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Modeling Alzheimer's disease:considerations for a better translational and replicable mouse model

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Neural Regeneration Research 2022年第11期17卷 2448-2449页

作者： joshua D.Cho Mu Yang Ismael Santa-Maria Taub Institute for Research on Alzheimer's Disease and the Aging Brain Department of Pathology&Cell BiologyColumbia University The Mouse NeuroBehavior Core.Institute for Genomic Medicine Columbia University

Alzheimer's disease (AD) mouse models have proven to be an invaluable tool for deepening our understanding of disease mechanisms and for developing ***,one common frustration is the lack of replicability in behavioral *** we have discussed in our recent publication (Cho et al.,2021),in the htau mouse model,the cognitive impairment reported in the original study has not been consistently replicated by different labs over the past *** variability in behavioral findings seems to exist in many,if not all,AD mouse models that have been behaviorally evaluated.

关键词： Alzheimer tau

Democratizing photogrammetry:an accuracy perspective

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Geo-Spatial Information Science 2023年第2期26卷 175-188页

作者： Jie Shan Zhixin Li Damon Lercel Kevan Tissue Joseph Hupy joshua Carpenter School of Civil Engineering Purdue UniversityWest LafayetteINUSA School of Aviation and Transportation Technology Purdue UniversityWest LafayetteINUSA

Photogrammetry is experiencing an era of democratization mostly due to the popularity and availability of many commercial off-the-shelf devices,such as drones and *** are used as the most convenient and effective tools for high-resolution image acquisition for a wide range of applications in science,engineering,management,and cultural ***,the quality,particularly the geometric accuracy,of the outcomes from such consumer sensors is still ***,the expected quality under different control schemes has yet to be thoroughly *** paper intends to answer those questions with a comprehensive comparative ***,in particular,structure from motion,has been used to reconstruct a 3D building model from smartphone and consumer drone images,as well as from professional drone images,all under various ground control *** from this study show that the positioning accuracy of smartphone images under direct geo-referencing is 165.4 cm,however,this could be improved to 43.3 cm and 14.5 cm when introducing aerial lidar data and total station surveys as ground control,*** results are found for consumer drone images as *** comparison,this study shows the use of the professional drone is able to achieve a positioning accuracy of 3.7 ***,we demonstrate that through the combined use of drone and smartphone images we are able to obtain full coverage of the entire target with a 2.3 cm positioning *** study concludes that smartphone images can achieve an accuracy equivalent to consumer drone images and can be used as the primary data source for building facade data collection.

关键词： Drone smartphone photogrammetry Structure from Motion(SfM) aero triangulation point clouds

Factors affecting the seismic behavior of segmental precast bridge columns

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Frontiers of Structural and Civil Engineering 2014年第4期8卷 388-398页

作者： Haitham DAWOOD Mohamed ELGAWADY joshua HEWES Virginia Polytechnic Institute and State University Blacksburg VA 24061-0002 USA Department of Civil Architectural and Environmental Engineering Missouri University of Science and Technology Rolla MO65409 USA Department of Civil and Environmental Engineering Northern Arizona University Flagstaff AZ 86011 USA

This manuscript discusses the design parameters that potentially affect the lateral seismic response of segmental precast post-tensioned bridge piers. The piers consist ofprecast circular cross section segments stacked one on top of the other with concentric tendons passing through ducts made in the segments during casting. The bottommost segments of the piers were encased in steel tubes to enhance ductility and minimize damage. An FE model was used to investigate different design parameters and how they influence the lateral force - displacement response of the piers. Design parameters investigated included the initial post-tensioning stress as a percentage of the tendon yield stress, the applied axial stresses on concrete due to post-tensioning, pier aspect ratios, construction details, steel tube thicknesses, and internal mild steel rebar added as energy dissipaters. Based on the data presented, an initial tendon stress in the range of 40%-60% of its yield stress and initial axial stress on concrete of approximately 20% of the concrete＇s characteristic strength is appropriate for most typical designs. These design values will prevent tendon yielding until lateral drift angle reaches approximately 4.5%. Changing the steel tube thickness, height, or a combination of both proved to be an effective parameter that may be used to reach a target performance level at a specific seismic zone.

关键词： finite element analysis concrete precast units bridges

Generative Neural Network Based Spectrum Sharing Using Linear Sum Assignment Problems

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China Communications 2020年第2期17卷 14-29页

作者： Ahmed BZaky joshua Zhexue Huang Kaishun Wu Basem MElHalawany Big Data Institute Shenzhen University518060China Benha University Benha13511Egypt Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ) Shenzhen UniversityShenzhen 518060China PCL Research Center of Networks and Communications Peng Cheng LaboratoryShenzhen 518060China

Spectrum management and resource allocation(RA)problems are challenging and critical in a vast number of research areas such as wireless communications and computer *** traditional approaches for solving such problems usually consume time and memory,especially for large-size *** different machine learning approaches have been considered as potential promising techniques for combinatorial optimization problems,especially the generative model of the deep neural *** this work,we propose a resource allocation deep autoencoder network,as one of the promising generative models,for enabling spectrum sharing in underlay device-to-device(D2D)communication by solving linear sum assignment problems(LSAPs).Specifically,we investigate the performance of three different architectures for the conditional variational autoencoders(CVAE).The three proposed architecture are the convolutional neural network(CVAECNN)autoencoder,the feed-forward neural network(CVAE-FNN)autoencoder,and the hybrid(H-CVAE)*** simulation results show that the proposed approach could be used as a replacement of the conventional RA techniques,such as the Hungarian algorithm,due to its ability to find solutions of LASPs of different sizes with high accuracy and very fast execution ***,the simulation results reveal that the accuracy of the proposed hybrid autoencoder architecture outperforms the other proposed architectures and the state-of-the-art DNN techniques.

关键词： autoencoder linear sum assignment problems generative models resource allocation

Effects of Enhanced UV-B Radiation and O3Stress on Physiological Characteristic of Winter Wheat Separately and in Combination

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Effects of Enhanced UV-B Radiation and O3Stress on Physiolog...

作者： joshua Appoh 南京信息工程大学

学位级别：硕士

Open-top chamber experiment with field-grown winter wheat （Triticum aestevum L） was conducted from6th March to20th May2010, at the Agro-meteorology Experiment Station of Nanjing University of Information Science and Technology. This was to access the single and the integrated effect of enhance UV-B radiation and ozone stress on the physiological characteristics of winter wheat. Darkening treatments and removing leaves methods were used to analyze contribution rate of different green organs to yield after flowering. Winter wheat was treated with enhanced UV-B radiation and ozone,8hours per day （9:00-17:00）, for a total of50d. Before fumigation, O3concentration around OTC （field） was detected by EC-9810（B） Ozone Monitoring Instrument for about11days （from9:00to17:00, the instrument automatically read a data every5min）. The result show that03concentrations was8.19-63.8n1·L-1, and8h average concentration was35.27nl· L-1. Enhanced UV-B and O3reduced chlorophyll of the flag leaf and the green organs, carotenoid and the gas exchange whereas the intercellular CO2concentration （Ci） changed slightly. The contents of Malondialdehyde, flavonoid, relative conductance increased due to UV-B and ozone treatment. The interactive effects were however, less than additive. The darkening treatment generally increased the chlorophyll contents but not much significant. Assessment of the yield characteristics at the final harvest showed that ozone and UV-d induced decreased the number of grain per ear, the weight of the ear stem and root and1000-grain weight. Generally the1000-grain weight and the grain weight per ear almost declined as a result of the removal of the flag leaf and the darkening of the green organs in the various chambers. The distribution of the dry matter of the ear under the flag leaf removal and the darkened treatments on the other hand decreased with an exception of the darkened sheath where increase occurred in most chambers whiles the proportion of the dry matter dis

关键词：光合作用叶绿素 UV-B辐射冬小麦生理特性

A perspective on environmental sustainability in the cement industry

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Waste Disposal and Sustainable Energy 2020年第3期2卷 161-164页

作者： joshua O.Ighalo Adewale George Adeniyi Department of Chemical Engineering Faculty of Engineering and TechnologyUniversity of IlorinIlorin P.M.B.1515Nigeria

Cement production is a major contributor to anthropogenic CO_(2) emissions and solid waste *** paper discusses some of the key issues as regards the slow progress in achieving environmental sustainability in the cement ***-niques such as carbon capture and storage(CCS),material substitution,alternative fuels and energy efficient technologies have been proposed as means of mitigating the negative environmental impact of cement *** was observed that much progress has been made in the area of eco-friendly research *** innovations(considered as disruptive by the mega co-operations)have had issues at the entrepreneurial *** so-called disruptive technologies have strug-gled to meet some performance requirements and satisfy funding evaluators thus are still difficult to fully *** systematisation of the environmental sustainability problem was discussed as a possible way forward both in the environ-mental,economic and social *** into the future,a greater emphasis on systematised decision-based approach could help breach the gap between on-paper plans and practical implementations to achieve environmental sustainability.

关键词： Cement Environment Waste Global warming Pollution Sustainability

Potential of vesicular stomatitis virus as an oncolytic therapy for recurrent and drug-resistant ovarian cancer

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Chinese Journal of Cancer 2011年第12期30卷 805-814页

作者： joshua F. Heiber Glen N. Barber Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine Sylvester Comprehensive Cancer Center Universityof Miami Miller School of Medicine

In the last decade, we have gained significant understanding of the mechanism by which vesicular stomatitis virus (VSV) specifically kills cancer cells. Dysregulation of translation and defective innate immunity are both thought to contribute to VSV oncolysis. Safety and efficacy are important objectives to consider in evaluating VSV as a therapy for malignant disease. Ongoing efforts may enable VSV virotherapy to be considered in the near future to treat drug-resistant ovarian cancer when other options have been exhausted. In this article, we review the development of VSV as a potential therapeutic approach for recurrent or drug-resistant ovarian cancer.

关键词：水泡性口炎病毒卵巢癌耐药性治疗 VSV 免疫缺陷癌细胞安全性

Design Method of FRP in Structures with Problem of Durability

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Design Method of FRP in Structures with Problem of Durabilit...

作者： Ayande joshua 海南大学

学位级别：硕士

纤维增强聚合物(FRP)棒材在结构混凝土中的应用因其与钢材相比具有重量轻、比强度高和刚性等诸多优点而获得认可。然而,与钢筋相比,FRP钢筋的较低弹性模量及其线性应力-应变行为往往导致脆性。为了应对这些挑战并提高FRP钢筋在混凝土结... 详细信息

纤维增强聚合物(FRP)棒材在结构混凝土中的应用因其与钢材相比具有重量轻、比强度高和刚性等诸多优点而获得认可。然而,与钢筋相比,FRP钢筋的较低弹性模量及其线性应力-应变行为往往导致脆性。为了应对这些挑战并提高FRP钢筋在混凝土结构中的性能,研究人员提出在混凝土结构中使用钢纤维钢筋混凝土(SFCB),它结合了FRP和钢筋的性能。然而,研究这种相对较新的增强材料的耐久性至关重要。这些复合材料在结构的整个使用寿命中所承受的持续应力会导致蠕变破裂而失效,即使在远低于瞬态静载荷的载荷下也是如此。在本研究中,选择了加载安排和测试方法。通过对试样施加恒定载荷(极限强度的28%和40%,0.4ffu),在高温(60°C)和标称温度(32°c)下检查了玻璃钢复合棒的蠕变性能。测试程序遵循美国混凝土协会(ACI)标准中概述的指导方针。这些测试的重点是研究材料在短时间内承受持续载荷后的抗拉强度保持性。使用50万小时半对数图分析强度降低。试样在指定温度下以0.28fu的恒定载荷暴露1000小时,其拉伸强度从77.47降至62KN,损失为20%。然而,当试样加载100小时和0.28ffu和0.4fu时,强度值分别下降了10%和13%。同样,在相同条件下暴露于0.4fu的试样显示拉伸强度降低至56.66kn,表明损失27%。很明显,连续载荷的大小是决定这种材料残余强度的关键因素。当SFCB材料在60°C下承受1000小时极限强度的28%时,强度下降幅度为59.65kn,相当于损失23%;当SFCB材料在60°C下承受最大容量40%的持续载荷1000小时时,强度下降幅度为55.1kn(30%)。然后讨论了获得的机械特性,为其长期性能提供了有价值的见解。除了研究材料的拉伸和蠕变行为外,还讨论了理论方法。研究结果有助于制定设计指南和预测模型,确保SFCB棒材的可靠和安全使用。最终,这些努力的目的是提高钢筋混凝土结构的整体性能和寿命使用钢-FRP基础加固系统。

关键词：纤维增强聚合物力学性能钢纤维复合棒蠕变行为耐久性

Geographic patterns of plant-herbivore interactions are driven by soil fertility

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Journal of Plant Ecology 2019年第4期12卷 653-661页

作者： joshua S.Lynn Jason D.Fridley Department of Biology Syracuse UniversitySyracuseNY 13244USA Department of Biology University of New MexicoAlbuquerqueNM 87131USA

Aims Geographic patterns of the intensity of plant herbivory in relation to climate factors have garnered little general support and appear to be species ***,plant-herbivore interactions are also driven by resource availability,such as soil nutrient content,and it remains unclear whether broad-scale variation in soil factors is reflected in herbivore consumption rates across species’***,we know little of how intraspecific variation in tissue quality associates with edaphic and climatic factors,and how this variation controls herbivore *** resource availability hypothesis(RAH)predicts that plant individuals growing in low-resource environments will have lower leaf nutritional quality and more constitutive defenses,which will result in lower rates of leaf *** We collected leaves from the old-field dominant species,Solidago altissima L.,from 20 sites across 10 degrees of latitude in the Eastern USA to determine the percentage leaf area consumed by insect *** obtained soil and climate data for each site,as well as plant functional and defensive traits,including specific leaf area(SLA),leaf carbon:nitrogen(C:N),and trichome *** Findings Although we found no significant latitudinal trend of leaf consump-tion rate,there was strong evidence that leaf herbivory decreased with leaf C:N and trichome density,which themselves decreased with soil N,supporting our hypothesis that the RAH applies for intraspecific variation across spatial ***,high precipitation seasonality and soil nitrogen predicted decreased *** results suggest that spatial variation in herbivory can be driven by factors other than herbivore communities and climatic gradients,and that bottom-up processes,where plant traits and soil fertility control leaf consumption,must be incorporated into spatial predictions of herbivory.

关键词： biogeography bottom-up controls old fields plant-insect interactions plant functional and defense traits