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Cavity-agnostic acoustofluidic manipulations e.able. by guide. fle.ural wave. on a me.brane.acoustic wave.uide.actuator

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Microsyste.s & Nanoe.gine.ring 2024年第2期10卷 153-171页

作者： Philippe.Vachon Srinivas Me.ugu Jaibir Sharma Amit Lal e.dwin J.Ng yul Koh joshua e.-y.lee Che.gkuo lee De.artme.t of e.e.trical and Compute. e.gine.ring National University of SingaporeSingaporeSingapore Institute.of Microe.e.tronics Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore SonicMe.S Laboratory School of Electrical and Computer EngineeringCornell UniversityIthacaNYUSA School of e.e.trical and Data e.gine.ring University of Technology SydneyUltimoNSWAustralia

This article.pre.e.ts an in-de.th e.ploration of the.acoustofluidic capabilitie. of guide. fle.ural wave.(GFWs)ge.e.ate. by a me.brane.acoustic wave.uide.actuator(MAWA).By harne.sing the.pote.tial of GFWs,cavity-agnostic advance. particle.manipulation functions are.achie.e.,unlocking ne. ave.ue. for microfluidic syste.s and lab-on-a-chip *** localize. acoustofluidic e.fe.ts of GFWs arising from the.e.ane.ce.t nature.of the.acoustic fie.ds the. induce.inside.a liquid me.ium are.nume.ically inve.tigate. to highlight the.r unique.and promising *** traditional acoustofluidic te.hnologie.,the.GFWs propagating on the.MAWA’s me.brane.wave.uide.allow for cavity-agnostic particle.manipulation,irre.pe.tive.of the.re.onant prope.tie. of the.fluidic ***,the.acoustofluidic functions e.able. by the.de.ice.de.e.d on the.fle.ural mode.populating the.active.re.ion of the.me.brane.*** de.onstrations using two type. of particle. include.in-se.sile.drople. particle.transport,mixing,and spatial se.aration base. on particle.diame.e.,along with stre.ming-induce. counte.-flow virtual channe. ge.e.ation in microfluidic PDMS *** e.pe.ime.ts e.phasize.the.ve.satility and pote.tial applications of the.MAWA as a microfluidic platform targe.e. at lab-on-a-chip de.e.opme.t and showcase.the.MAWA’s compatibility with e.isting microfluidic syste.s.

关键词： wave.uide fluid cavity

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Acoustofluidic localization of sparse.particle. on a pie.oe.e.tric re.onant se.sor for nanogram-scale.mass me.sure.e.ts

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Microsyste.s & Nanoe.gine.ring 2021年第4期7卷 117-125页

作者： Jingui Qian Habiba Be.um joshua e.-y.lee De.artme.t of e.e.trical e.gine.ring City University of Hong KongKowloonHong Kong SARChina State.Ke. Laboratory of Te.ahe.tz and Millime.e. Wave. City University of Hong KongKowloonHong Kong SARChina

The.ability to we.gh microsubstance. pre.e.t in low conce.trations is an important tool for e.vironme.tal monitoring and che.ical *** instance.de.e.oping a rapid analysis platform that ide.tifie. the.mate.ial type.of microplastics in se.wate. would he.p e.aluate.the.pote.tial toxicity to marine.*** this study,we.de.onstrate.the.inte.ration of two diffe.e.t te.hnique. that bring toge.he. the.functions of sparse.particle.localization and miniaturize. mass se.sing on a microe.e.trome.hanical syste.(Me.S)chip for e.hance. de.e.tion and minimization of ne.ative.*** drople. sample.for analysis is loade. onto the.Me.S chip containing a re.onant mass *** the.coupling of a surface.acoustic wave.SAW)from a SAW transduce. into the.chip,the.initially dispe.se. microparticle. in the.drople. are.localize. ove. the.de.e.tion are. of the.Me.S se.sor,which is only 200 pm *** accre.e. mass of the.particle. is the. calibrate. against the.re.ulting shift in re.onant fre.ue.cy of the.*** SAW de.ice.and Me.S chip are.de.achable.afte. use.allowing the.re.se.of the.SAW de.ice.part of the.se.up inste.d of the.disposal of both *** platform maintains the.stre.gths of noncontact and labe.-fre. dual-chip acoustofluidic de.ice.,de.onstrating for the.first time.an inte.rate. microparticle.manipulation and re.l-time.mass me.sure.e.t platform use.ul for the.analysis of sparse.microsubstance..

关键词： re.onant sparse mass

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Influe.ce.of indoor airflow on airborne.dise.se.transmission in a classroom

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Building Simulation 2024年第3期17卷 355-370页

作者： Mojtaba Zabihi Ri Li joshua Brinke.hoff School of e.gine.ring Faculty of Applied ScienceUniversity of British ColumbiaKelownaCanada

It has be.n wide.y acce.te. that the.most e.fe.tive.way to mitigate.airborne.dise.se.transmission in an indoor space.is to incre.se.the.ve.tilation airflow,me.sure. in air change.pe. hour(ACH).Howe.e.,incre.sing ACH did not e.fe.tive.y pre.e.t the.spre.d of *** be.te. unde.stand the.role.of ACH and airflow large.scale.patte.ns,a compre.e.sive.fully transie.t computational fluid dynamics(CFD)simulation of two-phase.flows base. on a discre.e.phase.mode.(DPM)was pe.forme. in a unive.sity classroom se.ting with pe.ple.*** inve.tigations e.compass various particle.size.,ve.tilation layouts,and flow *** findings de.onstrate. that the.particle.size.thre.hold at which particle. are.de.me. airborne.is highly influe.ce. by the.background flow stre.gth and large.scale.flow patte.n,ranging from 5µm to 10µm in the.case. *** e.fe.ts of occupants are.significant and must be.pre.ise.y accounte. for in re.piratory particle.transport *** e.hance. ve.tilation de.ign(UFAD-CDR)for unive.sity classrooms is introduce. that place. a pre.ium on mitigating airborne.dise.se.*** to the.base.ine.de.ign at the.same.ACH,this de.ign succe.sfully re.uce. the.maximum numbe. de.sity of re.piratory particle. by up to 85%.A nove. airflow-re.ate. parame.e.,Horizontality,is introduce. to quantify and conne.t the.large.scale.airflow patte.n with indoor ae.osol *** unde.score. that ACH alone.cannot e.sure.or re.ulate.air *** addition to the.ne.e.sary ACH for air e.change.minimizing horizontal bulk motion is e.se.tial for re.ucing ae.osol transmissibility within the.room.

关键词： ae.osol transmission airflow patte.n horizontality COVID-19 simulation classroom ve.tilation

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Bile.acid me.abolism and signaling in he.lth and dise.se.mole.ular me.hanisms and the.ape.tic targe.s

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Signal Transduction and Targe.e. The.apy 2024年第5期9卷 2014-2064页

作者： joshua S.Fle.shman Sunil Kumar De.artme.t of Pharmace.tical Scie.ce. College of Pharmacy and Health SciencesSt.John’s UniversityQueensNYUSA

Bile.acids,once.conside.e. me.e.die.ary surfactants,now e.e.ge.as critical modulators of macronutrie.t(lipid,carbohydrate.prote.n)me.abolism and the.syste.ic pro-inflammatory/anti-inflammatory *** acid me.abolism and signaling pathways play a crucial role.in prote.ting against,or if abe.rant,inducing cardiome.abolic,inflammatory,and ne.plastic conditions,strongly influe.cing he.lth and *** curative.tre.tme.t e.ists for any bile.acid influe.ce. dise.se.while.the.most promising and we.l-de.e.ope. bile.acid the.ape.tic was re.e.tly re.e.te. by the.***,we.provide.a bottom-up approach on bile.acids,me.hanistically e.plaining the.r bioche.istry,physiology,and pharmacology at canonical and non-canonical *** this me.hanistic mode. of bile.acids,we.e.plain how abnormal bile.acid physiology drive. dise.se.pathoge.e.is,e.phasizing how ce.amide.synthe.is may se.ve.as a unifying pathoge.ic fe.ture.for cardiome.abolic *** provide.an in-de.th summary on pre.e.isting bile.acid re.e.tor modulators,e.plain the.r shortcomings,and propose.solutions for how the. may be.***,we.rationalize.nove. targe.s for furthe. translational drug discove.y and provide.future.*** than dismissing bile.acid the.ape.tics due.to re.e.t se.backs,we.be.ie.e.that the.e.is imme.se.clinical pote.tial and a high like.ihood for the.future.succe.s of bile.acid the.ape.tics.

关键词： me.abolism re.e.te. shortcomings

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Phre.ic ne.ve.block: the.ke. to managing acute.biliary pain?

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World Journal of e.e.ge.cy Me.icine 2024年第1期15卷 62-63页

作者： Michae. Shalaby joshua Luftig De.artme.t of e.e.ge.cy Me.icine.and Critical Care Herbert Wertheim College of Medicine at Florida International UniversityMiami 33199USA Advance. e.e.ge.cy Ultrasound Mount Sinai Medical CenterMiami Beach 33140USA De.artme.t of e.e.ge.cy Me.icine Highland HospitalAlameda Health SystemOakland 94602USA

Ove. the.past two de.ade.,the.USA has witne.se. a ste.p rise.in the.incide.ce.of acute.chole.ystitis(AC),[1]e.e. among childre.,[2]with ove. 200,000 case. annually.[3]Patie.ts with AC ofte. pre.e.t to the.e.e.ge.cy de.artme.t(e.)e.pe.ie.cing se.e.e.distre.s,with most de.cribing the.r pain le.e. as“intole.able.”[4]Furthe.more.the.e.is usually a conside.able.de.ay be.ore.surge.y,with a me.ian time.from diagnosis of AC to surge.y of 28.5 h,[5]and a substantial pe.ce.tage.of patie.ts wait as long as 10 d.[6]Prolonge. de.ays be.ore.surge.y le.d to incre.se. opioid use.which is associate. with e.te.de. hospital stays and highe. rate. of re.dmission afte. chole.yste.tomy.[7]Furthe.more.opioids can le.d to vomiting,re.piratory de.re.sion,de.irium,and ultimate.y addiction.[8]We.propose.a nove. re.ional ane.the.ia te.hnique.for managing AC:right phre.ic ne.ve.*** me.hod could offe. improve. pain control and a more.favorable.risk profile.in se.e.te. patie.ts whe. compare. to curre.t e. practice..

关键词： pain ane.the.ia diagnosis

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Re.ilie.ce.confe.re. by APOe.R136S:a de.e.se.be.towe. by nature.to combat Alzhe.me.’s dise.se

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Signal Transduction and Targe.e. The.apy 2024年第3期9卷 831-832页

作者： Bin Xiao joshua Kuruvilla e.g-King Tan De.artme.t of Ne.rology National Neuroscience InstituteSingaporeSingapore Ne.roscie.ce.Acade.ic Clinical Program Duke-NUS Medical SchoolSingaporeSingapore Ne.roscie.ce.and Be.avioural Disorde.s Program Duke-NUS Medical SchoolSingaporeSingapore

In two re.e.t article. publishe. in Nature.Ne.roscie.ce.and Ce.l,Ne.son e. al.1 and Che. e. al.2 have.shown that a rare.APOe. Christchurch(APOe.Ch)variant,R136S,has prote.tive.e.fe.ts on ne.rode.e.e.ation in various Alzhe.me.’s dise.se.AD)mode. syste.s through atte.uating tau pathology and re.ulating its re.ate. ne.roimmune.*** e. *** Che. e. *** provide. e.ide.ce.that ide.tifying the.pathophysiologic clue. and pote.tial mole.ular targe.s from a prote.tive.variant such as APOe.R136S,can be.an attractive.viable.approach to de.e.op AD the.ape.tics.

关键词： prote.tive al. Alzhe.me.

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Me.hanically drive. asse.bly of biomime.ic 2D-mate.ial microte.ture. with bioinspire. multifunctionality

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Nano Re.e.rch 2024年第2期17卷 663-678页

作者： yang Li Lin Jing joshua M.Little.Haoche. yang Tsai-Chun Chung Po-ye. Che. De.artme.t of Che.ical and Biomole.ular e.gine.ring University of MarylandCollege ParkMD 20740USA Maryland Robotics Ce.te. University of MarylandCollege ParkMD 20742USA School of Mate.ials Scie.ce.and e.gine.ring Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature.provide. a we.lth of bio-inspiration for advance. mate.ial *** various nanomate.ials into biomime.ic microte.ture. with bioinspire. functionalitie. has spurre. incre.sing re.e.rch inte.e.ts and facilitate. te.hnological advance. in various *** re.e.t ye.rs,two-dime.sional mate.ials(2DMs)have.e.e.ge. as important building block units in the.biomimicry fie.d due.to the.r distinct che.ical,physical,e.e.trical,e.e.troche.ical,and catalytic *** this re.ie. article.various me.hanically drive. asse.bly approache. are.summarize. to fabricate.various ge.e.logie. of biomime.ic 2DM microte.ture. with bio-inspire. ***,se.ue.tial de.ormation strate.ie. are.discusse. to programmably construct highe. dime.sional 2DM microte.ture.,ranging from wrinkle./crumple.(one.time.de.ormation)to multiscale.hie.archie.(multiple.de.ormations).Ne.t,the.curre.t progre.s using highe. dime.sional 2DM microte.ture. to imitate.diffe.e.t biological structure. and/or induce.bio-inspire. multifunctionality is syste.atically *** showcase. of bio-inspiration and biomimicry using diffe.e.t 2DM nanoshe.ts are.highlighte.:(1)wrinkle.patte.ns of an e.rthworm that spur the.de.ign of strain se.sors with programmable.working range. and se.sitivitie.,(2)wrinkle.appe.rance.of a Shar-Pe. dog that motivate. the.fabrication of stre.chable.e.e.gy storage.de.ice.,(3)hie.archical scale.te.ture. of a de.e.t lizard that inspire.cation-induce. ge.ation platforms for 2DM ae.oge.s,and(4)wrinkle.skin of an e.e.hant that influe.ce. the.de.e.opme.t of 2DM prote.tive.skin for soft ***,challe.ge. and future.opportunitie. of adopting 2DM nanoshe.ts to asse.ble.biomime.ic microstructure. with syne.gistic functionalitie. are.discusse..

关键词： two-dime.sional(2D)mate.ials me.hanically drive. asse.bly biomime.ic microte.ture. functional nanocomposite bio-inspire. multifunctionality

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Progre.sion of e.ticke.ing imple.e.tation for state.transportation age.cie. for asphalt mate.ials

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Journal of Road e.gine.ring 2024年第1期4卷 80-92页

作者： joshua Withrow Gabrie. B.Dadi Hala Nasse.e.dine De.artme.t of Civil e.gine.ring University of KentuckyLexingtonKY 40506USA Ke.tucky Transportation Cabine. FrankfortKY 40622USA

e.ticke.ing,which has be.n promote. by the.Fe.e.al Highway Administration(FHWA)“e.e.y day counts”(e.C)initiative.utilize. software.applications to digitally track and store.information re.arding highway construction mate.ials paid by state.transportation age.cie.(STAs)by we.ght in unit bid contract *** ofte. face.imple.e.tation barrie.s such as institutional ine.tia,or the.re.istance.by stake.olde.s to adopt change. from the.status quo,including ne. *** purpose.of this pape. is to de.e.mine.the.progre.sion of STA e.ticke.ing policy adoption,spe.ifically with a focus on asphalt paving ope.ations,due.to the.COVID-19 *** accomplish this re.e.rch e.fort,pre.ious FHWA data,National Coope.ative.Highway Re.e.rch Program(NCHRP)data,and othe. lite.ature. are.re.ie.e. to de.e.mine.an imple.e.tation *** data is colle.te. from the.Ame.ican Association of State.Highway and Transportation Officials Committe. on Con-struction to gain curre.t fe.dback from STAs and the.r highway contractor partne.s afte. the.COVID-19 ***,a case.study fe.turing the.Ke.tucky Transportation Cabine.(KyTC),the.Ke.tucky Association of Highway Contractors(KAHC),and the.Plantmix Asphalt Industry of Ke.tucky(PAIKy)is pe.forme. to provide.more.in-de.th *** major finding include. a statistically significant re.ult indicating incre.se. imple.me.tation of e.ticke.ing for asphalt ope.ations within the.last two ye.rs,along with noting be.e.its including e.ploye. safe.y,task loading,and proje.t docume.tation along with conce.ns re.arding ce.lular conne.tivity and procure.e.t *** findings indicate.the.importance.of STAs inve.ting in partne.ship with con-tractors to improve.stake.olde. buy-in be.ore.proce.ding towards e.ticke.ing adoption.

关键词： Asphalt paving Construction inspe.tion e.ticke.ing COVID-19

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O'Hare.Airport roadway traffic pre.iction via data fusion and Gaussian proce.s re.re.sion

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Journal of Traffic and Transportation e.gine.ring(e.glish e.ition) 2024年第4期11卷 721-732页

作者： Damola M.Akinlana Arindam Fadikar Ste.an M.Wild Natalia Zuniga-Garcia joshua Auld De.artme.t of Mathe.atics and Statistics University of South Florida De.ision and Infrastructure.Scie.ce. Division Argonne National Laboratory Applie. Mathe.atics and Computational Re.e.rch Division Lawrence Berkeley National Laboratory De.artme.t of Industrial e.gine.ring and Manage.e.t Scie.ce. Northwestern University Argonne.National Laboratory Energy Systems Argonne.National Laboratory Energy Systems Lemont

This study propose. an approach of le.e.aging information gathe.e. from multiple.traffic data source. at diffe.e.t re.olutions to obtain approximate.infe.e.ce.on the.traffic distribution of Chicago's O'Hare.Airport are.. Spe.ifically, it propose. the.inge.tion of traffic datase.s at diffe.e.t re.olutions to build spatiote.poral mode.s for pre.icting the.distribution of traffic volume.on the.road ne.work. Due.to its good adaptability and fle.ibility for spatiote.poral data, the.Gaussian proce.s(GP) re.re.sion was e.ploye. to provide.short-te.m fore.asts using data colle.te. by loop de.e.tors(se.sors) and supple.e.te. by te.e.atics data. The.GP re.re.sion is use. to make.pre.ictions of the.distribution of the.proportion of se.sor data traffic volume.re.re.e.te. by the.te.e.atics data for e.ch location of the.se.sors. Conse.ue.tly, the.fitte. GP mode. can be.use. to de.e.mine.the.approximate.traffic distribution for a te.ting location outside.of the.training points. Policymake.s in the.transportation se.tor can find the.re.ults of this work he.pful for making informe. de.isions re.ating to curre.t and future.transportation conditions in the.are..

关键词： Spatio-te.poral Data fusion Gaussian proce.s Multimodal data Airport traffic O’Hare.Airport

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A Guide.to Chine.e.IP LaW

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城市漫步（GBA版） 2024年第4期 32-41页

作者： joshua Cawthorpe 不详

China ranke. first in the.world for pate.t applications in 2022,filing an astounding 1.6 *** following ye.r saw 921,000 inve.tion pate.ts,2,090,000 utility pate.ts,638,000 de.igns and almost 5 million re.iste.e. trade...

关键词： pate.t ranke. re.iste.e.

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