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Acute worsening of microvascular complications of diabetes mellitus during rapid glycemic control:The pathobiology and therapeutic implications

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World Journal of Diabetes 2024年第3期15卷 311-317页

作者： Dania Blaibel Cornelius James Fernandez joseph M Pappachan Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Department of Endocrinology and Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Faculty of science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

While chronic hyperglycaemia resulting from poorly controlled diabetes mellitus(DM)is a well-known precursor to complications such as diabetic retinopathy,neuropathy(including autonomic neuropathy),and nephropathy,a paradoxical intensification of these complications can rarely occur with aggressive glycemic management resulting in a rapid reduction of glycated ***,acute onset or worsening of retinopathy and treatment induced neuropathy of diabetes are more common among these complications,rarely other problems such as albuminuria,diabetic kidney disease,Charcot’s neuroarthropathy,gastroparesis,and urinary bladder dysfunction are also *** World Journal of Diabetes recently published a rare case of all these complications,occurring in a young type 1 diabetic female intensely managed during pregnancy,as a case report by Huret et *** is essential to have a comprehensive understanding of the pathobiology,prevalence,predisposing factors,and management strategies for acute onset,or worsening of microvascular complications when rapid glycemic control is achieved,which serves to alleviate patient morbidity,enhance disease management compliance,and possibly to avoid medico-legal issues around this rare clinical *** editorial delves into the dynamics surrounding the acute exacerbation of microvascular complications in poorly controlled DM during rapid glycaemic control.

关键词： Diabetes mellitus Microvascular complications Diabetic retinopathy Treatment induced neuropathy of diabetes Diabetic nephropathy Charcot’s neuropathy

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Irrigation and Thermal Buffering Using Mathematical Modeling

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Journal of Environmental & Earth sciences 2024年第1期6卷 19-32页

作者： Yara Yasser Elborolosy Harsho sanyal joseph Cataldo The Albert Nerken school of Engineering at the Cooper Union New YorkNY 10003US

Two methods of irrigation,drip,and sprinkler were studied to determine the response of the Javits green roof to *** control study was dry unirrigated *** irrigation consisted of irrigation tubes running through the green roof that would water the soil throughout and sprinkler irrigation used a sprinkler system to irrigate the green roof from *** all cases,the irrigated roofs had increased the soil moisture,reduced temperatures of both the upper and lower surfaces,reduced growing medium temperatures and reduced air temperatures above the green roof relative to the unirrigated *** buffered temperature fluctuations were also studied via air conditioner energy *** was a 28%reduction in air conditioner energy consumption and a 33%reduction in overall energy consumption between dry and irrigated *** of thermal resistance or s were determined for accuracy and for this study,there was little change which is ideal.A series of infra-red and thermal probe measurements were used to determine temperatures in the air and *** was determined that the sprinkler irrigation did a better job than the drip irrigation in keeping cooler temperatures within the green roof.A Mann-Whitney U test was performed to verify the variation in moisture temperatures buffering energy *** getting a p-values that the model is accurate for prediction and medium temperatures were statistically different.

关键词： Green roofs Irrigation Drip sprinkler Thermal buffering

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Effects of crop residues for animal consumption and soil enhancement on the electricity generation potential of residues:A case study of sawla-Tuna-Kalba district,Ghana

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 276-287页

作者： Augustine Awaafo Edward A.Awafo Meisam Mahdavi David Vera Gilbert Ayine Akolgo Emmanuel Amankwah francisco Jurado Department of Electrical Engineering University of JaénLinares 23700JaénSpain Department of Computer and Electrical Engineering University of Energy and Natural ResourcesSunyani P.O.Box 214Ghana Department of Agricultural and Bioresources Engineering University of Energy and Natural ResourcesSunyani P.O.Box 214Ghana

Many studies have estimated the potential of crop residues for energy generation globally and recognized its great potential,especially in rural areas where on-grid electricity is ***,crop residues have other equally important uses as animal feed and as mulch for soil enhancement,especially in rural farming ***,most of the known studies have neglected the estimation of the quantity of crop residues that will be required for feeding animals and also for the enhancement of soil through mulching in their energy potential estimation from crop *** these two important uses can lead to the over-exploitation of the residues for energy generation at the expense of conservation agriculture practices as well as depriving animals of quality feed which can lead to low crop yield and animal production,with the ability to cause hunger and *** study has assessed the potential of electricity generation from agricultural residues in the sawla-Tuna-Kalba district of Ghana using gasification technology,taking cognizance of the proportion of residues needed for animal consumption and soil *** results of the study indicate that out of the 207646.22 t of residues that can be generated from maize,yam,cassava,millet,sorghum,and groundnut,26830.36 t(representing 13%)will be required by sheep,goats,and cows for consumption,and 13936.17 t(representing 7%)will be required for mulching soils where the crops are ***,it was found that a total of 592.17 MW∙h of electricity can be generated from crop residues without animal consumption and soil enhancement needs,while 461.89 MW∙h could be generated from the residues,considering animal feed and soil *** study has indicated that it is not enough to consider soil enhancement and animal feeding in agricultural biomass power generation through recovery factors without the exact quantification of residues required for these purposes since this can lead to a vi

关键词： animal feed crop residue electricity generation soil enhancement

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Community-Based Hepatitis B Campaign in Asian Americans

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International Journal of Clinical Medicine 2024年第9期15卷 389-412页

作者： Chul s. Hyun soonsik Kim sarah Hyun joseph McMenamin The Center for Viral Hepatitis Englewood Cliffs NJ USA Korean Community services of Metropolitan New York Bayside NY USA Mailman school of Public Health Columbia University New York NY USA Christian & Barton LLP Richmond VA USA

Chronic hepatitis B (CHB) disproportionately affects minority groups in the Us, particularly Asian Americans, with numerous factors contributing to this disparity. Of the 2.4 million people living with chronic HBV in the Us, 60% are Asian American. Many are unaware of their status and lack access to proper clinical care, with less than ten percent receiving necessary antiviral treatment. Barriers to screening and care include lack of disease awareness, language and cultural barriers, and financial constraints. Additionally, healthcare providers and systems in the Us often overlook the importance of CHB, leading to inadequate care. In response, the Center for Viral Hepatitis (CVH) has implemented a community-based outreach program over the past sixteen years, employing a multifaceted approach involving all sectors of society and various organizations to combat health disparities in CHB. This grassroots campaign has proven highly effective, leveraging CVH’s leadership in spearheading numerous collaborative activities with community members, healthcare professionals, and policymakers. We have summarized the key points of CVH's efforts and their significance in combating CHB-related health disparities. The CHB screening and Awareness Campaign, tailored to the Asian American community, serves as a successful model for increasing CHB screening, linkage-to-care, and addressing socio-cultural barriers and health literacy. Insights from these outreach programs have guided the development of culturally relevant resources and education initiatives. These findings suggest that such community-driven approaches are essential for addressing health disparities. The strategies and outcomes of CVH’s efforts can inform future health initiatives for other minority communities in the Us and globally.

关键词： Chronic Hepatitis B (CHB) Hepatitis B Virus (HBV) Health Disparity Health Inequity Asian Americans Cultural Competence in Healthcare Community-Based screening Linkage-to-Care (LTC)

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte sergi Ferré francisco Ciruela synaptic structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (schirinzi et al.,2020).syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Comparisons of oxbow lake fish assemblages in relation to bigheaded carp establishment in the lower White River, Arkansas

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Ecological Processes 2024年第1期13卷 188-205页

作者： Michael A.Eggleton Cody J.salzmann joseph E.Kaiser shannon C.F.smith Department of Aquaculture and Fisheries University of Arkansas at Pine Bluff Arkansas Game and Fish Commission Virginia Institute of Marine science

Background since the late 1990s, bigheaded carps(largely silver carp [Hypophthalmichthys molitrix] but also bighead carp [H. nobilis]) have established throughout the lower Mississippi River basin. Using previously studied oxbow lakes in the lower White River basin, Arkansas, we compared current(2017, “post-carp” establishment) fish assemblages to historical(2002, “pre-carp” establishment) fish assemblages. Fish assemblages were comprehensively assessed using multiple gears, including boat electrofishing, mini-fyke nets, and experimental small-mesh gill *** T-tests suggested that fish assemblage indices of richness, diversity, evenness, and dominance were often greater(P st-carp period as reflected by boat electrofishing and experimental gill nets. However, all indices were generally similar(P > 0.05) between the pre-carp and post-carp period with fish assemblages depicted using mini-fyke nets. Nonmetric multidimensional scaling analyses indicated that fish assemblages differed structurally between pre-carp and post-carp periods. Assemblage differences were linked to both small and large abundance changes for more than 20 species. Abundances of gizzard shad(Dorosoma cepedianum), emerald shiner(Notropis atherinoides), pugnose minnow(Opsopoeodus emiliae), crappies(Pomoxis spp.), bluegill(Lepomis macrochirus), orangespotted sunfish(L. humilis), and yellow bass(Morone mississippiensis) declined between the pre-carp and postcarp periods. Conversely, abundances of weed shiner(N. texanus), pallid shiner(Hybopsis amnis), longear sunfish(L. megalotis), buffalofishes(Ictiobus spp.), and gars(Lepisosteus spp.) generally increased during the same *** Although not possible to conclude assemblage shifts were entirely related to bigheaded carps due to the absence of an appropriate reference system where carps did not establish, the wide establishment of these carps is one of the most pervasive changes to have occurred in the lower White

关键词： Bigheaded carp silver carp Aquatic nuisance species Fish assemblage Oxbow lake Large river

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High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang joseph Rich Chuyi Chen Ruoyu Zhong Ke Jin Ye He Jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel sadovsky Luke P.Lee Tony Jun Huang Department of Mechanical Engineering and Materials science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various ***,challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low ***,we report a high-yield(>90%)and rapid(solation method called FLocculation via Orbital Acoustic Trapping(FLOAT).The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid *** adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the *** demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid *** to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

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What is the effect of Tribulus terrestris on testicular morphology and sperm production?An experimental study in the rat model

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Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： Marcello Henrique Araujo Da silva Gabriela Faria Buys-Goncalves Joao Henrique Duque Reis Estrada francisco Jose Barcellos sampaio Diogo Benchimol de souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the student's t-test and considered significant when Pshowed no difference between the ***,testicular weight and volume,seminiferous tubule diameter,tunica propria surface density,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with Tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle Tribulus terrestris

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Understanding the oxidation chemistry of Ti_(3)C_(2)T_(x)(MXene)sheets and their catalytic performances

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Journal of Energy Chemistry 2024年第1期88卷 437-445,I0010页

作者： suvdanchimeg sunderiya selengesuren suragtkhuu solongo Purevdorj Tumentsereg Ochirkhuyag Munkhjargal Bat-Erdene Purevlkham Myagmarsereejid Ashley Dslattery Abdulaziz sRBati joseph Gshapter Dorj Odkhuu sarangerel Davaasambuu Munkhbayar Batmunkh Department of Chemistry Division of Natural SciencesSchool of Arts and SciencesNational University of MongoliaUlaanbaatar 14200Mongolia Queensland Micro-and Nanotechnology Centre School of Environment and ScienceGriffith UniversityNathan campusBrisbaneQueensland 4111Australia Department of Physics Incheon National UniversityIncheon 22012Republic of Korea Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt LuciaBrisbaneQueensland 4072Australia Adelaide Microscopy The University of AdelaideAdelaideSouth Australia 5005Australia Centre for Organic Photonics&Electronics School of Chemistry and Molecular BiosciencesThe University of QueenslandSt LuciaBrisbaneQueensland 4072Australia

Transition metal carbides and nitrides(MXenes)nanosheets are attractive two-dimensional(2D)materials,but they suffer from oxidation/degradation issues during storage and/or applications due to their sensitivity to water and *** the great research progress,the exact oxidation kinetics of Ti_(3)C_(2)T_(x)(MXene)and their final products after oxidation are not fully ***,we systematically tracked the oxidation process of few-layer Ti_(3)C_(2)T_(x) nanosheets in an aqueous solution at room temperature over several *** also studied the oxidation effects on the electrocatalytic properties of Ti_(3)C_(2)T_(x) for hydrogen evolution reaction and found that the overpotential to achieve a current density of 10 mA cm^(-2)increases from 0.435 to 0.877 V after three weeks of degradation,followed by improvement to stabilized values of around 0.40 V after eight *** results suggest that severely oxidized MXene could be a promising candidate for designing efficient *** to our detailed experimental characterization and theoretical calculations,unlike previous studies,black titanium oxide is formed as the final product in addition to white Ti(IV)oxide and disordered carbons after the complete oxidation of Ti_(3)C_(2)T_(x).This work presents significant advancements in better understanding of 2D Ti_(3)C_(2)T_(x)(MXene)oxidation and enhances the prospects of this material for various applications.

关键词： 2D materials MXene Chemical degradation Catalysis Hydrogen evolution reaction

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Direct recycling of Li-ion batteries from cell to pack level:Challenges and prospects on technology,scalability,sustainability,and economics

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Carbon Energy 2024年第6期6卷 1-39页

作者： joseph Jegan Roy Do Minh Phuong Vivek Verma Richa Chaudhary Michael Carboni Daniel Meyer Bin Cao Madhavi srinivasan Energy Research Institute@NTU(ERI@N) SCARCE LaboratoryNanyang Technological UniversitySingaporeSingapore school of Materials science and Engineering Nanyang Technological UniversitySingaporeSingapore CEA CNRSENSCMUniversity of MontpellierUMR 5257(ICSM)Bagnols-sur-Cèze CedexFrance school of Civil and Environmental Engineering Nanyang Technological UniversitySingaporeSingapore

Direct recycling is a novel approach to overcoming the drawbacks of conventional lithium-ion battery(LIB)recycling processes and has gained considerable attention from the academic and industrial sectors in recent *** primary objective of directly recycling LIBs is to efficiently recover and restore the active electrode materials and other components in the solid phase while retaining electrochemical *** technology's advantages over traditional pyrometallurgy and hydrometallurgy are costeffectiveness,energy efficiency,and sustainability,and it preserves the material structure and morphology and can shorten the overall recycling *** review extensively discusses the advancements in the direct recycling of LIBs,including battery sorting,pretreatment processes,separation of cathode and anode materials,and regeneration and quality enhancement of electrode *** encompasses various approaches to successfully regenerate high-value electrode materials and streamlining the recovery process without compromising their electrochemical ***,we highlight key challenges in direct recycling when scaled from lab to industries in four perspectives:(1)battery design,(2)disassembling,(3)electrode delamination,and(4)commercialization and *** on these challenges and changing market trends,a few strategies are discussed to aid direct recycling efforts,such as binders,electrolyte selection,and alternative battery designs;and recent transitions and technological advancements in the battery industry are presented.

关键词： battery design cathode regeneration direct recycling graphite recycling lithium-ion battery,scaling-up

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