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Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway

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World Journal of Gastroenterology 2024年第20期30卷 2709-2725页

作者： Kai-Di chen Kui-Ling Wang chen chen Yi-Jia Zhu Wen-Wen Tang Yu-Ji Wang Ze-Peng chen Lin-Hai He Yu-Gen chen Wei Zhang Jiangsu Province Hospital of chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina The No.1 clinical Medical college Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of colorectal Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Province Key Laboratory of Tumor Systems Biology and chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu collaborative Innovation center of chinese Medicine in Prevention and Treatment of Tumor The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BAcKGROUND constipation,a highly prevalent functional gastrointestinal disorder,induces a significant burden on the quality of patients'life and is associated with substantial healthcare ***,identifying efficient therapeutic modalities for constipation is of paramount *** stress is a pivotal contributor to colonic dysmotility and is the underlying pathology responsible for constipation ***,we postulate that hydrogen therapy,an emerging and promising intervention,can serve as a safe and efficacious treatment for *** To determine whether hydrogen-rich water(HRW)alleviates constipation and its potential *** constipation models were established by orally loperamide to Sprague-Dawley *** freely consumed HRW,and were recorded their 24 h total stool weight,fecal water content,and charcoal propulsion *** samples were subjected to 16S rDNA gene *** non-targeted metabolomic analysis,malondialdehyde,and superoxide dismutase levels were *** tissues were stained with hematoxylin and eosin,Alcian blue-periodic acid-Schiff,reactive oxygen species(ROS)immunofluorescence,and immunohistochemistry for cell growth factor receptor kit(c-kit),PGP 9.5,sirtuin1(SIRT1),nuclear factor-erythroid-2-related factor 2(Nrf2),and heme oxygenase-1(HO-1).Quantitative real-time PcR and western blot analysis were conducted to determine the expression level of SIRT1,Nrf2 and HO-1.A rescue experiment was conducted by intraperitoneally injecting the SIRT1 inhibitor,EX527,into constipated ***460 cells were induced with H2O2 and treated with the metabolites to evaluate ROS and SIRT1 *** HRW alleviated constipation symptoms by improving the total amount of stool over 24 h,fecal water content,charcoal propulsion rate,thickness of the intestinal mucus layer,c-kit expression,and the number of intestinal *** modulated intestinal microbiota imbalance and abnormaliti

关键词： Hydrogen-rich water constipation Sirtuin1 Oxidative stress Gut microbiota Serum metabolites

An automated approach to calculating the maximum diameters of multiple cutters and their paths for sectional milling of centrifugal impellers on a 4_(1/2)-axis cNc machine

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chinese Journal of Aeronautics 2019年第4期32卷 1030-1039页

作者： Baohai WU Zezhong c.chen Ming LUO Dinghua ZHANG Feiyan HAN School of Mechanical Engineering Northwestern Polytechnical University Department of Mechanical Industrial and Aerospace EngineeringConcordia University college of Mechanical Engineering Xi'an University of Science and Technology

Power generators and chemical engineering compressors include heavy and large centrifugal impellers. To produce these impellers in high-speed machining, a 4?-axis milling machine(or a 4-axis machine plus an indexing table) is often used in the industry, which is more rigid than a5-axis milling machine. Since impeller blades are designed with complex B-spline surfaces and impeller channels spaces vary significantly, it is more efficient to use multiple cutters as large as possible to cut a channel in sections and a blade surface in patches, instead of only using a small cutter to machine a whole blade and a channel. Unfortunately, no approach has been established to automatically calculate the largest diameters of cutters and their paths, which include the indexing table angles. To address this problem, an automated and optimization approach is proposed. Based on the structure of a 4?-axis machine, a geometric model for a cutter gouging/interfering the impeller is formulated, and an optimization model of the cutter diameter in terms of the indexing table angle is established at a cutter contact(cc) point on a blade surface. Then, the diameters of the tools,their orientations, and the indexing table angles are optimized, and each tool's paths are generated for machining its corresponding impeller section. As a test, an impeller is efficiently machined with these tools section by section; thus, this approach is valid. It can be directly used in the industry to improve efficiency of machining centrifugal impellers.

关键词： Automated path generation 4_(1/2)-Axis cNc machining centrifugal impeller machining cutter diameter optimization Sectional machining

Lysine demethylase 5B transcriptionally regulates TREM1 in human cardiac fibroblasts

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BIOcELL 2024年第7期48卷 1105-1113页

作者： cHUNLING LIANG JING chen XIAOJIE chen WEI YAN JIE YU Department of Emergency Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of cardiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100102China Department of Radiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China Department of cardiology Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102China

Background:A differential gene,triggering receptor expressed on myeloid cells 1(TREM1),was identiﬁed in blood sequencing datasets from myocardial infarction patients and healthy ***ﬁbrosis following myocardial infarction signiﬁcantly contributes to cardiac ***:This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardialﬁ***:Mimicking pathology by angiotensin II(Ang II)treatment of human cardiacﬁbroblasts(HcFs),the impacts of TREM1 knockdown on its proliferation,migration,and secretion of the pro-ﬁbrotic matrix were identiﬁ*** the Human Transcription Factor Database(HumanTFDB)website,lysine-speciﬁc demethylase 5B(KDM5B)was found to bind to the TREM1 promoter,which was further validated through luciferase reporter and chromatin immunoprecipitation(chIP).By promoting KDM5B overexpression,its effect on the regulation of TREM1 was ***:TREM1 knockdown suppressed the proliferation,migration,and secretion of the pro-ﬁbrotic matrix in HcFs upon Ang II ***5B bound to the TREM1 promoter and upregulated its transcriptional ***,KDM5B overexpression reversed the regulation of the above cellular phenotypes by TREM1 ***:This study sheds light on the positive regulation of TREM1 by KDM5B,demonstrating their role in promoting myocardialﬁ***ﬁnding provides a theoretical foundation for understanding disease pathology and potentially advancing the development of new targeted therapies.

关键词： cardiac fibroblasts Fibrosis Myeloid cell receptor Migration Proliferation

Presence of a long nuclear-localization signal sequence in homeodomain transcription factor Nkx 1.2

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Journal of Oceanology and Limnology 2024年第2期42卷 620-626页

作者： Xinyi LI Lihui chen Xinyuan WANG chen SUN Guangdong JI Guobin HU Zhenhui LIU college of Marine Life Science and Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China Laoshan Laboratory Qingdao 266237China

Homeodomains,a 60-amino acid sequence encoded by 180 nucleotides,are highly conserved DNA-binding motifs that are present in a variety of transcription factors in species ranging from yeast to *** NKX proteins belong to the homeodomain(HD)-containing transcription factor *** play vital roles in the regulation of ***1-2 is one member of the NKX *** present,information about its nuclear localization signal(NLS)sequence is *** studied the NLS sequence of zebrafish Nkx1.2 by introducing sequence changes such as deletion,mutation,and truncation,and identified an NLS motif(QNRRTKWKKQ)that is localized at the c-terminus of the ***,the deletion of two amino acid residues(RR)in this NLS motif prevents Nkx1.2 from entering the nucleus,indicating that the two amino acids are essential for Nkx1.2 nuclear ***,the NLS motif alone is unable to target cytoplasmic protein glutathione S-transferase(GST)to the *** intact homeodomain is necessary for mediating the complete nuclear transport of cytoplasmic *** most nuclear import proteins with short NLS sequences,a long NLS is present in zebrafish *** also demonstrated that the sequences of homeodomain of NKX1.2 are well conserved among different *** study is informative to verify the function of the NKX1.2 protein.

关键词： NKX1.2 NKX protein homeodomain nuclear localization signal(NLS) nuclear transport

Dietary supplementation with Neolamarckia cadamba leaf extract improves broiler meat quality by enhancing antioxidant capacity and regulating metabolites

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Animal Nutrition 2024年第2期17卷 358-372页

作者： cheng Wang Dandan chen Shou Wu Wei Zhou Xiaoyang chen Qing Zhang Li Wang State Key Laboratory of Swine and Poultry Breeding Industry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionMaoming BranchGuangdong Laboratory for Lingnan Modern AgricultureInstitute of Animal ScienceGuangdong Academy of Agricultural Sciences college of Forestry and Landscape Architecture Guangdong Province Research Center of Woody Forage Engineering TechnologyGuangdong Research and Development Center of Modern Agriculture (Woody Forage) Industrial TechnologyGuangdong Key Laboratory for Innovative Development and Utilization of Forest Plant GermplasmState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresourcesSouth China Agricultural University

This study was to evaluate the effect of supplementing the diet of broilers with Neolamarckia cadamba leaf extract(NcLE) on meat quality by evaluating antioxidant parameters and the expression of genes in the p38 mitogen-activated protein kinase/nuclear factor-erythroid 2-related factor 2/antioxidant responsive element(p38 MAPK/Nrf2/ARE) signaling pathway, coupled with Lc-MS-based metabolomic analysis. A total of 480 one-day-old male broilers were randomly allocated to four treatment groups—a control(cON)group, which was fed a basal diet, and three NcLE treatment groups, which were fed the basal diet supplemented with 100, 200, or 400 mg/kg NcLE(N1, N2, and N3 groups, respectively) for 42 d. compared with the cON group, meat quality was improved in the N2 and N3 groups, as evidenced by the higher p H45min(P ce(P cle(BM) and lower drip loss at48 h(P cle(LM). Moreover, BM antioxidant capacity was significantly enhanced in the N3group, characterized by an increase in the total antioxidant capacity(T-AOc), the concentrations of glutathione peroxidase(GSH-Px) and catalase(cAT), and the relative mRNA expression of p38 MAPK,extracellular-signal regulated kinase 1/2(ERK1/2), c-Jun N-terminal kinase(JNK), Nrf2, cAT, and GSH-Px(P c, increased GSH-Px and cAT concentrations,reduced malonaldehyde contents(P cAT, and superoxide dismutase(SOD)(P cs analysis revealed that Darabinono-1,4-lactone and lyso-PAF c-16-d4 were negatively correlated with shear force and cooking loss(P creased abundance in BM of the N3 group. L-Serine levels were upregulated while D-fructose 1,6-diphosphate contents were downregulated in the three NcLE groups. Finally, the differential metabolites in both BM and LM were involved in amino acid metabolism pathwa

关键词： Neolamarckia cadamba leaf extract Broiler Meat quality Antioxidant capacity Metabolomics

Defect engineered electrocatalysts for c-N coupling reactions toward urea synthesis

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chinese chemical Letters 2024年第8期35卷 7-14页

作者： Shengkai Li Yuqin Zou chen chen Shuangyin Wang Zhao-Qing Liu Guangzhou Key Laboratory for clean Energy and Materials/Key Laboratory for Water Quality and conservation of the Pearl River Delta Ministry of EducationGuangzhou UniversityGuangzhou 510006China State Key Laboratory of chemo/Bio-Sensing and chemometrics College of Chemistry and Chemical EngineeringAdvanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha 410082China

Urea is extensively used in agriculture and chemical industry,and it is produced on an industrial scale from cO_(2)and Haber-Bosch NH_(3)under relatively high temperature and high pressure conditions,which demands high energy input and generates masses of carbon *** conversion of cO_(2)and N sources(such as NO_(2)^(−),NO_(3)^(−),and N_(2))through electrocatalytic reactions under ambient conditions is a promising alternative to realize efficient urea *** note,the design of electrocatalyst is one of the key factors that can improve the efficiency and selectivity of c-N coupling *** engineer-ing is an intriguing strategy for regulating the electronic structure and charge density of electrocatalysts,which endows electrocatalysts with excellent physicochemical properties and optimized adsorption en-ergy of the reaction intermediates to reduce the kinetic *** this minireview,recent advances of defect engineered electrocatalysts in urea electrosynthesis from cO_(2)and various N reactants are firstly *** discussions of c-N coupling in these advances are presented,with the aim of directing future investigations on improving the urea ***,the prospects and challenges of de-fect engineered electrocatalysts for urea synthesis are *** overview is expected to provide in-depth understanding of structure-reactivity relationship and shed light on future electrocatalytic c-N coupling reactions.

关键词： Electrocatalysis Defective electrocatalyst co-reduction c-N coupling Urea synthesis

Durable Ru Nanocrystal with HfO_(2)Modification for Acidic Overall Water Splitting

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Nano-Micro Letters 2024年第9期16卷 462-477页

作者： Xiangkai Kong Jie Xu Zhicheng Ju changle chen School of Materials and Physics China University of Mining and TechnologyXuzhou 221116JiangsuPeople’s Republic of China Anhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation Huaibei Normal UniversityHuaibei 235000AnhuiPeople’s Republic of China School of chemistry and Materials Science University of Science and Technology of ChinaHefei 230026AnhuiPeople’s Republic of China School of chemistry and chemical Engineering Nanjing UniversityNanjing 210023JiangsuPeople’s Republic of China

Durable and efficient bi-functional catalyst,that is capable of both oxygen evolution reaction and hydrogen evolution reaction under acidic condition,are highly desired for the commercialization of proton exchange membrane water ***,we report a robust L-Ru/HfO_(2)heterostructure constructed via confining crystalline Ru nanodomains by HfO_(2)*** assembled with a proton exchange membrane,the bi-functional L-Ru/HfO_(2)catalyst-based electrolyzer presents a voltage of 1.57 and 1.67 V to reach 100 and 300 mA cm^(-2)current density,prevailing most of previously reported Ru-based materials as well as commercial Pt/c||RuO_(2)*** is revealed that the synergistic effect of HfO_(2)modification and small crystalline domain formation significantly alleviates the over-oxidation of *** importantly,this synergistic effect facilitates a dual-site oxide path during the oxygen evolution procedure via optimization of the binding configurations of oxygenated *** a result,the Ru active sites maintain the metallic state along with reduced energy barrier for the rate-determining step(^(*)O→^(*)OOH).Both of water adsorption and dissociation(Volmer step)are strengthened,while a moderate hydrogen binding is achieved to accelerate the hydrogen desorption procedure(Tafel step).consequently,the activity and stability of acidic overall water splitting are simultaneously enhanced.

关键词： Ruthenium Hafnium dioxide Oxygen evolution catalysis Anti-oxidation

Monothetic and conductive network and mechanical stress releasing layer on micron-silicon anode enabling high-energy solid-state battery

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Rare Metals 2024年第3期43卷 1017-1029页

作者： Xiang Han Min Xu Lan-Hui Gu chao-Fei Lan Min-Feng chen Jun-Jie Lu Bi-Fu Sheng Peng Wang Song-Yan chen Ji-Zhang chen college of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forestry ResourcesNanjing Forestry UniversityNanjing210037China Department of Physics Xiamen UniversityXiamen361005China Western Digital corporation MilpitasCA95035USA

Silicon has ultrahigh capacity,dendrite-free alloy lithiation mechanism and low cost and has been regarded as a promising anode candidate for solid-state *** to the low infiltration of solid-state electrolyte(SSE),not the unstable solid-electrolyte interphase(SEI),but the huge stress during lithiation-and delithiation-induced particle fracture and conductivity lost tend to be the main *** this study,starting with micron-Si,a novel monothetic carbon conductive framework and a MgO coating layer are designed,which serve as electron pathway across the whole electrode and stress releasing layer,*** addition,the in situ reaction between Si and SSE helps to form a LiF-rich and mechanically stable SEI *** a result,the mechanical stability and charge transfer kinetics of the uniquely designed Si anode are significantly ***,high initial coulombic efficiency,high capacity and durable cycling stability can be achieved by applying the Si@MgO@c anode in *** example,high specific capacity of 3224.6 mAh·g^(-1)and long cycling durability of 200 cycles are *** work provides a new concept for designing alloy-type anode that combines surface coating on particle and electrode structure design.

关键词： Lithium-ion battery(LIB) Solid-state electrolyte(SSE) Silicon anode Stress relief coating

Regulating Melting Process in the Energy Storage of Solid-Liquid PcM based on Double MRT-LBM Simulation

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Journal of Thermal Science 2024年第5期33卷 1688-1700页

作者： chen Weiqi SONG Zhichao QUAN Dongliang HE Yurong School of Energy Science&Engineering Harbin Institute of TechnologyHarbin 150001China Heilongjiang Key Laboratory of New Energy Storage Materials and Processes Harbin 150001China Zhengzhou Research Institute of Harbin Institute of Technology Zhengzhou 450000China Innovation&Research Institute of Hiwing Technology Academy Beijing 100074China

The melting process of solid-liquid phase change materials(PcM)has a significant impact on their energy storage *** more effectively apply solid-liquid PcM for energy storage,it is crucial to study the regulation of melting process of solid-liquid PcM,which is numerically investigated based on double multiple relaxation time lattice Boltzmann method(MRT-LBM)in this *** this work we pay more attention to the effects of different Stefan numbers(Ste)and Rayleigh numbers(Ra)on the melting *** results indicate that the PcM melting is greatly influenced by the Ste number and Ra number,which can be divided into the heat conduction dominant stage and the convection dominant stage,according to the onset time of convection Fo_(c).In order to describe the contribution of the heat conduction dominant stage to the whole melting process quantitatively,we firstly propose the ratio of the heat conduction dominant stage R_(pc),which can be defined as the ratio of Fo_(c)to the complete melting time Fo_(M).R_(pc)gradually decreases as the Ra number increases,and when the Ste number rises:R_(pc)=90.0%when Ste=1.0 and Ra=1×10^(5),R_(pc)=39.6%when Ste=0.1 and Ra=1×10^(5),and R_(pc)=14.0%when Ste=1.0 and Ra=1×10~7.A regime map about the effects of different Ste numbers and Ra numbers on R_(pc)has been further *** discovered findings would be helpful in regulating melting process in the energy storage of solid-liquid PcM.

关键词： latent thermal energy storage solid-liquid phase change double MRT-LBM dominant melting mechanism