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Epidemiological, Clinical and Etiological Profile of Rhythmic Emergencies at the University Hospital of Brazzaville, Republic of Congo

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World Journal of Cardiovascular Diseases 2022年第6期12卷 342-352页

作者： Suzy Gisèle Kimbally-Kaky Thibaut Naïbe Gankama Eric Gibrel Kimbally-Kaky jospin karel makani Bijou Moualengue Stéphane Méo Ikama Soodougoua Baragou Thierry Raoul Alexis Gombet Department of Cardiology and Internal Medicine University Hospital of Brazzaville Brazzaville Republic of Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Sylvanus Olympio University Hospital Lomé Togo Faculty of Health Sciences Lomé Togo Department of Emergency University Hospital of Brazzaville Brazzaville Republic of Congo

Objectives: To describe the epidemiological, clinical and etiological aspects of rhythmic emergencies at the University Hospital of Brazzaville. Patients and Methods: This was a retrospective descriptive study conducted in the cardiology and internal medicine department of the University Hospital of Brazzaville from January 1, 2014 to June 30, 2016. Were included, all patients admitted for a severe rhythm disorder diagnosed on the surface electrocardiogram. Rhythmic emergency was defined as a severe rhythm disorder of abrupt onset and required rapid management. Data entry and analysis were performed with Epi Info software version 3.5.1. Results: During the study period, 2269 patients were hospitalized, including 138 for a rhythmic emergency. The frequency of rhythmic emergencies was 6.1%. The patients were divided into 76 women and 62 men (sex ratio = 0.81). The mean age of the patients was 63.1 ± 16.9 years (extremes: 17 and 91 years). The socio-economic level was low for 103 patients (74.6%), medium for 26 (17.7%), and high for nine (6.6%). The average time to consultation was 13.7 ± 12.3 days. On admission, the signs were: heart failure (103 cases;74.6%) including 22 acute cases;dyspnea (94 cases;68%);palpitations (38 cases;27.5%);functional impotence (13 cases;9.4%);collapse (nine cases;6.5%);chest pain (two cases;1.4%). The type of rhythmic emergency was: rapid atrial fibrillation (103 cases;74.6%), ventricular tachycardia (14 cases;10.1%), junctional tachycardia (10 cases;7.2%), rapid atrial flutter (10 cases;7.2%), tachysystole (one case;0.7%). The context of occurrence was: hypokalemia (8 cases;5.8%), drunkenness (two cases;1.4%), acute gastroenteritis (one case;0.7%). Cardiovascular risk factors were: hypertension (62 cases;45.2%), smoking (17 cases;12.1%), dyslipidemia (12 cases;8.7%), diabetes (11 cases;8%), obesity (10 cases;7.2%). Underlying heart disease was: dilated cardiomyopathy (40 cases;29%), hypertensive cardiomyopathy (26 cases;18.8%), valvulopa

关键词： Cardiac Rhythm Disorders Atrial Fibrillation Dilated Cardiomyopathy Brazzaville

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基于三维地质-地球物理建模的深部成矿预测——以黑河地区永新金矿床为例

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吉林大学学报（地球科学版） 2024年第2期54卷 498-515页

作者：赵忠海崔晓梦孙景贵陈俊乔锴梁杉杉 Manirambona Alain jospin 辽宁工程技术大学矿业学院辽宁阜新123000 吉林大学地球科学学院长春130061

黑龙江省永新金矿床位于兴蒙造山带东段的兴安地块和松嫩地块交会拼合部位,是近几年新发现的大型金矿床。为了深入探讨永新金矿床外围及深部的成矿潜力,首先在典型矿床分析和音频大地电磁测深以及重磁联合剖面基础上,利用三维地质建模软... 详细信息

黑龙江省永新金矿床位于兴蒙造山带东段的兴安地块和松嫩地块交会拼合部位,是近几年新发现的大型金矿床。为了深入探讨永新金矿床外围及深部的成矿潜力,首先在典型矿床分析和音频大地电磁测深以及重磁联合剖面基础上,利用三维地质建模软件Creatar XModeling构建了区域和矿床三维地质模型,刻画了主要控矿地质体三维形态,揭示了区内深部构造地质特征、矿体空间分布特点及与各地质要素之间的关系。然后,采用立方体预测模型找矿方法,依据证据权法对研究区地质、地球物理等多源信息进行融合,圈定了8处深部找矿预测靶区。部分深部靶区钻孔发现了多处矿化信息,验证了本次深部预测的准确性和可靠性,指示研究区深部仍具有较大的成矿空间和潜力。

关键词：三维地质建模地质-地球物理模型深部成矿预测永新金矿床

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Effect of Biostimulants Based on Natural Products on the Growth and Nutritional Value of Bean (Phaseolus vulgaris L.)

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American Journal of Plant Sciences 2024年第7期15卷 492-518页

作者： Aimé Giresse Tzeuton Flore Eliane Eyenga Arouna Meshuneke Gaston Mbang Elock Fabrice Damien Wassom Walter jospin Timma Kom Marie Paule Djam Kengoum Erica Cabrelle Damtse Damtse Landry Silatsa Fotsing William Asah Che Marlyne Josephine Mananga Nicolas Niemenak Cécile Annie Ewané Laboratory of Plant Physiology and Biochemistry Higher Teachers Training College University of Yaound 1 Yaound Cameroon Department of Biochemistry Faculty of Sciences University of Yaound 1 Yaound Cameroon Laboratory of Food Sciences and Metabolism University of Yaoundé 1 Yaoundé Cameroon Laboratory of Phytoprotection and Valorisation of Genetic Resources of the Biotechnology Centre University of Yaound 1 Yaound Cameroon Department of Biological Sciences Higher Teachers Training College University of Yaound 1 Yaound Cameroon

Beans (Phaseolus vulgaris L.) are widely grown in Cameroon and play a key role in the fight against food insecurity, malnutrition and poverty. However, its cultivation encounters problems due to abiotic and biotic stresses, which leads to the use of synthetic fertilizers and pesticides, which cause significant damage to the environment and human health due to the presence of synthetics residues in the seeds, pods and in the leaves that are eaten. Promoting the use of natural products is becoming a necessity for organic and eco-responsible agriculture that limits contamination problems and improves people’s purchasing power. This study aims to assess the effect of biostimulants based on natural products on the growth and nutritional value of common bean (Phaseolus vulgaris L.). Bean seedlings from white variety (MEX-142) and red variety (DOR-701) were treated every seven days in the field from their pre-emergence, emergence and growth to their maturation under a randomized block experimental design. Six treatments and three repetitions with the biostimulants based on natural products and controls were thus performed and the agromorphological parameters were measured. After 120 days, the contents of growth biomarkers and defense-related enzymes were evaluated in leaves, while the contents of macromolecules, minerals and antinutrients were evaluated in seeds. These biostimulants significantly increased (P P < 0.0001) of antinutrients including oxalates, phytates, tannins and saponins in seeds compared to controls (T+ and T−). Treatment with biostimulants, in particular BS4, improves the performance of bean plants in the field as well as the biofortification of seeds regardless of the variety.

关键词： Phaseolus vulgaris L. Biostimulants Biofortification Growth and Defense Biomarkers Nutritional Value

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Epidemiological and Prognostic Aspects of Anemia during Heart Failure in Brazzaville (The Republic of the Congo)

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World Journal of Cardiovascular Diseases 2023年第7期13卷 396-403页

作者： Stéphane Méo Ikama Joffode Mobet Memougame Thibaut Oko jospin jospin makani Lydie Ocini Ngolet Bijou Moualengue Eric Gibrel Kimbally Kaky Thibaut Gankama Suzy Gisèle Kimbally Kaky Department of Cardiology University Hospital Center of Brazzaville Brazzaville The Republic of the Congo Department of Hematology Laboratory University Hospital Center of Brazzaville Brazzaville The Republic of the Congo Department of Clinical Hematology University Hospital Center of Brazzaville Brazzaville The Republic of the Congo

To improve the management of patients with heart failure and anemia at the University Hospital of Brazzaville, a cross-sectional study of patients diagnosed with heart failure condition (left or global heart failure) was conducted over a period of nine months from January 1 to September 30, 2017. A total of 171 patients were included during the study period. Study participants were divided into two groups: Group A included patients with an additional anemic condition (n = 57) and Group NA patients without anemia (n = 114). Anemia was defined as a hemoglobin rate of < 12 g/dL for men and <11 g/dL for women. All eligible patients admitted to the Department of Cardiology were included in the study. The frequency of anemia was 33.3%, with a mean hemoglobin level of 9.4 ± 1.5 g/dL. Men accounted for 46.9% of cases (n = 79) and women 53.8% (n = 92). The mean age of eligible patients was 57.5 ± 16.5 years. Of these, 46.2% (n = 75) had a secondary educational level and 53.8% (n = 92) had a low socioeconomic status. Heart failure was global in 153 cases (89.5%). Patients were on NYHA III-IV functional class in 112 cases (65.5%), with a statistically significant difference between anemic and non-anemic patients (p = 0.0001). The main underlying heart diseases were dilated cardiomyopathy (75.1%), hypertensive heart disease (10.5%), ischemic heart disease (6.5%), and valvular disease (4.7%). The comparison between the two groups (A and NA) showed a longer hospital length of stay (18.4 ± 8.9 versus 12.9 ± 7.6 days;p = 0.00001) and a higher mortality rate (4 versus 2 deaths). The re-hospitalization rate was more important in group A (n = 4) than in group NA (n = 1). Anemia is a common condition in patients with heart failure. It worsens the clinical features and prognosis.

关键词： Anemia Heart Failure Frequency Prognosis The Republic of the Congo

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Outcome of Patients with Lower Limbs Deep Vein Thrombosis at the University Hospital of Brazzaville (The Republic of the Congo)

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World Journal of Cardiovascular Diseases 2023年第12期13卷 845-853页

作者： Stéphane Méo Ikama Eric Gibrel Kimbally Kaky jospin makani Fresnel Ngoma Mabondzo Thibaut Naïbe Gankama Bijou Moualengue Suzy Gisèle Kimbally Kaky Department of Cardiologye University Hospital Center of Brazzaville Brazzaville Congo Faculty of Health Sciences Marien NGOUABI University of Brazzaville Brazzaville Congo Department of Radiology University Hospital Center of Brazzaville Brazzaville Congo

The aim of this study was to describe the characteristics of patients with deep vein thrombosis (DVT) of the pelvic limbs at the time of diagnosis, and their course after hospitalization, in order to improve the management of DVT in our context. This was a descriptive longitudinal study, based on cases of deep vein thrombosis recorded between 1 January 2015 and 30 September 2018, in the cardiology and internal medicine department of the Brazzaville University Hospital Centre. During the study period, 4678 patients were hospitalized, including 52 with DVT. Thirty-three were reassessed. The frequency of DVT was 1.1% and the average hospitalization rate was 13.9 cases/year. The 33 patients were divided into 20 women and 13 men (sex ratio: 0.65). The mean age of the patients was 51.4 ± 17.8 years (extremes: 16 and 85 years). The main aetiological factors were cancer (19.1%), sickle cell disease (3%) and HIV immunosuppression (3%). The predominant risk factors were: prolonged immobilization (42.9%), pregnancy, long travel and obesity in the same number of cases (n = 3, i.e. 14.2%). The DVT involved the left pelvic limb in 75.8% of cases. Anticoagulants were administered in all patients, and compression stockings were worn in 97% of cases. The mean time to re-evaluation was 10.9 ± 9.4 months (extremes: three and 35 months). The mean measurements of the limb where the thrombosis had occurred at diagnosis and reassessment showed a significant difference. Venous Doppler showed compressible veins (60.6%), varicosities (36.3%), incompressible veins (30.3%) and thrombus (21.2%). Complications were: post-phlebitic disease (42.4%), death (21.2%), pulmonary embolism (18.2%), recurrence (18.2%). The DVT remains relatively rare, and its conventional therapeutic management is satisfactory. Systematic venous Doppler ultrasound reassessment should enable patients at risk of recurrence to be identified.

关键词： Deep Vein Thrombosis Reassessment Complications Congo

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Aetiologic Factors of Anemia During Heart Failure in Brazzaville (The Republic of the Congo)

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World Journal of Cardiovascular Diseases 2023年第9期13卷 605-612页

作者： Stéphane Méo Ikama Joffode Mobet Memougame jospin makani Thibaut Oko Eric Gibrel Kimbally Kaky Lydie Ocini Ngolet Bijou Moualengue Thibaut Gankama Suzy Gisèle Kimbally Kaky Department of Cardiology University Hospital Center of Brazzaville Brazzaville The Republic of the Congo Department of Hematology Laboratory University Hospital Center of Brazzaville Brazzaville The Republic of the Congo Department of Clinical Hematology University Hospital Center of Brazzaville Brazzaville The Republic of the Congo

To contribute to improving the management of patients with heart failure and anemia in Brazzaville, a prospective and descriptive study was conducted in the University Hospital of Brazzaville for nine months (January 1st to September 30, 2017). Included 57 patients hospitalized for left or global heart failure and presenting anemia. Anemia was defined by an haemoglobin level < 12 g/dL in men and <11 g/dL in women. Proportionings of the reticulocytes rate, serum iron, ferritin, erythrocyte sedimentation rate (ESR) and/or C-reactive protein (CRP), electrophoresis of proteins, and evaluation of renal function by glomerular filtration rate (GFR), as well as the treatments of heart failure, and the auxiliary therapeutic ones, in particular the antithrombotic drugs, allowed aetiologic research. They were 20 men (35%) and 37 women (65%), old on average of 59 ± 17 years. The average rate of haemoglobin was 11.4 ± 1.4 g/dL. Heart failure was de novo in 24 cases (42.1%), old in 33 cases (57.9%);it was global in 54 cases (94.7%).The maintenance treatment associated diuretics in 32 cases (97%), angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) in 31 cases (94%), beta-blockers in two cases (6.1%), digoxin in four cases (12.1%), aspirin in five cases (15.1%) and anti-vitamin K in four cases (12.1%). Anemia was microcytic hypochromic in 30 cases (52.6%), normocytic normochromic in 20 cases (35.1%), and macrocytic normochromic in one case (1.7%). The main aetiologic factors were hemodilution in 46 cases (80.7%), renal insufficiency in 30 cases (52.3%), inflammation in 29 cases (50.8%), and iron deficiency in one case (1.7%). The HIV serology, carried out in 11 cases, was negative. Anemia is a frequent comorbidity among heart failure patients. Aetiologic research remains difficult in our context, and its often multifactorial origin.

关键词： Anemia Heart Failure Aetiologies Congo

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黑龙江建边农场地区遥感蚀变异常提取方法

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吉林大学学报（地球科学版） 2023年第4期53卷 1275-1287页

作者：赵忠海乔锴孙景贵陈俊崔晓梦梁杉杉 Manirambona Alain jospin 辽宁工程技术大学矿业学院辽宁阜新123000 吉林大学地球科学学院长春130061

黑龙江建边农场地区位于大兴安岭和小兴安岭交汇部位,该区多期的岩浆和构造演化历史导致了成矿地质背景的复杂性和多样性。本文在对黑龙江建边农场地区Landsat ETM影像数据进行解读的基础上,综合矿物光谱特征以及该地区的基础地质资料,... 详细信息

黑龙江建边农场地区位于大兴安岭和小兴安岭交汇部位,该区多期的岩浆和构造演化历史导致了成矿地质背景的复杂性和多样性。本文在对黑龙江建边农场地区Landsat ETM影像数据进行解读的基础上,综合矿物光谱特征以及该地区的基础地质资料,采用“去干扰-主成分分析与比值法结合-异常筛选”的方法体系提取了研究区铁染、羟基等矿化蚀变信息。结果表明:本次研究共圈定羟基矿化蚀变异常13处、铁染矿化蚀变异常17处;矿化蚀变异常以白垩纪火山地层为主,在空间分布上主要沿NE向断裂与NW向、NNW向及SN向断裂的交汇部位分布,与中生代火山岩和早白垩世—早石炭世侵入岩体接触带部位密切相关。结合已知的地质矿产资料及野外实地验证结果,发现该地区普遍发育褐铁矿、赤铁矿等铁染异常矿物以及碳酸盐化、绿泥石化等羟基异常矿物,提取出的铁染与羟基矿化蚀变异常与物化探异常套合较为紧密且与已知的金、铜、钼等矿点和矿化点吻合程度较高。

关键词：遥感矿化蚀变主成分分析比值法信息提取黑龙江建边农场地区

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Left Ventricular Hypertrophy and Predictive Factors among Congolese Hypertensive Patients

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World Journal of Cardiovascular Diseases 2018年第12期8卷 569-577页

作者： Stéphane Méo Ikama Bernice Mesmer Nsitou jospin makani Louis Igor Ondze-Kafata Bertrand Fikhaem Ellenga-Mbolla Thierry Raoul Gombet Suzy Gisèle Kimbally-Kaky Department of Cardiology Brazzaville University Hospital Center Brazzaville Congo

A cross-sectional study of hypertensive patients was carried out in Brazzaville between January 2011 and December 2013.?The objectives of the present study are to determine the different types of left ventricular hypertrophy (LVH)?and to identify the predictive factors of LVH. It included 556 hypertensive patients with LVH, characterized by left ventricular mass index (LVMI) > 135 g/m2?in men, and > 111 g/m2?in women. Patients’ sociodemographic data and echocardiographic parameters were gathered and analyzed. There were 342 males (61.5%) and 214 females (38.5%),?with?mean age 53.5 ± 11.5 years. The indications of the test were hypertension initial evaluation in 402 cases (72.3%), investigation of ischemic stroke in 62 cases (11.2%), heart failure in 58 cases (10.4%), dyspnea and chest pain in respectively 22 and 12 cases. Hypertension, old of 5.2 ± 4.5 years, was associated with overweight/obesity in 408 cases (73.4%), physical inactivity in 325 cases (58.5%), hypertension family history in 274 cases (49.3%), diabetes mellitus in 76 cases (13.7%), dyslipidemia in 63 cases (11.3%), tobacco use in 9 cases (1.6%). The prevalence of LVH was 49.4% and consisted into concentric LVH in 470 cases (84.5%), eccentric LVH in 70 cases (12.6%), and in 16 cases (2.9%),?it was a concentric left ventricular remodeling. Age, male gender, seniority of hypertension and treatment were predictive factors of LVH. The latter is the most predominant abnormality in the echocardiographic profile of Congolese hypertensive patients. Efficient management on hypertension will lead to reducing its morbidity and mortality.

关键词： Arterial Hypertension Left Ventricular Hypertrophy Predictive Factors Congo

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The Erectile Dysfunction among Congolese Hypertensive Patients

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World Journal of Cardiovascular Diseases 2018年第10期8卷 481-488页

作者： Stéphane Méo Ikama Odzebe-Anani Sévérin Bernice Mesmer Nsitou Melvin Atipo-Ondongo jospin makani Thierry Raoul Gombet Suzy Gisèle Kimbally-Kaky Department of Cardiology University Hospital Center of Brazzaville Brazzaville Congo Department of Urology University Hospital Center of Brazzaville Brazzaville Congo

The authors conducted an analytical cross-sectional study over a period of 3 months among hypertensive patients, in order to determine the frequency of the erectile dysfunction (ED), and to identify the predictive factors. It included treated hypertensive patients, presenting an ED, defined as the incapacity to obtain or maintain an erection sufficient for satisfactory sexual activity. On 265 hypertensive patients, 172 (65%) presented an ED. The average age was 58.2 ± 9.7 years. The associated cardiovascular risk factors were overweight/obesity in 99 cases (37.4%), sedentariness in 90 cases (34%), diabetes mellitus in 50 cases (19%), dyslipidemia in 12 cases (4.5%), and tobacco addiction in 6 cases (2.3%). Arterial hypertension (HTN), old of 6.7 ± 5.8 years, was treated by bitherapy in 129 cases (48.7%), and tritherapy in 102 cases (38.5%). The principal therapeutic classes used were ACE inhibitors/ARBs in 213 cases (81%), calcium antagonists in 205 cases (78%), thiazides in 137 cases (52.1%), and beta-blockers in 82 cases (31%). ED, severe in 124 cases (72%), and moderate in 48 cases (28%), consisted of a difficulty to maintain the erection in 78 cases (45.3%), to obtain the erection in 30 cases (17.4%), and the two partners in 64 cases (37.2%). In multivariate analysis, only the age, seniority of HTN, and the existence of diabetes mellitus were the predictive factors of ED. The early and effective assumption of responsibility of the AHT, as well as other cardiovascular risk factors whose diabetes, would make it possible to reduce the frequency of it, thus improving quality of life of the hypertensive patients.

关键词： Arterial Hypertension Erectile Dysfunction Frequency Predictive Factors Congo

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Global Cardiovascular Risk of the HIV Positive Patients Receiving Antiretroviral Therapy in Brazzaville

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World Journal of Cardiovascular Diseases 2019年第8期9卷 553-561页

作者： Stéphane Méo Ikama Franck Ekoba-Otende jospin makani Amélia Bokilo Bienvenu Ossibi-Ibara Louis Igor Ondze-Kafata Bertrand Fikhaem Ellenga-Mbolla Thierry Raoul Gombet Suzy Gisèle Kimbally-Kaky Department of Cardiology Brazzaville University Hospital Center Brazzaville Congo National Centre of Blood Transfusion Brazzaville Congo Department of Infectious Diseases Brazzaville University Hospital Center Brazzaville Congo

A cross-sectional, descriptive and analytical study was conducted from January to August 2015 at the Brazzaville Ambulatory Treatment Center and at?the National Blood Transfusion Center. The objective was to contribute to improving?the care of people living with HIV under antiretroviral therapy by assessing their global cardiovascular risk (CVR). The variables studied focused on the epidemiological, clinical and biological aspects. The global CVR was assessed?by the Framingham and WHO/ISH scores. There were 135 HIV-positive subjects,?including 64 treated patients and 71 untreated HIV+ subjects. The subjects were divided into 83 men (61.5%) and 52 women (38.5%), with an average age of 42.6 ± 2.9 old years. The subjects were single people (62.2%), of a secondary educational level (63.7%), and civil servants (32.6%). The main risk factors found were dyslipidaemia (60%), obesity (36%), smoking (12.6%), hypertension (5.9%), diabetes (0.7%). The metabolic syndrome was found in seven cases (11.3%). The global CVR according to the score of Framingham, initially moderated at 17.2%, and mean at 1.5% within treated patients, was mean at 9.4% and high at 1.6% of the subjects respectively at the sixth month of treatment (p CVR under antiretroviral therapy. Preventive actions are highly recommended.

关键词： HIV Infection Antiretroviral Therapy Metabolic Disorders Global Cardiovascular Risk Congo

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