检索结果-南通市图书馆

Bile acid metabolism and signaling in health and disease:molecular mechanisms and therapeutic targets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

signal Transduction and Targeted Therapy 2024年第5期9卷 2014-2064页

作者： joshua s.Fleishman sunil Kumar Department of Pharmaceutical sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNYUSA

Bile acids,once considered mere dietary surfactants,now emerge as critical modulators of macronutrient(lipid,carbohydrate,protein)metabolism and the systemic pro-inflammatory/anti-inflammatory *** acid metabolism and signaling pathways play a crucial role in protecting against,or if aberrant,inducing cardiometabolic,inflammatory,and neoplastic conditions,strongly influencing health and *** curative treatment exists for any bile acid influenced disease,while the most promising and well-developed bile acid therapeutic was recently rejected by the ***,we provide a bottom-up approach on bile acids,mechanistically explaining their biochemistry,physiology,and pharmacology at canonical and non-canonical *** this mechanistic model of bile acids,we explain how abnormal bile acid physiology drives disease pathogenesis,emphasizing how ceramide synthesis may serve as a unifying pathogenic feature for cardiometabolic *** provide an in-depth summary on pre-existing bile acid receptor modulators,explain their shortcomings,and propose solutions for how they may be ***,we rationalize novel targets for further translational drug discovery and provide future *** than dismissing bile acid therapeutics due to recent setbacks,we believe that there is immense clinical potential and a high likelihood for the future success of bile acid therapeutics.

关键词： metabolism rejected shortcomings

Resilience conferred by APOE-R136s:a defense bestowed by nature to combat Alzheimer’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

signal Transduction and Targeted Therapy 2024年第3期9卷 831-832页

作者： Bin Xiao joshua Kuruvilla Eng-King Tan Department of Neurology National Neuroscience InstituteSingaporeSingapore Neuroscience Academic Clinical Program Duke-NUS Medical SchoolSingaporeSingapore Neuroscience and Behavioural Disorders Program Duke-NUS Medical SchoolSingaporeSingapore

In two recent articles published in Nature Neuroscience and Cell,Nelson et al.1 and Chen et al.2 have shown that a rare APOE3 Christchurch(APOE3Ch)variant,R136s,has protective effects on neurodegeneration in various Alzheimer’s disease(AD)model systems through attenuating tau pathology and regulating its related neuroimmune *** et *** Chen et *** provided evidence that identifying the pathophysiologic clues and potential molecular targets from a protective variant such as APOE R136s,can be an attractive viable approach to develop AD therapeutics.

关键词： protective al. Alzheimer

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

signal Transduction and Targeted Therapy 2024年第1期9卷 105-149页

作者： Yumin Wang Jing Hu shuang Wu joshua s.Fleishman Yulin Li Yinshi Xu Wailong Zou Jinhua Wang Yukuan Feng Jichao Chen Hongquan Wang Department of Respiratory and Critical Care Medicine Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300060PR China Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430000PR China Department of Pharmaceutical sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Outpatient Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Beijing Key Laboratory of Drug Target and screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050PR China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060PR China

Ferroptosis,a unique modality of cell death with mechanistic and morphological differences from other cell death modes,plays a pivotal role in regulating tumorigenesis and offers a new opportunity for modulating anticancer drug *** epigenetic modifications and posttranslational modifications(PTMs)promote anticancer drug resistance,cancer progression,and *** studies indicate that epigenetic modifications can transcriptionally and translationally determine cancer cell vulnerability to ferroptosis and that ferroptosis functions as a driver in nervous system diseases(NsDs),cardiovascular diseases(CVDs),liver diseases,lung diseases,and kidney *** this review,we first summarize the core molecular mechanisms of ***,the roles of epigenetic processes,including histone PTMs,DNA methylation,and noncoding RNA regulation and PTMs,such as phosphorylation,ubiquitination,sUMOylation,acetylation,methylation,and ADP-ribosylation,are concisely *** roles of epigenetic modifications and PTMs in ferroptosis regulation in the genesis of diseases,including cancers,NsD,CVDs,liver diseases,lung diseases,and kidney diseases,as well as the application of epigenetic and PTM modulators in the therapy of these diseases,are then discussed in *** the mechanisms of ferroptosis regulation mediated by epigenetic modifications and PTMs in cancer and other diseases will facilitate the development of promising combination therapeutic regimens containing epigenetic or PTM-targeting agents and ferroptosis inducers that can be used to overcome chemotherapeutic resistance in cancer and could be used to prevent other *** addition,these mechanisms highlight potential therapeutic approaches to overcome chemoresistance in cancer or halt the genesis of other diseases.

关键词： diseases epigenetic overcome

Post-operative protein supplementation following orthopaedic surgery: A systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

sports Medicine and Health science 2024年第1期6卷 16-24页

作者： Andrew George Brendan M.Holderread Bradley s.Lambert joshua D.Harris Patrick C.McCulloch Houston Methodist Orthopedics and sports Medicine 6445 Main Street Suite 2300HoustonTX77030USA Houston Methodist Orthopedic Biomechanics Research Laboratory 6670 Bertner AveHoustonTX77030USA

Decreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle *** purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic surgery.A systematic review was conducted according to the Preferred Reporting Items for systematic Reviews and MetaAnalysis(PRIsMA).PubMed(MEDLINE),Embase,scopus,and Web of science were searched for randomized controlled trials that assessed protein or amino acid supplementation in patients undergoing orthopaedic *** investigators independently conducted the search using relevant Boolean *** outcomes included functional or physiologic measures of muscle atrophy or *** studies including 611 patients(224 males,387 females)were *** studies evaluated protein supplementation after ACL reconstruction(ACLR),3 after total hip arthroplasty(THA),5 after total knee arthroplasty(TKA),and 3 after surgical treatment of hip *** supplementation showed beneficial effects across all types of *** primary benefit was a decrease in muscle atrophy compared to placebo as measured by muscle cross sectional *** authors also demonstrated improved functional measures and quicker achievement of rehabilitation *** supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following ACLR,THA,TKA,and surgical treatment of hip *** effects often correlate with improved functional measures and quicker achievement of rehabilitation *** research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period.

关键词： Orthopaedic surgery Protein supplementation systematic review Muscle atrophy

O'Hare Airport roadway traffic prediction via data fusion and Gaussian process regression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 721-732页

作者： Damola M.Akinlana Arindam Fadikar stefan M.Wild Natalia Zuniga-Garcia joshua Auld Department of Mathematics and statistics University of South FloridaTampaFL 33620USA Decision and Infrastructure sciences Division Argonne National LaboratoryLemontIL 60439USA Applied Mathematics and Computational Research Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Industrial Engineering and Management sciences Northwestern UniversityEvanstonIL 60208USA Argonne National Laboratory Energy SystemsLemontIL 60439USA

This study proposes an approach of leveraging information gathered from multiple traffic data sources at different resolutions to obtain approximate inference on the traffic distribution of Chicago's O'Hare Airport ***,it proposes the ingestion of traffic datasets at different resolutions to build spatiotemporal models for predicting the distribution of traffic volume on the road *** to its good adaptability and flexibility for spatiotemporal data,the Gaussian process(GP)regression was employed to provide short-term forecasts using data collected by loop detectors(sensors)and supplemented by telematics *** GP regression is used to make predictions of the distribution of the proportion of sensor data traffic volume represented by the telematics data for each location of the ***,the fitted GP model can be used to determine the approximate traffic distribution for a testing location outside of the training *** in the transportation sector can find the results of this work helpful for making informed decisions relating to current and future transportation conditions in the area.

关键词： spatio-temporal Data fusion Gaussian process Multimodal data Airport traffic O'Hare Airport

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

利用气泡和油从水中捕获微塑料（英文）

Engineering 2024年第10期41卷 71-83页

作者： joshua saczek Xiaoxue Yao Vladimir Zivkovic Mohamed Mamlouk steven Wang stevin s.Pramana school of Engineering Newcastle University Department of Mechanical Engineering City University of Hong Kong

The removal of microplastics(MPs) from water using oil has shown early promise;however,incorporation of this technique into a feasible in situ method has yet to be ***,a simple yet effective method of MP capture from water using vegetable oil with bubbles is demonstrated to achieve high removal efficiencies of>98%.Comparisons are made with other methods of agitation,and higher removal efficiencies are observed when bubbles are *** to the low agitation provided by the bubbles,the oil layer remains unbroken,meaning that no oil is released into the bulk water *** this way,secondary contamination is avoided-unlike membrane filtration,another effective removal method,in which polymer-based membranes can break down due to chemical backwashing and *** is demonstrated that variation in MP size within the micrometer range(50-170 μm) has minor impact on the removal efficiency;however,100% removal is achieved for larger,millimeter-sized MPs(500-5000 μm).similarly,a high removal efficiency of greater than 99% is achieved in the capture of *** factors such as oil volume and water salinity are also investigated and *** on these results,the proposed method can be introduced into multiple setting types as a passive and continuous method of MP capture.

关键词： Microplastic Floatation Density separation Wetting

There's No Party Likean AmCham Party

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

城市漫步（GBA版） 2024年第6期 50-51页

作者： joshua Cawthorpe 不详

What on Earth is a Chamber of Commerce?We've been asking ourselves this question for years,and after attending the lavish AmCham spring Ball on May 18,we are no closer to finding the *** anything a chamber gives it an ominous,clandestine *** commerce to the mix,and one imagines a place where industrialists and freemasons meet behind closed doors.

关键词： spring closer Earth

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

What's-Up-Homie Tony

城市漫步（GBA版） 2024年第4期 30-31页

作者： joshua Cawthorpe 不详

We meet Tony at the LC sign offices,nestled in a commercial plaza next to a sprawling field of single-home vegetable gardens,a quintessential sight in Guangdong known as a"village-with in a-city."

关键词： Tony Guangdong village

The GOAT Celebrates Belated Grand Opening After Three Exciting Years

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

城市漫步（GBA版） 2024年第1期 I0010-I0011页

作者： joshua Cawthorpe 不详

The GOAT in Panyu held its official Grand Opening Party on January *** surely that has you asking yourself,"What's that you say?Didn't they open three years ago?"

关键词： Opening Grand yourself