统动力学特性

华中科技大学学报（自然科学版） 2023年第6期51卷 98-106页

作者：马琳罗冠炜兰州交通大学机电工程学院甘肃兰州730070 兰州交通大学甘肃省轨道交通装备系统动力学与可靠性重点实验室甘肃兰州730070

分别建立了含刚性、弹性、非线性赫兹三种约束的两自由度受迫振动系统的力学模型,通过多目标、多参数协同仿真在(ω,δ)-双参数平面获得了含不同约束模型的周期运动的种类、存在区域及分岔特性,比较了不同约束下系统动力学特性的异同,... 详细信息

分别建立了含刚性、弹性、非线性赫兹三种约束的两自由度受迫振动系统的力学模型,通过多目标、多参数协同仿真在(ω,δ)-双参数平面获得了含不同约束模型的周期运动的种类、存在区域及分岔特性,比较了不同约束下系统动力学特性的异同,发现其在低频率、小间隙参数条件下存在显著差异.重点分析了更加贴近实际碰撞过程的非线性赫兹约束下冲击振动系统的动力学特性,得到了低频域内基本周期冲击振动群的分布区域和转迁规律,发现了相邻基本周期冲击振动转迁过程中出现的两类转迁域(舌形域和迟滞域).进一步讨论了舌形域内亚谐冲击振动的模式类型及产生机理,分析了系统参数对周期运动在(ω,δ)-双参数平面上模式类型及存在区域的影响.

关键词：间隙赫兹约束冲击振动分岔转迁规律

Numerical simulation of ultrashort-pulse reflectometry(USPR)on EAST

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Plasma Science and Technology 2023年第12期25卷 105-114页

作者：俞潇烽陈冉李小良朱逸伦 Calvin W DOMIER 阮行磊黄泰豪郭晋林子钰徐国盛毛世峰 Neville C LUHMANN jr 叶民友 School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026People’s Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China University of California at Davis 1 Shields AvenueDavis CA 95616United States of America

The microwave reflectometer is a popular non-intrusive plasma density diagnostic instrument on tokamaks that provides centimeter and millisecond level *** ultrashort-pulse reflectometer(USPR)achieves plasma density measurement by emitting a chirped wave containing a broadband signal and measuring the time of flight from different frequency components.A USPR system is currently being built on EAST(Experimental Advanced Superconducting Tokamak)to meet the needs of diagnostic of the pedestal density evolution,such as high-frequency small edge-localized *** order to predict the density reconstruction of the EAST USPR system,this work presents a numerical simulation study of the beam propagation of the chirped wave of extraordinary waves(X-mode)in the plasma based on *** electron density profile has been successfully reconstructed by the reflection signal *** small gap between the right-hand cut-off layer and the electron cyclotron resonance layer,due to the low plasma density on the plasma edge,causes unexpected leakage from the transmitting microwave beam to the pedestal and the core *** kind of‘tunneling’effect will cause the reflected signal to have energy loss in the low-frequency *** study also discusses the influence of the poloidal magnetic field on the reflected *** spatial variation of the poloidal magnetic field will lead to the conversion between extraordinary(X)waves and ordinary(O)waves,which leads to energy loss in the reflected *** simulation results show that the‘tunneling’effect and the O-X mode conversion effect have little effect on the EAST USPR ***,the currently designed transmit power meets the working requirements.

关键词： reflectometer pedestal density profile beam mode conversion

Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs

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Science China(Life Sciences) 2022年第2期65卷 309-327页

作者： Ning Wang Yuchen He Silvia Liu Meagan J.Makarcyzk Guanghua Lei Alexander Chang Peter G Alexander Tingjun Hao Anne-Marie Padget Nuria de Pedro Tsapekos Menelaos Hang lin Department of Orthopaedic Surgery University of Pittsburgh School of MedicinePittsburgh PA 15219USA Department of Orthopedic Surgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Pathology University of Pittsburgh School of MedicinePittsburgh PA 15219USA Department of Bioengineering University of Pittsburgh Swanson School of EngineeringPittsburgh PA 15219USA Department of Bioinformatics University of Pittsburgh School of MedicinePittsburgh PA 15219USA McGowan Institute for Regenerative Medicine University of Pittsburgh School of MedicinePittsburgh PA 15219USA Department of Biology University of Pittsburgh Dietrich School of Arts and SciencePittsburgh PA 15219USA Department of Research B2B Life Length SLMadrid 28010Spain Xiangya Third Hospital Central South UniversityChangsha 410013China

Significant cellular senescence has been observed in cartilage harvested from patients with osteoarthritis(OA).In this study,we aim to develop a senescence-relevant OA-like cartilage model for developing disease-modifying OA drugs(DMOADs).Spe-cifically,human bone marrow-derived mesenchymal stromal cells(MSCs)were expanded in vitro up to passage 10(P10-MSCs).Following their senescent phenotype formation,P10-MSCs were subjected to pellet culture in chondrogenic *** from qRT-PCR,histology,and immunostaining indicated that cartilage generated from P10-MSCs displayed both senescent and OA-like phenotypes without using other OA-inducing agents,when compared to that from normal passage 4(P4)-***,the same gene expression differences observed between P4-MSCs and P10-MSC-derived cartilage tissues were also observed between the preserved and damaged OA cartilage regions taken from human samples,as demonstrated by RNA sequencing data and other analysis ***,the utility of this senescence-initiated OA-like cartilage model in drug development was assessed by testing several potential DMOADs and *** results suggest that pre-existing cellular senescence can induce the generation of OA-like changes in *** P4-and P10-MSCs derived cartilage models also represent a novel platform for predicting the efficacy and toxicity of potential DMOADs on both preserved and damaged cartilage in humans.

关键词： osteoarthritis MSC senescence cartilage tissue engineering disease-modifying OA drug senolytic

Productivity and nutritive quality of dallisgrass (<i>Paspalum dilatatum</i>) as influenced by cutting height and rate of fertilization with poultry litter or commercial fertilizer

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Agricultural Sciences 2013年第9期4卷 455-465页

作者： Elias J. Bungenstab Adolfo C. Pereira jr. John C. lin James L. Holliman Russell B. Muntifering Van Beek Nutrition Pocatello USA Elanco Animal Health Greenfield USA Department of Animal Sciences Auburn University Auburn USA

Dallisgrass (Paspalum dilatatum) is well adapted to the Black Belt region of the southeastern US, and information on its productivity and nutritive quality as influenced by fertility is needed. In each yr of a 2-yr study, an existing dallisgrass pasture that had been subdivided into 48 plots of 9.3 m2 each was fertilized with the equivalent of 34 (34N), 67 (67N), 101 (101N) or 134 (134N) kg N/ha from poultry litter (PL) or commercial fertilizer (CF;NH4NO3). In both years, primary-growth and vegetative regrowth forage was harvested in mid-August and late September, respectively, and forage from each harvest was clipped to either a 5- or 10-cm stubble height. Forage cut to a 5-cm height yielded 71% more (P < 0.001) DM than forage cut to a 10-cm height, but forage dry matter (DM) yields were not different between CF and PL treatments across years and fertilization rates. Concentration of crude protein (CP) was greater (P = 0.002) for CF than PL forage and increased for both fertilizer sources with increasing rates of N application. Forage concentrations of cell-wall constituents were not different between CF and PL treatments. Forage amended with CF had a higher concentration of Ca, Mg and Mn than PL-amended forage;however, forage amended with PL had a higher concentration of P and K than CF-amended forage. There was no effect of fertilizer source on forage concentration of Al, Cu or Zn. Results indicate that PL and CF were comparable for supporting productivity and nutritive quality of dallisgrass on Black Belt soils.

关键词： Dallisgrass Productivity Nutritive Quality Poultry Litter

The comparative efficacy of ezetimibe added to atorvastatin 10 mg versus uptitration to atorvastatin 40 mg in subgroups of patients aged 65 to 74 years or greater than or equal to 75 years

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Journal of Geriatric Cardiology 2011年第1期8卷 1-11页

作者： Ori Ben-Yehuda Nanette K. Wenger Christian Constance Franklin Zieve Mary E. Hanson Jian-Xin lin Arvind K. Shah Charlotte Jones-Burton Andrew M. Tershakovec University of California San Diego 200 West Arbor Drive La Jolla CA 92103 USA Emory University School of Medicine 49 Jess Hill Jr Dr SE Atlanta GA 30303 USA SHopital Maisonneuve-Rosemont Recherche Clinique/Polyclinique 5415 Boulevard de l＇Assomption Suite 295 Montreal Quebec QC H1T2M4 Canada McGuire VA Medical Center 1201 Broad Rock Blvd （151） Richmond VA 23249 USA Merck-Sharp ＆ Dohme One Merck Drive Whitehouse Station NJ 08889 USA

Background Coronary heart disease （CHD） risk increases with age; yet lipid-lowering therapies are significantly under-utilized in patients 〉 65 years. The objective was to evaluate the safety and efficacy of lipid-lowering therapies in older patients treated with atorvastatin 10 nag ＋ ezetimibe 10 mg （EZ/Atorva） vs. increasing the atorvastatin dose to 40 mg, Methods Patients 〉 65 years with atherosclerotic vascular disease （LDL-C ≥1.81 mmol/L） or at high risk for coronary heart disease （LDL-C 〉 2.59 mmol/L） were randomized to EZ/Atorva for 12 wk vs. uptitration to atorvastatin 20 nag for 6 wk followed by atorvastatin 40 nag for 6 wk. The percent change in LDL-C and other lipid parameters and percent patients achieving prespecified LDL-C levels were assessed after 12 wk. Results EZ/Atorva produced greater reductions in most lipid parameters vs. uptitration of atorvastatin in patients 〉 75 years （n = 228）, generally consistent with patients 65-74 years （n = 812）. More patients achieved LDL-C targets with combination therapy vs. monotherapy in both age groups at 6 wk and in patients 〉 75 years at 12 wk. At 12 wk, more patients 〉 75 years achieved LDL-C targets with monotherapy vs. combination therapy. EZ/Atorva produced more favorable improvements in most lipids vs. doubling or quadrupling the atorvastatin dose in patients 〉 75 years, generally consistent with the findings in patients 65-74 years. Conclusions Our results extended previous findings demonstrating that ezetimibe added to a statin provided a generally well-tolerated therapeutic option for improving the lipid profile in patients 65 to 74 years and 〉 75 years of age.

关键词： cholesterol absorption inhibitor LDL-C hypercholesterolemia statin

A Lens Assisted Phase Microscope Based on Ptychography

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Chinese Physics Letters 2012年第8期29卷 143-145页

作者： PAN Xing-Chen lin Qiang LIU Cheng ZHU Jian-Qiang Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800

Based on the recently developed ptychographical iterative engine(PIE),we suggest a lens assisted microscopy to realize quantitative phase imaging without using *** sample is imaged with a lens system;a pinhole on the image plane scans the image at a proper step interval;the diffraction pattern is recorded simultaneously by a CCD at Fresnel *** a slightly changed PIE algorithm,the phase image of the sample can be accurately reconstructed from the recorded diffraction *** main advantage of this suggested method lies in its capability to retrieve the phase information from the recorded intensity directly,and thus it has more flexibility over conventional interferometric *** feasibility of the suggested method is verified by reconstructing the modulus and phase image of a biological sample from a set of 10 by 10 diffraction patterns,and the result matches the analysis well.

关键词： record image slightly

Evaluation and spatio-temporal analysis of surface energy flux in permafrost regions over the Qinghai-Tibet Plateau and Arctic using CMIP6 models

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International Journal of Digital Earth 2022年第1期15卷 1947-1965页

作者： Junjie Ma Ren Li Zhongwei Huang Tonghua Wu Xiaodong Wu lin Zhao Hongchao Liu Guojie Hu Yao Xiao Yizhen Du Shuhua Yang Wenhao Liu Yongliang Jiao Shenning Wang Cryosphere Research Station on the Qinghai-Tibet Plateau State Key Laboratory of Cryospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouPeople’s Republic of China University of Chinese Academy of Sciences BeijingPeople’s Republic of China Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhouPeople’s Republic of China School of Geographical Sciences Nanjing University of Information Science & TechnologyNanjingPeople’s Republic of China Zaozhuang University ZaozhuangPeople’s Republic of China

The surface energy budget over the Qinghai-Tibet Plateau(QTP)and the Arctic significantly influences the climate system with global *** performances of 30 selected Coupled Model Intercomparison Project Phase 6(CMIP6)models were evaluated based on six sites in the QTP and *** simulation results for latent heat flux(LE)were more accurate in the QTP,where the correlation coefficient and root mean square error(RMSE)were 0.9 and 30 W m−2,*** results for sensible heat flux(H)were more accurate in the Arctic,the correlation coefficient and RMSE were 0.8 and 24 W m−2,***,the multiple models mean results revealed that the surface energy flux had seasonal variation and regional differences over the QTP and the *** the QTP,H was the lowest in winter,increased in spring,and reached the maximum in ***,the transitional changes in spring and autumn were not apparent in the Arctic,mainly due to seasonal net radiation difference between the two *** was affected by precipitation and surface soil moisture *** work is important for understanding land-atmosphere interactions and useful for improving the accuracy of land surface models simulations.

关键词： Qinghai-Tibet Plateau Arctic surface energy budget permafrost

MAXIMAL FUNCTION CHARACTERIZATIONS OF HARDY SPACES ASSOCIATED WITH BOTH NON-NEGATIVE SELF-ADJOINT OPERATORS SATISFYING GAUSSIAN ESTIMATES AND BALL QUASI-BANACH FUNCTION SPACES

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Acta Mathematica Scientia 2024年第2期44卷 484-514页

作者：林孝盛杨大春杨四辈袁文 Laboratory of Mathematics and Complex Systems(Ministry of Education of China) School of Mathematical SciencesBeijing Normal UniversityBeijing100875China School of Mathematics and Statistics Gansu Key Laboratory of Applied Mathematics and Complex SystemsLanzhou UniversityLanzhou730000China

Assume that L is a non-negative self-adjoint operator on L^(2)(ℝ^(n))with its heat kernels satisfying the so-called Gaussian upper bound estimate and that X is a ball quasi-Banach function space onℝ^(n) satisfying some mild *** HX,L(ℝ^(n))be the Hardy space associated with both X and L,which is defined by the Lusin area function related to the semigroup generated by *** this article,the authors establish various maximal function characterizations of the Hardy space HX,L(ℝ^(n))and then apply these characterizations to obtain the solvability of the related Cauchy *** results have a wide range of generality and,in particular,the specific spaces X to which these results can be applied include the weighted space,the variable space,the mixed-norm space,the Orlicz space,the Orlicz-slice space,and the Morrey ***,the obtained maximal function characterizations of the mixed-norm Hardy space,the Orlicz-slice Hardy space,and the Morrey-Hardy space associated with L are completely new.

关键词： Hardy space ball quasi-Banach function space Gaussian upper bound estimate non-negative self-adjoint operator maximal function