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Energy & Environmental Materials 2024年第3期7卷 282-290页

作者： Ai Lan Yiqun Li Huiwen zhu Jintao zhu Hong Lu Hainam Do Yifan Lv yonghua Chen Zhikuan Chen Fei Chen Wei Huang School of Flexible Electronics(Future Technologies)and Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 210009China Department of Chemical and Environmental Engineering University of Nottingham Ningbo ChinaNingbo 315000China Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics(IFE)and Xi'an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

The interfacial contacts between the electron transporting layers(ETLs)and the photoactive layers are crucial to device performance and stability for OSCs with inverted ***,atomic layer deposition(ALD)fabricated ultrathin Al_(2)O_(3)layers are applied to modify the ETLs/active blends(PM6:BTP-BO-4F)interfaces of OSCs,thus improving device *** ALD-Al_(2)O_(3)thin layers on ZnO significantly improved its surface morphology,which led to the decreased work function of ZnO and reduced recombination losses in *** simultaneous increase in open-circuit voltage(V_(OC)),short-circuit current density(J_(SC))and fill factor(FF)were achieved for the OSCs incorporated with ALD-Al_(2)O_(3)interlayers of a certain thickness,which produced a maximum PCE of 16.61%.Moreover,the ALD-Al_(2)O_(3)interlayers had significantly enhanced device stability by suppressing degradation of the photoactive layers induced by the photocatalytic activity of ZnO and passivating surface defects of ZnO that may play the role of active sites for the adsorption of oxygen and moisture.

关键词： atomic layer deposition interface modification organic solar cells stability

Cardiovascular risk burden,dementia risk and brain structural imaging markers:a study from UK Biobank

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General Psychiatry 2024年第1期37卷 94-102页

作者： Yaying Cao Gaohong zhu Chengwu Feng Jing Chen Wei Gan Yuan Ma yonghua Hu Klodian Dhana Trudy Voortman Jie Shen Ting Li Yan Zheng Changzheng Yuan Geng Zong Department of Food Nutrition and Health School of Medicine and HealthHarbin Institute of TechnologyHarbinHeilongjiangChina CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Department of Nuclear Medicine First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Neurology Department Zhongshan Hospital Affliated with Fudan UniversityShanghaiChina Medical Research Council Population Health Research Unit University of OxfordOxfordUK Department of Genetics Novo Nordisk Research Centre OxfordOxfordUK Harvard University T H Chan School of Public Health BostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Internal Medicine Rush University Medical CenterChicagolinoisUSA Department of Epidemiology rasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands Division of Human Nutrition and Health Wageningen University&ResearchWageningenThe Netherlands School of Public Health the Second Afliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina First Afiliated Hospital of Kunming Medical University KunmingYunnanChina State Key Laboratory of Genetic Engineering School f ife SCciencesFudan UniversityShanghaiChina Ministry of Education Key Laboratory of Public Health Safety School of Public HealthFudan UniversityShanghaiChina The Key Laboratory of Inteligent Preventive Medicine of Zhejang Province HangzhouZhejiangChina Shanghai Jiao Tong University Affiliated Sixth People's Hospital ShanghaiChina

Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains *** To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample,and to explore the role of genetics and CVD *** A prospective study among 354 654 participants free of CVD and dementia(2006-2010,mean age 56.4 years)was conducted within the UK Biobank,with brain magnetic resonance imaging(MRl)measurement availablefor 15104participants since *** risk burden was evaluated by the Framingham General Cardiovascular Risk Score(FGCRS).Dementia diagnosis was ascertained from inpatient and death register *** Overamedian 12.0-yearfollow-up,3998 all-cause dementia cases were *** FGCRS was associated with increasedall-cause dementia risk after adjusting for demographic,major lifestyle,clinical factors and the polygenic risk score(PRS)of Alzheimer's *** the high versus low tertile of FGCRS,the odds ratios(ORs)and 95%confidence intervals(Cls)were 1.26(1.12 to 1.41)for all-cause dementia,1.67(1.33 to 2.09)for Alzheimer's disease and 1.53(1.07 to 2.16)for vascular dementia(all p_(treng)<0.05).Incident stroke and coronary heart disease accounted for 14%(95%Cl:9% to 21%)of the association between FGCRS and all-cause *** were not detected for FGCRS and PRS on the risk of any dementia *** observed an 83%(95%Cl:47%to 128%)higher all-cause dementia risk comparing the high-high versus low-low FGCRS-PRS *** brain volumes,higher FGCRS was associated with greater log-transformed white matter hyperintensities,smaller cortical volume and smaller grey matter *** Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes.T

关键词： Cardiovascular diagnosis burden

Hierarchical learning of gastric cancer molecular subtypes by integrating multi-modal DNA-level omics data and clinical stratification

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Quantitative Biology 2024年第2期12卷 182-196页

作者： Binyu Yang Siying Liu Jiemin Xie Xi Tang Pan Guan Yifan zhu Xuemei Liu Yunhui Xiong Zuli Yang Weiyao Li yonghua Wang Wen Chen Qingjiao Li Li C.Xia Department of Statistics and Financial Mathematics School of MathematicsSouth China University of TechnologyGuangzhouChina School of Physics and Optoelectronics South China University of TechnologyGuangzhouChina Department of Pathology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina Department of Laboratory Medicine the Eighth Affiliated HospitalSun Yat-sen UniversityShenzhenChina

Molecular subtyping of gastric cancer(GC)aims to comprehend its genetic ***,the efficacy of current subtyping methods is hampered by their mixed use of molecular features,a lack of strategy optimization,and the limited availability of public GC *** is a pressing need for a precise and easily adoptable subtyping approach for early DNA-based screening and *** on TCGA subtypes,we developed a novel DNA-based hierarchical classifier for gastric cancer molecular subtyping(HCG),which employs gene mutations,copy number aberrations,and methylation patterns as *** incorporating the closely related esophageal adenocarcinomas dataset,we expanded the TCGA GC dataset for the training and testing of HCG(n=453).The optimization of HCG was achieved through three hierarchical strategies using Lasso-Logistic regression,evaluated by their overall the area under receiver operating characteristic curve(auROC),accuracy,F1 score,the area under precision-recall curve(auPRC)and their capability for clinical stratification using multivariate survival ***-specific DNA alteration biomarkers were discerned through difference tests based on HCG defined *** HCG classifier demonstrated superior performance in terms of overall auROC(0.95),accuracy(0.88),F1 score(0.87)and auPRC(0.86),significantly improving the clinical stratification of patients(overall p-value=0.032).Difference tests identified 25 subtype-specific DNA alterations,including a high mutation rate in the SYNE1,ITGB4,and COL22A1 genes for the MSI subtype,and hypermethylation of ALS2CL,KIAA0406,and RPRD1B genes for the EBV *** is an accurate and robust classifier for DNA-based GC molecular subtyping with highly predictive clinical stratification *** training and test datasets,along with the analysis programs of HCG,are accessible on the GitHub website(***/LabxSCUT).

关键词： DNA alterations gastric cancer hierarchical classification molecular subtyping multi-omics

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离心冷水机组动态仿真与控制开发研究

制冷与空调 2024年第5期24卷 30-35页

作者：祝用华美的集团(上海)有限公司

冷水机组控制系统影响机组的运行性能,利用仿真的方法对其进行设计可以加快设计效率、降低开发周期及成本。文章介绍了基于冷水机组动态仿真的智能控制器设计与仿真测试。首先在Modelica环境下基于热力学定律建立了冷水机组物理模型并... 详细信息

冷水机组控制系统影响机组的运行性能,利用仿真的方法对其进行设计可以加快设计效率、降低开发周期及成本。文章介绍了基于冷水机组动态仿真的智能控制器设计与仿真测试。首先在Modelica环境下基于热力学定律建立了冷水机组物理模型并进行了模型验证和测试,再将冷水机组仿真模型与控制器模型结合形成动态-控制仿真平台,在此平台上开发并测试了智能加载PID(Proportion、Integral、Differential,结合比例、积分和微分三种环节于一体)、智能整定PID等算法,结果表明,基于仿真平台的控制设计可行,智能PID控制器能很好地降低系统超调量、消除系统震荡,使机组稳定可靠运行。

关键词：冷水机组控制动态仿真智能PID

基于生成对抗网络数据增强的抗噪语音识别系统

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上海大学学报（自然科学版） 2024年第3期30卷 476-490页

作者：冯天宇朱永华上海大学上海电影学院上海200072

语音识别的研究始终存在数据集具有局限性的问题.通过数据增强可以提升训练数据的规模以及多样性,从而提升识别的准确率.提出了一种基于生成对抗网络(generative adversarial network,GAN)的语音数据生成方法,以改善噪声条件下的语音识... 详细信息

语音识别的研究始终存在数据集具有局限性的问题.通过数据增强可以提升训练数据的规模以及多样性,从而提升识别的准确率.提出了一种基于生成对抗网络(generative adversarial network,GAN)的语音数据生成方法,以改善噪声条件下的语音识别.首先,使用基础的GAN结构,逐帧生成基于光谱特征水平的语音样本;之后,针对缺乏真实标签用于训练的问题,又提出了一种利用非转录数据进行声学建模的无监督学习框架,并利用条件GAN结构探讨2种条件:每个语音帧的声学状态和与数据集中语音对应的原始干净语音.整合了条件信息的条件GAN可以直接提供真实标签用于声学建模.该方法在2个噪声任务(Aurora-4和AMI会议转录任务)上进行了评估.研究结果表明,在各种噪声条件(加性噪声、信道失真和混响)下,该方法都能显著提升性能.GAN生成的增强数据在先进的非常深度卷积神经网络(very deep convolutional network,VDCNN)声学模型上,可以降低6%14%的字错误率(worderrorrate,WER).

关键词：生成对抗网络声学模型数据增强噪声语音识别

成人先天性肝外门体静脉分流并肝脏肿瘤1例报告并文献复习

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中国普通外科杂志 2024年第7期33卷 1185-1191页

作者：李力吴琛朱永花姚爱华安徽医科大学附属阜阳医院普通外科安徽阜阳236000 江苏省人民医院肝胆中心江苏南京210003

背景与目的:成人先天性肝外门体静脉分流(CEPS)在临床上罕见,容易误诊,特别是合并肝脏肿瘤,给临床诊疗带来困难。本文报告1例成人无症状CEPS合并结节性肝脏肿瘤患者的诊治经过,探讨该病的临床特点及治疗方法。方法:回顾性分析江苏省人... 详细信息

背景与目的:成人先天性肝外门体静脉分流(CEPS)在临床上罕见,容易误诊,特别是合并肝脏肿瘤,给临床诊疗带来困难。本文报告1例成人无症状CEPS合并结节性肝脏肿瘤患者的诊治经过,探讨该病的临床特点及治疗方法。方法:回顾性分析江苏省人民医院收治的1例成人CEPS合并肝脏肿瘤的患者临床资料,复习国内外文献,总结该病的流行病学特点、临床表现和治疗方法。结果:患者,男性,47岁;因“发现肝脏占位性病变2个月”于2023年10月23日入院。根据超声、增强磁共振检查结果明确为成人CEPS,肝脏结节考虑为恶性肿瘤,通过微波消融治疗,随访后治疗效果满意。结论:成人CEPS临床表现各异,且该病容易并发肝脏肿瘤,目前尚无特征性的临床表现用于早期诊断和治疗。成人患者合并有肝脏结节性肿瘤,消融治疗是一种可选的方案。

关键词：血管畸形门静脉肝肿瘤消融技术

先天性胆管扩张症患者囊肿切除术后的预后情况以及术后发生胆道结石的风险因素分析

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中华肝胆外科杂志 2024年第2期30卷 114-118页

作者：朱永花孙敏吴琛张慧姚爱华南京医科大学第一附属医院肝胆中心南京210029 江苏大学附属宜兴医院肝胆胰外科无锡214200

目的观察先天性胆管扩张症患者囊肿切除术后的预后情况,探究影响术后发生胆道结石的风险因素。方法回顾性分析2004年5月至2022年1月南京医科大学第一附属医院收治的149例先天性胆管扩张症患者的临床资料,其中男性59例,女性90例,年龄32(2... 详细信息

目的观察先天性胆管扩张症患者囊肿切除术后的预后情况,探究影响术后发生胆道结石的风险因素。方法回顾性分析2004年5月至2022年1月南京医科大学第一附属医院收治的149例先天性胆管扩张症患者的临床资料,其中男性59例,女性90例,年龄32(21,47)岁。依据囊肿切除术后随访期间是否新发胆道结石分为2组:结石组(n=51)和非结石组(n=98)。记录患者的性别、年龄、病史、囊肿类型、胆道结石、吻合口狭窄以及癌变情况等临床资料。囊肿切除手术后对患者进行电话随访。logistic回归分析筛选囊肿切除术后发生胆道结石的风险因素。结果随访时间为120(24,211)个月。149例患者术后胆道结石、吻合口狭窄以及癌变的发生率分别为34.2%(51/149)、8.7%(13/149)和4.7%(7/149)。logistic回归分析结果显示,囊肿未完全切除(OR=3.332,95%CI:1.221~9.094)以及术后吻合口狭窄(OR=13.300,95%CI:2.586~68.401)的先天性胆管扩张症患者囊肿切除术后发生胆道结石的风险高(均P<0.05)。结论先天性胆管扩张症患者囊肿切除术后胆道结石的发生风险较高,囊肿残留以及术后吻合口狭窄是囊肿切除术后胆道结石发生的独立危险因素。

关键词：胆管先天性胆管扩张胆道结石术后并发症癌变

医院病房置换通风系统对空气传播感染风险的影响研究

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制冷与空调（四川） 2024年第2期38卷 182-188,195页

作者：朱永华南京市溧水区人民医院南京211200

医院负压隔离病房的高效通风对于降低院内交叉感染和减少能源消耗至关重要。研究了置换通风在负压隔离病房中的适用性。为了评价不同工况下的通风系统,使用室内的换气效率和室内污染物的去除效率的概念对通风系统进行了研究。主要采用... 详细信息

医院负压隔离病房的高效通风对于降低院内交叉感染和减少能源消耗至关重要。研究了置换通风在负压隔离病房中的适用性。为了评价不同工况下的通风系统,使用室内的换气效率和室内污染物的去除效率的概念对通风系统进行了研究。主要采用模拟对不同工况下室内的空气换气效率与污染物去除效果进行了研究,并采用实验的方式对模拟结果进行了验证。在研究工况中,分别考虑了换气次数变化,辐射墙壁变化和排风口位置变化对室内换气效率与污染物去除效率的影响。结果显示采用置换通风时,实际的换气效率介于0.5和1.0之间,污染物去除效率主要集中在0.73到2.0之间,同时医护人员呼吸高度出现了污染物的自锁现象。虽然置换通风系统可以降低室内的能耗,但是它同时也提高了医护人员的暴露风险。

关键词：负压隔离病房置换通风室内换气效率污染物去除效率

“发酵工程专业课程设计”课程“课堂+仿真+工厂”三维一体教学改革与探索

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微生物学通报 2024年第5期51卷 1774-1783页

作者：卓睿张蒙朱咏华李勇军湖南大学生物学院植物功能基因组学与发育调控湖南省重点实验室湖南长沙410082

“发酵工程专业课程设计”是湖南大学生物学院面向生物技术专业学生开设的特色本科实践环节课程,旨在加强学生实践和运用能力,鼓励学生将习得的微生物学和发酵工程知识在发酵工厂的实际应用中找到落脚点。传统的教学模式中,这门课程主... 详细信息

“发酵工程专业课程设计”是湖南大学生物学院面向生物技术专业学生开设的特色本科实践环节课程,旨在加强学生实践和运用能力,鼓励学生将习得的微生物学和发酵工程知识在发酵工厂的实际应用中找到落脚点。传统的教学模式中,这门课程主要以课堂讲授为主。由于涉及发酵生产线运行、发酵设备参数设计等实践性较强的内容,单纯的课堂讲授不易调动学生的课堂积极性,同时也难以让学生对授课内容产生直观清晰的认识。在此背景下,我们针对课程进行了改革优化,在课程教学中全面引入虚拟仿真教学和工厂实践的教学模式。力争通过新模式下“发酵工程专业课程设计”的教学实施,加强学生对发酵工程原理的掌握,并强化学生的实践和运用能力。本文总结了现阶段课程“课堂+仿真+工厂”三维一体的开展模式,并结合学生反馈对实际授课效果进行了反思,以期为高等院校教学改革提供参考。

关键词：发酵工程课程设计虚拟仿真教学改革