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Emergent reintubation following elective cervical surgery:A case series

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World Journal of Orthopedics 2017年第6期8卷 465-470页

作者： joshua Schroeder Stephan N Salzmann Alexander P Hughes James D beckman Jennifer Shue Federico P Girardi Spine Service Hospital for Special Surgery

AIM To review cases of emergent reintubation after cervical *** Patients who were emergently intubated in the postoperative period following cervical surgery were identified. The patients' prospectively documented demographic parameters, medical history and clinical symptoms were ascertained. Pre-operative radiographs were examined for the extent of their pathology. The details of the operative procedure were *** Eight hundred and eighty patients received anterioror combined anterior-posterior cervical surgery from 2008-2013. Nine patients(1.02%) required emergent reintubation. The interval between extubation to reintubation was 6.2 h [1-12]. Patients were kept intubated after reintubation for 2.3 d [2-3]. Seven patients displayed moderate postoperative edema. One patient was diagnosed with a compressive hematoma whichwas subsequently evacuated in the OR. Another patient was diagnosed with a pulmonary effusion and treated with diuretics. One patient received a late debridement for an infected hematoma. Six patients reported residual symptoms and three patients made a complete recovery. CONCLUSION Respiratory compromise is a rare but potentially life threatening complication following cervical surgery. Patients at increased risk should be monitored closely for extended periods of time post-operatively. If the airway is restored adequately in a timely manner through emergent re-intubation, the outcome of the patients is generally favorable.

关键词： Cervical surgery Complication Airway compromise Reintubation Hematoma

ACC／AHA2006年非心脏手术围手术期心血管评估指南更新：关于围手术期β-受体阻滞剂使用的专题更新--美国心脏病学会／美国心脏协会医疗指南工作组报告（非心脏手术围手术期心血管评估2002指南更新编写委员会）

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麻醉与镇痛 2008年第1期4卷 2-10页

作者： Lee A. Fleisher, MD, FACC joshua A. beckman, MD, FACC Kenneth A. Brown, MD, FACC, FAHA Hugh Calkins, MD, FACC, FAHA EUiott L. Chaikof, MD, PhD Kirsten E. Fleischmann, MD, MPH, FACC William K. Freeman, MD, FAC James B. Froehlich, MD, MPH, FACC Edward K. Kasper, MD, FACC Judy K Kersten, MD, FACC Barbara Riegel, DNSc, RN, FAHA John F. Robb, MD, FACC 李恒(译) 阎哲(译) 杨承祥(校) Society for Vascular Medicine and Biology Official Representative American Society of Nuclear Cardiology Official Representative Heart Rhythm Society Official Representative Society for Vascular Surgery Official Representative American Society of Echocardiography Official Representative Society of Cardiovascular Anesthesiologists Official Representative Society for Cardiovascular Angiography and Interventions Official Representative 不详

美国心脏病学会／美国心脏协会（ACC／AHA）医疗指南工作组尽力避免因编写委员会成员与企业的关系或个人利益而导致的任何实际的、可能的，或者是已发现的利益冲突。编写委员会的所有成员以及本文件的同行评议人必须对可能被视为是实际... 详细信息

美国心脏病学会／美国心脏协会（ACC／AHA）医疗指南工作组尽力避免因编写委员会成员与企业的关系或个人利益而导致的任何实际的、可能的，或者是已发现的利益冲突。编写委员会的所有成员以及本文件的同行评议人必须对可能被视为是实际上或是潜在的利益冲突进行声明。工作组对以上声明进行审查。在每次会议上，这些声明必须口头汇报给编写委员会的每位成员；当发生变动时，编写委员会对声明进行更新并再次核查。编写委员会成员和企业的关系见附表1，同行评议人与企业的关系见附表2。本指南旨在确定在大多数情形下满足大部分患者需求的方案。指南反映了对当前可获得的科学文献进行系统分析后专家们达成的共识，其目的在于提高医疗质量。如果将指南用于管理／投资决策，其终极目标应是医疗质量得到提高并服务于患者。关于具体患者的医疗问题，必须由医疗人员和患者根据具体情况共同做出最终决定。Sidney C Smith，Jr．，MD，FACC，FAHA ACC／AHA医疗指南工作组主席Elliot ***，MD，FACC，FAHA

关键词： ACC/AHA 美国心脏病学会美国心脏协会医疗指南 β-受体阻滞剂委员会工作组非心脏手术

An epigenetic perspective on the failing heart and pluripotent-derived-cardiomyocytes for cell replacement therapy

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Frontiers in Biology 2015年第1期10卷 11-27页

作者： joshua D. TOMPKINS Arthur D. RIGGS Department of Diabetes and Metabolic Disease Research Beckman Research Institute/City of Hope National Medical Center 1500 E DuarteRoad Duarte CA 91010 USA

As life expectancy rises, the prevalence of heart failure is steadily increasing, while donors for organ transplantation remain in short supply （Zwi-Dantsis and Gepstein, 2012）. Indeed, myocardial infarction represents the foremost cause of death within industrialized nations （Henning, 2011） and further, approximately 1% of all newborns harbor a congenital heart defect. Although medical interventions allow 〉 80% of those with cardiac defects to survive to adulthood, there are often extreme emotional and financial burdens that accompany such congenital anomalies, and many individuals will remain at a heightened risk for myocardial infarction throughout the remainder of their lives （Verheugt et al., 2010; Amianto et al., 2011）. In this review, we will discuss the nature of the failing heart and strategies for repair from an epigenetic standpoint. Significant focus will reside on pluripotent-to-cardiomyocyte differentiation for cell replacement, epigenetic mechanisms of cardiomyocyte differentiation, epigenetic ＂memories,＂ and epigenetic control of cardiomyocyte cell fate toward translational utility.

关键词： heart failure pluripotent cardiomyocytes epigenetics DNA methylation lncRNA

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激光辅助扫描隧道显微镜对纳米碳管的研究

激光辅助扫描隧道显微镜对纳米碳管的研究