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Fatty liver disease and risk of all cause and cause-specific mortality outcomes in the older population

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 949-952页

作者： josh Bilson Christopher d.Byrne School of Human development and Health Faculty of MedicineUniversity of SouthamptonSouthamptonUK National Institute for Health Research Southampton Biomedical Research Centre University of Southampton and University Hospital Southampton National Health Service Foundation TrustSouthamptonUK

Accumulating evidence in recent years has reinforced the notion that non-alcoholic fatty liver disease/metabolic dysfunction-associated fatty liver disease/metabolic dysfunction steatotic liver disease(NAFLd/MAFLd/MAS... 详细信息

关键词： Fatty liver disease(FLd) non-alcoholic fatty liver disease(NAFLd) metabolic dysfunction steatotic liver disease(MASLd) metabolic dysfunction-associated fatty liver disease(MAFLd) mortality age elderly older population

Machine learning predictions of irradiation embrittlement in reactor pressure vessel steels

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npj Computational Materials 2022年第1期8卷 795-805页

作者： Yu-chen Liu Henry Wu Tam Mayeshiba Benjamin Afflerbach Ryan Jacobs josh Perry Jerit George josh Cordell Jinyu Xia Hao Yuan Aren Lorenson Haotian Wu Matthew Parker Fenil doshi Alexander Politowicz Linda Xiao dane Morgan Peter Wells Nathan Almirall Takuya Yamamoto G.Robert Odette Materials Science and Engineering department University of Wisconsin-MadisonMadisonWI53706USA Hierarchical Green-Energy Materials(Hi-GEM)Research Center National Cheng Kung UniversityTainan70101TaiwanCHINA Materials Science and Engineering department National Cheng Kung UniversityTainan70101TaiwanCHINA Mechanical Engineering department University of CaliforniaSanta BarbaraCA93106USA

Irradiation increases the yield stress and embrittles light water reactor(LWR)pressure vessel *** this study,we demonstrate some of the potential benefits and risks of using machine learning models to predict irradiation hardening extrapolated to low flux,high fluence,extended life *** machine learning training data included the Irradiation Variable for lower flux irradiations up to an intermediate fluence,plus the Belgian Reactor 2 and Advanced Test Reactor 1 for very high flux irradiations,up to very high ***,the machine learning model predictions for the high fluence,intermediate flux Advanced Test Reactor 2 irradiations are superior to extrapolations of existing hardening *** successful extrapolations showed that machine learning models are capable of capturing key intermediate flux effects at high *** approaches,applied to expanded databases,could be used to predict hardening in LWRs under life-extension conditions.

关键词： life irradiation expanded

depression following a traumatic brain injury:uncovering cytokine dysregulation as a pathogenic mechanism

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Neural Regeneration Research 2018年第10期13卷 1693-1704页

作者： Colleen N.Bodnar josh M.Morganti Adam d.Bachstetter Spinal Cord & Brain Injury Research Center University of Kentucky department of Neuroscience University of Kentucky Sanders-Brown Center on Aging University of Kentucky

A substantial number of individuals have long-lasting adverse effects from a traumatic brain injury（TBI）. depression is one of these long-term complications that influences many aspects of life. depression can limit the ability to return to work, and even worsen cognitive function and contribute to dementia. The mechanistic cause for the increased depression risk associated with a TBI remains to be defined. As TBI results in chronic neuroinflammation, and priming of glia to a secondary challenge, the inflammatory theory of depression provides a promising framework for investigating the cause of depression following a TBI. Increases in cytokines similar to those seen in depression in the general population are also increased following a TBI. Biomarker levels of cytokines peak within hours-to-days after the injury, yet pro-inflammatory cytokines may still be elevated above physiological levels months-to-years following TBI, which is the time frame in which post-TBI depression can persist. As tumor necrosis factor α and interleukin 1 can signal directly at the neuronal synapse, pathophysiological levels of these cytokines can detrimentally alter neuronal synaptic physiology. The purpose of this review is to outline the current evidence for the inflammatory hypothesis of depression specifically as it relates to depression following a TBI. Moreover, we will illustrate the potential synaptic mechanisms by which tumor necrosis factor α and interleukin 1 could contribute to depression. The association of inflammation with the development of depression is compelling; however, in the context of post-TBI depression, the role of inflammation is understudied. This review attempts to highlight the need to understand and treat the psychological complications of a TBI, potentially by neuroimmune modulation, as the neuropsychiatric disabilities can have a great impact on the rehabilitation from the injury, and overall quality of life.

关键词： concussion major-depressive disorder chronic traumatic encephalopathy inflammation tumor necrosis factor α interleukin 1 microglia astrocytes synaptic physiology N-methyl-d-aspartic acid

Jason M. Wirth, Mountains, Rivers, and the Great Earth：Reading Gary Snyder and dogen in an Age of Ecological Crisis （reviewed by josh Hayes Hayes）

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Frontiers of Philosophy in China 2017年第4期12卷 666-671页

作者： josh Hayes Hayes Alvernia University

The great bell of the Gion Temple reverberates into every human heart to wake us to the fact that all is impermanent and fleeting. The withered flowers of the sala trees by Shakyamuni＇s deathbed remind us that even those flourishing with wealth and power will soon pass away. The life of fame and pride is as ephemeral as a springtime dream. The courageous and aggressive person too will vanish like a swirl of dust in the wind. --Heike Monogatari, 12th century, trans. Gary Snyder.

关键词： Jason M. Wirth Mountains

The Biodegradation of dispersed Oil does Not Induce Toxicity at Environmentally-Relevant Concentrations

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Open Journal of Marine Science 2019年第3期9卷 113-120页

作者： Roger C. Prince Bryan M. Hedgpeth Aaron d. Redman josh d. Butler ExxonMobil Biomedical Sciences Inc. Annandale NJ USA

Applying dispersants to spilled crude oil results in an oil in water dispersion of microscopic oil droplets that soon dilutes to levels below 1 ppm oil. These levels are substantially below those known to induce acute toxicity in 96-hour tests. We show here that oil hydrocarbons are biodegraded very rapidly in such situations (50% loss in 4 days in this experiment), and that no increase in acute toxicity to mysids (Americamysis bahia) is seen during this biodegradation, or over the following 20 days as the oil is further degraded (78% loss of detectable hydrocarbons in this experiment).

关键词： Oil Spills dispersants Biodegradation Acute Toxicity Hopane Americamysis bahia

Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions

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Light(Science & Applications) 2019年第1期8卷 927-935页

作者： Rekha Gautam Yinxiao Xiang josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen department of Physics and Astronomy San Francisco State UniversitySan FranciscoCA 94132USA department of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37240USA MOE Key Lab of Weak-Light Nonlinear Photonics TEDA Applied Physics Institute and School of PhysicsNankai UniversityTianjin 300457China Guangxi Key Lab for Relativistic Astrophysics Guangxi Colleges and Universities Key Lab of Novel Energy Materials and Related TechnologySchool of Physical Science and TechnologyGuangxi UniversityNanningGuangxi 530004China department of Physics and Astronomy California State University NorthridgeNorthridgeCA 91330USA Institut National de la Recherche Scientifique Universite du QuebecVarennesQC J3X 1S2Canada department of Physics Chemistry and BiologyLinkoping UniversityLinkoping SE-58183Sweden School of Mathematical and Physical Sciences University of SussexSussex HouseFalmerBrighton BN19RHUK department of Biomedical Engineering University of California IrvineIrvineCAUSA Clinical Laboratory Science Program San Francisco State UniversitySan FranciscoCA 94132USA Institute of Fundamental and Frontier Sciences University of Electronic Science and Tech.of ChinaChengdu 610054China ITMO University Saint Petersburg 197101Russia

Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as *** the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of ***,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic ***,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the *** tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient ***,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free *** use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental *** work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis.

关键词： nonlinearity suspensions nonlinear

Building a Casimir metrology platform with a commercial MEMS sensor

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Microsystems & Nanoengineering 2019年第1期5卷 523-531页

作者： Alexander Stange Matthias Imboden josh Javor Lawrence KBarrett david JBishop division of Material Science and Engineering Boston UniversityBostonMA 02215USA Institute of Microengineering Ecole Polytechnique Federale de LausanneNeuchatel 2000Switzerland department of Mechanical Engineering Boston UniversityBostonMA 02215USA department of Physics Boston UniversityBostonMA 02215USA department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA department of Biomedical Engineering Boston UniversityBostonMA 02215USA

The Casimir Effect is a physical manifestation of quantum fluctuations of the electromagnetic *** two metal plates are placed close together,typically much less than a micron,the long wavelength modes between them are frozen out,giving rise to a net attractive force between the plates,scaling as d^(−4)(or d^(−3)for a spherical-planar geometry)even when they are not electrically *** this paper,we observe the Casimir Effect in ambient conditions using a modified capacitive micro-electromechanical system(MEMS)*** a feedback-assisted pick-and-place assembly process,we are able to attach various microstructures onto the post-release MEMS,converting it from an inertial force sensor to a direct force measurement platform with pN(piconewton)*** this system we are able to directly measure the Casimir force between a silver-coated microsphere and goldcoated silicon *** device is a step towards leveraging the Casimir Effect for cheap,sensitive,room temperature quantum metrology.

关键词： quantum silver attractive

Probing the subcellular nanostructure of engineered human cardiomyocytes in 3d tissue

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Microsystems & Nanoengineering 2021年第1期7卷 133-140页

作者： josh Javor Jourdan K.Ewoldt Paige E.Cloonan Anant Chopra Rebeccah J.Luu Guillaume Freychet Mikhail Zhernenkov Karl Ludwig Jonathan G.Seidman Christine E.Seidman Christopher S.Chen david J.Bishop department of Mechanical Engineering Boston UniversityBostonMA 02215USA department of Biomedical Engineering Boston UniversityBostonMA 02215USA SMI Beamline 12-Id Brookhaven National LaboratoryUptonNY 11973USA department of Physics Boston UniversityBostonMA 02215USA division of Materials Science Boston UniversityBostonMassachusetts 02215USA department of Genetics Harvard Medical SchoolBostonMA 02215USA department of Electrical Engineering Boston UniversityBostonMA 02215USA

The structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)is essential for pharmaceutical testing,disease modeling,and ultimately therapeutic *** 3d-tissue platforms have improved the functional maturation of hiPSC-CMs,but probing cardiac contractile properties in a 3d environment remains challenging,especially at depth and in live *** small-angle X-ray scattering(SAXS)imaging,we show that hiPSC-CMs matured and examined in a 3d environment exhibit a periodic spatial arrangement of the myofilament lattice,which has not been previously detected in *** contractile force is found to correlate with both the scattering intensity(R^(2)=0.44)and lattice spacing(R^(2)=0.46).The scattering intensity also correlates with lattice spacing(R^(2)=0.81),suggestive of lower noise in our structural measurement than in the functional ***,we observed decreased myofilament ordering in tissues with a myofilament mutation known to lead to hypertrophic cardiomyopathy(HCM).Our results highlight the progress of human cardiac tissue engineering and enable unprecedented study of structural maturation in hiPSC-CMs.

关键词： cardiac cardiomyocytes spacing

Completion and stimulation trends in North American unconventional plays and resulting impact on well productivity

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钻探工程 2021年第10期48卷 1-12页

作者： Roman Galchenko Qing Liu Yan Gao Yu Liu david He josh Zhang Huailiang Liu Xiaohua Ke CNPC USA Houston TX 77042USA CNPC Engineering Technology R&d Company Limited Beijing 102206China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing 102249China

过去十年,非常规油气勘探开发在全球范围内大幅扩张。水平钻井和多级水力压裂技术也在不断地发展和创新,使得超长水平井成为可能。同时,因为压裂强度不断增加,作业者可以最大限度地提高储层接触面积和对储层的改造体积(SRV)。然而,完井... 详细信息

过去十年,非常规油气勘探开发在全球范围内大幅扩张。水平钻井和多级水力压裂技术也在不断地发展和创新,使得超长水平井成为可能。同时,因为压裂强度不断增加,作业者可以最大限度地提高储层接触面积和对储层的改造体积(SRV)。然而,完井优化方面的挑战仍然存在,作业者持续不断地尝试和试验各种完井与增产参数组合,以确保非常规油气藏开发的经济可行性。优选最佳的完井与增产参数组合是一项非常关键的任务,应结合油气田的具体储层特征进行优化。本文总结了2014—2020年间北美9个主要非常规油气藏的压裂增产趋势,包括Marcellus,Haynesville,Barnett,Utica,Bone Spring,Bakken,Wolfcamp Midland,Eagle Ford,Scoop/Stack。分析了各油气田几个关键的完井和增产参数的整体趋势,同时还评估了单个参数(如水平段压裂长度、支撑剂强度、段间距等)对井产能的影响。然后对比分析相应的初始井产量(90天平均初始产量),评估各个参数对产能的影响,从而确定每个完井参数的最佳范围,以实现产能最优化。

关键词：水力压裂多级完井增产趋势井产能水平段长度支撑剂强度用液强度段间距井间距非常规油气北美