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8-isoprostane as Oxidative Stress Marker in Coal Mine Workers

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Biomedical and Environmental Sciences 2016年第8期29卷 589-593页

作者： Zlatko Zimet Marjan Bilban Mateja Marc Malovrh Peter Korogec Borut Poljgak josko osredkar Mira Silar National Institute of Public Health Trubarjeva 21000 Ljubljana Slovenia Department of Public Health Faculty of Medicine University of Ljubljana Zaloka 4 1000 Ljubljana Slovenia University Clinic of Pulmonary and Allergic Diseases Golnik Golnik 36 4204 Golnik Slovenia Faculty of Health Sciences University of Ljubljana Zdravstvena pot 5 1000 Ljubljana Slovenia University Medical Centre Ljubljana Institute of Clinical Chemistry and Biochemistry Njegoeva 4 1000 Ljubljana Slovenia

This study was to investigate whether working in conditions of elevated concentrations of mine gases （CO2, CO, CH4, DMS） and dust may result in oxidative stress. Coal miners （n=94） from the Velenje Coal mine who were arranged into control group and three groups according to a number of consecutive working days. 8-isoprostane as a biological marker of oxidative stress was measured in exhaled breath condensate （EBC）.

关键词： conditions elevated concentrations

Discontinuation of therapy in inflammatory bowel disease: Current views

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World Journal of Clinical Cases 2024年第10期12卷 1718-1727页

作者： Antonio Meštrović Marko Kumric josko Bozic Department of Gastroenterology University Hospital of SplitSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia

The timely introduction and adjustment of the appropriate drug in accordance with previously well-defined treatment goals is the foundation of the approach in the treatment of inflammatory bowel disease(IBD).The therapeutic approach is still evolving in terms of the mechanism of action but also in terms of the possibility of maintaining *** patients with achieved long-term remission,the question of de-escalation or discontinuation of therapy arises,considering the possible side effects and economic burden of long-term *** each of the drugs used in IBD(5-aminosalycaltes,immunomodulators,biological drugs,small molecules)there is a risk of ***,studies show that more than 50%of patients who discontinue therapy will *** on the findings of large studies and meta-analysis,relapse of disease can be expected in about half of the patients after therapy withdrawal,in case of monotherapy with aminosalicylates,immunomodulators or biological ***,longer relapse-free periods are recorded with withdrawal of medication in patients who had previously been on combination therapies immunomodulators and anti-tumor necrosis *** needs to be stressed that randomised clinical trials regarding withdrawal from medications are still *** making a decision on discontinuation of therapy,it is important to distinguish potential candidates and predictive factors for the possibility of disease *** calprotectin level has currently been identified as the strongest predictive factor for *** other predictive factors have also been identified,such as:High Crohn's disease activity index or Harvey Bradshaw index,younger age(40 years),smoking,young age of disease onset,steroid use 6-12 months before *** important factor in the decision to withdraw medication is the success of re-treatment with the same or other *** decision to discontinue therapy must be based on in

关键词： Inflammatory bowel disease Therapy discontinuation Therapy de-escalation Ulcerative colitis Crohn’s disease

Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2024年第13期30卷 1899-1910页

作者： Ante Tonkic Marko Kumric Ivna Akrapovic Olic Doris Rusic Piero Marin Zivkovic Daniela Supe Domic Zeljko Sundov Ivan Males josko Bozic Biology of Neoplasms University of Split School of MedicineSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Gastroenterology University Hospital of SplitSplit 21000Croatia Department of Pharmacy University of Split School of MedicineSplit 21000Croatia Department of Medical Laboratory Diagnostics University Hospital of SplitSplit 21000Croatia Department of Health Studies University of SplitSplit 21000Croatia Department of Internal Medicine University of Split School of MedicineSplit 21000Croatia Department of Surgery University Hospital of SplitSplit 21000Croatia

BACKGROUND Population of patients with inflammatory bowel disease(IBD)is burdened by various extraintestinal manifestations which substantially contribute to greater morbidity and ***-differentiation factor-15(GDF-15)is often overexpressed under stress conditions,such as inflammation,malignancies,heart failure,myocardial ischemia,and many *** To explore the association between GDF-15 and IBD as serum concentrations of GDF-15 were shown to be an independent predictor of poor outcomes in multiple *** additional aim was to determine possible associations between GDF-15 and multiple clinical,anthropometric and laboratory parameters in patients with *** This cross-sectional study included 90 adult patients diagnosed with IBD,encompassing both Crohn’s disease(CD)and ulcerative colitis(UC),and 67 healthy age-and sex-matched *** patients underwent an extensive workup,including colonoscopy with subsequent histopathological *** activity was assessed by two independent gastroenterology consultants specialized in IBD,employing well-established clinical and endoscopic scoring ***-15 serum concentrations were determined following an overnight fasting,using electrochemiluminescence *** In patients with IBD,serum GDF-15 concentrations were significantly higher in comparison to the healthy controls[800(512-1154)pg/mL vs 412(407-424)pg/mL,P<0.001],whereas no difference in GDF-15 was found between patients with CD and UC[807(554-1451)pg/mL vs 790(509-956)pg/mL,P=0.324].Moreover,multiple linear regression analysis showed that GDF-15 levels predict CD and UC severity independent of age,sex,and C-reactive protein levels(P=0.016 and P=0.049,respectively).Finally,an association between GDF-15 and indices of anemia was ***,negative correlations were found between GDF-15 and serum iron levels(r=-0.248,P=0.021),as well as GDF-15 and hemoglobin(r=-0.351,P=0.021).Accordingly,in comparison to I

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Growth-differentiation factor-15 Anemia Extraintestinal manifestations

Role of novel biomarkers in diabetic cardiomyopathy

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World Journal of Diabetes 2021年第6期12卷 685-705页

作者： Marko Kumric Tina Ticinovic Kurir Josip A Borovac josko Bozic Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia Emergency Medicine Institute of Emergency Medicine of Split-Dalmatia CountySplit 21000Croatia

Diabetic cardiomyopathy(DCM)is commonly defined as cardiomyopathy in patients with diabetes mellitus in the absence of coronary artery disease and *** DCM is now recognized as a cause of substantial morbidity and mortality among patients with diabetes mellitus and clinical diagnosis is still inappropriate,various expert groups struggled to identify a suitable biomarker that will help in the recognition and management of DCM,with little success so ***,we thought it important to address the role of biomarkers that have shown potential in either human or animal studies and which could eventually result in mitigating the poor outcomes of *** the array of biomarkers we thoroughly analyzed,long noncoding ribonucleic acids,soluble form of suppression of tumorigenicity 2 and galectin-3 seem to be most beneficial for DCM detection,as their plasma/serum levels accurately correlate with the early stages of *** combination of relatively inexpensive and accurate speckle tracking echocardiography with some of the highlighted biomarkers may be a promising screening method for newly diagnosed diabetes mellitus type 2 *** purpose of the screening test would be to direct affected patients to more specific confirmation *** perspective is in concordance with current guidelines that accentuate the importance of an interdisciplinary team-based approach.

关键词： Diabetic cardiomyopathy Heart failure Biomarkers Diabetes mellitus Cardiomyopathy

Safety and efficacy of dual antiplatelet therapy after percutaneous coronary interventions in patients with end-stage liver disease

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World Journal of Cardiology 2021年第11期13卷 599-607页

作者： Zvonimir Ostojic Ana Ostojic josko Bulum Anna Mrzljak Department of Cardiology University Clinical Hospital ZagrebZagreb 10000Croatia Department of Gastroenterology and Hepatology University Hospital CenterZagreb 10000Croatia Department of Cardiovascular Diseases University Hospital Center ZagrebUniversity Clinical Hospital ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

The prevalence of coronary artery disease(CAD)increases in patients with endstage liver disease,with part of them receiving the percutaneous coronary intervention(PCI)as a treatment *** antiplatelet therapy(DAPT),a standard of care after PCI,could result in catastrophic consequences in this *** PCI and the start of DAPT,it is recommended to assess patient bleeding *** on novel findings,liver cirrhosis does not necessarily lead to a significant increase in bleeding ***,conventional methods,such as the international normalized ratio,might not be appropriate in assessing individual bleeding *** highest bleeding risk among cirrhotic patients has a subgroup with severe thrombocytopenia(50×10^(9)/L and prevent variceal *** is no solid evidence for DAPT in patients with ***,randomized trials investigating short(one month)DAPT duration after PCI with new drug-eluting stents(DES)in a high bleeding risk patient population can be implemented in patients with *** on retrospective studies(with older stents and protocols),PCI and DAPT appear to be safe but with a higher risk of bleeding complications with longer DAPT ***,novel methods in assessing CAD severity should be performed to avoid unnecessary PCI and potential risks associated with *** indicated,PCI should be performed over radial artery using contemporary *** medical therapy,such as proton pump inhibitors and beta-blockers,should be prescribed for lower bleeding risk *** approaches,such as thromboelastography and“preventive”upper endoscopies in PCI circumstances,warn clinical confirmation.

关键词： End-stage liver disease Cirrhosis Liver transplantation Coronary artery disease Percutaneous coronary intervention Antiplatelet therapy

Impact of the COVID-19 pandemic on inflammatory bowel disease patients:A review of the current evidence

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World Journal of Gastroenterology 2021年第25期27卷 3748-3761页

作者： Marko Kumric Tina Ticinovic Kurir Dinko Martinovic Piero Marin Zivkovic josko Bozic Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia Department of Gastroenterology University Hospital of SplitSplit 21000Croatia

Since the initial coronavirus disease 2019(COVID-19)outbreak in China in December 2019,the infection has now become the biggest medical issue of modern *** major contributors that amplified the impact of the disease and subsequently increased the burden on health care systems were high mortality among patients with multiple co-morbidities and overcapacity of intensive care *** the gastroenterology-related community,particular concern was raised with respect to patients with inflammatory bowel disease(IBD),as those patients are prone to opportunistic infections mainly owing to their immunosuppressive-based ***,we sought to summarize current knowledge regarding COVID-19 infection in patients with ***,it seems that IBD is not a comorbidity that poses an increased risk for COVID-19 acquisition,except in patients treated with ***,outcomes of the infected patients are largely dependent on therapeutic modality by which they are treated,as some worsen the clinical course of COVID-19 infection,whereas others seem to dampen the detrimental effects of ***,we discussed the present and the future impact of COVID-19 pandemic and concomitantly increased health care burden on IBD-management.

关键词： COVID-19 SARS-CoV-2 Inflammatory bowel disease Crohn’s disease Ulcerative colitis

Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers

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World Journal of Cardiology 2020年第8期12卷 373-408页

作者： Josip Anđelo Borovac Domenico D'Amario josko Bozic Duska Glavas Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Working Group on Heart Failure of Croatian Cardiac Society Zagreb 10000Croatia Department of Cardiovascular and Thoracic Sciences IRCCS Fondazione Policlinico A.GemelliUniversita Cattolica Sacro CuoreRome 00168Italy Clinic for Cardiovascular Diseases University Hospital of SplitSplit 21000Croatia

Heart failure(HF)is a complex clinical syndrome characterized by the activation of at least several neurohumoral pathways that have a common role in maintaining cardiac output and adequate perfusion pressure of target organs and *** sympathetic nervous system(SNS)is upregulated in HF as evident in dysfunctional baroreceptor and chemoreceptor reflexes,circulating and neuronal catecholamine spillover,attenuated parasympathetic response,and augmented sympathetic outflow to the heart,kidneys and skeletal *** these sympathoexcitatory effects on the cardiovascular system are sustained chronically they initiate the vicious circle of HF progression and become associated with cardiomyocyte apoptosis,maladaptive ventricular and vascular remodeling,arrhythmogenesis,and poor prognosis in patients with *** detrimental effects of SNS activity on outcomes in HF warrant adequate diagnostic and treatment ***,this review summarizes basic physiological concepts about the interaction of SNS with the cardiovascular system and highlights key pathophysiological mechanisms of SNS derangement in ***,special emphasis in this review is placed on the integrative and up-to-date overview of diagnostic modalities such as SNS imaging methods and novel laboratory biomarkers that could aid in the assessment of the degree of SNS activation and provide reliable prognostic information among patients with HF.

关键词： Autonomic nervous system Biomarkers Catecholamines Catestatin Chromaffin system Epinephrine Heart failure Myocardial failure Norepinephrine Sympathetic nervous system

Role of endoscopic ultrasound in anticancer therapy:Current evidence and future perspectives

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1863-1879页

作者： Andre Bratanic Dorotea Bozic Antonio Mestrovic Dinko Martinovic Marko Kumric Tina Ticinovic Kurir josko Bozic Department of Gastroenterology and Hepatology University Hospital of SplitSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia

The digestive system is one of the most common sites of malignancies in *** gastrointestinal tumors represent a massive global health burden both in terms of morbidity and health care expenditures,scientists continuously develop novel diagnostic and therapeutic methods to ameliorate the detrimental effects of this group of *** from the well-established role of the endoscopic ultrasound(EUS)in the diagnostic course of gastrointestinal and hepatobiliary malignancies,we have recently become acquainted with a vast array of its therapeutic possibilities.A multitude of previously established,evidence-based methods that might now be guided by the EUS emerged:Radiofrequency ablation,brachytherapy,fine needle injection,celiac plexus neurolysis,and endoscopic submucosal *** this review we endeavored to provide a comprehensive overview of the role of these methods in different malignancies of the digestive system,primarily in the treatment and symptom control in pancreatic cancer,and additionally in the management of hepatic,gastrointestinal tumors,and pancreatic cysts.

关键词： Pancreatic cancer Endoscopic ultrasound Endoscopic ultrasound-guided fine needle injection Pancreatic cyst Gastrointestinal tumor Portal vein

Six-Year Outcome after Valve Replacement and Resynchronization Therapy in TGA Patient

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Congenital Heart Disease 2021年第5期16卷 469-475页

作者： Jadranka Separovic Hanzevacki Marija Brestovac Vlatka Reskovic Luksic Blanka Glavas Konja Martina Lovric Bencic josko Bulum Darko Anic Department of Cardiovascular Diseases Clinical Hospital Centre ZagrebZagreb10000Croatia Department of Cardiac Surgery Clinical Hospital Centre ZagrebZagreb10000Croatia

Patients with complete transposition of the great arteries(TGA)treated by the Senning procedure have a higher risk of developing heart failure due to:a)additional work load of the systemic(morphologic right)ventricle(sRV),b)arrhythmias,mainly caused by surgical implications at the atria as well as c)worsening of systemic tricuspid *** present a unique case of a female patient who developed all these complications,who was successfully treated and was able to carry out a twin *** breakthrough approach was based on:*** reversibility potential of myocardial systolic dysfunction in a severe valvular lesion combined with continuous systemic afterload settings and permanent tachyarrhythmia,and *** of subsequently iatrogenic worsening of systemic ventricular function due to permanent *** replacement of systemic tricuspid valve(sTV)and cardiac resynchronization device(CRT)implantation after nodal ablation resulted in recovering of the systolic function and a positive remodeling of the *** reversal of a further decline in systolic function was achieved by permanent arrhythmia control,synchronous pacing with epicardial leads of CRT,sTV replacement as well as echocardiographic monitoring during pregnancy to determine the right time for *** years after delivery,the patient remains in NYHA Class I.

关键词： Transposition of the great arteries Cardiac resynchronization therapy Pregnancy in TGA patients