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hepatitis C virus treatment with glecaprevir and pibrentasvir in patients co-prescribed carbamazepine:Three case reports

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2023年第4期14卷 33-38页

作者： Michael Braude Dilip T Ratnam Louise Marsh joshua h abasszade Anouk T Dev Department of Gastroenterology and hepatology Monash HealthClayton 3168VICAustralia General Practice Margaret River Medical CentreMargaret River 6285Australia

BACKGROUND highly effective and well-tolerated direct-acting antiviral(DAA)therapies have revolutionised the management of hepatitis C virus(hCV);however,niche populations face treatment *** co-prescribed with several firstgeneration anti-epileptic drugs(AEDs)are contraindicated due to drug-drug interactions.A common example is carbamazepine whereby steady-state carbamazepine reduces the maximum concentration and area under the curve of velpatasvir,glecaprevir and pibrentasvir due to potent cytochrome P450(CYP)3A4 *** also induces P-glycoprotein which reduces glecaprevir and pibrentasvir’s area under curve to infinite *** and glecaprevir-pibrentasvir are contraindicated in patients who are co-prescribed carbamazepine due to the risk of reduced DAA therapeutic effect and consequently,virological treatment *** presents a challenge for patients in whom carbamazepine substitution is medically unfeasible,impractical or ***,the properties of current generation DAA therapies,including high-potency non-structural protein 5A inhibitory effect,may be sufficient to overcome reduced bioavailability arising from carbamazepine related CYP 3A4 and P-glycoprotein *** SUMMARY We present a case series of three patients with non-cirrhotic,treatment-naïve,genotype 1a,1b,and 3a hCV who were treated with a 12 wk course of glecaprevir-pibrentasvir,while co-prescribed carbamazepine for seizure ***-pibrentasvir combination therapy was chosen due to its potent in vitro activity and low barrier to pan-genotypic resistance associated *** therapy was dose-separated from carbamazepine to maximise time to peak concentration,and taken with meals to improve *** virological response at 12 wk was achieved in each patient with no adverse *** DAA therapies,including glecaprevir-pibrentasvir,warrant consideration as a therapeutic agent in people with hCV w

关键词： Antiepileptic drugs Drug interactions hepatitis C virus Sustained virological response health care access Case repor

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Phrenic nerve block: the key to managing acute biliary pain?

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World Journal of Emergency Medicine 2024年第1期15卷 62-63页

作者： Michael Shalaby joshua Luftig Department of Emergency Medicine and Critical Care Herbert Wertheim College of Medicine at Florida International UniversityMiami 33199USA Advanced Emergency Ultrasound Mount Sinai Medical CenterMiami Beach 33140USA Department of Emergency Medicine Highland HospitalAlameda Health SystemOakland 94602USA

Over the past two decades,the USA has witnessed a steep rise in the incidence of acute cholecystitis(AC),[1]even among children,[2]with over 200,000 cases annually.[3]Patients with AC often present to the emergency department(ED)experiencing severe distress,with most describing their pain level as“intolerable.”[4]Furthermore,there is usually a considerable delay before surgery,with a median time from diagnosis of AC to surgery of 28.5 h,[5]and a substantial percentage of patients wait as long as 10 d.[6]Prolonged delays before surgery lead to increased opioid use,which is associated with extended hospital stays and higher rates of readmission after cholecystectomy.[7]Furthermore,opioids can lead to vomiting,respiratory depression,delirium,and ultimately addiction.[8]We propose a novel regional anesthesia technique for managing AC:right phrenic nerve *** method could offer improved pain control and a more favorable risk profile in selected patients when compared to current ED practices.

关键词： pain anesthesia diagnosis

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Obstructive sleep apnea:Overlooked comorbidity in patients with diabetes

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World Journal of Diabetes 2024年第7期15卷 1448-1460页

作者： Eric D Tenda joshua henrina Jin h Cha Muhammad R Triono Ersananda A Putri Dahliana J Aristy Dicky L Tahapary Division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia head of Research Group Artificial Intelligence and Digital health Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia Division of Endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked *** delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose *** research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and *** review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weight loss Positive airway pressure

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Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

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Liver Research 2024年第1期8卷 46-53页

作者： joshua hefler Rena Pawlick Braulio A.Marfil-Garza Aducio Thiesen Nerea Cuesta-Gomez Sanaz hatami Darren h.Freed Constantine Karvellas David L.Bigam A.M.James Shapiro Department of Surgery Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada Department of Medicine Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada ChRISTUS-LatAm hub Excellence&Innovation Center MonterreyMexico Alberta Diabetes Institute University of AlbertaEdmontonABCanada Clinical Islet Transplant Program University of AlbertaEdmontonABCanada Department of Laboratory Medicine&Pathology Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada

Background and aim:The liver is susceptible to ischemia-reperfusion injury(IRI)during hepatic surgery,when the vessels are compressed to control bleeding,or liver transplantation,when there is an obligate period of *** hallmark of IRI comprises mitochondrial dysfunction,which generates reactive oxygen species,and cell death through necrosis or ***(CsA),which is a well-known immunosuppressive agent that inhibits calcineurin,has the additional effect of inhibiting the mito-chondrial permeability transition pore(mPTP),thereby,preventing mitochondrial swelling and ***-811,which is the nonimmunosuppressive analog of CsA,has a similar effect on the *** this study,we tested the effect of both agents on mitigating warm hepatic IRI in a murine *** and methods:Before ischemic insult,the mice were administered with intraperitoneal normal saline(control);CsA at 2.5,10,or 25 mg/kg;or NIM-811 at 10 mg/***,the mice were subjected to partial warm hepatic ischemia by selective pedicle clamping for 60 min,followed by 6 h of recovery after *** alanine transaminase(ALT)was measured,and the liver tissue was examined histologically for the presence of apoptosis and the levels of inflammatory ***:Compared with the control mice,the mice treated with 10 and 25 mg/kg of CsA and NIM-811 had significantly lower ALT levels(Phe liver tissue showed reduced histological injury scores after treatment with CsA at 2.5,10,and 25 mg/kg and NIM-811(P=0.041,h CsA at all doses(P=0.012,0.007,andhe pro-inflammatory cyto-kines,particularly interleukin(IL)-1β,IL-2,IL-4,IL-10,and keratinocyte chemoattractant/human growth-regulated oncogene significantly decreased in the mice treated with the highest dose of CsA(25 mg/kg)than those in the control ***

关键词： Cyclosporine(CsA) Cyclosporine analogue Liver surgery Ischemia-reperfusion injury(IRI) Animal model NIM-811

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Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

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Signal Transduction and Targeted Therapy 2024年第1期9卷 105-149页

作者： Yumin Wang Jing hu Shuang Wu joshua S.Fleishman Yulin Li Yinshi Xu Wailong Zou Jinhua Wang Yukuan Feng Jichao Chen hongquan Wang Department of Respiratory and Critical Care Medicine Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300060PR China Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430000PR China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Outpatient Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050PR China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060PR China

Ferroptosis,a unique modality of cell death with mechanistic and morphological differences from other cell death modes,plays a pivotal role in regulating tumorigenesis and offers a new opportunity for modulating anticancer drug *** epigenetic modifications and posttranslational modifications(PTMs)promote anticancer drug resistance,cancer progression,and *** studies indicate that epigenetic modifications can transcriptionally and translationally determine cancer cell vulnerability to ferroptosis and that ferroptosis functions as a driver in nervous system diseases(NSDs),cardiovascular diseases(CVDs),liver diseases,lung diseases,and kidney *** this review,we first summarize the core molecular mechanisms of ***,the roles of epigenetic processes,including histone PTMs,DNA methylation,and noncoding RNA regulation and PTMs,such as phosphorylation,ubiquitination,SUMOylation,acetylation,methylation,and ADP-ribosylation,are concisely *** roles of epigenetic modifications and PTMs in ferroptosis regulation in the genesis of diseases,including cancers,NSD,CVDs,liver diseases,lung diseases,and kidney diseases,as well as the application of epigenetic and PTM modulators in the therapy of these diseases,are then discussed in *** the mechanisms of ferroptosis regulation mediated by epigenetic modifications and PTMs in cancer and other diseases will facilitate the development of promising combination therapeutic regimens containing epigenetic or PTM-targeting agents and ferroptosis inducers that can be used to overcome chemotherapeutic resistance in cancer and could be used to prevent other *** addition,these mechanisms highlight potential therapeutic approaches to overcome chemoresistance in cancer or halt the genesis of other diseases.

关键词： diseases epigenetic overcome

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin hou hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite hayk harutyunyan joshua R.hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D hOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D hOIPs,they can self-hybridize into E–Ps at specific thicknesses of the hOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D hOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D hOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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Emerging roles of circular RNAs in retinal diseases

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Neural Regeneration Research 2022年第9期17卷 1875-1880页

作者： Aneliya hanineva Karen Sophia Park joshua J.Wang Margaret M.DeAngelis Michael h.Farkas Sarah X.Zhang Department of Ophthalmology and Ross Eye Institute Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA Research Service Veterans Administration Western New York Healthcare SystemBuffaloNYUSA Department of Biochemistry Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA

Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the *** research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal *** this review,we explore a relatively new field of research involving circular RNAs,whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just *** knowledge of circular RNAs function is limited given its novelty,current evidence has highlighted their roles as modulators of microRNAs,regulators of gene transcription,and biomarkers of disease development and ***,we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy,glaucoma,proliferative vitreoretinopathy,and age-related macular ***,we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases.

关键词： age-related macular degeneration circular RNA diabetic retinopathy glaucoma microRNA proliferative vitreoretinopathy retina

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Nanostructure and thermal power of highly-textured and single-crystal-like Bi_(2)Te_(3) thin films

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Nano Research 2022年第3期15卷 2382-2390页

作者： heng Zhang Jamo Momand joshua Levinsky Qikai Guo Xiaotian Zhu Gert h ten Brink Graeme R.Blake George Palasantzas Bart J.Kooi Zernike Institute for Advanced Materials University of GroningenNijenborgh 49747 AG GroningenThe Netherlands

Bi_(2)Te_(3)-based alloys are known to have outstanding thermoelectric *** structure–property relations have been studied,still,detailed analysis of the atomic and nano-scale structure of Bi_(2)Te_(3)thin film in relation to their thermoelectric properties remains poorly ***,highly-textured(hT)and single-crystal-like(SCL)Bi_(2)Te_(3)films have been grown using pulsed laser deposition(PLD)on Si wafer covered with(native or thermal)SiOx and mica *** films are highly textured with c-axis out-of-plane,but the in-plane orientation is random for the films grown on oxide and single-crystal-like for the ones grown on *** power factor of the film on thermal oxide is about four times higher(56.8μW·cm^(−1)·K^(−2))than that of the film on mica(12.8μW·cm^(−1)·K^(−2)),which is comparable to the one of the polycrystalline ingot at room temperature(RT).Reduced electron scattering in the textured thin films results in high electrical conductivity,where the SCL film shows the highest ***,its Seebeck coefficient shows a low *** measured properties are correlated with the atomic structure details unveiled by scanning transmission electron *** instance,the high concentration of stacking defects observed in the hT film is considered responsible for the increase of Seebeck coefficient compared to the SCL *** study demonstrates the influence of nanoscale structural effects on thermoelectric properties,which sheds light on tailoring thermoelectric thin films towards high performance.

关键词： Bi_(2)Te_(3)films highly-textured structure single-crystal-like structure thermoelectric properties pulsed laser deposition

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Picomolar antimalarial agent from a Chinese medicinal plant

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Science China Chemistry 2022年第1期65卷 82-86页

作者： Bin Zhou Flavia M.Zimbres joshua h.Butler Cheng-hui Xu Reagan S.haney Yan Wu Maria B.Cassera Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Biochemistry and Molecular Biology Center for Tropical and Emerging Global Diseases(CTEGD)University of GeorgiaAthensGeorgia 30602United States

In our long-term efforts searching for antimalarial agents from Chinese medicinal plants,seven novel dimeric sesquiterpenoids(1–7)with significant antimalarial activity were isolated and characterized from the whole plants of Sarcandra glabra *** by solid data acquired by diverse *** them,compound 3 with an EC50 value of 4.3 pM against the chloroquine-resistant Plasmodium falciparum is the most potent antimalarial agent reported hitherto,about 1,000-fold stronger than *** article further consolidates and refines our previously delineated structure-activity relationship for this antimalarial compound class.

关键词： medicinal plants dimeric sesquiterpenoids antimalarial agent structure-activity relationship

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Nah doped TiO_(2)as a high-performance catalyst for Mg/Mgh_(2)cycling stability and room temperature absorption

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Journal of Magnesium and Alloys 2023年第8期11卷 2740-2749页

作者： joshua Adedeji Bolarin Zhao Zhang hujun Cao Zhi Li Teng he Ping Chen Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianP.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Shangdong Energy Group Co. LTD.No.10777Jingshi RoadJinan CityShandong Province250014P.R.China School of Material Science and Engineering Xi'an Jiaotong UniversityXi'anShaanxi Province710049P.R.China

This paper presents the catalytic effect of Nah doped nanocrystalline TiO_(2)(designated as NaTiOxh)in the improvement of Mgh_(2)hydrogen storage *** catalyst preparation involves ball milling Nah with TiO_(2)for 3 *** addition of 5 wt%NaTiOxh powder into Mgh_(2)reduces its operating temperature to∼185℃,which is∼110℃lower than the additive-free as-milled Mgh_(2).The composite remarkably desorbs∼7.2 wt%h_(2)within 15 min at∼290℃and reabsorbs∼4.5 wt%h_(2)in 45 min at room temperature under 50 bar h_(2).Mgh_(2)dehydrogenation is activated at 57 kJ/mol by the *** importantly,the addition of 2.5 wt%NaTiOxh catalyst aids Mgh_(2)to reversibly produce∼6.1 wt%h_(2)upon 100 cycles within 475 hr at 300℃.Microstructural investigation into the catalyzed Mgh_(2)composite reveals a firm contact existing between NaTiOxh and Mgh_(2)***,the NaTiOxh catalyst consists of catalytically active Ti_(3)O_(5),and“rod-like”Na_(2)Ti_(3)O_(7)species liberated in-situ during preparation;these active species could provide multiple hydrogen diffusion pathways for an improved Mgh_(2)sorption ***,the elemental characterization identifies the reduced valence states of titanium(Tihich show some sort of reversibility consistent with h_(2)insertion and *** phenomenon is believed to enhance the mobility of Mg/Mgh_(2)electrons by the creation and elimination of oxygen vacancies in the defective(TiO_(2-x))*** findings have therefore moved Mgh_(2)closer to practical applications.

关键词： Magnesium hydride Nah doped nanocrystalline TiO_(2) Kinetics Room temperature absorption Reversibility

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