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Seasonal dynamics of foliar antioxidative enzymes and total anthocyanins in natural populations of Iris pumila L.

Journal of Plant Ecology 2010年第1期3卷 59-69页

作者： Ana Vuleta Sanja Manitasevic jovanovic Darka Seslija Branka Tucic Department of Evolutionary Biology Sinisa Stankovic Institute for Biological ResearchBelgradeSerbia Department of Biochemistry Sinisa Stankovic Institute for Biological ResearchBelgradeSerbia

Aims Plants in their natural habitats frequently cope with a multitude of abiotic stresses,such as high light intensity,extreme temperatures and water deficit,which often co-occur during periods of drought,especially in semi-arid and arid *** of plants to stressful environmental conditions usually induce overproduction of reactive oxygen species(ROS)that,as highly toxic derivatives of O_(2),can assault all cell macromolecules,leading to the disruption of cellular homeostasis and,consequently,the uncoupling of major metabolic processes,the photosynthesis and *** order to minimize ROS-mediated cellular damage,plants have evolved highly efficient antioxidative defense systems that include both enzymatic and non-enzymatic *** abiotic stress can also operate as a strong evolutionary force that shapes adaptations in natural plant populations,the aim of this study was to examine the seasonal variation patterns of two distinct antioxidative systems,ROS-scavenging enzymes and anthocyanin pigments,in the leaf tissue of a steppe plant,Iris pumila,as expressed under contrasting light conditions that the species regularly experiences in the *** We selected two natural populations of *** inhabiting the alternative radiation environments in the Deliblato Sands,a sunexposed dune site and a woodland *** specific activity of three antioxidative enzymes,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD)and the content of total anthocyanins were examined in leaves of *** plants collected from each of the 31 Iris clones(17 in the exposed population and 14 in the shaded population)once during each of the three seasons,spring,summer and autumn in ***,a fully expanded leaf was cut from each clonal plant between 15:00 and 16:00 h,immediately frozen in liquid nitrogen and stored at-70℃until *** Findings Generally,all three antioxidative enzymes were up-regulated in summer-harvested

关键词： SOD CAT POD anthocyanins seasonal variation

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Comethylation of p16 and MGMT genes in colorectal carcinoma:Correlation with clinicopathological features and prognostic value

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World Journal of Gastroenterology 2007年第8期13卷 1187-1194页

作者： Koviljka Krtolica Milena Krajnovic Slavica Usaj-Knezevic Dragan Babic Dusan jovanovic Bogomir Dimitrijevic Laboratory for Radiobiology and Molecular Genetics Institute of Nuclear Sciences "Vinca" P. O. BOX 522 Belgrade Serbia Institute of Oncology Sremska KamenicaSerbia Institute for Medical Statistics of Medical University BelgradeSerbia

AIM: To investigate the significance of p16 and O6- methylguanine-DNA methyltransferase (MGMT) genes promoter hypermethylation and K-ras mutations on colorectal tumorigenesis and progression. METHODS: p16 and MGMT methylation status was examined on 47 tumor samples, and K-ras mutational status was examined on 85 tumor samples. For methylation analysis, a methylation specific PCR (MS-PCR) method was used. RESULTS: p16 and MGMT promoter methylation was found in 51% (24/47) and 43% (20/47) of CRCs, respectively, and the K-ras mutation was found in 44% (37/85) of CRCs. Comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease within a two-year period of observation. Only 27% of patients with simultaneous p 16 and MGMT methylation showed the detectible occurrence of metastasis and/or death, compared to 67% of patients without double methylation or with no methylation (3/11 vs 22/33, P < 0.05, χ2-test). In addition, p16 and MGMT comethylation showed a trend toward an association with longer survival in patients with CRCs (35.5 ± 6.0 mo vs 23.1 ± 3.2 mo, P = 0.072, Log-rank test). Progression of the disease within a two-year period was observed in 66% of patients carrying the K-ras mutation, compared to only 19% of patients with wild type K-ras (29/44 vs 7/37, P < 0.001, χ2-test). The presence of the K-ras mutation significantly correlated to shortened overall survival (20.0 ± 1.9 mo vs 37.0 ± 1.8 mo, P < 0.001, Log-rank test). The comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease even when K-ras mutations were included in the analysis as an independent variable. CONCLUSION: Our data suggest that comethylation of promoters of p 16 and MGMT genes could have a prognostic value in patients with CRC. Specifically, concurrent methylation of both genes correlates with better prognosis.

关键词： Colorectal carcinoma DNA methylation p16 MGMT K-ras mutation

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The effects of selection for early and late reproduction on metabolite pools in Acanthoscelides obtectus Say

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Insect Science 2012年第3期19卷 303-314页

作者： Jelica Lazarevie Nikola Tucic Darka Se.slija jovanovic Josef Vecera Dalibor Kodrik Institute for Biological Research Belgrade Biological faculty University of Belgrade Belgrade Serbia Institute of Entomology Biology Centre Czech Academy of Sciences Ceske Budejovice Faculty of Sciences University of South Bohemia Ceske Budejovice Czech Republic

The present study was aimed at revealing the responses of metabolite pools to selection for alternative reproductive schedules in the seed beetle, Acanthoscelides obtectus Say （Coleoptera： Chrysomelidae： Bruchinae）. The levels of metabolites （free sugars, glycogen, lipids, soluble and hydrophobic proteins） that were determined in virgin females and males at three ages from adult eclosion onwards were compared among the base population （B） and two derived lines that were selected for either early （Y） or late （O） reproduction. The results showed differences in the accumulation of metabolites during pre-adult development, as well as in the pattern of their changes during adult ageing, Generally, in comparison to the B population, the short-lived beetles from the Y line showed increased protein content and reduced carbohydrate and lipid content, whereas the opposite was true for the long-lived beetles from the O line. Females from the O line exhibited slower utilization of energy reserves and a slower increase in protein contents than females from the Y line. Females contained higher levels of free sugars, glycogen and hydrophobic proteins and lower levels of lipids and soluble proteins than males, although the sexual dimorphism was not evenly expressed among lines. Age-specific changes in metabolite contents were slower in females than males. Our findings suggest that trade-offs among capital resources are a physiological basis of early/late fitness trade-offs and point to a conservation of resources that can be used for somatic maintenance.

关键词： ageing energy resources laboratory evolution proteins seed beetle,trade-off

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Pesticide-induced photoluminescence quenching of ultra-small Eu3+-activated phosphate and vanadate nanoparticles

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Journal of Materials Science & Technology 2020年第3期38卷 197-204页

作者： Jovana Perisa Zeljka Antic Chong-Geng Ma Jelena Papan Dragana jovanovic Miroslav D.Dramicanin Vinca Institute of Nuclear Sciences University of BelgradeP.O.Box 52211001 BelgradeSerbia College of Sciences Chongqing University of Posts and TelecommunicationsChongqing 400065China

The aim of this research was to investigate the luminescent behavior of ultra-small Eu3+-activated phosphate and vanadate nanoparticles in the presence of *** have an average diameter of approximately 2 nm with a narrow size *** monazite crystal structure of phosphate-based particles(space group P121/n1)and single tetragonal zircon-type structure of vanadate-based particles(space group of I41/amd)have been confirmed using X-ray diffraction *** synthesized Eu3+-activated colloidal nanoparticles show sharp emission peaks in the red spectral *** measurements revealed emission quenching upon addition of millimolar concentrations of following pesticides:4-Chloro-2-methyl-phenoxyacetic acid(MCPA),2,4-Dichlorophenoxyacetic acid(2,4-D)and N-(phosphonomethyl)glycine(Glyphosate).In both phosphate and vanadate-based colloidal nanoparticles luminescence quenching is more evident in the presence of 2,4-D pesticide with the lowest limit of detection(0.7μM)obtained for phosphate-based nanoparticles.

关键词： Phosphate/vanadate based colloidal nanoparticles Eu3+ Emission quenching Pesticide

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EUS diagnosis of ectopic opening of the common bile duct in the duodenal bulb: A case report

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World Journal of Gastroenterology 2005年第32期11卷 5068-5071页

作者： Miodrag Krstic Bojan Stimec Radmilo Krstic Milenko Ugljesic Srbislav Knezevic Ivan jovanovic Clinical Center of SerbiaBelgrade Serbia and Montenegro Institute for AnatomySchool of Medicine BelgradeSerbia and Montenegro

Among the various congenital anomalies of the biliary system,an ectopic opening of the common bile duct (CBD) in the duodenal bulb is extremely rare. ERCP is essential for diagnosing the anomaly. A 55-year-old male was admitted to hospital for severe right upper quadrant abdominal pain,followed by fever, chills, elevated body temperature and mild icterus. The diagnosis of ectopic opening of CBD in the duodenal bulb was established on endoscopic ultraso-nography (EUS),which clearly demonstrated dilated CBD, with multiple stones and air in the lumen, draining into the bulb. A normal pancreatic duct, which did not drain into the bulb, was also observed. This finding was confirmed on ERCP and *** far as we know, this is the first case of this anomaly diagnosed by EUS. Ectopic opening of the CBD in the duodenal bulb is not an incidental finding, but a pathologic condition which can be associated with clinical entities such as recurrent or intractable duodenal ulcer, recurrent biliary pain,choledocholithiasis or acute cholangitis. Endoscopic ultrasonography features allow preoperative diagnosis of this anomaly and can replace ERCP as a first diagnostic tool in such clinical circumstances. Embryology of the anomalies of the extrahepatic biliary tree has been also reviewed.

关键词： Ectopic opening Common bile duct Congenital anomaly Endoscopic ultrasound

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Sodium-glucose cotransporter 2 inhibitors’ mechanisms of action in heart failure

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World Journal of Diabetes 2020年第7期11卷 269-279页

作者： Petra Grubić Rotkvić Maja Cigrovski Berković Nikola Bulj luka Rotkvić Ivana Ćelap Department of Cardiology University Hospital10000 ZagrebCroatia Department of Endocrinology DiabetesMetabolism and Clinical PharmacologyUniversity HospitalZagreb 10000Croatia Department for Medicine of Sports and Exercise Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Cardiology University Hospital CentreZagreb 10000Croatia Department of Cardiology Magdalena Clinic for Cardiovascular DiseaseKrapinske Toplice 49217Croatia Department of Clinical Chemistry University Hospital CentreZagreb 10000Croatia

Three major cardiovascular outcome trials(CVOTs)with a new class of antidiabetic drugs-sodium-glucose cotransporter 2(SGLT2)inhibitors(EMPAREG OUTCOME trial with empagliflozin,CANVAS Program with canagliflozin,DECLARE-TIMI 58 with dapagliflozin)unexpectedly showed that cardiovascular outcomes could be improved possibly due to a reduction in heart failure risk,which seems to be the most sensitive outcome of SGLT2 *** other CVOT to date has shown any significant benefit on heart failure *** more impressive findings came recently from the DAPA-HF trial in patients with confirmed and well-treated heart failure:Dapagliflozin was shown to reduce heart failure risk for patients with heart failure with reduced ejection fraction regardless of diabetes ***,despite their possible wide clinical implications,there is much doubt about the mechanisms of action and a lot of questions to unravel,especially now when their benefits translated to nondiabetic patients,rising doubts about the validity of some current mechanistic *** time frame of their cardiovascular benefits excludes glucoselowering and antiatherosclerotic-mediated effects and multiple other mechanisms,direct cardiac as well as systemic,are suggested to explain their early cardiorenal *** are:Anti-inflammatory,antifibrotic,antioxidative,antiapoptotic properties,then renoprotective and hemodynamic effects,attenuation of glucotoxicity,reduction of uric acid levels and epicardial adipose tissue,modification of neurohumoral system and cardiac fuel energetics,sodiumhydrogen exchange *** most logic explanation seems that SGLT2 inhibitors timely target various mechanisms underpinning heart failure *** the proposed mechanisms of their action could interfere with evolution of heart failure and are discussed separately within the main text.

关键词： Sodium-glucose cotransporter 2 inhibitors Heart failure Cardiovascular outcomes Diabetes mellitus Physiological mechanisms Pleiotropic effects

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Franck-Condon factors and γ-Centroids for the A^1 ∑^＋ u-X^1∑^＋ 9 Band System of ^107,109Ag2： Comparison of the Observed and Calculated Absorption Band Strengths

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Chinese Physics Letters 2007年第9期24卷 2566-2568页

作者： A.Antic-jovanovic M.Kuzmanovic V.Bojovic Murtadha A.Khakoo Russ R.Laher Faculty of Physical Chemistry University of Belgrade PO Box 137 1001 Belgrade Serbia Department of Physics California State University Fullerton Fullerton CA 92834 USA Spitzer Science Center California Institute of Technology M/S 314-6 Pasadena CA 91125 USA

Franck-Condon factors and r-centrolds for the, A^1 ∑^＋ u-X^1∑^＋ 9 band system of ^107,109Ag2 are computed using Morse and Rydberg-Klein-Rees potentials for both lower and upper electronic states. The differences between the two sets of results are typically in the third decimal place for transitions involving vibrational levels with ν＇ and ν＂ up to about 15. Somewhat larger deviations appear for higher vibrational levels, but both sets of results follow the same pattern, which is to match well with the relative absorption band strength distribution in our experimental spectrum. The relative absorption band strengths are calculated by assuming that the electronic transition moment has only a weak dependence on the internuclear distance r. Good agreement between our measured and calculated absorption band strength ratios is found, which provides an excellent test of the calculated Franck- Condon factors and relative absorption band strengths. The r-centrold value for the （ν＇ = 0, ν＂ = 0） band is found to be approximately equal to the average value of r＇ and r＇＇e , indicating that the potentials of both states are not significantly aaharmonic around their minimum regions.

关键词： Franck-Condon Rydberg-Klein-Rees Comparison

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Insect Hydrocarbons. Biology, Biochemistry, and Chemical Ecology

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Insect Science 2012年第6期19卷 703-704页

作者： Sofija Pavkovic-Lucic Dragana Milicic luka Lucic Chair of Genetics and Evolution Faculty of BiologyUniversity of Belgrade Faculty of BiologyUniversity of Belgrade Serbia Belgrade 11000 Chair of Animal Morphology Systematics and Phylogeny Faculty of Biology University of Belgrade Faculty of BiologyUniversity of Belgrade Chair of Animal Development Institute of ZoologyFaculty of BiologyUniversity of Belgrade

Gary J. Blomquist and Anne-Genevirve Bagnbres （eds.）, Cambridge University Press, 2010 ISBN 978-0- 521-89814-0, Hardback, pp. 492, 70.00 Who of us does not know how magic is love dancing in dragonflies, or waggle honebees＇ dance, flushing in the firefly, or traveling of ＂orange cloud＂ during migration of monarch butterflies？ And, if those behaviors are magical for us, how magical are they for themselves？ How special is insect ＂vocabulary＂ during their communication？

关键词： Insect Hydrocarbons Biology Biochemistry

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Galectin-3 possible involvement in antipsychotic-induced metabolic changes of schizophrenia:A minireview

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World Journal of Diabetes 2021年第10期12卷 1731-1739页

作者： Milica M Borovcanin Katarina Vesic Milena jovanovic Natasa R Mijailovic Department of Psychiatry University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia Department of Neurology University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia PhD Studies University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia Clinic for Nephrology and Dialysis University Clinical Center KragujevacKragujevac 34000SumadijaSerbia Department of Pharmacy University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia

Recently,specific immunometabolic profiles have been postulated in patients with schizophrenia,even before full-blown disease and independent of antipsychotic *** profiling studies offer a promising potential for elucidating the cellular and molecular pathways that may be involved in the onset and progression of schizophrenia symptoms,and co-occurrent metabolic *** view of all this,we were intrigued to explore galectin-3(Gal-3)as a glycan,and in our previous study,we measured its elevated levels in remission of *** finding may be a consequence of antipsychotic treatment and may have an impact on the onset of inflammation,the development of obesity,and the presumed cognitive changes in *** the animal study,it was shown that downregulation of Gal-3 was beneficial in insulin regulation of obesity and cognitive *** involving plasma exchange are discussed in this review,particularly in the context of Gal-3 elimination.

关键词： Galectin-3 Schizophrenia Metabolic syndrome Insulin resistance Cognition Antipsychotics

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In situ synthesis of potassium tungstophosphate supported on BEA zeolite and perspective application for pesticide removal

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Journal of Environmental Sciences 2019年第7期31卷 136-147页

作者： Bojana Nedic Vasiljevic Milena Obradovic Danica Bajuk-Bogdanovic Maja Milojevic-Rakic Zoran jovanovic Nemanja Gavrilov Ivanka Holclajtner-Antunovic Faculty of Physical Chemistry University of Belgrade Belgrade 11158 Serbia Laboratory of Physics Vin?a Institute of Nuclear Sciences University of Belgrade Belgrade 11001 Serbia

Potassium tungstophosphate is supported on BEA zeolite by in situ synthesis for glyphosate removal. Spectroscopic measurements identified hydrogen bonding as a primal interaction of potassium salt and BEA zeolite. Composites are evaluated for glyphosate herbicide removal and adsorption process is analyzed using two isotherm models. Obtained adsorption capacities for all prepared composites lay between 45.2 and 92.2 mg of glyphosate per gram of investigated composite. Suspension acidity revealed that glyphosate is adsorbed mainly in the zwitter-ion form at the composite surface while the amount of potassium salt in the composites is crucial for the adsorption application. Exceptional adsorption behavior is postulated to come from a high degree of homogeneity among surface active sites which is confirmed by different experimental methods. Temperature programmed desorption of glyphosate coupled with mass spectrometer detected one broad, high-temperature peak which represents overlapped desorption processes from active sights of similar *** of potassium tungstophosphate affects active sites present in BEA zeolite for glyphosate desorption and significantly increases the amount of adsorbed pesticide in comparison to BEA zeolite. Supporting of potassium tungstophosphate on BEA zeolite via in situ synthesis procedure enables the formation of highly efficient adsorbents and revealed their perspective environmental application.

关键词： Composite materials Chemical synthesis Kinetics Adsorption Ultrasonics

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