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Concordance of the point-of-care circulating cathodic antigen test for the diagnosis of intestinal schistosomiasis in a low endemicity area

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Infectious Diseases of Poverty 2019年第3期8卷 99-100页

作者： Sergei Rodrigo Magalhaes de Sousa Isabelle Helena Lima Dias Alvaro Luan Santana Fonseca Bianca Rodrigues Contente joyce Favacho Cardoso Nogueira Tatyellen Natasha da Costa Oliveira Stefan Michael Geiger Martin Johannes enk Programa de Pos-Graduacao Strictu Sensu em Biologia Parasitaria na Amazonia da Universidade do estado do Para Tv.Perebebui2623-MarcoBelemPA 66087Brazil Laboratorio de Parasitoses Intestinais Esquistossomose e Malacologia(LPIEM)Secgao de ParasitologiaInstituto Evandro Chagas/SVS/MSAnanindeuaParaBrazil

Background:The Kato-Katz technique is recommended worldwide for the diagnosis of intestinal schistosomiasis,detecting parasite eggs in feces of infected ***,new tests have been developed in order to facilitate diagnosis,*** detection of specific antigens secreted by schistosomes,such as the circulating cathodic antigen(CCA).The aim of this study was to evaluate the performance of the point-of-care circulating cathodic antigen test(POC-CCA)compared to the Kato-Katz technique in a low prevalence area in the Amazon Region,located in the municipality of Primavera,State of Para,***:Positivity rates of the POC-CCA test and the Kato-Katz technique were *** sensitivity,specificity,accuracy and kappa coefficient were determined by comparing both *** reference standard was established using 16 Kato-Katz slides,12 of the first fecal sample,two of the second and two of the third *** study also included the concordance between POC-CCA results and different numbers and combinations of Kato-Katz ***:The prevalence of schistosomiasis according to the reference standard or POC-CCA test reached a rate of 9.4%or 23.9%,respectively,among a total of 372 *** positivity rates by the Kato-Katz technique increased from 2.4 to 9.4%,according to the increase in the number of slides examined and fecal samples colleaed.A sensitivity of 55.6%,specificity 76.9%,accuracy 76%and k coefficient of 0.06 was observed by comparing one slide of the first sample and *** 6 slides from three different samples,two slides of each,with POC-CCA resulted in a sensitivity of 583%,specificity 78.4%,accuracy 77%and k coefficient of ***,the comparison of 16 slides from three different samples with POC-CCA revealed a sensitivity of 65.7%,specificity 80.4%,accuracy 79%,and k coefficient of ***:The immunochromatographic test has the potential to be an important tool to combat schistosomiasis because of its practi

关键词： Schistosoma mansoni Kato-Katz POC-CCA Accuracy Diagnosis Low prevalence area

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Cardiac adverse events of immune checkpoint inhibitors in oncology patients:A systematic review and meta-analysis

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World Journal of Cardiology 2020年第11期12卷 584-598页

作者： Nso Nso Daniel Antwi-Amoabeng Bryce D Beutler Mark B Ulanja Jasmine Ghuman Ahmed Hanfy joyce Nimo-Boampong Sirri Atanga Rajkumar Doshi Sostanie enoru Nageshwara Gullapalli Department of Medicine Icahn School of Medicine at Mount SinaiQueensNY 10029United States Department of Internal Medicine University of NevadaReno School of MedicineRenoNV 89502United States Department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States Department of Internal Medicine Warren Alpert Medical School of Brown UniversityProvidenceRI 02903United States Department of Medicine United Health Services Wilson Medical CenterJohnson CityNY 13790United States Department of Cardiovascular Disease SUNY Downstate Health Science UniversityBrooklynNY 11203United States

BACKGROUND Immune checkpoint inhibitors(ICIs)are novel therapeutic agents used for various types of *** have revolutionized cancer treatment and improved clinical outcomes among cancer ***,immune-related adverse effects of ICI therapy are *** immune-related adverse events(irAes)are rare but potentially life-threatening *** To estimate the incidence of cardiovascular irAes among patients undergoing ICI therapy for various *** We conducted this systematic review and meta-analysis by searching PubMed,Cochrane CeNTRAL,Web of Science,and SCOPUS databases for relevant interventional trials reporting cardiovascular *** performed a single-arm meta-analysis using OpenMeta[Analyst]software of the following outcomes:Myocarditis,pericardial effusion,heart failure,cardiomyopathy,atrial fibrillation,myocardial infarction,and cardiac *** assessed the heterogeneity using the I2 test and managed to solve it with Cochrane’s leave-one-out *** risk of bias was performed with the Cochrane’s risk of bias *** A total of 26 studies were *** incidence of irAes follows:Myocarditis:0.5%[95%confidence interval(CI):0.1%-0.9%];Pericardial effusion:0.5%(95%CI:0.1%-1.0%);Heart failure:0.3%(95%CI:0.0%-0.5%);Cardiomyopathy:0.3%(95%CI:-0.1%-0.6%);atrial fibrillation:4.6%(95%CI:1.0%-14.1%);Myocardial infarction:0.4%(95%CI:0.0%-0.7%);and Cardiac arrest:0.4%(95%CI:0.1%-0.8%).CONCLUSION The most common cardiovascular irAes were atrial fibrillation,myocarditis,and pericardial *** rare,data from post market surveillance will provide estimates of the long-term prevalence and prognosis in patients with ICIassociated cardiovascular complications.

关键词： Atrial fibrillation Cancer Immune checkpoint inhibitors Immunotherapy Cardiovascular adverse events Pericardial effusion

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The world’s ten most feared fungi

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Fungal Diversity 2018年第6期93卷 161-194页

作者： Kevin D.Hyde Abdullah M.S.Al-Hatmi Birgitte Andersen Teun Boekhout Walter Buzina Thomas L.Dawson Jr. Dan C.eastwood e.B.Gareth Jones Sybren de Hoog Yingqian Kang joyce e.Longcore eric H.C.McKenzie Jacques F.Meis Laetitia Pinson-Gadais Achala R.Rathnayaka Florence Richard-Forget Marc Stadler Bart Theelen Benjarong Thongbai Clement K.M.Tsui Key Laboratory for Plant Diversity and Biogeography of east Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Ministry of Health Directorate General of Health ServicesIbriOman Department of Biotechnology and Biomedicine Technical University of Denmark2800 Kgs.LyngbyDenmark Institute for Biodiversity and ecosystem Dynamics(IBeD) University of AmsterdamAmsterdamThe Netherlands Westerdijk Fungal Biodiversity Institute UtrechtThe Netherlands R&D Institute for Hygiene Microbiology and Environmental MedicineMedical University GrazNeue Stiftingtalstrasse 68010 GrazAustria Institute for Medical Biology(IMB) Agency for ScienceTechnologyand Research(A_(*)STAR)SingaporeSingapore Departments of Drug Discovery and Biomedical Sciences and Biochemistry and Molecular Biology Center for Cell DeathInjury and RegenerationMedical University of South CarolinaCharlestonSCUSA Department of Bioscience Academic Office102First FloorWallace BuildingSwansea UniversitySingleton CampusSwanseaWalesUK Centre of expertise in Mycology Radboudumc/Canisius Wilhelmina Hospital(CWZ) NijmegenThe Netherlands Portsmouth Hampshire PO53DHUK Department of Microbiology and the Key Laboratory of Proteomics Guizhou Medical UniversityGuiyangChina School of Biology and ecology University of MaineOronoME 04469USA Manaaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand Department of Medical Microbiology and Infectious Diseases Canisius Wilhelmina Hospital(CWZ)NijmegenThe Netherlands INRA UR1264 MycSA71 av Edouard Bourlaux2003233882 Villenave D’Ornon CedexFrance Department Microbial Drugs Helmholtz Centre for Infection Researchand German Centre for Infection Research(DZIF)Partner Site Hannover-BraunschweigInhoffenstraße 738124 BraunschweingGermany Department of Pathology Sidra MedicineDohaQatar Department of Pathology and Laboratory Medicine Weill Corne

An account is provided of the world’s ten most feared *** areas of interest,we have organized the entries in the order of *** put four human pathogens first as this is of concern to most *** is followed by fungi producing mycotoxins that are highly harmful for humans;Aspergillus flavus,the main producer of aflatoxins,was used as an *** due to indoor air fungi may also directly affect our health and we use Stachybotrys chartarum as an *** everyone collects and eats edible ***,fatalities caused by mushroom intoxications often make news headlines and therefore we include one of the most poisonous of all mushrooms,Amanita phalloides,as an *** then move on to the fungi that damage our dwellings causing serious anxiety by rotting our timber structures and *** lacrymans,which causes dry rot is an excellent *** next example serves to represent all plant and forest *** we chose Austropuccinia psidii as it is causing devastating effects in Australia and will probably do likewise in New ***,we chose an important amphibian pathogen which is causing serious declines in the numbers of frogs and other amphibians *** we target the top ten most feared fungi,numerous others are causing serious concern to human health,plant production,forestry,other animals and our factories and *** highlighting ten feared fungi as an example,we aim to promote public awareness of the cost and importance of fungi.

关键词： Aflatoxicosis Batrachochytrium Candida auris Frog decline Poisonous fungi Human pathogens Indoor fungi Forest pathogens Wood decay

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HYPeRSTUDIO GARDeN :

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1997年

作者： JOSePH F. HOFMeISTeR joyce B. RODOWSKI.

来源：畅想之星图书光盘版（南... 评论

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High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence

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World Journal of Gastroenterology 2022年第35期28卷 5217-5229页

作者： essa A Mohamed Nasra H Giama Abubaker O Abdalla Hassan M Shaleh Abdul M Oseini Hamdi A Ali Fowsiyo Ahmed Wesam Taha Hager Ahmed Mohammed Jessica Cvinar Ibrahim A Waaeys Hawa Ali Loretta K Allotey Abdiwahab O Ali Safra A Mohamed William S Harmsen eimad M Ahmmad Numra A Bajwa Mohamud D Afgarshe Abdirashid M Shire joyce e Balls-Berry Lewis R Roberts Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States Center for Clinical and Translational Science Mayo ClinicRochesterMN 55905United States School of Nursing University of MinnesotaMinneapolisMN 55455United States Division of Digestive Diseases Emory School of MedicineAtlantaGA 30322United States Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Internal Medicine NewYork-Presbyterian QueensFlushingNY 11355United States Department of Pediatrics University of Nevada Las VegasLas VegasNV 89154United States Department of Quantitative Health Sciences Mayo ClinicRochesterMN 55905United States Department of Medicine Gargar Urgent Care and ClinicMinneapolisMN 55406United States Office of the Director Shire ScientificMinneapolisMN 55405United States Department of Neurology Washington University School of Medicine in St LouisSt LouisMO 63130United States Knight Alzheimer Disease Research Center Washington University School of MedicineSt LouisMO 63130United States

BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and *** previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in *** To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening *** We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV *** Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV *** age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,*** participants developed incident HCC during follow *** Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States ***-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients.

关键词： Viral hepatitis Liver disease Community engagement African Immigrant health

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升迁的秘密

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电子商务 2001年第12期2卷 108-112页

作者： joyce Slaton 傅军

人事工作花钱少些──省下来的钱体现在总结算帐上。以网络为基础的服务能节约纸面工作量，理顺收益，并帮助雇员们自己帮助自己。

关键词：人事工作人力资源管理企业互联网站服务系统

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胚胎期光照和皮质酮处理对日龄小鸡记忆的作用

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动物学报 1999年第4期45卷 413-419页

作者：胡家芬隋南匡培梓管林初 D.B.joyce 中国科学院心理研究所北京100101 密执根大学化学系

该实验对胚胎发育后期的鸭胚进行光孵化、暗孵化以及药物注射处理后，采用一次性味觉被动回避行为模式观察它们对出生后小鸡记忆保持的影响并对其作用机制进行了初步探讨。结果表明胚胎期光照可增强小鸡记忆的保持，使用精皮质激素受体... 详细信息

该实验对胚胎发育后期的鸭胚进行光孵化、暗孵化以及药物注射处理后，采用一次性味觉被动回避行为模式观察它们对出生后小鸡记忆保持的影响并对其作用机制进行了初步探讨。结果表明胚胎期光照可增强小鸡记忆的保持，使用精皮质激素受体措抗剂可阻断光照对小鸡记忆的增强作用，对暗化鸡胚注射皮质疏可以促进出生后小鸡记忆的保持，因此皮质酮可能参与了光照对小鸡记忆的增强过程；蛋白会成抑制剂在一定程度上阻断了皮质疏对小鸡记忆的增强作用，表明包括蛋白质合成在内的一些机制参与了这个过程。

关键词：日龄小鸡光照皮质酮胚胎期记忆保持

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Molecular Classification of Osteosarcoma:Towards Personalized Predictive Care

Molecular Classification of Osteosarcoma:Towards Personalize...

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中国抗癌协会第七届全国小儿肿瘤学术会议

作者： Ching C.Lau Tsz-Kwong Man Jianhe Shen joyce Gu Jaya Visvanathan Laszlo Perlaky John Hicks Mark johnson Nelson Davino Jeffrey Murray Lee Helman William Meyer Daniel Wai Timothy Triche Kwong-Kwok Wong Murali Chintagumpala Baylor College of Medicine HoustonTX Cook Children’s Hospital Fort WorthTX National Cancer Institute BethesdaMD University of Oklahoma Health Sciences Center Oklahoma CityOK Children’s Hospital Los Angeles Los AngelesCA.

Osteosarcoma is the most common malignant bone tumor in *** initial diagnosis is made with a biopsy, treatment consists of pre-operative chemotherapy followed by definitive surgery and post-operative *** degree of tumor necrosis in response to pre-operative chemotherapy is a reliable prognostic factor and is used to guide the choice of post-operative chemotherapy.

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Healthcare providers’ perceptions on screening for Intimate Partner Violence in healthcare: A qualitative study of four health centres in Uganda

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Open Journal of Preventive Medicine 2013年第1期3卷 1-11页

作者： Stephen Lawoko Gloria K. Seruwagi Iryne Marunga Milton Mutto emmanuel Ochola Geoffrey Oloya joyce Piloya Muhamadi Lubega Anaka Hospital Gulu Uganda Department of Public Health Sciences Karolinska Institutet Stockholm Sweden Gulu Referral Hospital Gulu Uganda Iganga Hospital Iganga Uganda Lacor Hospital Gulu Uganda Pincer Group International Kampala Uganda Victoria University Kampala Uganda

The current qualitative study explored the perceptions of healthcare providers on screening for Intimate Partner Violence (IPV) in healthcare in Uganda, to develop a conceptual framework for factors likely to hinder/promote IPV screening in the country. Using purposive sampling, the study enlisted 54 healthcare workers (doctors and nurses) from four hospitals (i.e. Gulu referral hospital, Iganga referral hospital, Lacor hospital, Anaka hospital) to participate in eight focus group discussions. Data was thematically analysed using Template Analysis. The study found support for an ecological framework suggesting a complex interaction of factors at the individual (e.g. poor skills in detection of IPV by health workers and unwillingness to disclose abuse by patients), organisational (e.g. understaffing and lack of protocols for IPV screening) and societal (e.g. societal acceptance of abuse of women and poor policy on IPV management) levels as potential barriers to the practice of IPV screening in healthcare Uganda. These findings have important implications on further training of healthcare workers to adequately screen for IPV, re-organisation of the healthcare system so that it is fully-fledged to accommodate IPV screening and improved collaboration between the health sector and other community advocates in IPV management. These initiatives should run concurrently with a concerted community sensitization effort aimed at modifying attitudes towards IPV among care providers and recipients a like, as well as preparing the general population to will-fully disclose IPV to healthworkers. Study limitations and implications for further research are discussed.

关键词： Intimate Partner Violence Screening Healthcare Perceptions Uganda

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好吧,但这真是文学吗?

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新东方英语（中英文版） 2012年第12期 53-55页

作者： C.Alan joyce Sarah Janssen 思雅达翻译社

也许你听说过乔伊斯的《尤利西斯》（Ulysses）很难读，但是你知道他的另一部作品里长达一百字字母的单词吗？字母e是英语中出现频率最高的字母，

关键词：文学《尤利西斯》出现频率乔伊斯字母

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