检索结果-南通市图书馆

Fatty Acids and Autism Spectrum Disorders: The Rett Syndrome Conundrum

Food and Nutrition Sciences 2013年第9期4卷 71-75页

作者： Claudio De Felice Cinzia Signorini Silvia Leoncini Alessandra Pecorelli Thierry Durand Jean-Marie Galano Valérie Bultel-Poncé Alexandre Guy Camille Oger Gloria Zollo Giuseppe Valacchi Lucia Ciccoli joussef hayek Child Neuropsychiatry Unit University Hospital AOUS Policlinico “S. M. Alle Scotte” Siena Italy Department of Life Science and Biotechnologies University of Ferrara Ferrara Italy Department of Food and Nutrition Kyung Hee University Seoul South Korea. Department of Molecular and Developmental Medicine University of Siena Siena Italy Department of Molecular and Developmental Medicine University of Siena Siena Italy Child Neuropsychiatry Unit University Hospital AOUS Policlinico “S. M. Alle Scotte” Siena Italy Institut des Biomolécules Max Mousseron (IBMM) Montpellier France Neonatal Intensive Care Unit University Hospital AOUS Policlinico “S. M. Alle Scotte” Siena Italy

Autism spectrum disorders (ASDs) are epidemically explosive clinical entities, but their pathogenesis is still unclear and a definitive cure does not yet exist. Rett syndrome (RTT) is a rare genetically determined cause of autism linked to mutations in the X-linked MeCP2 gene or, more rarely, in CDKL5 or FOXG1. A wide phenotypical heterogeneity is a known feature of the disease. Although several studies have focused on the molecular genetics and possible protein changes at different levels, to date very little attention has been paid to fatty acids in this disease, which could be considered as a natural paradigm for the ASDs. To this regard, a quite enigmatic feature of the disease is the evidence in the affected patients of an extensive peroxidation of polyunsaturated fatty acids (arachidonic acid, AA, docosaexahenoic acid, DHA, adrenic acid, AdA and, to a lesser extent, eicosapentaenoic acid, EPA), in contrast with amelioration of the redox changes and phenotypical severity following the supplementation of some of those same fatty acids (DHA + EPA). Therefore, fatty acids may represent a kind of Janus Bifrons in the particular context of RTT. Here, we propose a rational explanation for this apparent “fatty acid paradox” in RTT. A better understanding of this paradox could also be of help to get a better insight into the complex mechanism of action for polyunsaturated fatty acids in health and disease.

关键词： Fatty Acids Arachidonic Acid Docosahexaenoic Acid Adrenic Acid Eicosapentaenoic Acid Rett Syndrome Autism Spectrum Disorders

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：