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Lymphoepithelial cysts of the pancreas:a management dilemma

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 539-544页

作者： Julie Martin Keith J Roberts maria Sheridan Gavin A Falk Daniel joyce R Matthew Walsh Andrew M Smith Gareth Morris-Stiff Departments of Pancreatic Surgery St James's University Hospital Departments of Radiology St James's University Hospital Department of General Surgery Section of Surgical Oncology/HPB Cleveland Clinic Foundation

Pancreatic lymphoepithelial cysts（LECs） are rare,benign lesions that are typically unexpected post-operative pathological findings. We aimed to review clinical, radiological and pathological features of LECs that may allow their preoperative diagnosis. Histopathology databases of two large pancreatic units were searched to identify LECs and notes reviewed to determine patient demographic details, mode of presentation, investigations, treatment and outcome. Five male and one female patients were identified. Their median age was 60 years. Lesions were identified on computed tomography performed for abdominal pain in two patients, and were incidentally observed in four patients. Five LECs were located in the tail and one in the body of the pancreas, with a median cyst size of 5 cm. Obtaining cyst fluid was difficult and a largely acellular aspirate was yielded. The pre-operative diagnosis was mucinous cystic neoplasm in all patients. This series of patients were treated distal pancreatectomy and splenectomy. A retrospective review of radiological examinations suggested that LECs have a relatively low signal on T2 imaging and a high signal intensity on T1 weighted images. LECs appear more common in elderly males, and are typically incidental, large, unilocular cysts. Close attention to signal intensity on MRI may allow preoperative diagnosis of these lesions.

关键词： lymphoepithelial cyst pancreas

Microbiological biostimulant promotes rooting of olive cuttings

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International Journal of Agricultural and Biological Engineering 2021年第6期14卷 207-212页

作者： Giovana Ritter Fabíola Villa Daniel Fernandes da Silva Odair Alberton Fernanda Jaqueline Menegusso Tatiane Eberling joyce Dória Western ParanáState University(Unioeste) Campus Marechal Cândido Rondon.Marechal Cândido RondonPR85960-000Brazil Paranaense University(UNIPAR) UmuaramaPR87502-210Brazil Federal University of Lavras LavrasMG37200-000Brazil

The most widely used method of olive propagation is cutting,although for some cultivars the technique is still *** objective of this work was to evaluate the use of plant growth promoter bacteria and arbuscular mycorrhizal fungi in the rooting of olive *** experiments were conducted from October 2017 to January 2018 with cuttings from 4 olive cultivars(Ascolano 315,Koroneiki,maria da Féand Picual)from four-year-old *** first experiment consisted of 4 olive cultivars and 3 mycorrhizal species plus the control and the second experiment of 3 concentrations of commercial inoculant(Nitro1000®),containing Azospirillum brasilense plus *** cuttings were treated with 3000 mg/L of indolebutyric acid(IBA).The experimental design used in the two experiments was randomized blocks,in a 4×4 factorial scheme,containing 25 stakes per replicate and 3 *** cuttings were kept under weaver conditions and within a low rooting *** 75 d,the percentage of rooted cuttings,callus and sprouts,length of the largest root,number and length of shoots were *** use of FMA in maria da Féand Picual has a positive response to cutting rooting and the fungi benefit the quality of the seedlings by the higher number of shoots and larger root *** relation of Azospirillum brasilense cultivar is specific,being that,the cultivar Picual does not respond to inoculation of the bacterium having less viability in the propagation by *** da Féand Koroneiki have the best percentages of rooting with the use of 75.00 and 52.00 mL/L of inoculant,respectively.

关键词： Azospirillum brasilense Arbuscular mycorrhizal fungi Propagation Olea europaea L. microorganism

Effects of Microselective Neurotomy on Focal Spasticity and Description of the Surgical Technique

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Open Journal of Modern Neurosurgery 2021年第3期11卷 144-156页

作者： Sergio A. Sacchettoni joyce Bolaños Napoleon Torres Juan P. Abud Penelope Mantilla Luis Salazar maria-Fernanda Vargas Julio Rodriguez-Wulff Randy Balladares Ricardo Gomez Service of Neurosurgery Hospital Vargas de Caracas Caracas Venezuela Service of Neurosurgery Centro Medico Docente La Trinidad Caracas Venezuela Neurological Unit “NeuroQX” Centro Médico Integra Caracas Venezuela Université Grenoble Alpes Grenoble France

We studied the microselective neurotomy (MSN) and its advantages to alleviate disabling spasticity. The best indication for MSN is focal spasticity. We performed 298 MSN, 87 nerves on the upper limb, 211 nerves on the lower limb) in 68 patients. The initial causes were: stroke, cranial trauma, postoperative complications and multiple sclerosis. MSN procedures were performed on the median nerve (n = 40) for wrist and finger flexion;musculo-cutaneus nerve (n = 38) for elbow flexion;ulnaris nerve (n = 9) for cubital deviation of the hand;gastrocnemius nerve (n = 98) and soleus nerve (n = 49) for equinus foot, tibial posterior nerve (n = 45) for varus foot, and fascicles (or bundles) of the flexor digitorum for “claw” toes (n = 19). The main preoperative test to identify the responsible nerve was a neuromuscular block with local anesthesia (lidocaine or bupivacaine) injected into the site of the nerve connecting the spastic muscle. During surgery, the identified nerve was exposed and its epineurium opened. Nerve bundles were teased apart into individual rootlets and a number of rootlets cut were previously planned, according to the spasticity. Follow-up was performed for up to 10 years, with a mean period of 29 months. Results demonstrated a reduction of limb spasticity of 2 to 3 points: modified Ashworth scale (MAS). Pain and clonus were also diminished in the affected limb. In some cases, voluntary movement was once again possible. MSN is a useful alternative in those cases of focal spasticity where physiotherapy and nerve block with botulinum toxin or phenol no longer produce satisfactory results.

关键词： Focal Spasticity Microselective Neurotomy Neurosurgery of Spasticity

Use of the Tinetti Index to Assess Fall Risk in Patients with Sequelae of Stroke

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Journal of Biomedical Science and Engineering 2014年第14期7卷 1088-1094页

作者： Zuila maria de Figueiredo Carvalho joyce Miná Albuquerque Coelho Raelly Ramos Campos Deyse Cardoso de Oliveira Winner Gomes Machado Samia Jardelle Costa de Freitas Maniva Federal University of Ceará Fortaleza Brazil Fortaleza General Hospital Fortaleza Brazil

Background and Objective: The knowledge about risk of falls in patients with sequelae of stroke by applying a scale constitutes an important factor fort nurses since it allows planning for quality care and consequently improves the quality of life of such patients. The present study aimed to assess the risk of falls of patients with sequelae of stroke using Tinetti Index. Methods: Transversal descriptive study with 61 hospitalized patients. The data were collected through the application of Tinetti Index, the total score of which is 28 points. Results: The index evaluation shows que 47.9% had 19 points under the ideal score, indicating a high risk of falls, 41.7% from 24 to 28, indicating moderate risk and 10.4% from 19 to 23 points, indicating low risk of falls. The final average was (15.23), the median (16.50) and standard deviation (±11.034). Conclusions: There is a high risk of falls in this population, a quantification of impaired balance and gait anticipate the future risk of falls. The use of assessment instruments has important implications for improving the quality of life in patients with symptomatic stroke.

关键词： Tinetti Index Sequelae of Stroke Risk of Falls Nursing

Determination of isotretinoin in pharmaceutical formulations by reversed-phase HPLC

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Journal of Biomedical Science and Engineering 2010年第5期3卷 454-458页

作者： Carla Aiolfi Guimaraes Farid Menaa Bouzid Menaa Ivo Lebrun joyce S. Quenca-Guillen Aline Vivian Vatti Auada Lucildes P. Mercuri Paula Ferreira maria Inês Rocha Miritello Santoro 不详

The development of facile and rapid quantification of biologically active biomolecules such as isotretitoin in therapeutic drugs contained in many generic formu- lations is necessary for determining their efficiency and their quality to improve the human health care. Isotretritoin finds its applications in the maintenance of epithelial tissues. Different processes to date such as normal phase HPLC, or gas chromatrography am- ong others are able to separate and quantify isote- troin. However, the extraction is quite complex and in the case of HPLC, the analysis requires long retention times. In such context, an isocratic reversed- phase high-performance liquid chromatography (HP- LC) technique coupled with an UV-vis detector is described here for easy separation and quantification of 13-cis-retinoic (isotretinoin) from soft gelatin capsule formulations. The isotretinoin was extracted from three different commercial drug samples with tetrahydrofuran (THF) solvent by a procedure that can be completed in less than 10 minutes. Subsequent separation and quantification were accomplished in less than 5 minutes under isocratic reversed-phase conditions on a Lichrospher RP18 column and a mobile phase consisting of 0.01% TFA/acetonitrile (15/85, v/v) at a flow rate of 1.0 mL/min. Isotretoin was detected for the three samples via its UV-vis absorbance at 342 nm. The method was validated and the results showed good linearity, precision and accuracy for sensitive and selective quantitative determination of isotretinoin in the different pharmaceutical formulations. We found that the average isotretinoin content in two of the three commercial pro- ducts fell outside the 90-110% United States Pha- rmacopeia specifications. Consequently, the facile extraction and the precise method for the biomole- cule quantification open up tremendous possibilities in improving the quality control of drugs which can exist as different generic brands.

关键词： 13-Cis Retinoic Acid Reversed-Phase Chromatography Isotretitoin Extraction Isotretinoin Quantification Pharmaceuticals Formulation

Impact of a physical activity program on plasma concentrations of adiponectin, leptin and ghrelin in overweight and obese schoolchildren: A randomized controlled trial

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Health 2013年第11期5卷 1819-1828页

作者： Andre Everton de Freitas Joel Alves Lamounier Danusa Dias Soares Thiago Henrique de Oliveira Debora Romualdo Lacerda joyce Batista Andrade Flavia Komatsuzaki Leida maria Botion Adaliene Versiani Matos Ferreira Camilo Adalto mariano da Silva Dilermando Fazito Rezende Graduate Program in Child and Teenager Health Medicine SchoolFederal University of Minas GeraisBelo HorizonteBrazil Faculty of Health and Human Ecology Medicine SchoolVespasianoBrazil Graduate Program in Health Sciences Medicine SchoolFederal University of Sao Joao Del ReiCampus MidwestDivinopolisBrazil Laboratory of Exercise Physiology Federal University of Minas GeraisBelo HorizonteBrazil Laboratory of Metabolism Federal University of Minas GeraisBelo HorizonteBrazil School of Nursing Federal University of Minas GeraisBelo HorizonteBrazil School of Nutrition Federal University of Ouro PretoOuro PretoBrazil Faculty of Medicine Barbacena BarbacenaBrazil

Introduction: Child obesity has important consequences on the child’s health and is related to the risk of developing chronic diseases. That brings up the need for research assessing the impact of obesity-and overweight-reduction programs with close attention to methodology aspects and precise indicators of the impact of such programs. Goal: Assessing the impact of a physical activity program on the plasma concentrations of adiponectin, leptin, and ghrelin in overweight and obese schoolchildren. Methods: Randomized controlled trial, double-blind, with 6-to 9-year-old overweight and obese school-children. A sample of 79 schoolchildren randomly distributed into control and intervention groups was subjected to a physical activity program. The levels of adiponectin, leptin, ghrelin, body mass index, body fat percentage, anthropometry, lipid profile and glycemia were evaluated. The program’s impact was assessed through multivariate linear regression models. Result: When comparing the groups, a significant difference was found for adiponectin, which shows an increase in the proportion of subjects with higher adiponectin concentrations for the intervention group and a reduction in body mass index and body fat percentage. Conclusion: The impact of the intervention program was positive in increasing adiponectin levels associated with a reduction in body mass index and body fat percentage.

关键词： Obesity Overweight Schoolchildren Physical Activity Adipocitokines

Genotyping and Antifungal Susceptibility Profile of Sequential Candida albicans Isolated from the Oral Cavity of HIV-Infected Individuals

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Journal of Pharmacy and Pharmacology 2018年第4期6卷 350-361页

作者： Daniela Vanessa Moris joyce Marinho de Souza Marcia Souza Carvalho Melhem Marilena dos Anjos Martins Caroline Lucio Moreira Lenice Rosario de Souza Gioconda San-Blas maria Walderez Szeszs Lidia Raquel Carvalho Marcus Vinicius Pimenta-Rodrigues Rinaldo Poncio Mendes Tropical Diseases Area--Faculdade de Medicina de Botucatu Universidade Estadual Paulista "Julio de Mesquita Filho "--UNESP Sao Paulo Botucatu 18600-000 Brazil Masters in Health Seience--Universidade do Oeste Paulista--UNOESTE Sao Paulo Presidente Prudente 19067-175 Brazil Department of Biomedical Sciences--Universidade do Oeste Paulista--UNOESTE Presidente Prudente 19050-920 Brazil Instituto Adolfo Lutz Sao Paulo 01246-000 Brazil Venezuelan Institute for Scientific Research Center for Microbiology and Cell Biology Caracas 11 01204 Venezuela Biostatistics Department Instituto de Biociencias Universidade Estadual Paulista "Julio de Mesquita Filho "--UNESP Sao Paulo Botueatu 18600-000 Brazil

Objective： The study aimed to evaluate the genotypic profiles of C. albicans （Candida albicans） sequentially isolated throughout the course of HIV infections, and to determine its MIC （minimal inhibitory concentrations） to AMB （amphotericin B）, FLC （fluconazole）, KTC （ketoconazole）, and ITC （itraconazole）. Design： samples were collected from the oral cavity of HIV-positive individuals during 4 years, with a sterilized swab. MIC was performed by using the microdilution method AFST/EUCAST. The genetic similarities within and between sequential clones of C. albicans were assessed by DNA fingerprinting using the random amplification ofpolymorphic DNA technique. Results： A total of 142 oral samples were isolated from 59 HIV-infected individuals who attempted up to five visits each, with or without symptoms of oropharyngeal candidiasis. Profile analysis revealed that yeasts isolated over sequential visits from symptomatic or asymptomatic individuals showed 78% or 87% relatedness, respectively. The degree of similarity among C. albicans was higher for isolates from colonization than for those from infection. Genetically identical C. albicans samples also formed connected subelusters in sequential visits. In regard to susceptibility profile, all isolates were susceptible to AMB, FLC, KTC, and ITC and maintained this pattern all along, no differences in MICs of any given antifungal compound were observed for sequential C. albicans isolates. Conclusions： These data suggest that genotype and susceptibility to antifimgal drugs were maintained over time in sequentially isolates of C. albicans colonization and a diverse evolutionary genetic trend in C. albicans sequentially isolated from the oral eandidiasis of HIV infected individuals.

关键词： Genotyping Candida albicans sequential HIV- positive individuals oral cavity.

Oral PTCTS (Particulated Transialidase) Removes Serum Microparticles and Decreases Inflammation in Atherosclerotic Plaques of Rabbits

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Advances in Nanoparticles 2015年第4期4卷 107-115页

作者： Shérrira M. Garavelo Jaqueline J. Pereira Nilsa S. Y. Wadt Marcia M. Reis Renata N. Ikegami joyce T. Kawakami Abdelali Agouni Suely A. P. Palomino Dulcinéia Abdalla maria de Lourdes Higuchi Heart Institute (InCor) University of Sao Paulo Clinics Hospital Sao Paulo Brazil Faculty of Health and Medical Sciences (FHMS) University of Surrey Guildford UK College of Pharmacy Qatar University Doha Qatar Department of Clinical and Toxicological Analysis Faculty of Pharmaceutical Sciences University of Sao Paulo Sao Paulo Brazil

Background: Previous studies showed that atherosclerotic plaque vulnerability was related with microparticles (MPs)-vesicles larger than 100 nm, which released MMP9 collagenase. In our previous study, intramuscular injection of a new drug (PTCTS) normalized oxidized LDL serum levels and reduced rabbit atherosclerosis. Now, we studied administration of oral PTCTS in order to clarify anti-atherosclerotic mechanism of action, analyzing if the treatment removed MPs containing ox-LDL and Mycoplasma pneumoniae antigens and improved the immune response. Methods: We compared two groups of rabbits. Control group (CG, n = 6)—1% cholesterol enriched diet for 12 weeks;Treated group (TG, n = 8)—1% cholesterol enriched diet for 12 weeks with administration of PTCTS (400 μl/day) during the last 6 weeks of diet. The animals had their blood collected, in three different phases of the protocol before being fed with hypercholesterolemic diet, before being treated with water or PTCTS and at the moment of sacrifice. The serum was submitted to immunofluorescence technique to evaluate the quantity of microparticles marked with antibodies against Mycoplasma pneumoniae and ox-LDL. A fragment of aorta was submitted to immunohistochemical detection of antigens from MMP9, ox-LDL, NF-κB and IL-1β. Results: PTCTS showed significant reduction in MMP-9 (P = 0.001) and a tendency of reducing IL-1β (P = 0.09) in the aortic plaques compared with CG. In the serum, PTCTS was able to remove microparticles containing antigen of ox-LDL (P = 0.004) and Mycoplasma pneumoniae (P β and mycoplasma, as well as a better stabilization of the atheromatous plaque by reducing levels of MMP-9, avoiding plaque rupture, without causing mortality or toxicity.

关键词： Atherosclerosis Inflammation PTCTS Mycoplasma NF-κB

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潜力巨大的微技术世界

国外测井技术 2008年第5期23卷 60-67页

作者： Dan E.Angelescu Christopher Harrison Ronald van Hal joyce Wong Eric Donzier Olivier Vancauwenberghe Anthony R.H.Goodwin maria Manrique Yu-Chong Tai 美国马萨诸塞州Cambridge 法国Elancourt 美国得克萨斯州Sugar Land 英国剑桥加利福尼亚理工学院

20世纪80年代，在集成电路技术的基础上诞生了世界首套微机电和微流体系统。从那时起，微技术领域的发展可谓日新月异。如今，微技术已在环境条件极为复杂的油田领域得到广泛应用。

关键词：微技术世界集成电路技术微流体系统微机电