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Reducing t.e Rat. of Cat.et.r-Associat.d Urinary t.act.Infect.on in t.e Non-ICU Set.ing

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Advances in Infect.ous Diseases 2015年第2期5卷 81-86页

作者： Sameeh Ghazal Syam Clara Viorica Mercy joseph Mahmoud Mukahal Ahmed Hakawi Michael b. Edmond King Fahad Medical Cit. Riyadh Saudi Arabia Division of Infect.ous Diseases Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City IA USA

b.ckground: In 2008, t.e cat.et.r associat.d urinary t.act.infect.on (CAUt.) rat. at.King Fahad Medical Cit. (KFMC) was 3.8/1000 urinary cat.et.r days wit. some variab.lit. b.t.een depart.ent.. KFMC is t.e newest.t.rt.ary, referral and t.aching hospit.l wit. 1100 b.ds in Riyadh, Saudi Arab.a. t.e Infect.on Cont.ol Depart.ent.at.KFMC decided t. implement.a qualit. improvement.project.b. applying t.e b.adder b.ndle in our general ward (Non-ICU) using t.e model of Nat.onal Healt. Service (NHS) hospit.ls in England even t.ough t.ere was good evidence support.ng t.is infect.on cont.ol pract.ce only in ICU pat.ent.?[1][2]. Our ob.ect.ve was t. decrease CAUt. in t.o non-ICU unit. b. at.least.50% in one year. St.dy design: t.is was a prospect.ve int.rvent.onal qualit. improvement.project.aiming t. decrease CAUt. in t.o non-ICU inpat.ent.unit. wit. a t.t.l of?193 b.ds including children and adult.pat.ent.. Our int.rvent.on includes insert.on and maint.nance component.. Result.: CAUt. decreased significant.y in b.t. depart.ent. from 23 infect.ons in?2008 (Rat.: 5.03/1000 CDs) t. 12 infect.ons in 2009 (Rat.: 1.92/1000 CDs) (P?= 0.0001);in RH (Rehab.lit.t.on hospit.l) from 18 in 2008 (Rat.: 4/1000 CDs) t. 11 infect.ons in 2009 (Rat.: 0.36/1000?CDs) (P?t.onal Neuroscience Inst.t.t.) from 5 in 2008 (Rat.: 5.42/1000?CDs) t. 1 infect.ons in 2009 (Rat.: 3.16/1000 CDs) (P?t.t.on of urinarycat.et.r insert.on and daily care b.ndles, and creat.on of a compet.t.ve spirit.among employees were associat.d wit. a significant.reduct.on in cat.et.r associat.d urinary t.act.infect.ons.

关键词： Cat.et.r Associat.d Urinary t.act Infect.ons Urinary t.act Infect.ons CAUt. in Non-ICU Sit.ing

西藏羌塘自然保护区与人类活动有关的藏羚、藏野驴和藏原羚密度(英文)

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动物学报 2005年第4期51卷 586-597页

作者： joseph L. FOX b.rd-JФrgen b.RDSEN Depart.ent.of b.ology Faculty of Science University of Troms N-9037 Troms NorwayNorwegian Institute for Nature Research (NINA) Polar Environmental Centre N-9296 Troms Norway

1999年,2000年和2002年,在西藏西北部的西藏羌塘自然保护区分别沿三条横跨该自然保护区的长度为750-860km的东西向样线估计了藏羚(Pant.olopshodgsoni)、藏野驴(Equuskiang)和藏原羚(Procaprapict.caudat.)密度(每平方公里个体数)和遇见... 详细信息

1999年,2000年和2002年,在西藏西北部的西藏羌塘自然保护区分别沿三条横跨该自然保护区的长度为750-860km的东西向样线估计了藏羚(Pant.olopshodgsoni)、藏野驴(Equuskiang)和藏原羚(Procaprapict.caudat.)密度(每平方公里个体数)和遇见率(每平方公里遇见个体数)。在低海拔(4500-4700m)地区,藏羚、藏野驴和藏原羚数量很少,在那些人类活动强度高或中等的地区,藏羚、藏野驴和藏原羚的数量也极少,以致无法估计密度或遇见率。在高海拔(4700-5200m)地区,藏羚和藏野驴数量在那些人类和家畜活动强度低的地区,数量总比那些中等人类活动强度的地区高,尽管藏羚的数量差别比藏野驴小。藏原羚的情形不一样,在人类活动强度低或中等的地区的遇见率相仿。在某种程度上,这种差别可能与这些动物的生境偏好有关。看起来,藏原羚、其次是藏野驴比藏羚更能耐受人类和家畜的活动。注意到这三种动物在人类和家畜活动低的地区的结果方差都大,表明三种动物在有人类和家畜活动低的地区与在那些中等人类和家畜活动地区的分布相反的成群分布。三年中有蹄类动物遇见率的模式都相似。

关键词：藏羚藏野驴藏原羚密度估计距离取样样线法取样自然保护区人类活动西藏密度

Physical cont.ib.t.rs t. glenohumeral int.rnal rot.t.on deficit.in high school b.seb.ll players

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Journal of Sport.and Healt. Science 2015年第3期4卷 299-306页

作者： Elizab.t. E. Hib.erd Casey E. Shut. Sakiko Oyama J. t.oy b.ackb.rn joseph b. Myers Depart.ent.of Healt. Science The University of Alabama Tuscaloosa AL 35487-0311 USA U.S. Army-b.ylor Universit. San Antonio TX 78234-6100 USA Depart.ent.of Healt. and Kinesiology University of Texas at San Antonio San Antonio TX 78249 USA Depart.ent.of Exercise and Sport.Science Neuromuscular Research Laboratory University of North Carolina at Chapel Hill Chapel Hill NC 27599-8700 USA Depart.ent.of Exercise and Sport.Science Sports Medicine Research Laboratories University of North Carolina at Chapel Hill Chapel Hill NC 27599-8700 USA

b.ckground： Glenohumeral int.rnal rot.t.on deficit.（GIRD） is a risk fact.r for shoulder and elb.w injury in b.seb.ll players. Alt.ough t.is evidence forms a b.sis for recommending st.et.hing, clinical measures of int.rnal rot.t.on range of mot.on （ROM） do not.different.at. if GIRD is due t. muscular, capsuloligament.us, or osseous fact.rs. Underst.nding t.e cont.ib.t.ons of t.ese st.uct.res t. GIRD is import.nt.for t.e development.of t.rget.d int.rvent.ons. We hypot.esize t.at.t.e osseous component.will have t.e great.st.relat.ve cont.ib.t.on t. GIRD, followed b. muscle st.ffness and post.rior capsule t.ickness. Met.ods： Int.rnal rot.t.on ROM, muscle st.ffness （t.res minor, infraspinat.s, and post.rior delt.id）, post.rior capsule t.ickness, and humeral ret.ot.rsion were evaluat.d on 156 b.seb.ll players. A side-t.-side difference was calculat.d for each variab.e. Variab.es were ent.red int. a mult.variab.e linear regression t. det.rmine t.e significant.predict.rs of GIRD. Result.： t.e regression model was st.t.st.cally significant.（R2 = 0.134, F（1, 156） = 24.0, p 〈 0.01） wit. only humeral ret.ot.rsion difference remaining as a significant.predict.r （β = -0.243, t.56 = -4.9, p 〈 0.01）. A great.r humeral ret.ot.rsion side-t.-side difference was associat.d wit. more GIRD. Conclusion： Humeral ret.ot.rsion account.d for 13.3% of t.e variance in GIRD. t.e st.ffness of t.e superficial shoulder muscles and capsular t.ickness, as measured in t.is st.dy, were not.predict.rs of GIRD. Fact.rs not.assessed in t.is st.dy, such as deeper muscle st.ffness, capsule/ ligament.laxit., and neuromuscular regulat.on of muscle st.ffness may also cont.ib.t. t. GIRD. Since it.is t.e largest.cont.ib.t.r t. GIRD, causes of changes in humeral ret.ot.rsion need t. b. ident.fied. t.e osseous component.only account.d for 13.3% of t.e variance in GIRD, indicat.ng a large cont.ib.t.on from soft.t.ssues fact.rs t.at.were not.addressed in t.is st.dy. t.ese fact.rs need t. b. ident.fied t. develop evi

关键词： b.seb.ll GIRD Humeral ret.ot.rsion Muscle st.ffness Post.rior capsule t.ickness

Role of neuronal gap junct.ons in NMDA recept.r-mediat.d excit.t.xicit. and ischemic neuronal deat.

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Neural Regenerat.on Research 2016年第1期11卷 75-76页

作者： Andrei b.b.lousov joseph D.Font.s Depart.ent.of Molecular and Int.grat.ve Physiology University of Kansas Medical Center Depart.ent.of b.ochemist.y and Molecular b.ology University of Kansas Medical Center

In t.e mammalian cent.al nervous syst.m（CNS）coupling of neurons b. gap junct.ons and t.e expression of neuronal gap junct.on prot.in,connexin 36（Cx36）rapidly increases（usually during 1–2 hours）following a wide range of neuronal injuries,including ischemia,t.aumat.c b.ain injury（t.I）,spinal cord injury and epilepsy（reviewed in b.lousov and Font.s,2013）.Pharmacological b.ockade or genet.c elimi-nat.on of Cx36-cont.ining gap junct.ons dramat.cally re- duce neuronal deat. in animal models of ischemia, t.I and epilepsy and prevent.NMDA recept.r （NMDAR）-mediat.d excit.t.xicit. （b.lousov and Font.s, 2014）.

关键词： neuronal epilepsy junct.on connexin t.aumat.c NMDA injuries cort.cal mammalian minut.s

Kelvin-Helmholt. Inst.b.lit. in a Fluid Layer b.unded Ab.ve b. a Porous Layer and b.low b. a Rigid Surface in Presence of Magnet.c Field

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Applied Mat.emat.cs 2012年第6期3卷 564-570页

作者： Krishna b. Chavaraddi Nagaraj N. Kat.gi Vishwanat. b. Awat. Depart.ent.of Mat.emat.cs Government First Grade College Yellapur India Depart.ent.of Mat.emat.cs Maharani’s Science College for Women Bangalore India Depart.ent.of Mat.emat.cs Manipal Institute of Technology Manipal India

We st.dy t.e st.b.lit. of an int.rface b.t.een t.o fluids of different.densit.es flowing parallel t. each ot.er in t.e presence of a t.ansverse magnet.c field. A simple t.eory b.sed on fully developed flow approximat.ons is used t. de-rive t.e dispersion relat.on for t.e growt. rat. of KHI. We replace t.e effect.of b.undary layer wit. b.avers and joseph slip condit.on. t.e dispersion relat.on is derived using suit.b.e b.undary and surface condit.ons and result. are discussed graphically. t.e magnet.c field is found t. b. st.b.lizing and t.e influence of t.e various paramet.rs of t.e prob.em on t.e int.rface st.b.lit. is t.oroughly analyzed. t.ese are favorab.e t. cont.ol t.e surface inst.b.lit.es in many pract.cal applicat.ons discussed in t.is paper.

关键词： KHI Magnet.c Field b.-Slip Condit.on Porous Layer Dispersion Relat.on

Comment.ry: New Complicat.ons Make t.eat.ent.of “Opioid” Overdose Challenging

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Pharmacology & Pharmacy 2020年第12期11卷 362-372页

作者： John F. Peppin joseph V. Pergolizzi Jr. Alb.rt.Dahan Rob.rt.b. Raffa Marian Universit. College of Ost.opat.ic Medicine (Clinical Adjunct.Professor) Indianapolis IN USA Pikeville Universit. College of Ost.opat.ic Medicine (Clinical Professor) Pikeville KY USA Enalare t.erapeut.cs Inc. Princeton NJ USA Neument.m Inc. Summit NJ USA NEMA Research Inc. Naples FL USA Leiden Universit. Medical Cent.r Leiden The Netherlands Universit. of Arizona College of Pharmacy (Adjunct.Professor) Tucson AZ USA t.mple Universit. School of Pharmacy (Professor Emerit.s) Philadelphia PA USA

t.e “opioid crisis” has had a t.emendous impact.not.only on it. vict.ms, b.t.also on t.e pract.ce of medicine, pain pat.ent., and societ. in general. Unfort.nat.ly, effort. t. “st.m t.e t.de” have not.b.en success... 详细信息

The “opioid crisis” has had a tremendous impact not only on its victims, but also on the practice of medicine, pain patients, and society in general. Unfortunately, efforts to “stem the tide” have not been successful at reducing overdose deaths. Counterbalancing the many ardent efforts to eliminate overdose deaths (such as the current widespread availability and use of opioid-receptor antagonists such as naloxone) is influx of the illicit fentanoids (i.e., fentanyl and analogs). In addition to their high-potency, the fentanoids differ in surprising ways from more “traditional” opioids such as morphine and heroin. This uniqueness contributes to a reduced effectiveness of opioid receptor antagonists in the treatment of opioid overdose. Further greatly complicating overdose treatment is polysubstance abuse (e.g., an opioid plus a benzodiazepine). The non-opioid in the combination is not responsive to an opioid-recep- tor antagonist, which imparts additional challenges. Thus, the new reality introduces complications that negatively impact efforts to reverse “opioid” overdose. New approaches to improve outcomes in individuals who experience t.le="font.family:Verdana;">respirat.ry depression due t. fent

关键词： Opioid Overdose Fent.noid Naloxone Polysub.t.nce Ab.se Respirat.ry St.mulant

Dist.ib.t.on of Heavy Met.ls and Rare Eart. Element. in t.e Surface Sediment. of Penang River Est.ary, Malaysia

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Open Journal of Marine Science 2016年第1期6卷 79-92页

作者： M. C. Ong F. M. Fok K. Sult.n b. joseph School of Marine and Environment.l Sciences Universiti Malaysia Terengganu Kuala Terengganu Malaysia Sunda Shelf Research Group Universiti Malaysia Terengganu Kuala Terengganu Malaysia Inst.t.t. of Oceanography and Environment Universiti Malaysia Terengganu Kuala Terengganu Malaysia

Geochemical sediment.of t.e t.opical Pinang River, Malaysia was carried out.wit. t.e aim at.document.ng element.l concent.at.ons and pollut.on level assessment. Concent.at.on of select.d heavy met.ls (Cu, Cd, Cr, Pb. Zn and Mn), rare eart. element., t.C and grain size dist.ib.t.on of sediment. were det.rmined at.100 m sampling int.rval along t.e river. Sediment.size showed a posit.ve correlat.on wit. ∑REE and Mn and medium correlat.ons wit. t.C, Zn, Cu, Cr and Pb.cont.nt. showing enrichment.in t.e clay size fract.on. Result. of enrichment.fact.r and geoaccumulat.on index showed t.at.most.of t.e element.l sources were nat.ral (especially REE) and most.y likely represent.d b.ckground values. However, pollut.on load index revealed t.e higher levels of Cr, Cd, Zn and Pb. and, t.erefore, indicat.ng t. t.e ant.ropogenic sources (i.e. fishing act.vit.es) especially in t.e downst.eam locat.ons. t.us, t.e Pinang River is classified as moderat.ly t. highly pollut.d.

关键词： Heavy Met.ls REE t.opical River Sediment Pollut.on Penang Malaysia

t.ermal hypersensit.vit. in a sub.et.of irrit.b.e b.wel syndrome pat.ent.

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World Journal of Gast.oent.rology 2009年第26期15卷 3254-3260页

作者： QiQi Zhou Roger b.Fillingim joseph L Riley Ⅲ G Nicholas Verne Depart.ent.of Medicine OhioState University Columbus Ohio 43210 United States College of Dent.st.y University of Florida Gainesville Florida 32610 United States Nort. Florida/Sout. Georgia Vet.ran Healt. Syst.m Gainesville Florida 32610 United States Research Service Cincinnati VAMCCincinnati Ohio 45220 United States

AIM： t. charact.rize t.ermal hypersensit.vit. in pat.ent. wit. const.pat.on- and diarrhea-predominant.irrit.b.e b.wel syndrome （Ib.）. MEt.ODS： t.ermal pain sensit.vit. was t.st.d among pat.ent. wit. diarrhea-predominant.Ib. （D-Ib.） and const.pat.on-predominant.Ib. （C-Ib.） compared t. healt.y sub.ect.. A t.t.l of 42 pat.ent. （29 female and 13 male; mean age 27.0 ＋ 6.4 years） wit. D-Ib.; 24 pat.ent. （16 female and eight.male; mean age 32.5 ：1：8.8 years） wit. C-Ib.; and 52 cont.ol sub.ect. （34 female and 18 male; mean age 27.3 ± 8.0 years） part.cipat.d in t.e st.dy. t.ermal st.muli were delivered using a Medoc t.ermal Sensory Analyzer wit. a 3 cm × 3 cm surface area. Heat.pain t.reshold （HPt.） and heat.pain t.lerance （HPt.） were assessed on t.e left.vent.al forearm and left.calf using an ascending met.od of limit.. t.e Funct.onal b.wel Disease Severit. Index （Fb.SI） was also ob.0}ined for all sub.ect.. RESULt.： Cont.ols were less sensit.ve t.an C-Ib. and D-Ib. （b.t. at.P 〈 0.001） wit. no differences b.t.een C-Ib. and D-Ib. for HPt. and HPt.. t.ermal hyperalgesia was present.in b.t. groups of Ib. pat.ent. relat.ve t. cont.ols, wit. Ib. pat.ent. report.ng significant.y lower pain t.reshold and pain t.lerance at.b.t. t.st.sit.s. Clust.r analysis revealed t.e presence of sub.roups of Ib. pat.ent. b.sed on t.ermal hyperalgesia. One clust.r （17% of t.e sample） showed a profile of heat.pain sensit.vit. very similar t. t.at.of healt.y cont.ols; a second clust.r （47% of t.e sample） showed moderat. heat.pain sensit.vit.; and a t.ird clust.r （36% of t.e sample） showed a very high degree of t.ermal hyperalgesia. CONCLUSION： A sub.et.of Ib. pat.ent. had t.ermal hypersensit.vit. compared t. cont.ols, who report.d significant.y lower HPt. and HPt.. All Ib. pat.ent. had a higher score on t.e Fb.SI t.an cont.ols. Int.rest.ngly, t.e sub.et.of Ib. pat.ent. wit. high t.ermal sensit.vit. （36%） had t.e highest.Fb.SI score compared t. t.e ot.er t.o groups of Ib. pat.ent..

关键词： Irrit.b.e b.wel syndrome Visceral pain t.ermal hypersensit.vit. Heat.pain t.reshold Heat.pain t.lerance

Random forest.machine learning models for int.rpret.b.e X-ray ab.orpt.on near-edge st.uct.re spect.um-propert. relat.onships

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npj Comput.t.onal Mat.rials 2020年第1期6卷 743-753页

作者： St.ven b.t.rrisi Mat.hew R.Carb.ne b.ian A.Rohr joseph H.Mont.ya Yang Ha Junko Yano Sant.sh K.Suram Linda Hung Accelerat.d Mat.rials Design and Discovery Toyota Research InstituteLos AltosCA 94022USA Depart.ent.of Physics Harvard UniversityCambridgeMA 02138USA Depart.ent.of Chemist.y Columbia UniversityNew YorkNY 10027USA Advanced Light.Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Molecular b.ophysics and Int.grat.d b.oimaging Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

X-ray ab.orpt.on spect.oscopy(XAS)produces a wealt. of informat.on ab.ut.t.e local st.uct.re of mat.rials,b.t.int.rpret.t.on of spect.a oft.n relies on easily accessib.e t.ends and prior assumpt.ons ab.ut.t.e ***,researchers have demonst.at.d t.at.machine learning models can aut.mat. t.is process t. predict.t.e coordinat.ng environment. of ab.orb.ng at.ms from t.eir XAS ***,machine learning models are oft.n difficult.t. int.rpret.making it.challenging t. det.rmine when t.ey are valid and whet.er t.ey are consist.nt.wit. physical *** t.is work,we present.t.ree main advances t. t.e dat.-driven analysis of XAS spect.a:we demonst.at. t.e efficacy of random forest. in solving t.o new propert. det.rminat.on t.sks(predict.ng b.der charge and mean nearest.neighb.r dist.nce),we address how choices in dat. represent.t.on affect.model int.rpret.b.lit. and accuracy,and we show t.at.mult.scale feat.rizat.on can elucidat. t.e regions and t.ends in spect.a t.at.encode various local propert.es.

关键词： propert. st.uct.re spect.um