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Recent advances in the biosynthesis of coumarin and its derivatives

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Green Chemical Engineering 2024年第2期5卷 150-154页

作者： Yusong Zou Yuxi Teng joy Li Yajun Yan School of Chemical Materials and Biomedical EngineeringCollege of EngineeringThe University of GeorgiaAthensGA30602USA North Oconee High School BogartGA30622USA

Coumarin and its derivatives,presenting in many organisms(plants,fungi,and bacteria),are critical metabolites composed of fused benzene andα-pyrone rings.With unique biological and chemical properties,coumarin derivatives possess great technological potential in the agrochemicals,pharmaceuticals,food,and cosmetic industries.The increasing demand for coumarin derivatives accelerates the research in biological and chemical synthesis to provide stable and scalable sources of coumarins.However,the complex structures and unknown pathways have limited the progress in the biosynthesis of coumarin derivatives.Here,we summarize recent developments and provide a detailed analysis of coumarin derivative biosynthetic pathways in different organisms.

关键词： Coumarin derivatives Biosynthetic pathways Biotransformation Metabolic engineering

Utilization of Artificial Intelligence-Enabled Technologies by Agripreneurs in Ondo State, Nigeria

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Agricultural Sciences 2024年第4期15卷 439-448页

作者： Oluwatoyin joy Omole Oluwatosin O. Fasina department of Agricultural Extension and Communication Technology Federal University of Technology Akure Akure Nigeria

The research investigated the adoption of artificial intelligence (AI) technol-ogies among agricultural entrepreneurs in Ondo state, Nigeria. A purposive sample of 120 participants involved in agriculture was selected for the study. Socioeconomic characteristics analysis revealed that the mean age of the re-spondents was 48.3 years. A majority (77%) of the respondents were male, and approximately 68% were married. Regarding education, 32.5% had completed secondary education, while 32.5% had tertiary education. The av-erage annual income was 1,166,800 naira, with a significant proportion (71.7%) identifying as Christians. The study found a significant association between respondents’ awareness levels and their adoption of AI-enabled technologies (χ2 = 7.714, p = 0.005). Based on these findings, it is recom-mended that extension officers receive training in the latest agricultural technologies, including those enabled by AI. Furthermore, the study suggests the introduction of easily accessible and user-friendly AI technologies to farmers to enhance their productivity and income with minimal or no cost implications.

关键词： Artificial Intelligence Agripreneurs Awareness

Structure design of Underwater Micro Robot

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Modern Mechanical Engineering 2024年第1期14卷 12-24页

作者： Md Shahriar Sujan joy Howlader Md Jahangir Alam Md Al Imran Tapu College of Harbor Coastal & Offshore Engineering Hohai University Nanjing China department of Computer Science and Information Technology College of Computer and Information Hohai University Nanjing China College of Civil and Transportation Engineering Hohai University Nanjing China

A submergible robot model has been presented, and for 3d printing measures, their parts have been modified enough. It has been shown in our design that using printable connectors—a few engines and weight arrangements can be carried out, permitting distinctive moving prospects. After presenting our configuration and delineating a bunch of potential structures, a helpful model dependent on open-source equipment and programming arrangements has been presented conditionally. The model can be effectively tried in a few makes-a plunge streams and lakes throughout the planet. The unwavering quality of the printed models can be strained distinctly in generally shallow waters. Nonetheless, we accept that their accessibility will inspire the overall population to construct and test submerged robots, subsequently accelerating the improvement of imaginative arrangements and applications.

关键词： Submergible Robot Thruster Adapter Raspberry Pi 3d Printer Open Source Software

透明质酸填充剂HYC-24/HYC-24+治疗中国中、重度鼻唇沟皱褶患者满意度的真实世界研究

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中华整形外科杂志 2024年第4期40卷 436-443页

作者：曹令宋为民徐士亮隋志甫 joy Maglambayan Vaishali Patel 北京丽都医疗美容医院整形外科北京100101 杭州颜术悦容医疗美容诊所美容皮肤科杭州州310008 广州粤秀整形外科医院整形外科广州1510600 Allergan Aesthetics(艾伯维旗下公司) 新加坡117439 AllerganAesthetics(艾伯维旗下公司) 美国加利福尼亚州尔湾市92612

目的评估中国中度至重度鼻唇沟皱褶(NLF)患者在真实的临床实践环境中接受HYC-24/HYC-24+治疗后的结局满意度。方法本研究是一项前瞻性、观察性、多中心、真实世界队列研究。纳入2018年8月至2020年8月于北京丽都医疗美容医院、杭州颜术... 详细信息

目的评估中国中度至重度鼻唇沟皱褶(NLF)患者在真实的临床实践环境中接受HYC-24/HYC-24+治疗后的结局满意度。方法本研究是一项前瞻性、观察性、多中心、真实世界队列研究。纳入2018年8月至2020年8月于北京丽都医疗美容医院、杭州颜术悦容医疗美容诊所和广州粤秀整形外科医院接受HYC-24/HYC-24+治疗,并随访长达1年的中国患者,年龄18至65岁、患有中度至重度NLF,且在研究入组前6个月内未接受过NLF的美容治疗。在第1、6、9和12个月进行治疗后研究访视,仅第6个月和第9个月为必须进行的访视。患者报告结局的主要终点包括:FACE-Q结局满意度问卷总分(评分范围为0~100分,分数越高表示结局越好,患者越满意),FACE-Q皱纹评估-NLF问卷总分较基线的平均变化(评分范围为0~100分,评分越高表示患者在过去1周内越不受到NLF的困扰),以及在FACE-Q患者感知年龄视觉模拟评分法(VAS)上报告比实际年龄看起来更年轻的患者比例。研究者评估终点包括整体美容效果改善量表(GAIS)评分≥1分的患者比例,以及使用鼻唇沟皱褶严重程度量表(NLFSS)评估NLF严重程度改善≥1分的患者比例。使用SAS 9.4软件进行统计分析,计量资料采用±s表示,计数资料用例数(%)表示,不同访视时间与基线的比较,采用Wilcoxon符号秩检验。结果共52例患者入组并接受治疗,其中,7例因访视时间超出访视评估窗而未被纳入第6个月有效性的分析数据集,仅9例患者完成了第12个月的访视。所有患者均为中国籍女性,年龄26~62岁,平均为40.7岁。FACE-Q结局满意度问卷总分第6个月时为(68.76±21.03)分(38~100分),第9个月时为(65.44±18.24)分(24~100分),表明患者对治疗的满意度较高。FACE-Q皱纹评估-NLF问卷总分基线时为(42.4±15.1)分(10~69分),第6个月时为(76.9±20.6)分(36~100分),第9个月时为(74.2±16.7)分(36~100分),均较基线得分明显升高(P均<0.01),第6个月和第9个月时问卷总分较基线的平均变化分别为34.9分和31.8分,表明治疗后NLF造成的困扰较轻。FACE-Q患者感知年龄VAS报告认为比实际年龄看起来更年轻的患者比例从基线时的28.9%(15/52)分别增加到第6个月的77.8%(35/45)和第9个月的73.1%(38/52),与基线相比,差异均有统计学意义(P<0.01)。在每次基线后访视时,所有患者的GAIS量表得分改善均≥1分,表明研究者认为患者NLF外观均有所改善。在NLFSS评价方面,分别有97.8%(44/45)和82.7%(43/52)的患者在第6个月和第9个月的NLFSS改善程度≥1分。试验期间无不良事件报告。结论在真实临床实践环境中,对中国患者施用HYC-24/HYC-24+后,使用经验证的问卷调查显示,患者对结局表示满意。患者还报告称治疗后看起来比实际年龄年轻,并且受NLF的困扰较少。临床医生报告结局与患者报告结局一致,表明NLF有所改善。

关键词：鼻唇沟,鼻唇褶透明质酸患者满意度亚裔整形手术

design and Analysis of Power and Transmission System of downhole Pure Electric Command Vehicle

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Journal of Transportation Technologies 2024年第1期14卷 31-52页

作者： Md Jahangir Alam Md Shahriar Sujan Md. Al Imran Tapu joy Howlader College of Civil and Transportation Engineering Hohai University Nanjing China College of Harbor Coastal & Offshore Engineering Hohai University Nanjing China department of Computer Science and Technology College of Computer and Information Hohai University Nanjing China

Electric vehicles use electric motors, which turn electrical energy into mechanical energy. As electric motors are conventionally used in all the industry, it is an established development site. It’s a mature technology with ideal power and torque curves for vehicular operation. Conventional vehicles use oil and gas as fuel or energy storage. Although they also have an excellent economic impact, the continuous use of oil and gas threatened the world’s reservation of total oil and gas. Also, they emit carbon dioxide and some toxic ingredients through the vehicle’s tailpipe, which causes the greenhouse effect and seriously impacts the environment. So, as an alternative, electric car refers to a green technology of decarbonization with zero emission of greenhouse gases through the tailpipe. So, they can remove the problem of greenhouse gas emissions and solve the world’s remaining non-renewable energy storage problem. Pure electric vehicles (PEV) can be applied in all spheres, but their special implementation can only be seen in downhole operations. They are used for low noise and less pollution in the downhole process. In this study, the basic structure of the pure electric command vehicle is studied, the main components of the command vehicle power system, namely the selection of the drive motor and the power battery, are analyzed, and the main parameters of the drive motor and the power battery are designed and calculated. The checking calculation results show that the power and transmission system developed in this paper meets the design requirements, and the design scheme is feasible and reasonable.

关键词： Pure Electric Vehicles Transmission Gears Electronic differential Control Algorithms

Beta-HCG Levels and Ovarian Ultrasonography Results among Non-Pregnant Women of Reproductive Age in Port Harcourt, Nigeria: A Cross-Sectional Study

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Journal of Biosciences and Medicines 2024年第5期12卷 233-241页

作者： Celine C. Agonsi Francis Anacletus Joel Aluko Chinemerem Eleke joy C. Samuel African Centre of Public Health and Toxicological Research (ACE-PUTOR) University of Port Harcourt Choba Nigeria department of Nursing Science University of Port Harcourt Choba Nigeria

Background: Certain ovarian cancers that were previously common in postmenopausal women are now increasingly observed in women of reproductive age. The research on using β-HCG as a diagnostic biomarker for ovarian cancer in women of reproductive age is ongoing. Aim: This study assessed the level of serum β-HCG in non-pregnant women of reproductive age and determined its potential association with suspicious ovarian ultrasonography results. Methods: The study was conducted in Port Harcourt, Nigeria. This study adopted a cross-sectional design on a quota sample of 224 case notes of women aged 18 - 40 years obtained from eight diagnostic centres. A data extraction form was used for data collection. data analysis employed descriptive statistics, Chi-square, Fisher’s exact test, and Odds Ratio at 95% confidence and 5% significance levels. Results: About 5.8% of the participants exhibited detectable levels of serum β-HCG above 5 IU/L (World Health Organization reference) at a mean concentration of 5.87 (±1.75) IU/L. About 4.0% of the participants had suspicious ovarian lesions identified through ultrasonography. Participants with elevated serum β-HCG levels above the WHO reference were 59 times more likely to have suspicious ovarian lesions (Odds ratio: 59.4, 95%CI: 12.3 - 287.8, p β-HCG level and age (p = 0.041) as well as parity (p Conclusion: Serum β-HCG levels above the WHO reference in non-pregnant women were associated with suspicious ovarian lesions. More rigorous primary research, systematic reviews, and meta-analyses are needed to confirm the findings of this study.

关键词： Biomarkers Ovarian Cancer Pregnancy Ultrasonography

风云变幻的繁花之路行走上海百年香色今犹在星安干

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城市地理 2024年第2期 28-37页

作者：六水刘诗楠(图) 宋奕(图) 左小朵(图) joy(图) 周俊骅(图) Cheng(图) 不详

“魔都”上海道路万千,网红之路也层出不穷,例如因电视剧《繁花》而大热的南京路、茂名南路,因电影《酱园弄》而成为新晋网红打卡地的乍浦路,还有代表着上海城市历史活话本的思南路等等。《繁花》虽已结局,但上海的繁花之路却永不落幕。

关键词：繁花《繁花》话本南京路电视剧

黄河路的时代光影解读魔都,重忆一段金光绮梦

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城市地理 2024年第2期 18-27页

作者：祥兰阿苗艾丽卡酱(图) 刘黄俊(图) 左小朵(图) joy Neko(图) 不详

20世纪90年代的黄河路处处充满繁华之景,尤其是1993年黄河路美食街的正式开张,让这里成为了上海的新景观。20世纪90年代,改革开放的春风顺着蛇蜓流尚的黄浦江吹到了上海黄河路,这里商贾云集,饭馆林立,从而引来八方食客。后来,归于沉寂... 详细信息

20世纪90年代的黄河路处处充满繁华之景,尤其是1993年黄河路美食街的正式开张,让这里成为了上海的新景观。20世纪90年代,改革开放的春风顺着蛇蜓流尚的黄浦江吹到了上海黄河路,这里商贾云集,饭馆林立,从而引来八方食客。后来,归于沉寂的短街,又随着电视剧《繁花》的热播,闯入大众视野,引起众人对于“魔都”上世纪的追忆和回顾。

关键词：黄河路美食街《繁花》新景观大众视野 20世纪90年代黄浦江

Macrophage Nrf2,an anti-inflammatory signal in hepatic ischemia/reperfusion injury

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Cellular & Molecular Immunology 2023年第5期20卷 427-428页

作者： joy X.Jiang department of Molecular Biosciences UC DavisRm.30091089 Veterinary Medicine Dr.DavisCA95616US

Recently,the manuscript entitled Macrophage nuclear factor erythroid 2-related factor 2(Nrf2)deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3(Timp3)-mediated RhoA/ROCK pathway in the ischemic liver by Rao and colleagues in Hepatology 2022,vol.75[1]described a novel role of Nrf2 in innate immunity in response to hepatic ischemia/reperfusion injury(IRI).Nrf2 is generally considered a redox signaling controller and drives protective signals as an antioxidant gene in multiple organs and diseases.

关键词： Nrf2 hepatic Macrophage