检索结果-南通市图书馆

Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis

Genes & Diseases 2022年第1期9卷 108-115页

作者： joy m.davis Binglu Cheng madeline m.Drake Qiang Yu Baibing Yang Jing Li Chunhui Liu mamoun Younes Xiurong Zhao Jennifer m.Bailey Qiang Shen Tien C.Ko Yanna Cao Department of Surgery The University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Pathology&Laboratory medicine The University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Neurology The University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Internal medicine The University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Genetics Louisiana State University Health Sciences CenterNew OrleansLA 70112USA

Chronic pancreatitis(CP)is a major risk factor of pancreatic ductal adenocarcinoma(PDAC).How CP promotes pancreatic oncogenesis remains unclear.A characteristic feature of PDAC is its prominent desmoplasia in the tumor microenvironment,composed of activated fibroblasts and *** can be characterized as m1 or m2,with tumor-inhibiting or-promoting functions,*** reported that Gremlin 1(GREm1),a key pro-fibrogenic factor,is upregulated in the stroma of *** current study aimed to investigate the expression of GREm1 and correlation between GREm1 and macrophages within the pancreas during chronic inflammation and the development of *** mRNA in situ hybridization,we detected GREm1 mRNA expression withinα-smooth muscle actin(SmA)-positive fibroblasts of the pancreatic *** designated FibroblastsGrem1+marginally increased from CP to pancreatic intraepithelial neoplasia(PanIN)and *** PDAC,FibroblastsGrem1+increased with higher pathological tumor stages and in a majority of PDAC subtypes ***,FibroblastsGrem1+positively correlated with total macrophages(macCD68+)and m2 macrophages(m2CD163+)in *** begin exploring potential molecular links between FibroblastsGrem1+and macrophages in PDAC,we examined the expression of macrophage migration inhibitory factor(mIF),an endogenous counteracting molecule of GREm1 and an m1 macrophage promoting *** IHC staining of mIF,we found mIF to be expressed by tumor cells,positively correlated with GREm1;by IHC co-staining,we found mIF to be negatively correlated with m2CD163+*** findings suggest that GREm1 expression by activated fibroblasts may promote PDAC development,and GREm1/mIF may play an important role in macrophage phenotype.

关键词： Fibroblasts Gremlin 1 macrophage migration inhibitory factor macrophages

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Estimating the effects of meteorology on Pm_(2.5) reduction during the 2008 Summer Olympic Games in Beijing, China

引用

Frontiers of Environmental Science & Engineering 2011年第3期5卷 331-341页

作者： Liu YANG Ye WU Jerry m.davis Jiming HAO School of Environment Tsinghua UniversityBeijing 100084China Office of Air Quality Planning and Standards Health and Environmental Impacts DivisionUS Environmental Protection AgencyRaleighNC 27513USA

Particulate pollution was a critical challenge to the promise of good air quality during the 2008 Beijing Olympic Games,which took place from August 8th to *** ensure good air quality for the Games,several temporary emission control measures were implemented in Beijing and surrounding *** particulate matter concentration decreased significantly during the Olympic period;however,it is difficult to distinguish the effectiveness of those control measures since meteorology also affects ambient Pm_(2.5) *** this work,a multiple linear regression model based on continuous field monitoring at a roadside site was conducted to evaluate the effects of meteorology and emission control measures on the reduction of Pm_(2.5) during the 2008 Olympic *** hourly data set was divided into two time periods,the no control period,June 22nd to July 4th,and the control period,July 28th to August *** response variable was Pm_(2.5) and the meteorology covariates used in the model were hourly temperature,dew point temperature,wind speed and *** direction was not a significant predictor of Pm_(2.5) levels in either the control or the no control *** the meteorologically-based regression coefficients from the two time periods,meteorology was found to contribute to at least a 16%reduction in Pm_(2.5) levels in the roadside microenvironment;while the pollution control measures contributed to at least a 43%reduction in Pm_(2.5) levels.

关键词： meteorology emission control measures Beijing Olympic Games Pm_(2.5) linear statistical models

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A pentaploid-based linkage map of the ancestral octoploid strawberry Fragaria virginiana reveals instances of sporadic hyper-recombination

引用

Horticulture Research 2020年第1期7卷 1796-1810页

作者： Thomas m.davis Yilong Yang Lise L.mahoney Daniel C.Frailey Department of Agriculture Nutritionand Food SystemsUniversity of New HampshireDurhamNH 03824USA

The first high-resolution genetic linkage map of the ancestral octoploid(2n=8x=56)strawberry species,Fragaria virginiana,was constructed using segregation data obtained from a pentaploid progeny *** novel mapping population of size 178 was generated by crossing highly heterozygous *** hybrid“LB48”as a paternal parent with diploid(2n=2x=14)Fragaria vesca“Hawaii 4”.The LB48 linkage map comprises 6055 markers genotyped on the Axiom®IStraw90 strawberry SNP *** map consists of 28 linkage groups(LGs)organized into seven homoeology groups of four LGs each,and excludes a small 29th LG of undefined *** member of each homoeology group was assignable to an“A”subgenome associated with ancestral diploid Fragaria vesca,while no other subgenomes were *** an intriguing discrepancy within homoeology group VI,synteny comparisons with the previously published Fragaria×ananassa DA×mO linkage map revealed substantial *** initial map construction,examination of crossover distributions revealed that six of the total 5162(=29 chromosomes/individual×178 individuals)chromosomes making up the data set exhibited abnormally high crossover counts,ranging from 15 to 48 crossovers per chromosome,as compared with the overall mean of 0.66 crossovers per *** of these six hyper-recombinant(HypR)chromosomes occurred in a different LG and in a different *** calculated upon exclusion of the six HypR chromosomes,the canonical(i.e.,broadly representative)LB48 map had 1851 loci distributed over a total map length of 1873 cm,while their inclusion increased the number of loci by 130,and the overall map length by 91 *** of these hyper-recombinant chromosomes points to the existence of a sporadically acting mechanism that,if identified and manipulable,could be usefully harnessed for multiple purposes by geneticists and breeders.

关键词： Fragaria straw linkage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immunology taught by humans

Immunology taught by humans

引用

第八届全国免疫学学术大会

作者： mark m.davis Howard Hughes medical Institute Stanford University School of Medicine

While we have learned a great deal about basic immunology from the laboratory mouse model,it has significant limitations in terms of genetics,environmental exposure and evolutionary distance from human *** we used both peptide-mHC tetramers and systems biology approaches to study the human immune *** respect to theαβT cell repertoire,we find that healthy adults have an abundance of self-specific

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

湖北省庙河地区钉螺细胞色素C氧化酶1基因差异的研究

引用

中国寄生虫学与寄生虫病杂志 2001年第1期19卷 41-44页

作者：石朝辉邱持平夏明仪冯正 George m.davis 中国预防医学科学院寄生虫病研究所世界卫生组织疟疾血吸虫病和丝虫病合作中心卫生部寄生虫病原与媒介生物学重点实验室上海200025 美国费城自然科学院

目的　比较湖北省庙河沿岸地区钉螺CO1基因序列的差异 ,探讨光壳螺与肋壳螺差异的原因。方法　在该地区选 7个点 (上游 4个点 ,下游 3个点 )采集钉螺 ,用CTAB法提取钉螺基因组DNA ,PCR方法扩增CO1基因 ,纯化后测序 ,运用ESEE软件排序并... 详细信息

目的　比较湖北省庙河沿岸地区钉螺CO1基因序列的差异 ,探讨光壳螺与肋壳螺差异的原因。方法　在该地区选 7个点 (上游 4个点 ,下游 3个点 )采集钉螺 ,用CTAB法提取钉螺基因组DNA ,PCR方法扩增CO1基因 ,纯化后测序 ,运用ESEE软件排序并比较变异位点 ,观察各点钉螺的CO1基因单倍体型 ,运用PHYLIP软件计算遗传距离 ,绘制基因进化树。结果　获得CO1基因大小为 638bp ,上游和下游累积变异位点数分别为 2 9和 46,两者差异具有显著性 ;各采集点内钉螺按变异位点多少可分为两组 ;各采集点间存在有相同的基因单倍体型 ;上游和下游螺群之间的遗传距离为 0 0 2 2 1± 0 0 10 5 ;在FITCH绘制的基因进化树上 ,上游和下游地区钉螺交错分布在同一亚种不同的两个分支中。结论　在不同的生态环境下 ,下游地区钉螺CO1基因的变异强度比上游大 ;庙河各采集点螺群间存在一定的基因流动 ;庙河地区螺群属湖北钉螺湖北亚种 (O h hupensis) ,可能存在着两种不同进化速率的螺群。

关键词：细胞色素C氧化酶湖北钉螺基因差异日本血吸虫

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

γ拟钉螺等位基因的研究

引用

中国寄生虫学与寄生虫病杂志 1999年第2期17卷 84-86页

作者：曾肖芃陈翠娥丁建祖 GEORGE m.davis 浙江省医学科学院寄生虫病研究所美国费城自然科学院

目的：探讨γ拟钉螺分类演化的遗传学基础。方法：用微量平面淀粉胶电泳法，检测浙江省开化及淳安县６个螺群宋氏γ拟钉螺和１个螺群中国γ拟钉螺的２４种等位基因酶谱。结果：共测得２９个位点，宋氏γ拟钉螺多态位点所占比例为６．９... 详细信息

目的：探讨γ拟钉螺分类演化的遗传学基础。方法：用微量平面淀粉胶电泳法，检测浙江省开化及淳安县６个螺群宋氏γ拟钉螺和１个螺群中国γ拟钉螺的２４种等位基因酶谱。结果：共测得２９个位点，宋氏γ拟钉螺多态位点所占比例为６．９％－１３．８％；中国γ拟钉螺全部为单态位点。宋氏γ拟钉螺的种内Ｎｅｉ氏遗传距离（Ｎｅｉ＇ｓＤ）小于０．１２；但宋氏γ拟钉螺与中国γ拟钉螺两者种间Ｎｅｉ＇ｓＤ为０．７３。结论：在等位基因水平显示γ拟钉螺种内变异不明显，种间差异显著。

关键词：钉螺宋氏γ拟钉螺中国γ拟钉螺等位基因酶谱

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

mining diversity of the natural biorefinery housed within Tipula abdominalis larvae for use in an industrial biorefinery for production of lignocellulosic ethanol

引用

Insect Science 2010年第3期17卷 303-312页

作者： Dana m. Cook joy Doran-Peterson microbiology Department University of Georgia Athens Georgia USA

Although they are the largest taxonomic group of animals, relatively few insects have been examined for symbiotic relationships with micro-organisms. However, this is rapidly changing because of the potential for examination of the natural insectmicrobe-lignocellulose interactions to provide insights for biofuel technology. micro-organisms associated with lignocellulose-consuming insects often facilitate the digestion of the recalcitrant plant diet; therefore these microbial communities may be mined for novel lignocellulose-degrading microbes, or for robust and inexpensive biocatalysts necessary for economically feasible biofuel production from lignocellulose. These insect-microbe interactions are influenced by the ecosystem and specific lignocellulose diet, and appre- ciating the whole ecosystem-insect-microbiota-lignocellulose as a natural biorefinery provides a rich and diverse framework from which to design novel industrial processes. One such natural biorefinery, the Tipula abdominalis larvae in riparian ecosystems, is reviewed herein with applications for biochemical processes and overcoming challenges involved in conversion of lignocellulosic biomass to fuel ethanol. From the dense and diverse T. abdominalis larval hindgut microbial community, a cellulolytic bacterial isolate, 27C64, demonstrated enzymatic activity toward many model plant polymers and also produced a bacterial antibiotic. 27C64 was co-cultured with yeast in fermentation of pine to ethanol, which allowed for a 20% reduction of commercial enzyme. In this study, a micro-organism from a lignocellulose-consuming insect was successfully applied for improvement of biomass-to-biofuel technology.

关键词： ethanol hydrolytic enzymes insect-associated microorganisms lignocellulose

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kinematic and Dynamic Analysis of a 3-■US Spatial Parallel manipulator

引用

Chinese Journal of mechanical Engineering 2020年第1期33卷 114-130页

作者： mervin Joe Thomas m.L.joy A.P.Sudheer mechatronics/Robotics Lab Department of Mechanical EngineeringNational Institute of Technology CalicutKozhikodeIndia

Parallel Kinematic machines(PKms)are being widely used for precise applications to achieve complex motions and variable poses for the end effector *** are found in medical,assembly and manufacturing industries where accuracy is *** is often desired to have a compact and simple architecture for the robotic *** this paper,the kinematic and dynamic analysis of a novel 3-PRUS(P:prismatic joint,R:revolute joint,U:universal joint,S:spherical joint)parallel manipulator with a mobile platform having 6 Degree of Freedom(Do F)is *** kinematic equations for the proposed spatial parallel mechanism are formulated using the modified Denavit-Hartenberg(DH)technique considering both active and passive *** kinematic equations are used to derive the Jacobian matrix of the mechanism to identify the singular points within the workspace.A Jacobian based sti ness analysis is done to understand the variations in sti ness for different poses of the mobile platform and further,it is used to decide trajectories for the end effector within the singularity free *** analytical model of the robot dynamics is presented using the Euler-Lagrangian approach with Lagrangian multipliers to include the system *** gravity and inertial forces of all links are considered in the mathematical *** analytical results of the dynamic model are compared with ADAmS simulation results for a pre-defined trajectory of the end effector.

关键词： Parallel manipulator Kinematic modelling Workspace analysis Euler-Lagrangian modelling Singularity analysis Stiffness analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

借助湿度—贝尔图理解锌碳配比

引用

电池 1991年第2期21卷 32-39页

作者： Stuart m.davis 比利时西特马公司

1 配方与配比为了便于讨论,我们分别给这两个词下个定义,尽管事实上,这两个词在通常谈话中是可以互换的。配方:给定的干混合物。

关键词：电池表观电解液贝尔

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The biological stress of early weaned piglets

引用

Journal of Animal Science and Biotechnology 2013年第2期4卷 124-127页

作者： joy m Campbell Joe D Crenshaw Javier Polo APC Inc. 2425 SE Oak Tree CourtAnkenyIA USA

Pigs experience biological stress such as physiological, environmental, and social challenges when weaned from the sow. The process of weaning is one of the most stressful events in the pig＇s life that can contribute to intestinal and immune system dysfunctions that result in reduced pig health, growth, and feed intake, particularly during the first week after weaning. Technological improvements in housing, nutrition, health, and management have been used to minimize some of the adverse effects of weaning stress, but a greater understanding of the biological impact of stress is needed to improve strategies to overcome weaning stress. The focus of this review paper is to briefly describe how the biological stress associated with weaning impacts intestinal morphology, structure, physiology, and intestinal immune responses that can impact subsequent production efficiencies such as growth, intake, morbidity, and mortality.

关键词： Biological stress Intestine Pig Weaning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：