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Reflecting on tuberculosis case notification and treatment outcomes in the Volta region of Ghana:a retrospective pool analysis of a multicentre cohort from 2013 to 2017

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Global Health Research and Policy 2019年第1期4卷 1-13页

作者： Eric Osei Samuel Oppong Daniel Adanfo Bless Ativor Doepe Andrews Owusu Augustine Goma Kupour joyce der Department of Population and Behavioural Sciences School of Public HealthUniversity of Health and Allied SciencesHoGhana Department of Epidemiology School of Public HealthUniversity of Health and Allied SciencesHoGhana

Background:Tuberculosis(TB)remains a petrified condition with a huge economic and health impact on families and health systems in *** of TB programme performance indicators can provide reliable data for direct measurement of TB incidence and *** study reflects on the trends of TB case notification and treatment outcomes and makes comparison among 10 districts of the Volta region of ***:This was a retrospective analysis of surveillance data of a cohort of TB cases from 2013 to *** of case notification and treatment outcomes were examined and *** regression was used to determine the independent relationship between patients and disease characteristics and unsuccessful treatment *** ratios,95%confidence intervals and p-values were ***:A gradual declining trend of case notification of all forms of TB was noticed,with an overall case notification rate(CNR)of 65 cases per 100,000 population during the period.A wide variation of case notification of TB was observed among the districts,ranging from 32 to 124 cases per 100,000 ***,treatment success rate decreased slightly from 83.1%during the first year to 80.2%in 2017,with an overall treatment success rate of 82.5%(95%CI:81.3-83.8%).Treatment failure,death,and lost to follow up rates were 0.8%(range 0.5-1.2%),13.5%(range 12.4-14.7%),and 3.1%(range 2.6-3.8%)*** treatment success rate among districts ranged from 70.5%in South Tongu to 90.8%in Krachi West *** after treatment interruption(Adjusted odds ratio[AOR]:3.62;95%CI:1.66-7.91;P90%set by the World Health Organiz

关键词： Tuberculosis Case notification Treatment outcomes Volta region Ghana

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The Presence of Antisperm Antibodies in Semen of Subfertile Men—Positive ASA in Subfertile Men

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Open Journal of Obstetrics and Gynecology 2021年第2期11卷 88-101页

作者： Kim Kamphorst joyce Faber Paul Jan Quirien van der Linden Deventer Ziekenhuis Department of Gynaecology Obstetrics and Reproductive Medicine Deventer The Netherlands

Background: In more than 50% of male subfertility, the aetiology remains unknown. Antisperm antibodies (ASA) might be involved, however the exact role of ASA in unexplained male subfertility is not clear, yet. Objective: The aim of this study was to examine 1) the prevalence of ASA in subfertile men, 2) the possible causes of the presence of ASA, and 3) the influence of ASA on sperm parameters and fertilization including assisted reproductive technologies (ART) and pregnancy outcomes. Study Design, Size, Duration: In this retrospective single center study, all men with semen analyses between January 2003 and December 2017 were included as well as all subfertile couples getting treatment if at least one sperm analysis showed a spermMar test ≥50%. Methods: Collected parameters were: intoxications, medication and professions that could have an adverse effect on fertility, sperm parameters, the type and amount of ART, mode of conception, pregnancy rates and outcomes. Results: 3098 semen analyses were performed. In total, 233 ASA positive men were observed, including 175 subfertile couples with an ASA positive man in the additional analyses. The prevalence of ASA in the subfertile population was 8.2%. The presence of ASA was significantly associated with the presence of oligoasthenoteratozoospermia (OAT), asthen

关键词： Retrospective Antisperm Antibodies Infertility IgG IgA

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