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Journal of Analysis and Testing 2019年第2期3卷 140-149页

作者： joshua D.Walmsley joshua W.Hill Partha saha Caleb M.Hill Department of Chemistry University of WyomingLaramieWY 82071USA

Optically targeted electrochemical cell microscopy(OTECCM)was applied to measure electrocatalytic rates at individual Cu nanoparticles(NPs)under electrolyte conditions relevant to CO_(2) *** electrocatalytic responses from individual NPs were found to exhibit a wide variation in behavior,with significant NP-to-NP variations in the magnitude of electrocata-lytic currents and necessary overpotentials being *** of these quantities with metrics of NP size suggest no significant variations in the inherent electrocatalytic activity of the NPs with *** element simulations of diffusion in this system demonstrate the observed diffusion-limited currents are significantly smaller than expected,attributable to the presence of a significant amount of residual ligand on the surface of the Cu NPs,which were prepared via an organic phase *** results presented here further demonstrate the promise of techniques which employ correlated optical and electrochemical measurements,such as OTECCM,for studying electrocatalysis at individual NPs.

关键词： Electrochemistry Electrochemical microscopy Nanoparticles CO_(2)reduction

Resonant magnetoelastic microstructures for wireless actuation of liquid flow on 3D surfaces and use in glaucoma drainage implants

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Microsystems & Nanoengineering 2015年第1期1卷 26-34页

作者： Venkatram Pepakayala joshua stein Yogesh Gianchandani Center for Wireless Integrated Microsensing and systems(WIMs2) Department of Electrical Engineering and Computer ScienceUniversity of MichiganAnn ArborMIUSA Department of Ophthalmology and Visual sciences University of MichiganAnn ArborMIUSA

Magnetoelastic resonators made from metal alloy foils are widely used for miniature wireless anti-theft tags and have also been explored for use in various sensing *** annealing within three-dimensional(3D)molds,these foils can be formed into curved ***,magnetoelastic materials present an opportunity for the development of a new class of wireless,actuators that have small form factors and low surface profiles and that can conform to curved *** paper describes passive,wireless,resonant magnetoelastic actuators intended for the generation of fluid flow on the surfaces of implantable Ahmed glaucoma drainage *** actuators are remotely excited to resonance using a magnetic field generated by external *** fluid flow is intended to limit cellular adhesion to the surface of the implant,as this adhesion can ultimately lead to implant encapsulation and *** actuators are micromachined from planar 29-μm-thick foils of Metglas 2826MB(Fe_(40)Ni_(38)Mo_(4)B_(18)),an amorphous magnetoelastic alloy,using photochemical *** 10.3×5.6 mm^(2),the planar structures are annealed in 3D molds to conform to the surface of the drainage device,which has an aspherical *** actuator designs are described,with varying shapes and resonant mode *** resonant frequencies for the different designs vary from 520 Hz to 4.7 *** velocities of up to 266μm s^(−1) are recorded at a wireless activation range of 25–30 mm,with peak actuator vibration amplitudes of 1.5μ*** actuators such as those described here have the potential to greatly enhance the effectiveness of glaucoma drainage devices at lowering eye pressure and may also be useful in other areas of medicine.

关键词： actuator fibrosis glaucoma magnetostriction Metglas

Nociceptors are needed to guide tooth development,function,repair,and regeneration

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Neural Regeneration Research 2023年第7期18卷 1503-1504页

作者： sarah B.Peters joshua J.Emrick Division of Biosciences College of DentistryThe Ohio State UniversityColumbusOHUSA Department of Biologic and Materials sciences&Prosthodontics School of DentistryUniversity of MichiganAnn ArborMIUSA

Toothaches have received widespread attention and commentary dating back to ancient times,appearing in Egyptian texts from over 3000 years ago and the writings of Hippocrates,Aristotle,and *** studies of the innervation of dental pulp and dentin date back to at least the 1800’s,yet our understanding of the basis for tooth pain is still *** treatments for toothache continue to be drastic and irreversible,including removal of the dental pulp or extraction of the *** the trigeminal sensory innervation of the tooth pulp is commonly the origin of toothache pain,it is also indispensable for normal function and physiology,and should be retained as an integral part of the repaired *** or regeneration of the dental pulp and its innervation could represent the next step in restorative dentistry,but a better understanding of the roles of the tooth’s sensory nerve supply and the mechanisms underlying its development and repair is needed.

关键词： function irreversible repair

Cost-Effectiveness of Interventions for Alternate Food to Address Agricultural Catastrophes Globally

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International Journal of Disaster Risk science 2016年第3期7卷 205-215页

作者： David C.Denkenberger joshua M.Pearce Global Catastrophic Risk Institute Department of Civil and Architectural Engineering Tennessee State University Department of Materials science and Engineering Michigan Technological University Department of Electrical and Computer Engineering Michigan Technological University

The literature suggests there is about a 1 % risk per year of a 10 % global agricultural shortfall due to catastrophes such as a large volcanic eruption, a medium asteroid or comet impact, regional nuclear war, abrupt climate change, and extreme weather causing multiple breadbasket failures. This shortfall has an expected mortality of about 500 million people. To prevent such mass starvation, alternate foods can be deployed that utilize stored biomass. This study developed a model with literature values for variables and, where no values existed,used large error bounds to recognize uncertainty. Then Monte Carlo analysis was performed on three interventions: planning, research, and development. The results show that even the upper bound of UsD 400 per life saved by these interventions is far lower than what is typically paid to save a life in a less-developed country. Furthermore, every day of delay on the implementation of these interventions costs 100–40,000 expected lives(number of lives saved multiplied by the probability that alternate foods would be required). These interventions plus training would save 1–300 million expected lives. In general, these solutions would reduce the possibility of civilization collapse, could assist in providing food outside of catastrophic situations, and would result in billions of dollars per year of return.

关键词： Agricultural catastrophe Alternate food Global catastrophic risk Intervention cost-effectiveness

Exploration of channel width scaling and edge states in transition metal dichalcogenides

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Nano Research 2018年第4期11卷 1768-1774页

作者： Feng Zhang Chia-Hui Lee joshua A. Robinson Joerg Appenzeller Department of Electrical and Computer Engineering Brick Nanotechnology Center Purdue University West Lafayette IN 47907 USA Department of Materials science and Engineering The Pennsylvania State University University Park PA 16802 USA

We explore the impact of edge states in three types of transition metal dichalcogenides （TMDs）, namely metallic Td-phase WTe2 and semiconducting 2H-phase MoTe2 and Mos2, by patterning thin flakes into ribbons with varying channel widths. No obvious charge depletion at the edges is observed for any of these three materials, in contrast to observations made for graphene nanoribbon devices. The semiconducting ribbons are characterized in a three-terminal field-effect transistor （FET） geometry. In addition, two ribbon array designs have been carefully investigated and found to exhibit current levels higher than those observed for conventional one-channel devices. Our results suggest that device structures incorporating a high number of edges can improve the performance of TMD FETs. This improvement is attributed to a higher local electric field, resulting from the edges, increasing the effective number of charge carriers, and the absence of any detrimental edge-related scattering.

关键词： two-dimensional (2D)-layered materials edge states WTe2 MoTe2 Mos2 channel width scaling

Elbow ulnar collateral ligament injuries in athletes: Can we improve our outcomes?

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World Journal of Orthopedics 2016年第4期7卷 229-243页

作者： Lauren H Redler Ryan M Degen Lucas s McDonald David W Altchek joshua s Dines sports Medicine and shoulder service Hospital for Special Surgery

Injury to the ulnar collateral ligament(UCL) most commonly occurs in the overhead throwing athlete. Knowledge surrounding UCL injury pathomechanics continues to improve, leading to better preventative treatment strategies and rehabilitation programs. Conservative treatment strategies for partial injuries, improved operative techniques for reconstruction in complete tears, adjunctive treatments, as well as structured sport specific rehabilitation programs including resistive exercises for the entire upper extremity kinetic chain are all important factors in allowing for a return to throwing in competitive environments. In this review, we explore each of these factors and provide recommendations based on the available literature to improve outcomes in UCL injuries in athletes.

关键词： Elbow Ulnar collateral ligament Valgus instability Tommy John surgery Rehabilitation Overhead athlete Improved outcomes

Yttrium-90 microsphere selective internal radiation therapy for liver metastases following systemic chemotherapy and surgical resection for metastatic adrenocortical carcinoma

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World Journal of Clinical Oncology 2018年第1期9卷 20-25页

作者： Mina s Makary Lawrence s Krishner Evan J Wuthrick Mark P Bloomston joshua D Dowell Division of Vascular and Interventional Radiology Department of Radiology the Ohio State University Comprehensive Cancer Center Division of Medical Oncology Department of Internal Medicine the Ohio State University Comprehensive Cancer Center Department of Radiation Oncology the Ohio State University Comprehensive Cancer Center Division of surgical Oncology Department of Surgery and James Cancer Hospital and Richard Solove Research Institute the Ohio State University Comprehensive Cancer Center

Adrenocortical carcinoma(ACC)is a rare malignancy with generally poor outcomes and limited treatment *** surgical resection can be curative for early local disease,most patients present with advanced ACC owing to nonspecific *** those patients,treatment options include systemic chemotherapy and locoregional therapies including radiofrequency ablation and transarterial *** present the first reported case of utilizing yttrium-90 microsphere selective internal radiation therapy(sIRT)in combination with first line EDP-M(Etoposide,Doxorubicin,Cisplatin,Mitotane)chemotherapy and debulking surgical primary tumor resection for treatment of metastatic *** complete radiologic response has been maintained after twelve months with resolution of clinical *** findings prompt the need for further consideration and studies to elucidate the role of sIRT in combination with systemic and surgical treatment for metastatic ACC.

关键词： Adrenocortical carcinoma Hepatic metastases Radioembolization Yttrium-90

synaptic electronics and neuromorphic computing

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science China(Information sciences) 2016年第6期59卷 56-81页

作者： Navnidhi K.UPADHYAY saumil JOsHI J.joshua YANG Department of Electrical and Computer Engineering University of Massachusetts

In order to map the computing architecture and intelligent functions of the human brain on hardware, we need electronic devices that can emulate biological synapses and even neurons, preferably at the physical level. Beginning with the history of neuromorphic computation, in this article, we will briefly review the architecture of the brain and the learning mechanisms responsible for its plasticity. We will also introduce several memristive devices that have been used to implement electronic synapses, presenting some important milestones in this area of research and discussing their advantages, disadvantages, and future prospects.

关键词： memristors neuromorphic engineering RRAM synapses synaptic devices

Effect of bone loss in anterior shoulder instability

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World Journal of Orthopedics 2015年第5期6卷 421-433页

作者： Grant H Garcia Joseph N Liu David M Dines joshua s Dines Department of Orthopedic surgery Hospital for Special Surgery

Anterior shoulder instability with bone loss can be a difficult problem to treat. It usually involves a component of either glenoid deficiency or a Hill-sachs lesion. Recent data shows that soft tissue procedures alone are typically not adequate to provide stability to the shoulder. As such, numerous surgical procedures have been described to directly address these bony deficits. For glenoid defects, coracoid transfer and iliac crest bone block procedures are popular and effective. For humeral head defects, both remplissage and osteochondral allografts have decreased the rates ofrecurrent instability. Our review provides an overview of current literature addressing these treatment options and others for addressing bone loss complicating anterior glenohumeral instability.

关键词： Latarjet Remplissage Glenoid deficiency Hill-sachs lesion Anterior instability

Acoustofluidic localization of sparse particles on a piezoelectric resonant sensor for nanogram-scale mass measurements

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Microsystems & Nanoengineering 2021年第4期7卷 117-125页

作者： Jingui Qian Habiba Begum joshua E.-Y.Lee Department of Electrical Engineering City University of Hong KongKowloonHong Kong SARChina state Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong Kong SARChina

The ability to weigh microsubstances present in low concentrations is an important tool for environmental monitoring and chemical *** instance,developing a rapid analysis platform that identifies the material type of microplastics in seawater would help evaluate the potential toxicity to marine *** this study,we demonstrate the integration of two different techniques that bring together the functions of sparse particle localization and miniaturized mass sensing on a microelectromechanical system(MEMs)chip for enhanced detection and minimization of negative *** droplet sample for analysis is loaded onto the MEMs chip containing a resonant mass *** the coupling of a surface acoustic wave(sAW)from a sAW transducer into the chip,the initially dispersed microparticles in the droplet are localized over the detection area of the MEMs sensor,which is only 200 pm *** accreted mass of the particles is then calibrated against the resulting shift in resonant frequency of the *** sAW device and MEMs chip are detachable after use,allowing the reuse of the sAW device part of the setup instead of the disposal of both *** platform maintains the strengths of noncontact and label-free dual-chip acoustofluidic devices,demonstrating for the first time an integrated microparticle manipulation and real-time mass measurement platform useful for the analysis of sparse microsubstances.

关键词： resonant sparse mass