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Trends of dengue infections in Malaysia,2000-2010

Asian Pacific Journal of Tropical Medicine 2013年第6期6卷 462-466页

作者： Md.Shahin Mia Rawshan Ara Begum A.C.Er Raja Datuk Zaharaton Raja Zainal Abidin joy jacqueline pereira Institute for Environment and Development Universiti Kebangsaan Malaysia43600UKMBangiSelangor D.E.Malaysia Southeast Asia Disaster Prevention Research Institute Universiti Kebangsaan Malaysia43600UKMBangiSelangor D.E.Malaysia School of Development and Environmental Studies Faculty of Social Science and Humanities Universiti Kebangsaan Malaysia43600UKMBangiSelangor D.E.Malaysia

Objective:To analyze trends of dengue incidences and deaths in Malaysia from 2000 to 2010 as well as the predominant dengue virus serotypes during the last ***:We used the national data on annual reported cases,deaths,incidence rate,mortality rate,and case fatality rate of dengue fever(DF) and dengue hemorrhagic fever(DHF) as well as dengue virus serotypes prevalent in Malaysia during the last ***/ regression lines were fitted to investigate the trend of dengue incidences and deaths due to the disease for a 11-year period(2000-2010).For the distribution of national incidence rate,mortality rate,and case fatality rate of DF and DHF, descriptive statistics using mean and 95%confidence intervals(C/) for means,and range were ***:The number of dengue cases and number of deaths have increased,on average, by 14%and 8%per year *** average annual incidence rate of DF per 100 000 populations was higher as compared to that of ***,the yearly mean mortality rate of DHF per 100 000 populations was greater than that of *** simultaneous circulation of all four dengue serotypes has been found in *** a particular dengue virus serotype predominates for at least two years before it becomes replaced by another ***: The dengue situation in Malaysia has worsened with an increasing number of reported oases and deaths during the last *** increasing trend of dengue highlights the need for a more systematic surveillance and reporting of the disease.

关键词： Dengue Dengue hemorrhagic fever Trend Malaysia

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Myenteric neurons and intestinal mucosa of diabetic rats after ascorbic acid supplementation

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World Journal of Gastroenterology 2008年第42期14卷 6518-6524页

作者： Priscila de Freitas Maria Raquel Maral Natali Renata Virginia Fernandes pereira Marcilio Hubner Miranda Neto jacqueline Nelisis Zanoni Department of Morphophysiological Sciences Enteric Neurons LaboratoryState University of Maringá Avenida Colombo 5790 Maringá87020-900 Paraná Brazil

AIM: To investigate the effect of ascorbic acid (AA) dietary supplementation on myenteric neurons and epithelial cell proliferation of the jejunum of adult rats with chronic diabetes mellitus. METHODS: Thirty rats at 90 d of age were divided into three groups: Non-diabetic, diabetic and diabetic treated with AA (DA) (1 g/L). After 120 d of treatment with AA the animals were killed. The myenteric neurons were stained for myosin-V and analyzed quantitatively in an area of 11.2 mm2/animal. We further measured the cellular area of 500 neurons per group. We also determined the metaphasic index (MI) of the jejunum mucosa layer of about 2500 cells in the intestinal crypts, as well as the dimensions of 30 villi and 30 crypts/animal. The data area was analyzed using the Olympus BX40 microscope. RESULTS: There was an increase of 14% in the neuronal density (792.6 ± 46.52 vs 680.6 ± 30.27) and 4.4% in the cellular area (303.4 ± 5.19 vs 291.1 ± 6.0) respectively of the diabetic group treated with AA when compared to control diabetic animals. There were no signifi cant differences in MI parameters, villi height or crypt depths among the ***: Supplementation with AA in the diabetic animal promoted moderate neuroprotection. There was no observation of alteration of the cellular proliferation of the jejunum mucosa layer of rats with chronic diabetes mellitus with or without supplementation with AA.

关键词： Ascorbic acid Diabetes mellitus Intestinalmucosa layer Myenteric neurons Myosin-V

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Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats

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World Journal of Gastroenterology 2013年第38期19卷 6416-6426页

作者： Paulo Emilio Botura Ferreira Cláudia Regina Pinheiro Lopes Angela Maria pereira Alves der Paulo Belato Alves David Robert Linden jacqueline Nelisis Zanoni Nilza Cristina Buttow Department of Morphological Sciences Universidade Estadual de MaringáMaringáPR. CEP 87020-900Brazil Department of Physiology and Biomedical Engineering and Enteric NeuroScience Program Mayo Clinic College of MedicineRochesterMN 55905United States

AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic ***:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups:control(C),control supplemented with quercetin(200 mg/kg quercetin body weight)(CQ),diabetic(D)and diabetic supplemented with quercetin(DQ).Immunohistochemical double staining technique was performed with HuC/D(general population)/nitric oxide synthase(nNOS),HuC-D/S-100and *** analysis of the general neuronal population HuC/D-IR,the nNOS-IR(nitrergic subpopulation)and the enteric glial cells(S-100)was performed,and the morphometry and the reduction in varicosity population(VIP-IR)in these populations were ***:Diabetes promoted a significant reduction(25%)in the neuronal density of the HuC/D-IR(general population)and the nNOS-IR(nitrergic subpopulation)compared with the C *** also significantly increased the areas of neurons,glial cells and VIP-IR *** with quercetin in the DQ group prevented neuronal loss in the general population and increased its area(P<0.001)and the area of nitrergic subpopulation(P<0.001),when compared to C *** induced a VIP-IR and glial cells areas(P<0.001)in DQ group when compared to C,CQ and D ***:In diabetes,quercetin exhibited a neuroprotective effect by maintaining the density of the general neuronal population but did not affect the density of the nNOS subpopulation.

关键词： Diabetes Myenteric plexus Neuroprotection Neuronal nitric oxide synthase Vasoactive intestinal polypeptide Enteric glia

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Chemical composition, antiparasitic and cytotoxic activities of aqueous extracts of Ziziphus joazeiro Mart

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Asian Pacific Journal of Tropical Biomedicine 2019年第5期9卷 222-226页

作者： jacqueline Cosmo ANDrade Ana Raquel pereira da Silva Ant?nia Thassya Lucas dos Santos Maria Audilene Freitas Yedda Maria Lobo Soares de Matos Maria Flaviana Bezerra Morais Braga Camila Fonseca Bezerra Maria Isabeli pereira Gon?alo Maria Celeste Vega Gomez Míriam Rolóm Cathia Coronel Paulo Riceli Vasconcelos Ribeiro Edy Sousa de Brito Henrique Douglas Melo Coutinho Microbiology and Molecular Biology Laboratory Biological Chemistry Department Regional University of Cariri-URCA Bioassays Laboratory-LABIO Federal University of Cariri-UFCA Brejo Santo University campus (CE) Center for the Development of Scientific Research Moisés Bertoni Foundation/Díaz Gill Laboratories Natural Products Chemistry Multiuser Laboratory LMQPN Embrapa Tropical Agroindustry

Objective: To compare the in vitro antiparasitic activity of aqueous extracts from Ziziphus joazeiro leaves and stem bark against Trypanosoma cruzi, Leishmania braziliensis, and Leishmania infantum, as well as to evaluate its cytotoxicity in mammalian cells, in addition to identifying the chemical composition of the extracts. Methods: Ziziphus joazeiro leaf and stem bark aqueous extracts were prepared by cold extraction maceration and subjected to ultra-efficient liquid chromatography coupled to a quadrupole/time of flight system. The susceptibility assays used Trypanosoma cruzi CLB5 strains and promastigote forms of Leishmania braziliensis and Leishmania infantum for antiparasitic activity of the extracts. Moreover, mammalian fibroblasts NCTC clone 929 were used for cytotoxicity analysis. Results: Terpenoid compounds, flavonoids and phenolic acid were identified in extracts. The stem bark aqueous extracts presented more significant results in terms of antiparasitic activity compared with the leaf aqueous extracts, especially against Leishmania braziliensis and Leishmania infantum promastigote forms with an IC50 < 500 μg/mL. The cytotoxicity evaluation showed moderate toxicity of the stem bark aqueous extracts, which is relevant information for the rational use of this plant part since it is widely used by the population. Conclusions: These preliminary results may contribute to the formulation of new therapeutic agents against this group of neglected diseases, so further investigations are required to delineate the mechanisms of action mainly of the aqueous extract of stem bark of Ziziphus joazeiro.

关键词： Antiepimastigote Antipromastigote UPLC-MS-ESI-QTOF

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Maternal mental disorders in pregnancy and the puerperium and risks to infant health

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World Journal of Clinical Pediatrics 2012年第4期1卷 20-23页

作者： Priscila Krauss pereira Lúcia Abelha Lima Letícia Fortes Legay jacqueline Fernandes de Cintra Santos Giovanni Marcos Lovisi Institute of Public Health Studies Federal University of Rio de JaneiroRio de JaneiroCEP 21944-970RJBrazil

Prenatal and postnatal period presents the highest prevalence of mental disorders in women's lives and depression is the most frequent one,affecting approximately one in every five *** aggravating factor here is that during this period psychiatric symptoms affect not only women's health and well-being but may also interfere in the infant's intra and extra-uterine *** the causes of the relationship between maternal mental disorders and possible risks to a child's health and development remain unknown,it is suspected that these risks may be related to the use of psychotropic drugs during pregnancy,to substance abuse and the mother's ***,after delivery,maternal mental disorders may also impair the ties of affection(bonding) with the newborn and the ma-ternal capacity of caring in the post-partum period thus increasing the risk for infant infection and malnutrition,impaired child growth that is expressed in low weight and height for age,and even behavioral problems and vulnerability to presenting mental disorders in *** speaking,research on this theme can be divided into the type of mental disorder analyzed: studies that research minor mental disorders during pregnancy such as depression and anxiety find an association between these maternal disorders and obstetric complications such as prematurity and low birth weight,whereas studies that evaluate severe maternal mental disorders such as schizophrenia and bipolar disorder have found not only an association with general obstetric complications as well as with congenital malformations and perinatal ***,the success of infant growth care programs also depends on the mother's mental well *** findings have led to the need for new public policies in the field of maternal-infant care geared toward the population of ***,more research is necessary so as to confirm the association between all factors with greater scientific rigor.

关键词： Maternal welfare Mental disorders Pregnancy Puerperium Infant health

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Fourteen Actions and Six Proposals for Science and Technology-Based Disaster Risk Reduction in Asia Second Asian Science and Technology Conference for Disaster Risk Reduction:SciencePolicy Dialogue for Implementation of the Sendai Framework,April 2018

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International Journal of Disaster Risk Science 2018年第2期9卷 275-279页

作者： Peijun Shi Rajib Shaw Ali Ardalan Emily Ying Yang Chan Jamilur Reza Choudhury Peng Cui Bojie Fu Guoyi Han Qunli Han Takako Izumi Fumiko Kasuga Antonia Yulo Loyzaga joy jacqueline pereiraShirish Kumar Ravan David Sanderson Vinod Kumar Sharma Frank Thomalla Sugeng Triutomo Siquan Yang Qian Ye Ming Wang Yaqiao Wu Renhe Zhang Wenjian Zhang Ying Li Saini Yang State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Academy of Disaster Reduction and Emergency Management Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Graduate School of Media and Governance Keio UniversityShonan Fujisawa Campus(SFC)FujisawaKanagawa 252-0882Japan Department of Disaster and Emergency Health Tehran University of Medical SciencesTehranIran Faculty of Medicine The Chinese University of Hong KongHong KongChina University of Asia Pacific DhakaBangladesh The Institute of Mountain Hazards and Environment(IMHE) Chinese Academy of SciencesChengduChina Faculty of Geographical Science Beijing Normal UniversityBeijingChina Stockholm Environment Institute StockholmSweden Integrated Research on Disaster Risk BeijingChina International Research Institute of Disaster Science(IRIDeS) Tohoku UniversitySendaiJapan Future Earth TokyoJapan Manila Observatory Quezon CityPhilippines Southeast Asia Disaster Prevention Research Initiative(SEADPRI-UKM) Universiti Kebangsaan MalaysiaBangiMalaysia United Nations Office for Outer Space Affairs(UNOOSA) ViennaAustria The University of New South Wales Sydney SydneyAustralia Disaster Management/Consultant at Indian Institute of Public Administration New DelhiIndia Stockholm Environment Institute BangkokThailand Disaster Risk Reduction Foundation Daerah Khusus IbukotaIndonesia National Disaster Reduction Center of China Ministry of Emergency ManagementBeijingChina Integrated Risk Governance Program Academy of Disaster Reduction and Emergency ManagementFaculty of Geographical ScienceBeijing Normal UniversityBeijingChina Fudan University ShanghaiChina World Meteorological Organization GenevaSwitzerland

1 Introduction The Sendai Framework for Disaster Risk Reduction 2015–2030 shifts the focus from managing disasters to reducing *** a shift requires a better understanding of risk in all its dimensions of environment,... 详细信息

关键词： disaster Actions Reduction governance dimensions managing vulnerability technological innovative urgent

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诠释传统奢华——深圳华润城润玺滨江住宅

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中国建筑装饰装修 2021年第10期 80-85页

作者： Ashley Rumsey Stanley Sun Seth Powers Onyi Chan jacqueline pereira

一家总部位于加拿大多伦多的室内设计事务所。事务所综合在世界各地项目的设计经验,以尖锐独特的眼光,塑造各种融合艺术和自然科学的空间。其项目遍布全球,团队专注于各种类型和规模的设计工作。高端国际酒店、时尚品牌商店、高层住宅... 详细信息

一家总部位于加拿大多伦多的室内设计事务所。事务所综合在世界各地项目的设计经验,以尖锐独特的眼光,塑造各种融合艺术和自然科学的空间。其项目遍布全球,团队专注于各种类型和规模的设计工作。高端国际酒店、时尚品牌商店、高层住宅、创意体验景点设计等项目屡获殊荣。他们坚持对每个项目进行深入地了解和探索,贯彻以人为本的设计理念。

关键词：高层住宅景点设计室内设计国际酒店时尚品牌诠释传统滨江事务所

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Northeastern Brazilian Marine Atmospheric Corrosion Performances of Galvanized Steel and Copper Specimens

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Journal of Chemistry and Chemical Engineering 2011年第5期5卷 435-442页

作者： Kelly jacqueline Campos Brambilla Princia Aparecida Morais pereira Kleber Franke Portella Paulo CosarInone Fernando Piazza Jose Maurilio da Silva Guilherme Cunha da Silva Sergio Luiz Henke Mairio Seixas Cabussu Dailton Pedreira Cerqueira Rogerio Nascimento Salles Instituto de Tecnologia para o Desenvolvimento Departamento de Materiais Curitiba Parandz PoBox： 19067 81531-980 Brazil Companhia de Eletricidade da Bahia COELBA Departamento de Engenharia de Manuten96o Granjas Rura~ Pres. Vargas s/nSalvador BA 41.290-000 Brazil

Copper, in turn, is the most useful material in the field of electricity, especially in electrical contacts. Already, the zinc is the most useful metal in atmospheric exposure conditions which is used in sheet form as castings, but whose most important application is as a coating for corrosion protection of steel structures. Salvador, it has disadvantages as an environment conducive to corrosion, by setting up a wet surface time t4, high corrosive environment （C4）. This work was proposed to study the performance of these metals compared to the effects of air pollution of an industrial site. For both atmospheric corrosion sites （ACS） were implanted natural weathering standard in order to assess the aggressiveness of atmospheric contaminants on the performance of metal specimens （galvanized steel and copper）. In determining their corrosion rates which were analyzed for sulfate and chloride ions, atmospheric, given the proximity of this ACS to the seafront, due to these propitiate the acceleration of corrosion. The results allowed observation that the average local concentration of the sulfate was higher than the chloride, because of the proximity of the pollutant source, and that the corrosion rate of galvanized steel was more significant than 61.5% of copper.

关键词： Atmospheric corrosion copper galvanized steel performance.

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Chemical characterization UPLC-ESI-QToF-MSE,antibacterial and antibiofilm potential of Sarcomphalus joazeiro(MART.)Hauenschild

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Food Bioscience 2022年第6期50卷 1249-1259页

作者： Nara J.S.Araújo Ana Raquel P.Silva Maria S.Costa Thiago S.Freitas José M.Barbosa Filho Yedda M.L.S.Matos Maria Flaviana B.Morais-Braga Francisco N.pereira Junior C.A.P.Silva Erlânio O.Souza Paulo R.V.Ribeiro Bruna Caroline Gonçalves Vasconcelos de Lacerda Edlane Martins de Andrade Henrique D.M.Coutinho jacqueline C.Andrade-Pinheiro Programa de pós-graduação em Ciências da Saúde Universidade Federal do CaririUFCADivino Salvador284CEP63180-000BarbalhaCEBrazil Programa de pós-graduação em Biotecnologia Universidade Estadual do CearáUECEAv.Dr Munguba1700CEP60714-903FortalezaCEBrazil Departamento de Química Biológica Universidade Regional do CaririURCACel Antônio Luis1161CEP63105-000CratoCEBrazil Laboratório de Tecnologia Farmacêutica Universidade Federal da ParaíbaUFPBCidade Universitária5009CEP58051-970João PessoaPBBrazil Laboratório de Bioensaios – LABIO Universidade Federal do Cariri – UFCAR.Olegário Emidio de Araujos/nCEP63260-000Brejo SantoCEBrazil Faculdade de Tecnologia do Cariri FATECAmália Xavier de OliveiroCEP63040-000Juazeiro do NorteCEBrazil Embrapa Agroindústria Tropical R.Pernambuco2270 - Pici60511-110FortalezaCEBrazil CECAPE College.Av.Padre Cícero 3917 - São JoséJuazeiro do NorteCE63024-015Brazil

The present study aims to demonstrate the chemical composition of the ethanolic extract of Sarcomphalus joazeiro bark and to evaluate its antibacterial and antibiofilm *** that,the ethanolic extract of the stem bark was prepared,and chemical characterization was carried out in *** inhibitory concentration and antibiotic modification test were performed by the microdilution *** and antiformation assays were evaluated by the crystal violet *** the chemical characterization,the presence of 24 peaks was *** activity showed minimum inhibitory concentration≥2048μg/*** the evaluations of the potentiating activity,synergism was the most *** the formation analysis,it was observed that most strains showed moderate biofilm *** was concluded that saponin derivatives are the major secondary metabolites in the analyzed extract and that it presents relevant synergism with the antibiotics studied and a significant ability to inhibit bacterial biofilm formation.

关键词： Biofilm Saponins Synergism Inhibition

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Diabetic and Prediabetic Profile of Patients in a Family Health Care Unit of Salvador, Northeastern Brazil

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Open Journal of Endocrine and Metabolic Diseases 2016年第1期6卷 66-71页

作者： João Zallio Coelho Pedro Julião Zallio Coelho Sanchela Raiane pereira de Oliveira Alex Farias Soares jacqueline Novais Santana Paulo Ricardo Bacelar Macedo Juliana Silveira de Freitas Danilo Guimarães Nogueira Andrade Mirella Hansen de Almeida Denise Rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School Sao Paulo Brazil Visiting Physician Joslin Diabetes Center Harvard University Boston USA Visiting Scientist Harvard T. H. Chan School of Public Health Harvard University Boston USA

Diabetes Mellitus is one of the most prevalent diseases in the world. In Brazil, 8.7% of the population between 20 and 79 years of age has diabetes, estimating 11.6 million diabetics. It is commonly associated with other co-morbidities such as hypertension, dyslipidemia and obesity, which put these patients into a high cardiovascular risk profile. This study was performed using the medical records of enrolled population attending a Family Health Unit of Alto do Coqueirinho, Salvador, Northeastern Brazil, consisting of one doctor, one nurse, one dentist, one nursing technician and six community health workers. Medical records and data provided by the system of the Primary Care Information (SIAB), showed total of 2495 patients. Considering the prevalence morbidities in this population, hypertension was present in 9.8% of patients and Type 2 Diabetes in only 3.6%. Since the prevalence of morbidities is the key indicator to the development of public health policies, it seems important a better knowledge on the prevalence rates of diabetes, prediabetes and its co-morbidities of this population. Future plans and projects for health professionals will be based on a consistent medical record.

关键词： Diabetes Prediabetes Comorbidities Family Health Unit

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