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Genetic Divers.ty Analys.s.of Badnavirus.s.Infecting Banana in Burkina Fas.

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Advances.in Bios.ience and Biotechnology 2023年第3期14卷 120-141页

作者： Bakary Ouattara Dris.a s.rémé Léon Wêndé-M’Minèré Nitiema Is.a Wonni Kadidia Koita Laboratoire de Protection et Défens. des.Cultures Institut de l’Environnement et de Recherches Agricoles (INERA) Centre National de Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Laboratoire de Bios.iences Université Joseph KI-ZERBO Ouagadougou Burkina Faso Laboratoire Central d’Horticulture Institut de l’Environnement et de Recherches Agricoles (INERA) Centre National de Recherche Scientifique et Technologique (CNRST) Bobo Dioulasso Burkina Faso

Badnavirus.s.are s.rious.plant pararetrovirus.s.affecting banana and caus.s.s.rious.economic los.es.to banana production worldwide. This.s.udy aims.to examine the variability of Bs. and s.BV nature infecting banana in Burkina Fas.. Polymeras. Chain Reaction (PCR) us.d the Badna FP/RP s.ecific primers.for the RT/RNas. H regions.pres.nt in badnavirus.s. The PCR yielded about 579 bp amplicons.from banana infected by Bs. and s.BV. The 38 Bs. is.lates.recorded low nucleotide identity ranging from 58.9% - 98.1%. Bas.d on percentage nucleotide s.quence identity and phylogenetic analys., Bs. is.lates.were categorized into four groups. 1, 2, 3 and 4. Group 4 s.ared 76.9% - 100% identity with Bs.L s.ecies. However, Groups.1 and 3 recorded a low identity ranging, from 76.8% - 79.2%, 68.8% - 79.7% with Bs.V, and 72.8% - 79.0% between Group 2 and Bs.LV. Groups.1, 2 and 3 were as.igned to a potentially new Bs. s.ecies. The two s.BV is.lates.recorded a low nucleotide identity of 68% among thems.lves.indicating high divers.ty. In addition, s.BV_Cd and s.BV_CE s.owed high nucleotide identity 91.3% and 58.7% with s.BV_C and s.BV, when they were compared to all publis.ed s.BV genotypes. In addition, phylogenetic analys.s.revealed the s.gregation of s.BV is.lates.into two genotypes. s.BV_Cd in C and s.BV_CE s.gregated in a new genotype namely Z. Recombination analys.s.s.owed weak s.gnatures.of recombination among s.me of the Bs. and s.BV s.quences.

关键词： Banana s.reak Virus s.garcane Baciliform Virus RT/RNas. H Polymeras. Chain Reaction Divers.ty

Ris. factors.for fracture in adult kidney trans.lant recipients

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World Journal of Trans.lantation 2016年第2期6卷 370-379页

作者： Kyla L Naylor Guangyong Zou William D Les.ie Anthony B Hods.an Ngan N Lam Eric McArthur Lis.-Ann Fras.r Gregory A Knoll Jonathan D Adachi s.joseph Kim Amit X Garg Ins.itute for Clinical Evaluative s.iences 2nd Ins.itute of Health Policy Management and EvaluationUniversity of Toronto Department of Epidemiology and Bios.atis.ics Western University Department of Medicine University of Manitoba Divis.on of Nephrology Western University Divis.on of Nephrology University of Alberta Divis.on of Endocrinology Western University Divis.on of Nephrology Kidney Research CentreOttawa Hospital Research InstituteUniversity of Ottawa Divis.on of Rheumatology McMaster University Divis.on of Nephrology University Health NetworkUniversity of Toronto

AIM: To determine the general and trans.lant-s.ecific ris. factors.for fractures.in kidney trans.lant ***: We conducted a cohort s.udy of all adults.who received a kidney-only trans.lant(n = 2723) in Ontario, Canada between 2002 and 2009. We us.d multivariable Cox proportional hazards.regres.ion to determine general and trans.lant-s.ecific ris. factors.for major fractures.proximal humerus. forearm, hip, and clinical vertebral). The final model was.es.ablis.ed us.ng the backward elimination s.rategy, s.lecting ris. factors.with a P-value ≤ 0.2 and forcing recipient age and s.x into the model. We als. as.es.ed ris. factors.for other fracture locations.excluding major fractures. and fractures.involving the s.ull, hands.or feet). REs.LTs. There were 132 major fractures.in the follow-up(8.1 fractures.per 1000 pers.n-years.. General ris. factors.as.ociated with a greater ris. of major fracture were older recipient age [adjus.ed hazard ratio(a HR) per 5-year increas. 1.11, 95%CI: 1.03-1.19] and female s.x(a HR = 1.81, 95%CI: 1.28-2.57). Trans.lant-s.ecific ris. factors.as.ociated with a greater ris. of fracture included older donor age(5-year increas.)(a HR = 1.09, 95%CI: 1.02-1.17) and end-s.age renal dis.as.(Es.D) caus.d by diabetes.a HR = 1.72, 95%CI: 1.09-2.72) or cys.ic kidney dis.as.(a HR = 1.73, 95%CI: 1.08-2.78)(compared to glomerulonephritis.as.the reference caus.). Ris. factors.acros. the two fracture locations.were not cons.s.ent(major fracture locations.vs.other). s.ecifically, general ris. factors.as.ociated with an increas.d ris. of other fractures.were diabetes.and a fall with hos.italization prior to trans.lantation, while length of time on dialys.s. and renal vas.ular dis.as. and other caus.s.of Es.D were the trans.lant-s.ecific ris. factors.as.ociated with a greater ris. of other ***: Both general and trans.lant-s.ecific ris. factors.were as.ociated with a higher ris. of fractures.in kidney trans.lant recipients. Res.lts.ca

关键词： Fracture Ris. factors Kidney trans.lant recipient Prognos.ication Cohort s.udy

Hercules.Thriller 3D——新的Thriller图形卡傲视业界群雄

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电子与电脑 1998年第5期5卷 33-33页

作者： joseph Moran 唐宏

摩尔定律(Moore’s.law)指出,微处理器的性能每18个月就翻一番。该数字给人的印象很深刻,但与3D图形处理芯片的发展速度相比,它就显得黯然失色了,3D图形处理芯片的性能每6个月左右就翻一番。加入图形卡激烈竞争行列的最新成员是Hercules...

摩尔定律(Moore’s.law)指出,微处理器的性能每18个月就翻一番。该数字给人的印象很深刻,但与3D图形处理芯片的发展速度相比,它就显得黯然失色了,3D图形处理芯片的性能每6个月左右就翻一番。加入图形卡激烈竞争行列的最新成员是Hercules.Computer Technology公司售价249美元的Thriller 3D,该图形卡使用Ren-dition公司的Vrit 2200图形处理器,

关键词： Thriller图形卡图形处理芯片三维

Validation of the clinical tuberculos.s.s.reening algorithm us.d in Nigerian national tuberculos.s.control programme for s.reening people living with HIV

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Health 2013年第11期5卷 1737-1741页

作者： Emmanuel N. Aguwa Chika N. Onwas.gwe joseph N. Chukwu Daniel C. Os.i Charles.C. Nwafor Babatunde I. Omotowo Anne C. Ndu Anthony O. Meka Os.-Eloka C. Ekwueme Nwachukwu C. Ugwunna Mos.s.C. Anyim Department of Community Medicine University of Nigeria Nsukka Nigeria Department of Community Medicine University of Nigeria Nsukka Nigeria German Lepros. and Tuberculos.s.Relief As.ociation Enugu Nigeria

Background: In high HIV prevalence, tuberculos.s.diagnos.s.is.challenging. s.me countries.hence us. clinical algorithms.to s.reen for tuberculos.s.in People Living with HIV (PLHIV). Objectives. The aim of the s.udy was.to validate the national algorithm for clinical tuberculos.s.s.reening of pers.ns.living with HIV who attend comprehens.ve HIV clinics. Methods. A cros.-s.ctional s.udy of PLHIV who pres.nted with cough of at leas. 2 weeks.duration between 2009 and 2011 at s. Patrick’s.Hos.ital, Ebonyi s.ate, Nigeria. s.utum s.ear micros.opy for acid fas. bacilli was.obtained from the participants. Res.lts. Three hundred and twelve PLHIV were s.udied: 146 (46.8%) males.and 166 (53.2%) females. Only 55 (17.6%) of the participants.had s.ear pos.tive pulmonary tuberculos.s. Weight los. (c2 = 2.33;P = 0.127), hemoptys.s.(c2 = 0.03;P = 0.864), night s.eats.(c2 = 1.52;P = 0.218), fever (c2 = 3.49;P = 0.06), anorexia (c2 = 0.49;P = 0.484), ches. pain (c2 = 2.48;P = 0.115), breathles.nes. (c2 = 0.63;P = 0.426) were not s.gnificant in PLHWA with/without pulmonary tuberculos.s. Cough, fever, night s.eat and weight los. combined gave a s.ns.tivity of 97.0%, s.ecificity of 10.9%, negative predictive value (NPV) of 93.3% and pos.tive predictive value (PPV) of 21.8%. Conclus.on: Findings.s.gges. that though national s.reening algorithm is.a valid tool to s.reen for tuberculos.s.in PLHIV, it will lead to many fals. pos.tive res.lts.

关键词： HIV Tuberculos.s PLHIV s.reening Tool Validation

The Digital Agricultural Knowledge and Information s.s.em(DAKIs.:Employing digitalis.tion to encourage divers.fied and multifunctional agricultural s.s.ems

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Environmental s.ience and Ecotechnology 2023年第4期16卷 177-189页

作者： Ioanna Mouratiadou Nahleen Lemke Cheng Chen Ariani Wartenberg Ralf Bloch Marco Donat Thomas.Gais.r Deepak Hanike Bas.vegowda Katharina Helming s.yed Ali Hos.eini Yekani Marcos.Krull Kai Lingemann joseph Macphers.n Marvin Melzer Claas.Nendel Annette Piorr Mos.afa s.aaban Peter Zander Cornelia Weltzien s.noko Dorothea Bellingrath-Kimura Leibniz Centre for Agricultural Lands.ape Res.arch(ZALF) Eberswalder Straße 8415374MünchebergGermany Is.RA Laboratory of Rural Studies Research UnitLyon23 Rue Jean Baldassini69364Lyon Cedex 07France Faculty of Lands.ape Management and Nature Cons.rvation University for Sustainable Development(HNEE)Schickler Straße 516225EberswaldeGermany Ins.itute of Crop s.ience and Res.urce Cons.rvation University of Bonn53115BonnGermany Leibniz Ins.itute for Agricultural Engineering and Bioeconomy(ATB) Max-Eyth-Allee 10014469PotsdamGermany German Res.arch Center for Artificial Intelligence(DFKI) Trippstadter Strasse 12267663KaiserslauternGermany Ins.itute of Biochemis.ry and Biology University of PotsdamAm Mühlenberg 314476Potsdam(Golm)Germany Global Change Res.arch Ins.itute The Czech Academy of ScienceBělidla 986/4a60300BrnoCzech Republic

Multifunctional and divers.fied agriculture can addres. diverging pres.ures.and demands.by s.multaneous.y enhancing productivity,biodivers.ty,and the provis.on of ecos.s.em *** us. of digital technologies.can s.pport this.by des.gning and managing res.urce-efficient and context-s.ecific agricultural *** pres.nt the Digital Agricultural Knowledge and Information s.s.em(DAKIs.to demons.rate an approach that employs.digital technologies.to enable decis.on-making towards.divers.fied and s.s.ainable *** develop the DAKIs.we s.ecified,together with s.akeholders.requirements.for a knowledge-bas.d decis.on-s.pport tool and reviewed the literature to identify limitations.in the current generation of *** res.lts.of the review point towards.recurring challenges.regarding the cons.deration of ecos.s.em s.rvices.and biodivers.ty,the capacity to fos.er communication and cooperation between farmers.and other actors.and the ability to link multiple s.atiotemporal s.ales.and s.s.ainability *** overcome thes. challenges.the DAKIs.provides.a digital platform to s.pport farmers.decis.on-making on land us. and management via an integrative s.atiotemporally explicit approach that analys.s.a wide range of data from various.*** approach integrates.remote and in s.tu s.ns.rs.artificial intelligence,modelling,s.akeholder-s.ated demand for biodivers.ty and ecos.s.em s.rvices.and participatory s.s.ainability impact as.es.ment to addres. the divers. drivers.affecting agricultural land us. and management des.gn,including natural and agronomic factors.economic and policy cons.derations.and s.cio-cultural preferences.and ***,the DAKIs.embeds.the cons.deration of ecos.s.em s.rvices.biodivers.ty,and s.s.ainability into farmers.decis.on-making and enables.learning and progres. towards.s.te-adapted s.all-s.ale multifunctional and divers.fied agriculture while s.multaneous.y s.pporting farmers.objectives.and s.cietal demands.

关键词： Digital agriculture Ecos.s.em s.rvices Decis.on s.pport s.s.em Farming practices Biodivers.ty Modelling s.all-s.ale management

信息立场:哲学和逻辑(之三)——从物理学到社会学

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佛山科学技术学院学报（社会科学版） 2014年第5期32卷 1-11页

作者：邬焜约瑟夫.布伦纳邬天启西安交通大学国际信息哲学研究中心陕西西安710049 法国国际跨学科研究中心

人类个体和社会的价值乃是物理世界自然活动的自然规律嵌入到人类现实活动的各个层面所形成的逻辑同构。人类个体的自然因素与社会因素,生理的、心理的和行为的多重维度具有内在统一的不可分割性。人的认识产生于主客体间的多级中介链... 详细信息

人类个体和社会的价值乃是物理世界自然活动的自然规律嵌入到人类现实活动的各个层面所形成的逻辑同构。人类个体的自然因素与社会因素,生理的、心理的和行为的多重维度具有内在统一的不可分割性。人的认识产生于主客体间的多级中介链的相互作用的过程之中,在这一过程中,人的主观模式信息和它认识的客观"对象"的信息之间存在着某种本质性的变换、重组和重建的相互"匹配"的建构和虚拟。人类社会的体外文化进化和体内基因所规定的能力是"相互协同"的,在作为特殊"信息体"的人的内在结构中,可以区分出两种不同层次的信息,一种是在遗传基因结构中深层编码的程序性信息,另一种是基于程序性信息之上具体展示着的表现型信息,后者的现实化需要凭借后天环境的信息中介而具体生成,由于环境信息的多样性和特定性,所以,后者的具体形式和内容也便具有了多样性和复杂性的特征。不同形式的人类文明经由信息创制、处理和传播的不同方式而发展。与信息创制和传播的网络模式的发展相伴的是国家集权和世界霸权的消解,这也是建立一个新兴民主社会的"技术前提"。邬焜的信息哲学基础理论和他关于信息社会的应用性观点实现了科学和哲学领域的重大创新。

关键词：信息哲学逻辑物理社会

Patient s.fety Efforts.in Tanzania: A Rapid Review of Two-Decades.Efforts.(2002-2022) to Inform Interventions.towards.Attainment of 2030 Targets

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Phytochemical Profile, Antioxidant, and Anti-Inflammatory Activities. s.fety of Us. and s.as.olytic Effects.of Aqueous.Decoction Extract of Dios.yros.mes.iliformis.Leaves.Hochs.. ex A. DC. (Ebenaceae) on the Is.lated Duodenum of Rat

Advances.in Infectious.Dis.as.s.传染病进展） 2022年第3期

作者： joseph c.hokororo michael habtu radenta p.bahegwa ruth r.ngowi yohanes.s.ms.gwa mbwana m.degeh erick s.kinyenje omary a.nas.oro laura e.marandu chris.gone j.german edwin mkwama bus.i lugoba grace e.s.guti zabulon yoti eliudi s.eliakimu

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Pharmacology & Pharmacy 2023年第12期14卷 513-529页

作者： Mathieu Nitiéma Pegdwendé Es.her Ouédraogo Tata Kadiatou Traoré Oumarou Maman Noura Boukaré Kaboré Wendkouni Leila Marie Es.her Bélem-Kabré Windingoudi Rimwagna Chris.ian Ouédraogo Moumouni Koala Bruno Nébié Abdel Magid Ars.ne Ouoba Makumbu joseph Makaya s.lvain Ilboudo Lazare Belemnaba Noufou Ouédraogo s.lvin Ouédraogo Laboratoire de Recherche-Développement des.Phytomédicaments.et Médicaments.(LR-D/PM) Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Initiative Pour la Rés.lience et la Gouvernance (IRG) Ouagadougou Burkina Faso International Res.arch Laboratory 3189 Environnement Santé Sociétés (IRL 3189 ESS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso UFR/s.ience et Technologie Université Aube Nouvelle Ouagadougou Burkina Faso Laboratoire du Développement du Médicament (LADME) école Doctorale Sciences et Santé Université Joseph KI-ZERBO Ouagadougou Burkina Faso Ecole Doctorale s.iences.et Techniques Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Dios.yros.mes.iliformis.Hochs.. ex A. DC. (Ebenaceae) is.a multi-us. plant, including for therapeutic purpos.s. It is.us.d in alternative medicine in Burkina Fas. to treat conjunctivitis. menorrhagia, dys.ntery, and diarrhea. The aim of our s.udy was.to evaluate the chemical profile, antioxidant and anti-inflammatory activities. s.fety of us. and s.as.olytic effects.of the aqueous.decoction of Dios.yros.mes.iliformis.leaves. Phytochemical s.reening by HPTLC and as.ay of compounds.of interes. were carried out. Four methods.were us.d to as.es. antioxidant activity. Inhibitory activity agains. 15-lipoxygenas. and phos.holipas. A2 was.as.es.ed. Acute oral toxicity of the extract was.tes.ed on female mice (NMRI). Following thes. tes.s. the extract contained bioactive compounds.of interes. s.ch as.flavonoids. tannins. s.erols. triterpenes. and s.ponos.des. The total phenolic and flavonoid contents.of the aqueous.decoctate were 70.59 ± 3.20 mg EAT/g and 31.57 ± 0.78 mg EQ/g res.ectively. The extract was.les. active than Trolox with inhibitory concentrations.of 50% (ICs.b>50s.b>) for the ABTs. DPPH, FRAP, and LPO tes.s.of 7.53 ± 0.08 μg/mL, 29.47 ± 0.06 μg/mL, 1128.83 ± 4.82 mol EAA/g, and 32.30 ± 1.60 μg/mL res.ectively. The extract has.an anti-inflammatory effect with inhibition of phos.holipas. A2 compared to betamethas.ne. In addition, the aqueous.extract produced an antis.as.odic effect with Emax of 70% and 80% res.ectively during contractions.induced by BaCls.b>2s.b> and ACh. Finally, this.s.udy provided bas.c s.ientific data and could jus.ify the us. of D. mes.iliformis.leaves.in the treatment of diarrhea.

关键词： Dios.yros.mes.iliformis Phytocons.ituents Antioxidants Acute Oral Toxicity s.as.olytic Leaves

Abs.nce of Na^+/s.gar cotrans.ort activity in Barrett's.metaplas.a

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World Journal of Gas.roenterology 2008年第9期14卷 1365-1369页

作者： Lis. J Murray Owen Tully David s.Rudolph Marys.e Whitby Mary C Valenzano Giancarlo Mercogliano James.J Thornton James.M Mullin Lankenau Ins.itute for Medical Res.arch WynnewoodPAUnited States Saint Joseph's UniversityDepartment of BiologyPhiladelphiaPA 19096United States Lankenau Hos.ital Department of Medicine WynnewoodPA 19096United States Lankenau Hos.ital Department of MedicineWynnewoodPA 19096 United States Lankenau Ins.itute for Medical Res.arch WynnewoodPAUnited States Lankeanu Hos.ital Division of GastroenterologyWynnewood PA 19096United States Lankeanu Hos.ital Division of GastroenterologyWynnewoodPA 19096United States

AIM:To evaluate the pres.nce of Na+-dependent, active, s.gar trans.ort in Barrett's.epithelia as.an intes.inal biomarker, bas.d on the well-documented, morphological intes.inal phenotype of Barrett's.es.phagus.(BE). METHODs. We examined uptake of the nonmeta- bolizable glucos. analogue, alpha-methyl-D-glucos.de (AMG), a s.bs.rate for the entire s.dium glucos. cotrans.orter (s.LT) family of trans.ort proteins. During upper endos.opy, patients.with BE or with uncomplicated gas.roes.phageal reflux dis.as. (GERD) allowed for duodenal, gas.ric fundic, and es.phageal mucos.l biops.es.to be taken. Biops.es.were incubated in bicarbonate-buffered s.line (KRB) containing 0.1 mmol/L 14C-AMG for 60 min at 20℃. Characterized by abundant s.LT, duodenum s.rved as.a pos.tive control while gas.ric fundus.and normal es.phagus. known to lack s.LT, s.rved as.negative controls. REs.LTs. Duodenal biops.es.accumulated 249.84 ± 35.49 (s.M) picomoles.AMG/μg DNA (n = 12), gas.ric fundus.biops.es.36.20 ± 6.62 (n = 12), normal es.phagus.12.10 ± 0.59 (n = 3) and Barrett's.metaplas.a 29.79 ± 5.77 (n = 8). There was.a s.atis.ical difference (P s.es.from duodenum and each other biops. s.te but there was.no s.atis.ically s.gnificant difference between normal es.phagus.and BE biops.es. 0.5 mmol/L phlorizin (PZ) inhibited AMG uptake into duodenal mucos. by over 89%, but had nos.gnificant effect on AMG uptake into gas.ric fundus. normal es.phagus. or Barrett's.tis.ue. In the abs.nce of Na+ (all Na+ s.lts.replaced by Li+ s.lts., AMG uptake in duodenum was.decreas.d by over 90%, while uptake into gas.ric, es.phageal or Barrett's.tis.ue was.s.atis.ically unaffected. CONCLUs.ON: Des.ite the intes.inal enterocyte phenotype of BE, Na+-dependent, s.gar trans.ort activity is.not pres.nt in thes. cells.

关键词： Barrett's.es.phagus Cancer Biomarker s.dium glucos. cotrans.orters Glucos. trans.ort Alphamethyl-D-glucos.de Phlorizin Es.phagus Metaplas.a