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Quantitative Progress Evaluation of Post-stroke Patients Using a Novel Bimanual Cable-driven Robot

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Journal of Bionic Engineering 2021年第6期18卷 1331-1343页

作者： Thiago alves Rogério Sales gonçalves Giuseppe Carbone Laboratory of Automation and Robotics School of Mechanical EngineeringFederal University of UberlândiaUberlândia38400-902Brazil Department of mechanical Energy and Management EngineeringUniversity of Calabria87036RendeItaly

Rehabilitation is the most effective way to reduce motor impairments in post-stroke *** process demands several hours with a specialized *** resources and personnel shortages,the literature reports a high interest in robotic assisted rehabilitation ***,cable-driven robotic architectures are attracting significant research interest for post-stroke ***,the existing cable-driven robots are mostly unilateral devices allowing the rehabilitation only of the most affected *** leaves unaddressed the rehabilitation of bimanual activities,which are predominant within the common Activities of Daily Living(ADL).Thus,this paper presents a specific novel design to achieve bimanual rehabilitation tasks that has been named as BiCAR ***,this paper provides a full insight on the BiCAR system as well as on its dedicated developed software *** particular,BiEval software has been developed as based on a serious game strategy and a virtual reality environment to track the patient exercising duration,motion ranges,speeds,and forces over time for achieving a quantitative assessment of the rehabilitation ***,the paper presents the BiCAR/BiEval capabilities by referring to a pilot Randomized Controlled Trial(RCT).The clinical trials have been used to validate the BiCAR/BiEval in terms of engineering feasibility and user acceptance to achieve an innovative cost-oriented integrated hardware/software device for the bimanual assistive rehabilitation of post-stroke patients.

关键词： Cable-driven robots Low cost Stroke rehabilitation Bimanual Progress tracking Serious games

Coincidence Wecken Property for Nilmanifolds

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Acta mathematica Sinica,English Series 2019年第2期35卷 239-244页

作者： Daciberg gon?alves Peter WONG Departamento de matemática-ImE-Universidade de S?o Paulo Rua do Mat?o Department of mathematics Bates College

Let f, g: X → Y be maps from a compact infra-nilmanifold X to a compact nilmanifold Y with dim X ≥ dim Y. In this note, we show that a certain Wecken type property holds, i.e., if the Nielsen number N(f, g) vanishes then f and g are deformable to be coincidence free. We also show that if X is a connected finite complex X and the Reidemeister coincidence number R(f, g) = ∞ then f ～ f' so that C(f', g) = {x ∈ X | f'(x) = g(x)} is empty.

关键词： Nielsen coincidence theory nilmanifolds

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Using Extreme Value Theory to Assess the mortality Risk of Tornado Outbreaks

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International Journal of Disaster Risk Science 2023年第1期14卷 14-25页

作者： Vilane gonçalves Sales Eric Strobl Department of Economics University of Bern3012BernSwitzerland Oeschger Centre for Climate Change Research University of Bern3012BernSwitzerland World Trade Institute University of Bern3012BernSwitzerland

The majority of tornado fatalities occur during severe thunderstorm occurrences that produce a large number of tornadoes,termed tornado *** study used extreme value theory to estimate the impact of tornado outbreaks on fatalities while accounting for climate and demographic *** findings indicate that the number of fatalities increases with the increase of tornado ***,this study undertook a counterfactual analysis to determine what would have been the probability of a tornado outbreak under various climatic and demographic *** results of the counterfactual study indicate that the likelihood of increased mortality increases as the population forecast *** El Niño events,on the other hand,reduce the likelihood of further *** Niña events are expected to increase probability of fatalities.

关键词： Climate change Demography Extreme value theory Fatalities Tornado outbreaks

COVID-19,liver dysfunction and pathophysiology:A conceptual discussion

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World Journal of Gastroenterology 2022年第6期28卷 683-688页

作者： Jucier gonçalves Júnior Department of Internal medicine Division of RheumatologySão Paulo UniversitySão Paulo 01246-903StateBrazil

The intra and extracellular pathways of hepatic injury by coronavirus disease 2019(COVID-19)are still being *** them is important to treat this viral disease and other liver and biliary tract ***,this paper aims to present three hypotheses about liver injury caused by COVID-19:(1)The interactions between severe acute respiratory syndrome coronavirus 2 spike protein and membrane receptors in the hepatocyte;(2)The dysbiosis and"gutliver axis"disruption in patients with serious clinical presentations of COVID-19;and(3)The inflammatory response exacerbated through the production of interleukins such as ***,despite these new perspectives,the pathophysiological process of liver injury caused by COVID-19 is still complex and ***,understanding all these variables is a challenge to science but also the key to propose individualized and effective patient therapies.

关键词： COVID-19 Intracellular signaling peptides and proteins Immunopathology Liver diseases Liver injury SARS-CoV-2

Using risk-benefit analysis to control Salmonella in chicken meat

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Food Quality and Safety 2021年第4期5卷 375-387页

作者： Eduardo Cesar Tondo Claudia Titze Hessel gonçalves Department of Food Science Institute of Food Science and Technology of the Federal University of Rio Grande do Sul-ICTA/UFRGSPorto AlegreRSBrazil

We have created a risk-benefit analysis(RBA)model to assist in food safety decision-making by analyzing Salmonella control in Brazilian chicken ***,we described the issues in a risk profile and used a 5x5 matrix to rank the risks associated with *** then classified the magnitude of benefits and costs of control measures using another ***,we verified the beneficial effects of recommended control measures using Quantitative microbiological Risk Assessment(QmRA).The RBA classified Salmonella contamination as risk 6,indicating that control measures should be taken in the short and medium *** also recommended the adoption of biosecurity measures on farms to reduce the prevalence of Salmonella in birds,better control of carcass washings and chiller tank management,and information placement on packages and campaigns to raise the awareness of the population about the need to control Salmonella contamination before *** the other hand,it did not recommend better controls at scalding and *** confirmed the beneficial effects of the recommended control *** example,as Salmonella prevalence in poultry increased from 4.04 per cent to 50 per cent,the risk of infection per serving also increased from 0.0080 to *** better controls in washings and chiller tank management did not affect the risk of infection,it reduced Salmonella counts on *** assume that the presence of Salmonella on carcasses was due to improper thermal processing or cross-contamination,which increased the risk from 0.0080 to *** RBA demonstrated the logic involved in the adoption of control measures,and this can be helpful in the risk management of food safety issues.

关键词： Risk management risk perception food safety

Nielsen Theory on 3-manifolds Covered by S^2× R

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Acta mathematica Sinica,English Series 2015年第4期31卷 615-636页

作者： Daciberg gonalves Peter WONG Xue Zhi ZHAO Dept. de matemtica-ImE-USP Caixa Postal 66.281-CEP 05314-970So Paulo-SP Brasil Department of mathematics Bates College Department of mathematics & Institute of mathematics and Interdisciplinary Science Capital Normal University

Let f ： m→ m be a self-map of a closed manifold m of dimension dim m ≥ 3. The Nielsen number N（f） of f is equal to the minimal number of fixed points of f＇ among all self-maps f＇ in the homotopy class of f. In this paper, we determine N（f） for all self-maps f when m is a closed 3-manifold with S^2× R geometry. The calculation of N（f） relies on the induced homomorphisms of f on the fundamental group and on the second homotopy group of m.

关键词： Lefschetz number Nielsen number 3-manifolds

Behavioral and endocrine responses to noninteractive live and video conspecifics in males of the Siamese fighting fish

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Current Zoology 2023年第5期69卷 568-577页

作者： Deepa Alex Sara DCardoso Andreia Ramos David gonçalves Institute of Science and Environment University of Saint JosephRua de Londres 106Macao SARChina

The physiological mechanisms underlying variation in aggression in fish remain poorly *** possibly confounding variable is the lack of standardization in the type of stimuli used to elicit *** presentation of controlled stimuli in videos,*** playback,can provide better control of the fight ***,this technique has produced conflicting results in animal behavior studies and needs to be carefully *** this,a similar response to the video and an equivalent live stimulus needs to be ***,different physiological responses may be triggered by live and video stimuli,and it is important to demonstrate that video images elicit appropriate physiological ***,the behavioral and endocrine responses of male Siamese fighting fish Betta splendens to a matched-for-size conspecific fighting behind a one-way mirror,presented live or through video playback,were *** video playback and live stimulus elicited a strong and similar aggressive response by the focal fish,with a fight structure that started with stereotypical threat displays and progressed to overt *** plasma levels of the androgen 11-ketotestosterone were elevated as compared to controls,regardless of the type of *** also increased in response to the video images,as previously described for live fights in this *** results show that the interactive component of a fight and its resolution are not needed to trigger an endocrine response to aggression in this *** study also demonstrates for the first time in a fish a robust endocrine response to video stimuli and supports the use of this technique for researching aggressive behavior in ***.

关键词： aggression androgens corticosteroids Betta splendens one-way mirror video playback

Branch retinal vein thrombosis and visual loss probably associated with pegylated interferon therapy of chronic hepatitis C

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World Journal of Gastroenterology 2006年第28期12卷 4602-4603页

作者： Luciana Lofego gonalves Alberto Queiroz Farias Patrícia Lofego gonalves Elbio Antonio D'Amico Flair José Carrilho Santa Casa de misericórdia de Vitória Espírito Santoand University of Sao Paulo School of MedicineBrazil University of Sao Paulo School of medicine Brazil Federal University of Espírito Santo School of medicine Brazil

Ophthalmological complications with interferon therapy are usually mild and reversible, not requiring the withdrawal of the treatment. We report a case of a patient who had visual loss probably associated with interferon therapy. Chronic hepatitis C virus infection （genotype la） was diagnosed in a 33-year old asymptomatic man. His past medical history was unremarkable and previous routine ophthalmologic check-up was normal. Pegylated interferon alpha and ribavirin were started. Three weeks later he reported painless reduction of vision. Ophthalmologic examination showed extensive intraretinal hemorrhages and cottonwool spots, associated with inferior branch retinal vein thrombosis. Antiviral therapy was immediately discontinued, but one year later he persists with severely decreased visual acuity. This case illustrates the possibility of unpredictable and severe complications during pegylated interferon therapy.

关键词： Hepatitis C Interferon Visual loss