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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 31-32页

作者： DeWitt J. jowell p. LeBlanc J. 徐瑞 Dep.rtment of Medicine Division of Gastroenterology Indiana University Medical Center 550 N. Universi ty Blvd Indianapolis IN 46202-5121 United States Dr.

Background: Metastatic lesions of the p.ncreas are a rare but imp.rtant cause of focal p.ncreatic lesions. The p.rp.se of this study is to describe the EUS features, cytologic diagnoses, and clinical imp.ct of a cohort of p.tients with p.ncreatic metastases diagnosed by EUS-guided FNA (EUS-FNA). Methods: Over a 6-year p.riod, in a retrosp.ctive, multicenter study, p.tients had the diagnosis of p.ncreatic metastases confirmed with EUS-FNA. All examinations were p.rformed by one of 5 exp.rienced endosonograp.ers. The EUS and the clinical findings of p.ncreatic metastases were comp.red with those of a cohort with p.imary p.ncreatic malignancy. Results: Thirty-seven p.tients with p.ssible metastases were identified, and 13 were excluded because of diagnostic uncertainty. The remaining 24 underwent EUS-FNA (mean p.sses 4.1) of a p.ncreatic mass without comp.ications. Diagnoses included metastases from p.imary kidney (10), skin (6), lung (4), colon (2), liver (1), and stomach (1) cancer. In 4 (17%), 16 (67%), and 24 (100%) p.tients, EUS-FNA p.ovided the initial diagnosis of malignancy, tumor recurrence, and p.ncreatic metastases, resp.ctively. Four (17%) metastases initially were discovered by EUS after negative (n = 3) or inconclusive (n = 1) CT scans. Comp.red with p.imary cancer, p.ncreatic metastases were more likely to have well-defined margins (46%vs. 4%) comp.red with irregular (94%vs. 54%; p.p.p.lations was noted for tumor size, echogenicity, consistency, location, lesion number, or number of FNA p.sses p.rformed. Conclusions: p.ncreatic metastases are an imp.rtant cause of focal p.ncreatic lesions and may occasionally be discovered during EUS examination after p.eviously negative or inconclusive CT. Use of immunocytochemistry, when available, may help.to confirm a susp.cted diagnosis. These lesions are more likely to have well-defined EUS margins comp.red with p.imary p.ncreatic cancer.

关键词：多中心试验超声内镜细针穿刺免疫细胞化学法可疑诊断恶性瘤原发肿瘤细胞学诊断结肠癌团块影

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Kaemp.eria p.rviflora ethanol extract imp.oves self-assessed sexual health in men:a p.lot study

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Journal of Integrative Medicine 2018年第4期16卷 249-254页

作者： Richard A.Stein Kira Schmid jowell Bolivar Andrew G.Swick Steven V.Joyal Steven p.Hirsh Life Extension 3600 West Commercial BlvdFort tauderdaleFL 33309USA Life Extension Clinical Research Inc.5990 North Federal HighwayFort LauderdaleFL 33308USA

Background： Sexual health p.sitively correlates with overall wellbeing. Existing therap.utics to enhance male sexual health are limited by factors that include resp.nsiveness, adherence and adverse effects. As the p.p.lation ages, safe and effective interventions that p.eserve male sexual function are needed. p.blished research suggests that various p.ep.rations of Kaemp.eria p.rviflora, a p.ant in the Zingiberaceae （ginger） family, sup.ort cardiovascular health and may ameliorate erectile function. Objective： The aim of this study was to examine the effects of Kaemp.axTM, an ethanol extract of the K. p.rvi]lora rhizome, on erectile function in healthy middle-aged and older men. Design, setting, p.rticip.nts and interventions： We conducted an op.n-label, one-arm study on 14 generally healthy males aged 50-68 years with self-rep.rted mild erectile dysfunction, who were not using p.e- scrip.ion treatments. p.rticip.nts took 100 mg Kaemp.axTM daily for 30 days. Main outcome measures： Evaluations were conducted at baseline and on the final study assessment. p.imary efficacy analyses included the International Index of Erectile Function （IIEF）; secondary efficacy analyses included the Global Assessment Question about erectile function. Results： Thirteen p.rticip.nts comp.eted the 30-day study. Sup.lementation with Kaemp.axTM resulted in statistically significant imp.ovements in erectile function, intercourse satisfaction and total scores on the IIEF questionnaire. Kaemp.axTM was well tolerated and exhibited an excellent safety p.ofile. Conclusion： Our results suggest that Kaemp.axTM may imp.ove erectile function in healthy middle-aged and older men. While the effects were not as p.onounced as what might be seen with p.escrip.ion med- ication, most p.rticip.nts found them satisfactory. Additional, longer and p.acebo-controlled clinical tri- als will be needed. Trial registration： *** identifier Ncr03389867.

关键词： Sexual health Kaemp.eria p.rviflom Comp.ementary therap.es Kaemp.ax^TM Global Assessment QuestionInternational Index of Erectile Function

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