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Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma

World journal of Gastroenterology 2013年第47期19卷 8873-8879页

作者： De-Leung Gu Yen-Hsieh Chen jou-ho shih Chi-Hung Lin Yuh-Shan jou Chian-Feng Chen Institute of Biomedical Sciences Academia Sinica Institute of Microbiology and Immunology School of Life ScienceNational Yang-Ming University Bioinformatics Program Taiwan International Graduate ProgramAcademia Sinica Genome and Systems Biology Degree Program National Taiwan University VYM Genome Research Center National Yang-Ming University

High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma(HCC)cohorts confirmed previously identified frequently mutated somatic genes,such as TP53,CTNNB1 and AXIN1,and identified several novel genes with moderate mutation frequencies,including ARID1A,ARID2,MLL,MLL2,MLL3,MLL4,IRF2,ATM,CDKN2A,FGF19,PIK3CA,RPS6KA3,JAK1,KEAP1,NFE2L2,C16orf62,LEPR,RAC2,and *** classification of these mutated genes suggested that alterations in pathways participating in chromatin remodeling,Wnt/β-catenin signaling,JAK/STAT signaling,and oxidative stress play critical roles in HCC ***,because there are few druggable genes used in HCC therapy,the identification of new therapeutic targets through integrated genomic approaches remains an important *** a large amount of HCC genomic data genotyped by high density single nucleotide polymorphism arrays is deposited in the public domain,copy number alteration(CNA)analyses of these arrays is a cost-effective way to reveal target genes through profiling of recurrent and overlapping amplicons,homozygous deletions and potentially unbalanced chromosomal translocations accumulated during HCC ***,integration of CNAs with other high-throughput genomic data,such as aberrantly coding transcriptomes and non-coding gene expression in human HCC tissues and rodent HCC models,provides lines of evidence that can be used to facilitate the identification of novel HCC target genes with the potential of improving the survival of HCC patients.

关键词： Copy number alteration High-density single nucleotide polymorphism arrays Driver genes Hepatocellular carcinoma

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Dynamic characteristics of a switch and crossing on the West Coast main line in the UK

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Railway Engineering Science 2022年第2期30卷 183-203页

作者： jou-Yi shih Paul Weston Mani Entezami Clive Roberts Birmingham Centre for Railway Research and Education University of BirminghamBirmingham B152TTUK ZynaMic Engineering AB 12070 StockholmSweden

Railway switches and crossings constitute a small fraction of linear track length but consume a large proportion of the railway track system maintenance *** switch and crossing(S&C)faults rarely prevent trains from running,switches and crossings are the source of many faults and need continual *** the rare occasions when trains are prevented from running the cost of the disruption is very *** monitoring of the point operating equipment that moves the switchblades has been in use for many years but condition monitoring of the state of the switch in terms of the support and mechanical damage as trains pass over has only recently started to become *** this end,it is important to understand the correlation between S&C faults and sensor data that can detect those *** paper assesses some of the data collected from multiple sensors variously positioned on and around a switch and crossing on the UK mainline for a few days of normal train ***,geophones,and strain gauges were installed at the locations where they were anticipated to be most *** at the load transfer point on the crossing nose were estimated from two separate strain gauge bridges and possible use of acceleration on the crossing is *** between different data are analysed and assessed and correlation between peak estimated load transfer forces and accelerations is *** on the analysis,conclusions are drawn about the different types of dynamic information around S&Cs that can be obtained from a variety of sensor types.

关键词： Railway Accelerometer Condition monitoring Impact force Switch and crossing Strain gauge

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K-theoretic classification of fermionic operator mixings in holographic conformal field theories

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Science Bulletin 2016年第14期61卷 1115-1125页

作者： shih-Hao ho Feng-Li Lin Department of Physics Taiwan Normal University

In this paper, we apply the K-theory scheme of classifying the topological insulators/superconductors to classify the topological classes of the massive multi-flavor fermions in anti-de Sitter(Ad S) space. In the context of Ad S/conformal field theory(CFT) correspondence, the multi-flavor fermionic mass matrix is dual to the pattern of operator mixing in the boundary CFT. Thus, our results classify the possible patterns of operator mixings among fermionic operators in the holographic CFT.

关键词： Topological insulators/superconductorsSPT phases AdS/CFT correspondence K-theoretical classification Bulk/Edgecorrespondence holographic CFT

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Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes

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Regenerative Biomaterials 2022年第1期9卷 424-433页

作者： Chien-Liang ho Lynn L.H.Huang Shyh-jou Shieh Institute of Clinical Medicine College of MedicineNational Cheng Kung University138 Sheng-Li RoadTainan 70403TaiwanChina Division of Plastic and Reconstructive Surgery Department of SurgeryNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung University138 Sheng-Li RoadTainan 70403TaiwanChina Research Center of Excellence in Regenerative Medicine National Cheng Kung University1 University RoadTainan 70101TaiwanChina Department of Biotechnology and Bioindustry Sciences College of Bioscience and BiotechnologyNational Cheng Kung University1 University RoadTainan 70101Taiwan International Center for Wound Repair and Regeneration National Cheng Kung University1 University RoadTainan 70101TaiwanChina School of Medicine National Cheng Kung University1 University RoadTainan 70101TaiwanChina

Autologous chondrocytes(C cells)are effective sources of cell therapy for engineering cartilage tissue to repair chondral defects,such as degenerative *** expansion of cells with C cell characteristics has become a major challenge due to inadequate donor sites and poor proliferation of mature C *** perichondrial progenitor cells(P cells)from the cambium layer of the perichondrium possessed significantly higher mesenchymal stem cell markers than C *** the transwell co-culture system,P cells increased the passaging capacity of C cells from P6 to P9,and the cell number increased 128 *** system increased the percentage of Alcian blue-positive C cells from 40%in P6 to 62%in P9,contributing about 198 times more Alcian blue-positive C cells than the control group.C cells co-cultured with P cells also exhibited higher proliferation than C cells cultured with P cellconditioned *** results were obtained in nude mice that were subcutaneously implanted with C cells,P cells or a mixture of the two cell types,in which the presence of both cells enhanced neocartilage formation in ***,P cells enhanced the proliferation of C cells in a dose–dependent manner and prolonged the longevity of mature C cells for clinical applications.

关键词： chondrocytes cell proliferation perichondrial progenitor cells paracrine effect neocartilage formation

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Immobilized microalgal system:An achievable idea for upgrading current microalgal wastewater treatment

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Environmental Science and Ecotechnology 2023年第2期14卷 3-17页

作者： Meina Han Chaofan Zhang shih-Hsin ho State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090PR China

Efficient wastewater treatment accompanied by sustainable“nutrients/pollutants waste-wastewaterresources/energy nexus”management is acting as a prominent and urgent global issue since severe pollution has occurred *** wastes from wastewater into the value-added microalgalbiomass stream is a promising goal using biological wastewater treatment *** review proposed an idea of upgrading the current microalgal wastewater treatment by using immobilized microalgal ***,a systematic analysis of microalgal immobilization technology is displayed through an in-depth discussion on why using immobilized microalgae for wastewater ***,the main technical approaches employed for microalgal immobilization and pollutant removal mechanisms by immobilized microalgae are ***,from high-tech technologies to promote large-scale production and application potentials in diverse wastewater and bioreactors to downstream applications lead upgradation closer,the feasibility of upgrading existing microalgal wastewater treatment into immobilized microalgal systems is thoroughly ***,several research directions are proposed toward the future immobilized microalgal system for microalgal wastewater treatment ***,it appears that using immobilization for further upgrading the microalgae-based wastewater treatment can be recognized as an achievable alternative to make microalgal wastewater treatment more *** information and perspectives provided in this review also offer a feasible reference for upgrading conventional microalgae-based wastewater treatment.

关键词： Microalgae Immobilized microalgal system Biological wastewater treatment Removal mechanisms Technical upgrading

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Sustainable biochar as an electrocatalysts for the oxygen reduction reaction in microbial fuel cells

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Green Energy & Environment 2021年第5期6卷 644-659页

作者： Shengnan Li shih-Hsin ho Tao Hua Qixing Zhou Fengxiang Li Jingchun Tang College of Environmental Science and Engineering Ministry of Education Key Laboratory of Pollution Processes and Environmental CriteriaRemediation and Pollution Control for Urban Ecological EnvironmentalNankai UniversityTianjin300350China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China

Microbial fuel cells(MFCs)have gained remarkable attention as a novel wastewater treatment that simultaneously generates *** low activity of the oxygen reduction reaction(ORR)remains one of the most critical bottlenecks limiting the development of *** date,although research on biochar as an electrocatalyst in MFCs has made tremendous progress,further improvements are needed to make it economically ***,biochars have been considered to be ORR electrocatalysts with developmental *** this review,the ORR mechanism and the essential requirements of ORR catalysts in MFC applications are ***,the focus is to highlight the material selection,properties,and preparation of biochar electrocatalysts,as well as the evaluation and measurement of biochar ***,in order to provide comprehensive information on the specific applications of biochars in the field of MFCs,their applications as electrocatalysts,are then discussed in detail,including the uses of nitrogen-doped biochar and other heteroatom-doped biochars as electrocatalysts,poisoning tests for biochar catalysts,and the cost estimation of biochar ***,profound insights into the current challenges and clear directions for future perspectives and research are concluded.

关键词： Biochar Electrocatalysts Oxygen reduction reaction Microbial fuel cells Pyrolysis

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Revolutions in algal biochar for different applications:State-of-the-art techniques and future scenarios

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Chinese Chemical Letters 2020年第10期31卷 2591-2602页

作者： Yi-Di Chen Feiyu Liu Nan-Qi Ren shih-Hsin ho School of Civil and Environmental Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

Algae are potential feedstock for the production of bioenergy and valuable *** the extraction of specific value-added products,algal residues can be further conve rted into biogas,biofuel,and biochar through various thermochemical treatments such as conventional pyrolysis,microwave pyrolysis,hydrothermal conversion,and *** compositions and physicochemical characteristics of algal biochar that dete rmine the subsequent applications are compre hensively *** biochar carbonized at high-temperature showed remarkable performance for use as supercapacitors,CO_(2) adsorbents,and persulfate activation,due to its graphitic carbon structure,high electron transport,and specific surface *** algal biochar produced by pyrolysis at mode rate-temperature exhibits high performance for adsorption of pollutants due to combination of miscellaneous functional groups and po rous structures,whereas coal fuel can be obtained fro m algae via torrefaction by pyrolysis at relatively low-tempe *** aim of this review is to study the production of algal biochar in a cost-effective and environmental-friendly method and to reduce the environmental pollution associated with bioenergy *** zero emission enerev production.

关键词： Algae Algal residue Thermochemical processes Pyrolysis Biochar

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Publishing a sound paper of environmental science and ecological technology:Some experiences and tips for young researchers

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Environmental Science and Ecotechnology 2023年第1期13卷 1-4页

作者： shih-Hsin ho Nan-Qi Ren School of Environment Harbin Institute of TechnologyChina State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyChina

Two factors are of great significance for enhancing young researchers'international engagement:continuously improving their academic level and publishing advanced progress in scientific *** journals in the field of environmental science and ecological technology(ESET)are committed to improving research independency of young researchers,so as to promote excellent scientific research *** this editorial,we integrate major challenges that young researchers must cope with in preparing their submissions.

关键词： preparing young sound

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Effective purification of oily wastewater using lignocellulosic biomass:A review

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Chinese Chemical Letters 2022年第6期33卷 2807-2816页

作者： Meng Wang Hsu-Sheng Tsai Chaofan Zhang Chengyu Wang shih-Hsin ho State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150001China Laboratory for Space Environment and Physical Sciences Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Bio-based Material Science& Technology(Northeast Forestry University) Ministry of EducationHarbin 150040China

Due to the frequent occurrence of oil spills and the large-scale production of oily wastewater, the treatment of oily sewage has become an important issue for sustainable development. Recently, materials prepared from lignocellulosic biomass(LCB) for oil-water separation have been found to be effective due to their high separation efficiency, good recyclability, and superior sustainability. however, few reviews have focused on the advantages and limitations of LCB for sewage treatment. This review summarizes the performance of modified LCB in oily wastewater treatment, in terms of the advanced modification methods applied and the structural dimensions of LCB materials according to the principle of superwetting oil-water separation. Research on the preparation technologies, separation mechanisms, and treatment efficiency of different LCB materials are briefly summarized, along with the characteristics of different LCB material types for oily wastewater treatment. Finally, the future prospects and challenges faced in the development of LCB materials are discussed.

关键词： Lignocellulosic biomass Superwetting Oily wastewater Wastewater treatment Oil-water separation

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Sustainable Seawater Desalination and Energy Management:Mechanisms,Strategies,and the Way Forward

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Research 2024年第3期2023卷 595-611页

作者： Meng Wang Yen Wei Ruoxin Li Xin Wang Chengyu Wang Nanqi Ren shih-Hsin ho State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150001China Department of Chemistry Tsinghua UniversityBeijing 100084China Key Laboratory of Bio-based Material Science&Technology(Northeast Forestry University) Ministry of EducationHarbin 150040China.

Solar-driven desalination systems have been recognized as an effective technology to address the water ***,evaporators prepared based on advanced manufacturing technologies have emerged as a promising tool in enhancing ocean energy *** this review,we discussed the thermal conversion,energy flow,salt deposition mechanisms,and design strategies for solar-driven desalination systems,and explored how to improve the desalination performance and energy use efficiency of the systems through advanced manufacturing *** future perspectives,we determined the feasibility of coupling solar-driven solar desalination systems with multi-stage energy utilization systems and emerging artificial intelligence technologies,for which conclusions are given and new directions for future desalination system development are ***,exciting opportunities and challenges in the face of basic research and practical implementation are discussed,providing promising solutions and blueprints for green and novel desalination technologies while achieving sustainable development.

关键词： Sustainable Solar directions

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