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treating acute large vessel occlusion stroke:to bridge or not to bridge?

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Stroke & Vascular Neurology 2021年第3期6卷 324-327页

作者： Yunyun Xiong Yuesong Pan Raul G Nogueira Zeguang Ren tudor G jovin Yongjun Wang Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Neurology Marcus Stroke and Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGeorgiaUSA Neurosurgery Cleveland Clinic Martin HealthPort St LucieFloridaUSA Cooper Neurologic Institute Cooper University HospitalCamdenNew JerseyUSA Neurology Cooper Medical School of Rowan UniversityCamdenNew JerseyUSA

Hot debates exist regarding whether patients who had an acute large vessel occlusion stroke(LVOS)can skip tissue plasminogen activator(tPA)and go directly to thrombectomy in comprehensive stroke *** head-to-head randomised clinical trials(RCts)of direct endovascular treatment(dEVt)versus bridge therapy(Bt)with intravenous alteplase have been recently completed in the Asian *** DIRECt-Mt(Direct Intraarterial thrombectomy in Order to Revascularize Acute Ischemic Stroke Patients with Large Vessel Occlusion Efficiently in Chinese tertiary Hospitals:a Multicenter Randomized Clinical trial)Study randomly enrolled 656 patients who had an acute ischaemic stroke with anterior circulation LVOS across 41 large teaching hospitals in China to receive Bt or dEVt within 4.5 hours after symptom onset.

关键词： acute occlusion Acute

Effects of Rice Variety and Growth Location in Cambodia on Grain Composition and Starch Structure

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Rice science 2014年第1期21卷 47-58页

作者： Seila SAR Morgan J.tIZZOttI jovin HASJIM Robert G.GILBERt University of Queensland Centre for Nutrition and Food Sciences Queensland Alliance for Agriculture and Food Innovation

the effects of variety and growth location on grain composition and starch structures were investigated using three rice （Oryza sativa L.） cultivars （Phka Romduol, Sen Pidao and IR66） with different amylose contents. All the three cultivars were planted in three different agro-climatic zones （Phnom Penh, Coastal and Plateau） of Cambodia. the protein content of polished grains increased when rice was planted at a location with higher average temperature, but their lipid content decreased. the amylose content and degree of branching were not greatly affected by the minor temperature differences among the growing locations. Starch fine structures characterized by the chain-length distribution were significantly different among the cultivars, but not significantly among different locations. the results suggested that protein and lipid biosyntheses were more sensitive to the environmental temperature than that of starch in rice grains.

关键词： rice physicochemical property starch fine structure size-exclusion chromatography growth location

阻碍坦桑尼亚政府组织员工绩效的社会经济因素研究

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阻碍坦桑尼亚政府组织员工绩效的社会经济因素研究

作者： GABAGAMBI jovin PEtER 中国科学技术大学

学位级别：硕士

很多组织在刚成立几年后迅速衰败,其中重要的原因之一是其员工工作绩效差。世界上任何一个机构的成功都主要取决于其管理层的才能以及其所有雇员的绩效。坦桑尼亚政府雇员普遍工作效率低下,在绝大多数政府组织中都是极大的问题,这使得... 详细信息

很多组织在刚成立几年后迅速衰败,其中重要的原因之一是其员工工作绩效差。世界上任何一个机构的成功都主要取决于其管理层的才能以及其所有雇员的绩效。坦桑尼亚政府雇员普遍工作效率低下,在绝大多数政府组织中都是极大的问题,这使得政府机构不能够及时而有效地为人民提供公共服务。本篇研究的目的在于探索坦桑尼亚联合共和国(URt)政府机构内部阻碍雇员工作绩效的多种因素,具体旨在解决以下几个问题:哪些社会因素导致了坦桑尼亚国内政府机构的雇员在工作中绩效不佳?哪些经济学因素导致了坦桑尼亚国内政府机构的雇员在工作中绩效不佳?采取什么样的措施能够解决坦桑尼亚国内政府机构雇员工作绩效低下的问题?由于种种经济与社会原因而导致员工工作绩效低下,是目前大部分坦桑尼亚的政府机构都面临的主要问题,因此,通过本研究解决这些问题显得尤为重要。本研究采用定性与定量的方法收集数据,其中包括问卷调查、观察报告以及采访等形式,在坦桑尼亚国内两个政府机构内,即国家社会保障基金(NSSF)和坦桑尼亚电力供应有限公司(tANESCO),对300位受访对象进行研究。一方面,本研究向受访者发放300份调查问卷,回收了 287份,回收率达到95.6%;另一方面,本研究通过文献查阅来获得第二手数据进行进一步研究。数据通过IBM SPSS软件进行相关分析。研究结果表明,多种不同的社会与经济因素导致了坦桑尼亚国内政府机构雇员工作绩效低下,例如工资较低、工作环境差、领导力不足、缺乏沟通、许多人拥有充足的资源却缺乏竞争意识等等。工作中员工绩效差的情况已经在坦桑尼亚国内许多政府机构中引起了不满,因此,解决坦桑尼亚国内政府机构雇员工作绩效低下的最好办法是首先充分理解工作绩效低下的成因,在此基础上,坦桑尼亚政府才能够进一步找到提高雇员工作绩效的永久性解决方案,并且进一步推广,以改善国内所有政府机构内部工作人员的工作状态。最后,基于本研究的成果,我们认为,政府应该首先重视并积极采取可能的措施来处理坦桑尼亚政府机构雇员工作绩效低下的问题,例如,政府应该提升雇员的工资,并且在他们加班时提供额外的工作福利作为酬劳。另外,政府应该改善工作环境以提高雇员的工作绩效,例如,改善政府办公室的条件从而为雇员创造一个便于沟通的工作环境。同时,政府应该确保在高级管理层和底层雇员之间有良好的沟通渠道以促进良好工作环境的建立因为政府雇员之间良好的沟通交流可以催化其在日常办公室工作中表现良好。政府还应该确保员工在工作环境中拥有足够的基本资源,例如电脑、打印机、扫描仪等等,从而简化雇员每日的职务,并推进工作的高效进行。另一方面,坦桑尼亚政府需要确保在政府机构中雇用有才能和有经验的员工,从而确保其能够为人民提供良好的公共服务。

关键词：雇员绩效政府机构不胜任低薪水管理

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卒中介入治疗培训指南：国际多学会共识文件

国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh tJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson t Pongpech S Rodesch G Soderman M taylor A Krings t Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson t Fiehler J turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka t Iihara K Ishii A Higashi t Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow t Sugiu K tanaka M terada t Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo t Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi tM Mack WJ Mctaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ tarr RW Frei DF Pabo M Nogueira RG Zaidat OO jovin t Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Rolling Meadows IL USA American Society of Neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and therapeutic Neuroradiology (AAFItN) Bali Indonesia Australian and New Zealand Society of Neuroradiobgy-Conjomt Committee for Recognition of training in Interventional Neuroradiology (CCINR) representing the RANZCR (ANZSNR) ANZAN and NSA Sydney Australia Canadian Interventional Neuro Group (CING) Edmonton AB Canada World Federation of Interventional and therapeutic Neuroradiology (WFItN) Gold Coast Australia European Society of Neuroradiology (ESNR) Milan Italy European Society of Minimally Invasive Neurologic therapy (ESMINt) Nice France Japanese Society for Neuroendovascular therapy (JSNEt) Okayama Japan Sociedad Ibero Latino Americana de Neuroradiologica (SILAN) Cartagena Colombia Society of Neurolnterventional Surgery (SNIS) Washington DC USA Society of Vascular and Interventional Neurology (SVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

thrombectomy in stroke

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中华物理医学与康复杂志 2015年第8期37卷 634-634页

作者： jovin tG Chamorro A Cobo E

BACKGROUND AND OBJECtIVE Mechanical thrombectomy has been proven to be of benefit when implemented early after ischemic stroke *** study compared the efficacy and safety of combined neurovascular thrombectomy and medical therapy with medical therapy alone for patients with acute ischemic *** Eligible patients were18 to 80 years of age with acute ischemic stroke by large proximal vessel occlusion,seen at one of

关键词：血栓中风药物治疗疗效比较切除术脑卒中缺血发病

High concentration of calcium ions in Golgi apparatus

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Cell Research 1994年第1期4卷 97-108页

作者： XUE SHAOBAI M. RoBERt NICOUD JIE CUI D.J.ARNDt jovin(Depariment of Biology, Beijing Normal University, Beijing 100875, China)(Max-Planck-Institute fur Biophysikalische Chemie,Gottingen, Germany) Department of Biology Beijing Normal University Beijing China Max-Planck-Institute fSr Biophysikalische Chemie GSttingen Germany

the interphase NIH3t3 cells were vitally fluorescentstained with calcium indicator fluo-3 and Glogi probe C6NBD-ceramide, and then the single cells were examined by laser scanning confocal microscopy (LSCFM) for subcellular distributions of Ca2+ and the location of Golgi apparatus. In these cells, the intracellular Ca2+ were found to be highly concentrated in the Golgi apparatus. the changes of distribution of cytosolic high Ca2+ region and the Golgi apparatus coincided with the cell cycle *** calcium free medium, when the plasma membrane of the cells which had been loaded with fluo-3/AM were permeated by digitonin, the fluorescence of the Golgi region decreased far less than that of the cytosol. Our results indicated that the Glogi lumen retained significantly high concentration of free calcium.

关键词： intracellular free calcium fluo-3/AM Golgi apparatus C6-NBD-ceramide laser scanning confocal microscopy intracellular calcium store

高强度的钙离子探针Fluo-3定位在NIH 3t3细胞的高尔基氏体中

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高强度的钙离子探针Fluo-3定位在NIH 3T3细胞的高尔基氏体中

Impact of 1,7-malaria reactive community-based testing and response(1,7-mRCtR)approach on malaria prevalence intanzania

中国细胞生物学学会第五次会议

作者：薛绍白 M．Robert-Nicoud D．Arndt-jovin 北京师范大学生物系德国马普生物物理化学研究所

用10μM fluo-3 AM对3t3细胞染色, 发现在细胞核附近有一个高强度的fluo-3荧光区域。在ZH 3细胞中也有类似发现。其他作者用钙离子探针fura-2,Indo-1以及离子显

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Infectious Diseases of Poverty 2023年第6期12卷 103-104页

作者： Wei Chang Jessica Cohen Duo‑Quan Wang Salim Abdulla Muhidin Kassim Mahende tegemeo Gavana Valerie Scott Hajirani M.Msuya Mary Mwanyika‑Sando Ritha John ANjau Shen‑Ning Lu Silas temu Honorati Masanja Wilbald Anthony Maru Aregawi W Naveen Sunder tang Kun Katia Bruxvoort jovin Kitau Fadhila Kihwele Godlove Chila Mihayo Michael Marcia Castro Nicolas AMenzies Sein Kim Xiao Ning Xiao‑Nong Zhou Prosper Chaki Yeromin P.Mlacha Department of Global Health and Population Harvard T.H. Chan School of Public Health Boston USA Chinese Center for Disease Control and Prevention National Institute of Parasitic Diseases Shanghai People’s Republic of China School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Chinese Center for tropical Diseases Research Shanghai People’s Republic of China WHO Collaborating Centre for tropical Diseases Shanghai People’s Republic of China Ifakara Health Institute Dar es Salaam United Republic of Tanzania Africa Academy for Public Health Dar es Salaam Tanzania Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania National Center for International Research on tropical Diseases Ministry of Science and Technology Shanghai People’s Republic of China Global Malaria Programme World Health Organization Geneva Switzerland Bentley University Waltham USA Vanke School of Public Health Tsinghua University Beijing People’s Republic of China School of Public Health University of Alabama at Birmingham Birmingham USA the Pan-African Mosquito Control Association (PAMCA) KEMRI Headquarters Nairobi Kenya

Background Progress in malaria control has stalled in recent years and innovative surveillance and response approaches are needed to accelerate malaria control and elimination eforts in endemic areas of ***‑ing on a previous China-UK-tanzania pilot study on malaria control,this study aimed to assess the impact of the 1,7-malaria Reactive Community-Based testing and Response(1,7-mRCtR)approach implemented over two years in three districts of *** the 1,7-mRCtR approach provides community-based malaria testing via rapid diagnostic tests and treat‑ment in villages with the highest burden of malaria incidence based on surveillance data from health *** used a diference-in-diferences quasi-experimental design with linear probability models and two waves of crosssectional household surveys to assess the impact of 1,7-mRCtR on malaria *** conducted sensitivity analyses to assess the robustness of our results,examined how intervention efects varied in subgroups,and explored alternative explanations for the observed *** Between October 2019 and September 2021,244,771 community-based malaria rapid tests were com‑pleted in intervention areas,and each intervention village received an average of 3.85 rounds of *** prevalence declined from 27.4%at baseline to 11.7%at endline in the intervention areas and from 26.0%to 16.0%in the control areas.1,7-mRCtR was associated with a 4.5-percentage-point decrease in malaria prevalence(95%confdence interval:−0.067,−0.023),equivalent to a 17%reduction from the *** Rufji,a district characterized by lower prevalence and where larviciding was additionally provided,1,7-mRCtR was associated with a 63.9%decline in malaria *** the 1,7-mRCtR approach reduced malaria *** implementation interruptions due to the COVID-19 pandemic and supply chain challenges,the study provided novel evidence on the efectiveness of community-based reactive approache

关键词： Malaria Surveillance and response Incidence rate Community-health worker Health facility Communitybased testing and treatment 1,7-mRCtR tanzania

血管和介入神经病学学会（SVIN）卒中介入实验室共识（SILC）标准：在大血管闭塞性卒中机械血栓切除时代用于建立卒中介入实验室的7 M管理方法

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国际脑血管病杂志 2017年第6期25卷 481-497页

作者： tanzilia Shams Osama Zaidat Dileep Yavagal Andrew Xavier tudor jovin Vallabh Janardhan 段振晖胡挺朱武生 Frome the texas Stroke Institute HCA North Texas DivisionDallas-Fort Worth Tex. Mercy Neuroseience and Stroke Center Toledo Ohio JacksonMemorial Hospital University of Miami Health System Miami Fla. Detroit Medical Center Wayne State UniversityDetroit Mich. UPMC Stroke Institute University of Pittsburgh Medical Center Pittsburg Pa. 南方医科大学南京临床医学院南京军区南京总医院神经内科 210002

与过去20年里心肌梗死介入治疗的发展相似，卒中介入治疗正在迅速发展。随着卒中介入治疗在全球范围内呈指数级增长，在对卒中介入实验室进行标准化以便于安全、有效和及时治疗方面显然存在未能满足的需求。为了实现这一目标，血管和介... 详细信息

与过去20年里心肌梗死介入治疗的发展相似，卒中介入治疗正在迅速发展。随着卒中介入治疗在全球范围内呈指数级增长，在对卒中介入实验室进行标准化以便于安全、有效和及时治疗方面显然存在未能满足的需求。为了实现这一目标，血管和介入神经病学学会（Society of Vascular and Interventional Neurology, SVIN）写作委员会采用7M管理方法制定了卒中介入实验室共识（Stroke Interventional Laboratory Consensus, SILC）标准，用于卒中中心内各卒中介入实验室的建设和标准化。SILC标准包括：（1）人力：包括医疗和行政主管、主治医师、住院医师、后备人员以及卒中生存链内的所有相关人员；（2）设备：硬件设施和血管造影设备；（3）材料：医疗器械库存、药品和血管造影用品；（4）方法：用于优化卒中诊治流程的标准化方案；（5）数量指标：针对单位和介入医师的现有认证标准；（6）质量指标：用作质量保证的基准；（7）安全指标：辐射和操作安全实践标准。

关键词：急性缺血性卒中大血管闭塞血管内治疗卒中干预质量标准