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Generation of induced secretome from adipose-derived stem cells specialized for disease-specific treatment:An experimental mouse model

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World Journal of Stem Cells 2020年第1期12卷 70-86页

作者： Ok-Hee Kim Ha-Eun Hong Haeyeon Seo Bong Jun Kwak Ho Joong Choi Kee-Hwan Kim joseph ahn Sang Chul Lee Say-June Kim Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Division of Hepato-biliary Pancreatic SurgerySeoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Uijeongbu St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Department of Surgery Daejeon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 34943South Korea

BACKGROUND Recently,the exclusive use of mesenchymal stem cell(MSC)-secreted molecules,named as the secretome,have been evaluated for overcoming the limitations of cell-based therapy while maintaining its *** To improve cell-free therapy by adding disease-specificity through stimulation of MSCs using disease-causing *** We collected the secretory materials(named as inducers)released from AML12 hepatocytes that had been pretreated with thioacetamide(TAA)and generated the TAA-induced secretome(TAA-isecretome)after stimulating adipose-derived stem cells with the *** TAA-isecretome was intravenously administered to mice with TAA-induced hepatic failure and those with partial *** TAA-isecretome infusion showed higher therapeutic potential in terms of(1)restoring disorganized hepatic tissue to normal tissue;(2)inhibiting proinflammatory cytokines(interleukin-6 and tumor necrosis factor-α);and(3)reducing abnormally elevated liver enzymes(aspartate aminotransferase and alanine aminotransferase)compared to the naïve secretome infusion in mice with TAA-induced hepatic ***,the TAA-isecretome showed inferior therapeutic potential for restoring hepatic function in partially hepatectomized *** analysis of TAA-isecretome identified that antioxidant processes were the most predominant enriched biological networks of the proteins exclusively identified in the *** addition,peroxiredoxin-1,a potent antioxidant protein,was found to be one of representative components of TAA-isecretome and played a central role in the protection of TAA-induced hepatic *** Appropriate stimulation of adipose-derived stem cells with TAA led to the production of a secretome enriched with proteins,especially peroxiredoxin-1,with higher antioxidant *** results suggest that appropriate stimulation of MSCs with pathogenic agents can lead to the production of a secretome specialized for protecting agains

关键词： Adipose-derived stem cells Disease-specificity Mesenchymal stem cells Secretome Peroxiredoxin-1 Thioacetamide Toxic hepatic failure

Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells

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World Journal of Stem Cells 2019年第11期11卷 990-1004页

作者： Kee-Hwan Kim Jae Im Lee Ok-Hee Kim Ha-Eun Hong Bong Jun Kwak Ho Joong Choi joseph ahn Tae Yun Lee Sang Chul Lee Say-June Kim Department of Surgery Uijeongbu St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Daejeon St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 34943South Korea

BACKGROUND Recently,the exclusive use of mesenchymal stem cell(MSC)-secreted molecules,called secretome,rather than cells,has been evaluated for overcoming the limitations of cell-based therapy,while maintaining its ***,the use of na?ve secretome may not fully satisfy the specificity of each ***,it appears to be more advantageous to use the functionally reinforced secretome through a series of processes involving physico-chemical adjustments or genetic manipulation rather than to the use na?ve *** To determine the therapeutic potential of the secretome released from miR-122-transfected adipose-derived stromal cells(ASCs).METHODS We collected secretory materials released from ASCs that had been transfected with antifibrotic miR-122(MCM)and compared their antifibrotic effects with those of the na?ve secretome(CM).MCM and CM were intravenously administered to the mouse model of thioacetamide-induced liver fibrosis,and their therapeutic potentials were *** MCM infusion provided higher therapeutic potential in terms of:(A)Reducing collagen content in the liver;(B)Inhibiting proinflammatory cytokines;and(C)Reducing abnormally elevated liver enzymes than the infusion of the na?ve *** proteomic analysis of MCM also indicated that the contents of antifibrotic proteins were significantly elevated compared to those in the na?ve *** We could,thus,conclude that the secretome released from miR-122-transfected ASCs has higher antifibrotic and anti-inflammatory properties than the na?ve *** miR-122 transfection into ASCs provides a specific way of potentiating the antifibrotic properties of ASC secretome,it could be considered as an enhanced method for reinforcing secretome effectiveness.

关键词： Adipose-derived stem cells Liver fibrosis MicroRNAs miR-122 Mesenchymal stem cells Secretome

Hepatocellular carcinoma surveillance:current practice and future directions

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Hepatoma Research 2022年第1期8卷 157-168页

作者： joseph Cahn Yi-Te Lee Vatche GAgopian Yazhen Zhu Sungyong You Hsian-Rong Tseng Ju Dong Yang Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905USA California NanoSystems Institute Crump Institute for Molecular ImagingUniversity of CaliforniaLos AngelesCA 90095USA Department of Molecular and Medical Pharmacology University of CaliforniaLos AngelesCA 90095USA Department of Surgery University of CaliforniaLos AngelesCA 90095USA Jonsson Comprehensive Cancer Center University of CaliforniaLos AngelesCA 90048USA Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical CenterLos AngelesCA 90048USA Departments of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048USA Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCA 90048USA Comprehensive Transplant Center Cedars-Sinai Medical Center Los AngelesCA 90048USA

Hepatocellular carcinoma(HCC)is among the leading causes of cancer incidence and mortality *** of individuals with cirrhosis or other conditions that confer a high risk of HCC development is essential for early detection and improved overall *** ultrasonography with or without alpha-fetoprotein is widely recommended as the standard method for HCC surveillance,but it has limited sensitivity in early disease and may be inadequate in certain *** review article will provide a comprehensive overview of the current landscape of HCC surveillance,including the rationale and indications for HCC surveillance,standard methods for HCC surveillance,and their strengths/*** surveillance methods such as the role of cross-sectional imaging,emerging circulating biomarkers,as well as the problem of under-utilization of HCC surveillance and surveillance-related harms will also be discussed in this review.

关键词： Hepatocellular carcinoma surveillance cirrhosis hepatitis B virus alpha-fetoprotein liquid biopsy under-utilization

Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether

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World Journal of Gastroenterology 2019年第39期25卷 5936-5952页

作者： Dong Do You Suk Joon Cho Ok-Hee Kim Jin Sook Song Kyu-Seok Hwang Sang Chul Lee Kee-Hwan Kim Ho Joong Choi Ha-Eun Hong Haeyeon Seo Tae Ho Hong Jung Hyun Park Tae Yoon Lee joseph ahn Jae-Kyung Jung Kwan-Young Jung Say-June Kim Department of Surgery St.Vincent's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 16247South Korea College of Pharmacy Chungbuk National UniversityCheongju 28644South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Bio and Drug Discovery Division Korea Research Institute of Chemical TechnologyDaejeon 34114South Korea Department of Surgery Daejeon St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 34943South Korea Department of Surgery Uijeongbu St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Department of Biomedicine and Health Science College of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Eunpyeong St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 03312South Korea Department of Medicinal Chemistry and Pharmacology University of Science and TechnologyDaejeon 34113South Korea

BACKGROUND The use of methyl-tertiary butyl ether(MTBE)to dissolve gallstones has been limited due to concerns over its toxicity and the widespread recognition of the safety of laparoscopic *** adverse effects of MTBE are largely attributed to its low boiling point,resulting in a tendency to ***,if there is a material with a higher boiling point and similar or higher dissolubility than MTBE,it is expected to be an attractive alternative to *** To determine whether tert-amyl ethyl ether(TAEE),an MTBE analogue with a relatively higher boiling point(102°C),could be used as an alternative to MTBE in terms of gallstone dissolubility and *** The in vitro dissolubility of MTBE and TAEE was determined by measuring the dry weights of human gallstones at predetermined time intervals after placing them in glass containers with either of the two *** in vivo dissolubility was determined by comparing the weights of solvent-treated gallstones and control(dimethyl sulfoxide)-treated gallstones,after the direct infusion of each solvent into the gallbladder in both hamster models with cholesterol and pigmented *** The in vitro results demonstrated a 24 h TAEE-dissolubility of 76.7%,56.5%and 38.75%for cholesterol,mixed,and pigmented gallstones,respectively,which represented a 1.2-,1.4-,and 1.3-fold increase in dissolubility compared to that of *** the in vitro experiment,the 24 h-dissolubility of TAEE was 71.7%and 63.0%for cholesterol and pigmented gallstones,respectively,which represented a 1.4-and 1.9-fold increase in dissolubility compared to that of *** addition,the results of the cell viability assay and western blot analysis indicated that TAEE had a lower toxicity towards gallbladder epithelial cells than *** We demonstrated that TAEE has higher gallstone dissolubility properties and safety than those of *** such,TAEE could present an attractive alternative to MTBE if our findings

关键词： Tert-amyl ethyl ether Gallstones Methyl-tert-butyl ether Contact litholytic agent

Joint arthroplasty Perioperative Surgical Home:Impact of patient characteristics on postoperative outcomes

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World Journal of Orthopedics 2016年第6期7卷 376-382页

作者： Duy L Phan Kyle ahn joseph B Rinehart Michael-David Calderon Wei-Der Wu Ran Schwarzkopf Department of Orthopaedic Surgery Universityof California Irvine Medical Center Department of Anesthesiology University of CaliforniaIrvine Medical Center Division of Adult Reconstruction Departmentof Orthopaedic Surgery New York University Langone Medical Center

AIM:To determine the impact of different characteristics on postoperative outcomes for patients in a joint arthroplasty Perioperative Surgical Home(PSH) ***:A retrospective review was performed for patients enrolled in a joint arthroplasty PSH program who had undergone primary total hip arthroplasty(THA) and total knee arthroplasty(TKA).Patients were preoperatively stratified based on specific procedure performed,age,gender,body mass index(BMI),American Society of Anesthesiologists Physical Classification System(ASA) score,and Charleston Comorbidity Index(CCI) *** primary outcome criterion was hospital length of stay(LOS).Secondary criteria including operative room(OR) duration,trans-fusion rate,Post-Anesthesia Care Unit(PACU) stay,readmission rate,post-operative complications,and discharge *** each outcome,the predictor variables were entered into a generalized linear model with appropriate response and assessed for predictive relationship to the dependent *** level was set to ***:A total of 337 patients,200 in the TKA cohort and 137 in the THA cohort,were eligible for the *** two-third of patients were *** age averaged 64 years and preoperative BMI averaged 29 kg/*** majority of patients were ASA score Ⅲ and CCI score *** analysis,ASA score was the only variable predictive for LOS(P = 0.0011) and each increase in ASA score above 2 increased LOS by approximately 0.5 *** score was also the only variable predictive for readmission rate(P = 0.0332).BMI was the only variable predictive for PACU duration(P = 0.0136).Specific procedure performed,age,gender,and CCI score were not predictive for any of the outcome *** duration,transfusion rate,postoperative complications or discharge disposition were not significantly associated with any of the predictor ***:The joint arthroplasty PSH model reduces postoperative outcome variability for patients with different preo

关键词： Perioperative Surgical Home Arthroplasty Length of stay American Society of Anesthesiologists Physical Classification System Body mass index

Personalized composite scaffolds for accelerated cell-and growth factor-free craniofacial bone regeneration

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Bioactive Materials 2024年第11期41卷 427-439页

作者： Mirae Kim Xinlong Wang Yiming Li Zitong Lin Caralyn P.Collins Yugang Liu Yujin ahn Hsiu-Ming Tsal joseph W.Song Chongwen Duan Yi Zhu Cheng Sun Tong-Chuan He Yuan Luo Russell R.Reid Guillermo A.Ameer Department of Biomedical Engineering Northwestern UniversityEvanstonIL60208USA Center for Advanced Regenerative Engineering Northwestern UniversityEvanstonIL60208USA Department of Preventive Medicine Feinberg School of MedicineNorthwestern UniversityChicagoIL60611USA Department of Mechanical Engineering Northwestern UniversityEvanstonIL60208 USA Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-ChampaignUrbanaIL61820USA Department of Radiology The University of ChicagoChicagoIL60637USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL60637USA Clinical and Translational Sciences Institute Northwestern UniversityChicagoIL60611USA Center for Collaborative AI in Healthcare Institute for AI in MedicineNorthwestern UniversityChicagoIL60611USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago Medical CenterChicagoIL60637USA Department of Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL60611USA Chemistry of Life Process Institute Northwestern UniversityChicagoIL60208USA International Institute for Nanotechnology Northwestern UniversityEvanstonIL60208USA

Approaches to regenerating bone often rely on integrating biomaterials and biological signals in the form of cells or ***,from a translational point of view,these approaches are challenging due to the sourcing and quality of the biologic,unpredictable immune responses,complex regulatory paths,and high *** describe a simple manufacturing process and a material-centric 3D-printed composite scaffold system(CSS)that offers distinct advantages for clinical *** CSS comprises a 3D-printed porous polydiolcitrate-hydroxyapatite composite elastomer infused with a polydiolcitrate-graphene oxide hydrogel *** a micro-continuous liquid interface production 3D printer,we fabricate a precise porous ceramic scaffold with 60 wt%hydroxyapatite resembling natural *** resulting scaffold integrates with a thermoresponsive hydrogel composite in situ to fit the defect,which is expected to enhance surface contact with surrounding tissue and facilitate *** antioxidative properties of citrate polymers prevent long-term inflammatory *** CSS stimulates osteogenesis in vitro and in *** 4 weeks in a calvarial critical-sized bone defect model,the CSS accelerated ECM deposition(8-fold)and mineralized osteoid(69-fold)compared to the *** spatial transcriptomics,we demonstrated the comprehensive biological processes of CSS for prompt *** material-centric approach delivers impressive osteogenic properties and streamlined manufacturing advantages,potentially expediting clinical application for bone reconstruction surgeries.

关键词： Craniofacial bone regeneration Composite scaffold Material-centric approach3D printing Citrate biomaterial

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用于先进PCB制造工艺的叠层封装(英文)

电子工业专用设备 2007年第5期36卷 40-50页

作者： joseph Y. Lee Jinyong ahn JeGwang Yoo Joonsung Kim Hwa-Sun Park Shuichi Okabe Samsung Electro-Mechanics Co. LTD. Suwon Gyunggi-Do Korea 443-743

在20世纪90年代,球栅阵列封装(BGA)和芯片尺寸封装(CSP)在封装材料和加工工艺方面达到了极限。这2种技术如同20世纪80年代的表面安装器件(SMD)和70年代通孔安装器件(THD)一样,在电学、机械、热性能、尺寸、质量和可靠性方面达到最大值... 详细信息

在20世纪90年代,球栅阵列封装(BGA)和芯片尺寸封装(CSP)在封装材料和加工工艺方面达到了极限。这2种技术如同20世纪80年代的表面安装器件(SMD)和70年代通孔安装器件(THD)一样,在电学、机械、热性能、尺寸、质量和可靠性方面达到最大值。目前,三维封装正在成为用于未来采用的先进印制板(PCB)制造工艺的下一个阶段。它们可以分为圆片级封装、芯片级封装、和封装面。叠层封装(PoP)是一种封装面叠层封装类型的三维封装技术[15]。

关键词：三维封装叠层封装三维芯片叠层封装多芯片封装折叠封装

Analysis of COVID-19 Guideline Quality and Change of Recommendations:A Systematic Review

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Health Data Science 2021年第1期2021卷 88-109页

作者： Siya Zhao Shuya Lu Shouyuan Wu Zijun Wang Qiangqiang Guo Qianling Shi Hairong Zhang Juanjuan Zhang Hui Liu Yunlan Liu Xianzhuo Zhang Ling Wang Mengjuan Ren Ping Wang Hui Lan Qi Zhou Yajia Sun Jin Cao Qinyuan Li Janne Estill joseph LMathew Hyeong Sik ahn Myeong Soo Lee Xiaohui Wang Chenyan Zhou Yaolong Chen School of Public Health Lanzhou UniversityLanzhouChina Institute of Health Data Science Lanzhou UniversityLanzhouChina Department of Pediatric Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital ChengduChina Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina The First School of Clinical Medicine Lanzhou UniversityLanzhouChina National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren’s Hospital of Chongqing Medical UniversityChongqingChina Institute of Global Health University of GenevaGenevaSwitzerland Institute of Mathematical Statistics and Actuarial Science University of BernBernSwitzerland Advanced Pediatrics Centre PGIMER ChandigarhChandigarhIndia Department of Preventive Medicine Korea UniversitySeoulRepublic of Korea Korea Cochrane Centre SeoulRepublic of Korea Evidence Based Medicine SeoulRepublic of Korea Korea University School of Medicine SeoulRepublic of Korea Korea Institute of Oriental Medicine DaejeonRepublic of Korea University of Science and Technology DaejeonRepublic of Korea London Southbank University LondonUK Tianjin University of Traditional Chinese Medicine TianjinChina WHO Collaborating Centre for Guideline Implementation and Knowledge Translation LanzhouChina Guideline International Network Asia China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province Lanzhou UniversityLanzhouChina Lanzhou University GRADE Center China

*** of coronavirus disease 2019(COVID-19)clinical practice guidelines(CPGs)and expert consensus statements have been developed and published since the outbreak of the ***,these CPGs are of widely variable ***,this review is aimed at systematically evaluating the methodological and reporting qualities of COVID-19 CPGs,exploring factors that may influence their quality,and analyzing the change of recommendations in CPGs with evidence *** searched five electronic databases and five websites from 1 January to 31 December 2020 to retrieve all COVID-19 *** assessment of the methodological and reporting qualities of CPGs was performed using the AGREE II instrument and RIGHT *** and evidence used to make recommendations in the CPGs regarding some treatments for COVID-19(remdesivir,glucocorticoids,hydroxychloroquine/chloroquine,interferon,and lopinavir-ritonavir)were also systematically *** the statistical inference was performed to identify factors associated with the quality of *** included a total of 92 COVID-19 CPGs developed by 19 ***,the RIGHT checklist reporting rate of COVID-19 CPGs was 33.0%,and the AGREE II domain score was 30.4%.The overall methodological and reporting qualities of COVID-19 CPGs gradually improved during the year *** associated with high methodological and reporting qualities included the evidence-based development process,management of conflicts of interest,and use of established rating systems to assess the quality of evidence and strength of *** recommendations of only seven(7.6%)CPGs were informed by a systematic review of evidence,and these seven CPGs have relatively high methodological and reporting qualities,in which six of them fully meet the Institute of Medicine(IOM)criteria of ***,a rapid advice CPG developed by the World Health Organization(WHO)of the seven CPGs got the highest overa

关键词： register formal transparency

Investigation and evaluation of randomized controlled trials for interventions involving artificial intelligence

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Intelligent Medicine 2021年第2期1卷 61-69页

作者： Jianjian Wang Shouyuan Wu Qiangqiang Guo Hui Lan Estill Janne Ling Wang Juanjuan Zhang Qi Wang Yang Song Nan Yang Xufei Luo Qi Zhou Qianling Shi Xuan Yu Yanfang Ma joseph LMathew Hyeong Sik ahn Myeong Soo Lee Yaolong Chen School of Public Health Lanzhou UniversityLanzhouGansu 730000China Institute of Global Health University of GenevaGenevaSwitzerland Institute of Mathematical Statistics and Actuarial Science University of BernBernSwitzerland Department of Health Research Methods Evidence and ImpactFaculty of Health SciencesMcMaster UniversityHamiltonCanada McMaster Health Forum McMaster UniversityHamiltonCanada Iberoamerican Cochrane Centre-Biomedical Research Institute Sant Pau(IIB Sant Pau) BarcelonaSpain Evidence-based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouGansu 730000China The First School of Clinical Medicine Lanzhou UniversityLanzhouGansu 730000China Advanced Pediatrics Centre PGIMER ChandigarhChandigarhIndia Department of Preventive Medicine Korea UniversitySeoulKorea Korea Cochrane Centre SeoulKorea Evidence Based Medicine SeoulKorea Korea University School of Medicine SeoulKorea Korea Institute of Oriental Medicine DaejeonKorea University of Science and Technology DaejeonKorea London Southbank University LondonUK Tianjin University of Traditional Chinese Medicine Tianjin 301617China Lanzhou University Institute of Health Data Science LanzhouGansu 730000China Key Laboratory of Evidence Based Medicine&Knowledge Translation of Gansu Province LanzhouGansu 730000China

Objective Complete and transparent reporting is of critical importance for randomized controlled trials(RCTs).The present study aimed to determine the reporting quality and methodological quality of RCTs for interventions involving artificial intelligence(AI)and their *** We searched MEDLINE(via PubMed),Embase,Web of Science,CBMdisc,Wanfang Data,and CNKI from January 1,2016,to November 11,2020,to collect RCTs involving *** also extracted the protocol of each included RCT if it could be ***-AI(Consolidated Standards of Reporting Trials-Artificial Intelligence)statement and Cochrane Collaboration’s tool for assessing risk of bias(ROB)were used to evaluate the reporting quality and methodological quality,respectively,and SPIRIT-AI(The Standard Protocol Items:Recommendations for Interventional Trials-Artificial Intelligence)statement was used to evaluate the reporting quality of the *** associations of the reporting rate of CONSORT-AI with the publication year,journal’s impact factor(IF),number of authors,sample size,and first author’s country were analyzed univariately using Pearson’s chi-squared test,or Fisher’s exact test if the expected values in any of the cells were below *** compliance of the retrieved protocols to SPIRIT-AI was presented *** Overall,29 RCTs and three protocols were considered *** CONSORT-AI items“title and abstract”and“interpretation of results”were reported by all RCTs,with the items with the lowest reporting rates being“funding”(0),“implementation”(3.5%),and“harms”(3.5%).The risk of bias was high in 13(44.8%)RCTs and not clear in 15(51.7%)*** one RCT(3.5%)had a low risk of *** compliance was not significantly different in terms of the publication year,journal’s IF,number of authors,sample size,or first author’s *** of the 35 SPIRIT-AI items(funding,participant timeline,allocation concealment mechanism,implementation,data management,auditing,declaration of in

关键词： Artificial intelligence Randomized controlled trials Reporting quality Methodological quality