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Phytocheniical and pharmacological evaluation of prop roots of Pandanus fascicularis Lam

Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 649-653页

作者： jothimani rajeswari Karthikeyan Kesavan Balasundaram Jayakar Srinivas College of Pharmacy Srinivas Group of CollegeMangaloreKarnatakaIndia Department of Pharmaceutics Institute of TechnologyBanaras Hindu University.VaranasiU.PIndia Vinayaka Mission's College of Pharmacy SalemTamil NaduIndia

Objective:To evaluate the anti-inflammatory and analgesic activities of the ethanol and aqueous extracts of prop roots of Pandanus fascicularis(***) Lam(pandanaceae).And provide experimental evidence for its traditional use such as rheumatoid arthritis and spasmodic. Methods:The anti-inflammatory activity was observed by carrageenan-induced edema of the hind paw of *** activities of prop roots of *** were determined using acetic acid induced writhing model and tail clip method in mice and rat,*** ethanol fraction was then subjected to chromatographic analysis and a compound has been isolated and characterized by IR,~1H-NMR and mass ***:Edema suppressant effect of ethanol extract was found to be 37.03%inhibition whereas aqueous extract was found to be 63.22%inhibition after 3 h which was nearly equivalent to that of 10 mg/kg of indomethacin (67.81%).Percentage inhibition of writhing compared to control were 63.15%,54.38%,14.90%for aspirin,aqueous extract and ethanolic extract,*** ethanol and aqueous extracts show significant activity against appropriate controls after 60 min of treatment on tail clip method. The structure of the isolated compound is may be characterized as Hepta deca-5-ene-l-ol by analysis it’s IR,H-NMR and mass spectroscopy ***:The extracts of prop roots of *** produce significant analgesic and anti-inflammatory activities,supporting the traditional application of this herb in treating various diseases associated with inflammation and pain.

关键词： Pandanus fascicularis Lam Anti-inflammation Analgesic Aqueous extract Ethanol extract Writhing Tail clip

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