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Journal of Forestry Research 2018年第5期29卷 1299-1306页

作者： Shuangshuang Chu Douglass F.Jacobs joshua l.sloan li Xue Daoming Wu Shucai Zeng College of Forestry and landscape Architecture South China Agricultural University Department of Forestry and Natural Resources Purdue University

The ecological effects of eucalypt plantations（EPs） have garnered increasing *** understand their effect on soil quality at a landscape scale,and to determine whether soil quality parameters differ due to different stand types,we evaluated soil characteristics in twenty-one groups of EPs,Pinus massoniana ***（PMPs） and natural broadleaved forests（NBFs）across Guangdong Province,*** the physical characteristics of soil hydrology and the properties of soil nutrients in A and B horizons were *** showed that,compared to NBFs,EPs and PMPs produced a shallower litter layer,reduced canopy density,higher soil bulk density,significantly lower total porosity,non-capillary porosity,total water volume,and hygroscopic water in the A horizon（P〈0.05）.Moreover,total N,available K,and soil organic carbon（SOC） in EPs and PMPs were significantly lower than in *** and PMPs did not differ significantly in N,P or K content,but PMPs had significantly lower SOC and boron in the A horizon than *** p H and poor capacity to buffer acidification generally occurred in all cover *** EPs and PMPs showed a decline in soil properties relative to NBFs,but EPs and PMPs exhibited no significant *** results indicate that actions are needed to ameliorate the potential negative effects on soil quality in forestry plantations.

关键词： Eucalyptus Pinus massoniana Plantations Soil organic matter Soil acidification Moisture retention capacity

Obstructive sleep apnea:Overlooked comorbidity in patients with diabetes

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World Journal of Diabetes 2024年第7期15卷 1448-1460页

作者： Eric D Tenda joshua Henrina Jin H Cha Muhammad R Triono Ersananda A Putri Dahliana J Aristy Dicky l Tahapary Division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia Head of Research Group Artificial Intelligence and Digital Health Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia Division of Endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked *** delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose *** research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and *** review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weight loss Positive airway pressure

Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

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liver Research 2024年第1期8卷 46-53页

作者： joshua Hefler Rena Pawlick Braulio A.Marfil-Garza Aducio Thiesen Nerea Cuesta-Gomez Sanaz Hatami Darren H.Freed Constantine Karvellas David l.Bigam A.M.James Shapiro Department of Surgery Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada Department of Medicine Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada CHRISTUS-latAm Hub Excellence&Innovation Center MonterreyMexico Alberta Diabetes Institute University of AlbertaEdmontonABCanada Clinical Islet Transplant Program University of AlbertaEdmontonABCanada Department of laboratory Medicine&Pathology Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada

Background and aim:The liver is susceptible to ischemia-reperfusion injury(IRI)during hepatic surgery,when the vessels are compressed to control bleeding,or liver transplantation,when there is an obligate period of *** hallmark of IRI comprises mitochondrial dysfunction,which generates reactive oxygen species,and cell death through necrosis or ***(CsA),which is a well-known immunosuppressive agent that inhibits calcineurin,has the additional effect of inhibiting the mito-chondrial permeability transition pore(mPTP),thereby,preventing mitochondrial swelling and ***-811,which is the nonimmunosuppressive analog of CsA,has a similar effect on the *** this study,we tested the effect of both agents on mitigating warm hepatic IRI in a murine *** and methods:Before ischemic insult,the mice were administered with intraperitoneal normal saline(control);CsA at 2.5,10,or 25 mg/kg;or NIM-811 at 10 mg/***,the mice were subjected to partial warm hepatic ischemia by selective pedicle clamping for 60 min,followed by 6 h of recovery after *** alanine transaminase(AlT)was measured,and the liver tissue was examined histologically for the presence of apoptosis and the levels of inflammatory ***:Compared with the control mice,the mice treated with 10 and 25 mg/kg of CsA and NIM-811 had significantly lower AlT levels(Ply).Moreover,the liver tissue showed reduced histological injury scores after treatment with CsA at 2.5,10,and 25 mg/kg and NIM-811(P=0.041,ly)and significant decrease in apoptosis after treatment with CsA at all doses(P=0.012,0.007,andly).levels of the pro-inflammatory cyto-kines,particularly interleukin(Il)-1β,Il-2,Il-4,Il-10,and keratinocyte chemoattractant/human growth-regulated oncogene significantly decreased in the mice treated with the highest dose of CsA(25 mg/kg)than those in the control ***

关键词： Cyclosporine(CsA) Cyclosporine analogue liver surgery Ischemia-reperfusion injury(IRI) Animal model NIM-811

The effect of laves phases and nano-precipitates on the electrochemical corrosion resistance of Mg-Al-Ca alloys under alkaline conditions

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Journal of Magnesium and Alloys 2024年第6期12卷 2447-2461页

作者： Markus Felten Veronika Chaineux Siyuan Zhang Ali Tehranchi Tilmann Hickel Christina Scheu joshua Spille Marta lipińska-Chwałek Joachim Mayer Benjamin Berkels Marcus Hans Imke Greving Silja Flenner Sandra Sefa Daniela Zander Chair of Corrosion and Corrosion Protection RWTH Aachen UniversityAachen 52072 Germany Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany Central Facility for Electron Microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbHJülich 52428Germany Mathematical Image and Signal Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany Materials Chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The electrochemical corrosion mechanisms of Mg alloys were extensively studied in previous investigations of different chemical com-positions,modified surface states and various electrolyte ***,recent research focused on the active state of Mg dissolution,leading to unresolved effects of secondary phases adjacent to a stableα-solid solution passive *** present study investigates the fundamental electrochemical corrosion mechanisms of three different laves phases with varying phase morphologies and phase fractions in the passive state of Mg-Al-Ca *** microstructure was characterized by(transmission-)electron microscopy and synchrotron-based transmission X-ray *** electrochemical corrosion resistance was determined with a standard three-electrode setup and advanced in-situ flow cell measurements.A new electrochemical activity sequence(C15>C36>α-Mg>C14)was obtained,as a result of a stable passive layer formation on theα-solid ***,nm-scale Mg-rich precipitates were identified within the laves phases,which tend to inhibit the corrosion kinetics.

关键词： laves phase STEM Magnesium Corrosion Passive layer

Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason lynch Christopher E.Stevens Christopher Munley Chentao li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

A system-on-chip microwave photonic processor solves dynamic RF interference in real time with picosecond latency

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light(Science & Applications) 2024年第1期13卷 91-102页

作者： Weipeng Zhang joshua C.lederman Thomas Ferreira de lima Jiawei Zhang Simon Bilodeau leila Hudson Alexander Tait Bhavin J.Shastri Paul R.Prucnal Department of Electrical and Computer Engineering Princeton UniversityPrinceton08544NJUSA NEC laboratories America Princeton08540NJUSA Department of Electrical and Computer Engineering Queen’s UniversityKingstonK7L 3N6OntarioCanada Department of Physics Engineering Physics and AstronomyQueen’s UniversityKingstonK7L 3N6OntarioCanada

Radio-frequency interference is a growing concern as wireless technology advances,with potentially life-threatening consequences like interference between radar altimeters and 5 G cellular *** transceivers mix signals with varying ratios over time,posing challenges for conventional digital signal processing(DSP)due to its high *** challenges will worsen as future wireless technologies adopt higher carrier frequencies and data ***,conventional DSPs,already on the brink of their clock frequency limit,are expected to offer only marginal speed *** paper introduces a photonic processor to address dynamic interference through blind source separation(BSS).Our system-on-chip processor employs a fully integrated photonic signal pathway in the analogue domain,enabling rapid demixing of received mixtures and recovering the signal-of-interest in under 15 *** reduction in latency surpasses electronic counterparts by more than three orders of *** complement the photonic processor,electronic peripherals based on field-programmable gate array(FPGA)assess the effectiveness of demixing and continuously update demixing weights at a rate of up to 305 *** compact setup features precise dithering weight control,impedance-controlled circuit board and optical fibre packaging,suitable for handheld and mobile *** experimentally demonstrate the processor’s ability to suppress transmission errors and maintain signal-to-noise ratios in two scenarios,radar altimeters and mobile *** work pioneers the real-time adaptability of integrated silicon photonics,enabling online learning and weight adjustments,and showcasing practical operational applications for photonic processing.

关键词： processor mixing dynamic

Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第3期16卷 224-234页

作者： joshua J.MAlAGO Catherine l.SANGU Department of Pathology Faculty of Veterinary MedicineSokoine University of Agriculture c/o Walter Oseko

Intrarectal infusion of butyrate improves colorectal disorders including ulcerative colitis （UC）. However, it is not established whether systemically administered butyrate benefits such patients. The current study aimed at ex- ploring and comparing the potential of intraperitoneally, intrarectally, and orally administered butyrate against acetic acid （AA）-induced UC in rats. Intrarectal administration of 2 ml of 50% AA was done after or without prior treatment of rats for 7 consecutive days with 100 mg/kg sodium butyrate （SB） intraperitoneally, intrarectally, or orally. Rats were sacrificed after 48 h of hA-treatment. Subsequently, colon sections were processed routinely for histopathological examination. We clinically observed diarrhea, loose stools, and hemoccult-positive stools, and histologically, epithelial loss and ulceration, crypt damage, goblet cell depletion, hemorrhage, and mucosal infiltration of inflammatory cells. The changes were significantly reduced by intraperitoneal, intrarectal, or oral butyrate, with intraperitoneal butyrate exhibiting the highest potency. It is concluded that intraperitoneal administration of butyrate abrogates the lesions of hA-induced UC and its potency surpasses that of intrarectal or oral butyrate.

关键词： Butyrate Oral administration Intraperitoneal administration Intrarectal administration Acetic acid,Ulcerative colitis

l-Arginine Supplementation Mitigates Dichlorvos-Induced Haematocardiotoxicity, and Oxidative Stress in Male Wistar Rats

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Open Journal of Applied Sciences 2024年第7期14卷 1886-1903页

作者： Waidi Adeoye Saka Yusuff Dimeji Igbayilola Jabba Hamidu lawan Taoheed Kolawole Muftaudeen Ridwanullahi Adejumo Tolulope Deborah Alu Mary Ikuomola joshua Tinuade Ojelere Victor Odufa Adegoke Department of Physiology College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Oyo State Nigeria Department of Human Physiology College of Medicine and Health Sciences Baze University Abuja Nigeria Department of Biological Sciences Faculty of Computing and Applied Sciences Baze University Abuja Nigeria

Due to its toxicity, dichlorvos—a common organophosphate pesticide—poses significant risks to human health. This study utilized male Wistar rats to explore the potential protective effects of l-arginine supplementation against dichlorvos-induced toxicity, focusing on cardiotoxicity, haematotoxicity and oxidative stress. The rats were divided into four groups: Control, l-arginine (l), Dichlorvos (D), and l-arginine + Dichlorvos (l + D). Dichlorvos was administered to the D group, l-arginine (100 mg/kg) to the l group, and both l-arginine and dichlorvos to the l + D group. The study evaluated various parameters, including cardiovascular, oxidative stress markers, and haematological indices. Significant changes in haematological parameters such as haemoglobin (Hb), haematocrit (HCT), and red blood cell count (RBC) indicated haematotoxicity after dichlorvos administration. Additionally, elevated cardiac markers, including lactate dehydrogenase (lDH) and creatine kinase-MB (CK-MB), suggested cardiotoxic effects. Exposure to dichlorvos also resulted in decreased antioxidant enzyme levels and increased oxidative stress indicators like malondialdehyde (MDA). Remarkably, l-arginine supplementation mitigated the damage caused by dichlorvos. It normalized the altered haematological parameters, demonstrating its protective effect against haematotoxicity. The rise in cardiac markers was reduced with l-arginine supplementation, indicating protection against cardiotoxicity. Moreover, l-arginine significantly decreased oxidative stress, as evidenced by lower MDA levels and restored antioxidant enzyme activity. In conclusion, l-arginine supplementation in male Wistar rats showed promising protective effects against dichlorvos-induced cardiotoxicity, haematotoxicity and oxidative stress. This suggests that l-arginine may offer a beneficial intervention to mitigate the adverse effects of dichlorvos on blood and heart health, paving the way for potential treatments for pesticide poison

关键词： Dichlorvos l-Arginine Cardiovascular Function Haematological Parameters Oxidative Stress

Common genetic variants in the TP53 pathway and their impact on cancer

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Journal of Molecular Cell Biology 2019年第7期11卷 578-585页

作者： Thibaut Barnoud joshua l.D.Parris Maureen E.Murphy Program in Molecular and Cellular Oncogenesis The Wistar InstitutePhiladelphiaPA 19104USA Cell and Molecular Biology Program Perelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA

The TP53 gene is well known to be the most frequently mutated gene in human *** addition to mutations,there are > 20 different coding region single-nucleotide polymorphisms (SNPs) in the TP53 gene,as well as SNPs in MDM2,the negative regulator of *** of these SNPs are known to alter p53 pathway *** makes p53 rather unique among cancer-critical genes,*** coding regions of other cancer-critical genes like Ha-Ras,RB,and PI3KCA do not have non-synonymous coding region SNPs that alter their function in *** next frontier in p53 biology will consist of probing which of these coding region SNPs are moderately or strongly pathogenic and whether they influence cancer risk and the efficacy of cancer *** challenge after that will consist of determining whether we can tailor chemotherapy to correct the defects for each ofthese *** we review the SNPs in TP53 and MDM2 that show the most significant impact on cancer and other *** also propose avenues for how this information can be used to better inform personalized medicine approaches to cancer and other diseases.

关键词： p53 Pro47Ser Pro72Arg PAS MDM2 SNP309

Utility of combining spectral domain optical coherence tomography structural parameters for the diagnosis of early Glaucoma: a mini-review

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Eye and Vision 2018年第1期5卷 91-101页

作者： Jean-Claude Mwanza joshua l.Warren Donald l.Budenz Department of Ophthalmology School of MedicineUniversity of North Carolina at Chapel HillChapel HillNCUSA Department of Biostatistics Yale UniversityNew HavenCTUSA

Optical coherence tomography(OCT)has moved to the forefront of imaging modalities in the management of glaucoma and retinal *** is modifying how glaucoma and glaucoma progression are diagnosed clinically and augmenting our understanding of the *** provides multiple parameters from various anatomic areas for glaucoma diagnosis,evaluation of treatment efficacy,and progression *** the use of multiple parameters has increased the likelihood of detecting early structural changes,diagnosing glaucoma in early stages is often challenging when the damages are subtle and not apparent on OCT scans,in addition to the fact that assessment of OCT parameters often yields conflicting *** promising approach is to combine multiple individual parameters into a composite parameter from the same test to improve diagnostic accuracy,sensitivity,and *** review presents current evidence regarding the value of spectral domain OCT composite parameters in diagnosing early glaucoma.

关键词： Optical coherence tomography Combination of parameters Early glaucoma