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Short-term outcomes after the loading phase of intravitreal bevacizumab and subthreshold macular laser in non-center involved diabetic macular edema

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 981-985页

作者： Edgar Cuervo-Lozano Jesus Hernan Gonzalez-Cortes Abraham Olvera-Barrios Ezequiel Trevino-Cavazos josue rodriguez-pedraza Karim Mohamed-Noriega Jesus Mohamed-Hamsho Ophthalmology Department University Hospital "Jose Eleuterio Gonzalez" and Faculty of Medicine the Autonomous University of Nuevo Leen Monterrey 64460 Mexico

AIM： To compare the effectiveness of intravitreal bevacizumab and subthreshold macular photocoagulation （SMP）, for the treatment of non-center involved diabetic macular edema （non-CI DME）. METHODS： Prospective, randomized, controlled clinical study included patients with type 2 diabetes, non-CI DME and best-corrected visual acuity （BCVA） of 0.30 logMAR or better. Each eye was randomized into three groups： group 1, monthly intravitreal bevacizumab; group 2, single SMP; group 3, single SMP and monthly bevacizumab. Main outcome measures were BCVA, and macular thickness measured with optical coherence tomography as macular central subfield thickness （CST）, macular area of greater thickness （MAGT） and total macular volume （TMV）. Results were analyzed after 3mo. RESULTS： A total of 32 eyes were included. Group 3 improved in BCVA （0.19±0.16 to 0.12±0.14 logMAR; P=0.041） and in TMV （7.90±0.57 to 7.65±0.73 mm3; P=0.025）. Group 1 improved in MAGT （325±26.26 to 298.20±44.85 μm; P=0.022） and TMV （7.79±0.57 to 7.50±0.56 mm3, P=0.047）. Group 2 didn’t show significant improvement of any variable. CONCLUSION： The loading phase of bevacizumab as monotherapy or combined with SMP is superior to SMP as monotherapy in providing short-term visual and anatomical improvement in non-CI DME.

关键词： non-center involved diabetic macular edema intravitreal bevacizumab subthreshold macular photocoagulation intravitreal antiangiogenic

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Mid-term results of patterned laser trabeculoplasty for uncontrolled ocular hypertension and primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1199-1204页

作者： Gustavo Espinoza Yuly Andrea Castellanos-Castellanos Angelica pedraza-Concha Ignacio rodriguez-Una Maria Fernanda Acuna Juan Camilo Parra Centro Oftalmologico Virgilio Galvis BucaramangaSantander 681004Colombia Fundacion Oftalmologica de Santander BucaramangaSantander 681004Colombia Universidad Industrial de Santander BucaramangaSantander 680002Colombia Instituto Oftalmologico Fernandez-Vega Universidad de OviedoOviedo 33012Spain

AIM:To describe the safety and efficacy of patterned laser trabeculoplasty(PLT)as an adjunctive treatment in primary open angle glaucoma(POAG)and ocular hypertension(OHT)after 18-month follow-up in Hispanic ***:A single-center,retrospective study was *** patients with OHT or POAG undergoing PLT from June 2016 to August 2016 were included in the *** parameters were intraocular pressure(IOP),the number of IOP-lowering medications,best corrected visual acuity(BCVA),laser parameters and postoperative adverse *** efficacy outcome measures were the proportion of eyes achieving an IOP reduction≥20%at 18 mo versus baseline medicated IOP or a reduction in the number of medications while maintaining IOP ***:From 40 PLT-treated eyes(mean baseline IOP 20.3±1.7 mm Hg),24 patients were analyzed(age 63.4±7.3 y).The mean IOP reductions from baseline across visits(months 1,3,6,9,12,and 18)ranged from 14.1%to 20.8%.Success rate after 18-month follow-up was 61.7%with a mean IOP of 16±3.2 mm Hg(P<0.001).The number of glaucoma IOP-lowering medications per eye(preoperative 2.1±1.1 and postoperative 2.3±1.1,P=0.86)and the mean BCVA(preoperative 0.10±0.22 and postoperative 0.11±0.22 logMAR,P=0.42)remained *** events comprised transitory IOP spikes in 4 eyes(10%)and peripheral anterior synechiae in 7 eyes(17.5%).CONCLUSION:Mid-term results of PLT show that this procedure may be an efficacious and safe technique to approach medically uncontrolled OHT or POAG patients.

关键词： glaucoma intraocular pressure ocular hypertension patterned laser trabeculoplasty

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Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina

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World Journal of Clinical Oncology 2022年第6期13卷 423-428页

作者： Federico Esteso Natalia Soledad Tissera Juan Manuel O'Connor Romina Luca Eduardo Huertas Fernando Sánchez Loria Ivana pedraza Alejandro Pairola Fernando Brancato Lisandro Paganini Mariana Kucharczyk Mora Amat Maria Teresa Pombo Mariana Galli Luisina Bruno Luis Caro Andrés rodriguez Diego Enrico Federico Waisberg Matías Chacón Department of Gastrointestinal Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Surgery Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Pathology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiation Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Gastroenterology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina

Given the increasing complexity of cancer care,multidisciplinary tumor boards have become essential in daily clinical oncology *** Project Extension for Community Healthcare Outcomes(ECHO)initiative developed an innovative telementoring model using a"hub and spoke"design consisting of a team of experts(hub)that offers a full service to multiple participants(the spokes)during regularly scheduled sessions discussing patients'clinical *** Alexander Fleming Cancer Institute in Buenos Aires was the first hub in Latin America to implement Project ECHO for gastrointestinal *** our 3-year experience,80 patients from 37 centers were evaluated within Project ECHO and a range of three to five cases were discussed in each *** our perspective,the impact of this novel approach was a remarkable strategy to reduce care disparities by equalizing access to high-quality medical knowledge in a multidisciplinary environment for medical ***,it was shown to have a cost-effective impact directly on the patients and the local health system,since relevant costs were saved after unnecessary treatments,studies and travel expenses were avoided.

关键词： Tumor board Virtual Gastrointestinal Cancer disparities Oncology Extension for Community Healthcare Outcomes project

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