检索结果-南通市图书馆

Institutional analysis of intra-and post-operative tracheostomy management for risk reduction

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-head and Neck Surgery 2022年第4期8卷 370-377页

作者： Laura E.henry Ellen A.Paul joshua h.atkins Niels D.Martin Ara A.Chalian Christopher h.Rassekh Department of Otorhinolaryngology-head and Neck Surgery University of PennsylvaniaPhiladelphia19104PAUSA Department of Anesthesiology and Critical Care University of PennsylvaniaPhiladelphia19104PAUSA Department of Traumatology Surgical Critical Careand Emergency SurgeryUniversity of PennsylvaniaPhiladelphia19104PAUSA

Objectives:Determine variability in intra-and post-operative management of tracheostomies(trachs)at our institution as existing literature suggests that trachs are a frequent trigger for airway-related *** the development of an institution-wide protocols for trach ***:A 39-question online survey was sent to 55 providers who perform open and percutaneous trachs at three of the hospitals within our large,urban,academic medical *** providers were identified by surveillance of the operating room schedules for 1 ***:The survey was completed by 40 of the 53 eligible providers(75.5%).Response rate by question *** included members of all departments that perform trachs at our institution(Otorhinolaryngology,Trauma Surgery,Thoracic Surgery,General Surgery,Cardiovascular Surgery and Interventional Pulmonology).While most responses demonstrated uniformity in practice,notable variations included the following:80%of percutaneous trach providers stated that morbid obesity was not a contraindication to performing a trach outside of the operating room(n=20)while 58%of open trach providers stated that morbid obesity was a contraindication;only 35%of open trach providers perform a Bjork flap(n=350).The survey also identified significant variability in practice with regards to timing of trach suture ***:Lack of uniformity was identified in several practices related to intra-and post-operative tracheostomy *** did,however,trend toward consensus in many *** results are being used to establish a more consistent approach to tracheostomy management across our institution to ensure standardization of practice amidst the rapidly evolving practices of trach *** for practice:With ongoing evolution in the methods of trach placement and its management,the concepts put forth here will be a resource for health care providers at other institutions to consider intra-institutional analysis and

关键词： Open tracheostomy Percutaneous tracheostomy Quality improvement Risk reduction Standardization

Phrenic nerve block: the key to managing acute biliary pain?

在线全文

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2024年第1期15卷 62-63页

作者： Michael Shalaby joshua Luftig Department of Emergency Medicine and Critical Care Herbert Wertheim College of Medicine at Florida International UniversityMiami 33199USA Advanced Emergency Ultrasound Mount Sinai Medical CenterMiami Beach 33140USA Department of Emergency Medicine Highland HospitalAlameda Health SystemOakland 94602USA

Over the past two decades,the USA has witnessed a steep rise in the incidence of acute cholecystitis(AC),[1]even among children,[2]with over 200,000 cases annually.[3]Patients with AC often present to the emergency department(ED)experiencing severe distress,with most describing their pain level as“intolerable.”[4]Furthermore,there is usually a considerable delay before surgery,with a median time from diagnosis of AC to surgery of 28.5 h,[5]and a substantial percentage of patients wait as long as 10 d.[6]Prolonged delays before surgery lead to increased opioid use,which is associated with extended hospital stays and higher rates of readmission after cholecystectomy.[7]Furthermore,opioids can lead to vomiting,respiratory depression,delirium,and ultimately addiction.[8]We propose a novel regional anesthesia technique for managing AC:right phrenic nerve *** method could offer improved pain control and a more favorable risk profile in selected patients when compared to current ED practices.

关键词： pain anesthesia diagnosis

Obstructive sleep apnea:Overlooked comorbidity in patients with diabetes

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第7期15卷 1448-1460页

作者： Eric D Tenda joshua henrina Jin h Cha Muhammad R Triono Ersananda A Putri Dahliana J Aristy Dicky L Tahapary Division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia head of Research Group Artificial Intelligence and Digital health Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia Division of Endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked *** delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose *** research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and *** review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weight loss Positive airway pressure

Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver Research 2024年第1期8卷 46-53页

作者： joshua hefler Rena Pawlick Braulio A.Marfil-Garza Aducio Thiesen Nerea Cuesta-Gomez Sanaz hatami Darren h.Freed Constantine Karvellas David L.Bigam A.M.James Shapiro Department of Surgery Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada Department of Medicine Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada ChRISTUS-LatAm hub Excellence&Innovation Center MonterreyMexico Alberta Diabetes Institute University of AlbertaEdmontonABCanada Clinical Islet Transplant Program University of AlbertaEdmontonABCanada Department of Laboratory Medicine&Pathology Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada

Background and aim:The liver is susceptible to ischemia-reperfusion injury(IRI)during hepatic surgery,when the vessels are compressed to control bleeding,or liver transplantation,when there is an obligate period of *** hallmark of IRI comprises mitochondrial dysfunction,which generates reactive oxygen species,and cell death through necrosis or ***(CsA),which is a well-known immunosuppressive agent that inhibits calcineurin,has the additional effect of inhibiting the mito-chondrial permeability transition pore(mPTP),thereby,preventing mitochondrial swelling and ***-811,which is the nonimmunosuppressive analog of CsA,has a similar effect on the *** this study,we tested the effect of both agents on mitigating warm hepatic IRI in a murine *** and methods:Before ischemic insult,the mice were administered with intraperitoneal normal saline(control);CsA at 2.5,10,or 25 mg/kg;or NIM-811 at 10 mg/***,the mice were subjected to partial warm hepatic ischemia by selective pedicle clamping for 60 min,followed by 6 h of recovery after *** alanine transaminase(ALT)was measured,and the liver tissue was examined histologically for the presence of apoptosis and the levels of inflammatory ***:Compared with the control mice,the mice treated with 10 and 25 mg/kg of CsA and NIM-811 had significantly lower ALT levels(Phe liver tissue showed reduced histological injury scores after treatment with CsA at 2.5,10,and 25 mg/kg and NIM-811(P=0.041,h CsA at all doses(P=0.012,0.007,andhe pro-inflammatory cyto-kines,particularly interleukin(IL)-1β,IL-2,IL-4,IL-10,and keratinocyte chemoattractant/human growth-regulated oncogene significantly decreased in the mice treated with the highest dose of CsA(25 mg/kg)than those in the control ***

关键词： Cyclosporine(CsA) Cyclosporine analogue Liver surgery Ischemia-reperfusion injury(IRI) Animal model NIM-811

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 105-149页

作者： Yumin Wang Jing hu Shuang Wu joshua S.Fleishman Yulin Li Yinshi Xu Wailong Zou Jinhua Wang Yukuan Feng Jichao Chen hongquan Wang Department of Respiratory and Critical Care Medicine Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300060PR China Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430000PR China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Outpatient Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050PR China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060PR China

Ferroptosis,a unique modality of cell death with mechanistic and morphological differences from other cell death modes,plays a pivotal role in regulating tumorigenesis and offers a new opportunity for modulating anticancer drug *** epigenetic modifications and posttranslational modifications(PTMs)promote anticancer drug resistance,cancer progression,and *** studies indicate that epigenetic modifications can transcriptionally and translationally determine cancer cell vulnerability to ferroptosis and that ferroptosis functions as a driver in nervous system diseases(NSDs),cardiovascular diseases(CVDs),liver diseases,lung diseases,and kidney *** this review,we first summarize the core molecular mechanisms of ***,the roles of epigenetic processes,including histone PTMs,DNA methylation,and noncoding RNA regulation and PTMs,such as phosphorylation,ubiquitination,SUMOylation,acetylation,methylation,and ADP-ribosylation,are concisely *** roles of epigenetic modifications and PTMs in ferroptosis regulation in the genesis of diseases,including cancers,NSD,CVDs,liver diseases,lung diseases,and kidney diseases,as well as the application of epigenetic and PTM modulators in the therapy of these diseases,are then discussed in *** the mechanisms of ferroptosis regulation mediated by epigenetic modifications and PTMs in cancer and other diseases will facilitate the development of promising combination therapeutic regimens containing epigenetic or PTM-targeting agents and ferroptosis inducers that can be used to overcome chemotherapeutic resistance in cancer and could be used to prevent other *** addition,these mechanisms highlight potential therapeutic approaches to overcome chemoresistance in cancer or halt the genesis of other diseases.

关键词： diseases epigenetic overcome

Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin hou hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite hayk harutyunyan joshua R.hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D hOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D hOIPs,they can self-hybridize into E–Ps at specific thicknesses of the hOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D hOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D hOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

Metal-insulator-semiconductor(MIS) photoelectrodes: distance improves performance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2021年第8期8卷 7-8页

作者： joshua Jack Zhiyong Jason Ren Department of Civil and Environmental Engineering and the Andlinger Center for Energy and the Environment Princeton University

hydrogen（h2） is a clean energy carrier with enormous potential to support deep decarbonization towards net-zero and a circular carbon economy. however, h2production itself can be carbon and energy intensive, as 96% of global h2synthesis is currently conducted via thermochemical processes such as steam reforming and coal gasification that rely on fossil fuels [1].

关键词：

Sodium arsenite reduces severity of dextran sulfate sodium-induced ulcerative colitis in rats

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第4期9卷 341-350页

作者： joshua J. MALAGO hortensia NONDOLI Department of Pathology Faculty of Veterinary Medicine Sokoine University of Agriculture P.O. Box 3203 Morogoro Tanzania Regional Immigration Office P.O. Box 649 Mtwara Tanzania

The histopathological features and the associated clinical findings of ulcerative colitis (UC) are due to persistent inflammatory response in the colon mucosa. Interventions that suppress this response benefit UC patients. We tested whether sodium arsenite (SA) benefits rats with dextran sulfate sodium (DSS)-colitis. The DSS-colitis was induced by 5% DSS in drinking water. SA (10 mg/kg; intraperitoneally) was given 8 h before DSS treatment and then every 48 h for 3 cycles of 7, 14 or 21 d. At the end of each cycle rats were sacrificed and colon sections processed for histological examination. DSS induced diarrhea, loose stools, hemoccult positive stools, gross bleeding, loss of body weight, loss of epithelium, crypt damage, depletion of goblet cells and infiltration of inflammatory cells. The severity of these changes increased in the order of Cycles 1, 2 and 3. Treatment of rats with SA significantly reduced this severity and improved the weight gain.

关键词： Ulcerative colitis Dextran sulfate sodium Sodium arsenite Rats

Scientifically advanced woody media for improved water quality from livestock woodchip heavy-use areas

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2017年第3期11卷 35-43页

作者： Laura Christianson David DeVallance joshua Faulkner Thomas Basden Crop Sciences University of Illinois Urbana IL 61801 USA Wood Science and Technology West Virginia University Morgantown WV 26506 USA University of Vermont Extension UVM Center for Sustainable Agriculture Burlington VT 05401 USA West Virginia University Extension West Virginia University Morgantown WV 26506 USA

Overwintering cattle on pastures in many areas can damage the pasture and lead to impaired water quality. During these times, use ofa woodchip heavy-use area （hUA） presents advantages such as a soft, supportive, and dry toot surface for animals and protection of the pasture and pasture soils. however, woodchip hUAs can also be a centralized source of high nutrient loads due to their drainage outflows. A column study was conducted to assess the nutrient load reduction potential of： 1 ） six types of wood media （including torrefied wood media and biochar） that could be used in a woodchip hUA versus a gravel control, and 2） providing a 48 h retention time within the wood media to enhance nitrogen removal through denitrification. The woody media provided significant liquid waste volume reduction compared to the gravel in simulated events （53%-61% vs. 39% reductions, respectively）, and there may be additional liquid storage capacity in the woodchips not utilized during these rapid events. Substantial total nitrogen removal by the wood treatments （mean removal efficiencies 〉 50%） was observed across the sinmlated events, although nitrate leaching also occurred. Nitrate removal was enhanced during the 48 h retention test which showed removal was governed by availability of labile carbon （i.e., fresh woodchips exhibited 〉 70% nitrate removal）. The retention test also indicated biochar mixtures provided some of the best total phosphorus removal, but the greatest benefits across all parameters was provided by the Mixed hardwood treatment.

关键词： Overwinter heavy-use area Nutrient pollution Torrefied Woodchip