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Magnetic resonance imaging markers for early diagnosis of Parkinson's disease

Neural Regeneration Research 2012年第8期7卷 611-619页

作者： Silvia marino Rosella Ciurleo Giuseppe Di Lorenzo Marina Barresi Simona De Salvo Sabrina Giacoppo Alessia Bramanti Pietro Lanzafame Placido Bramanti Neurobioimaging Laboratory IRCCS Centro Neurolesi "Bonino Pulejo" Messina 98124 Italy

Parkinson＇s disease （PD） is a neurodegenerative disorder characterized by selective and progressive degeneration, as well as loss of dopaminergic neurons in the substantia nigra. In PD, approximately 60-70% of nigrostriatal neurons are degenerated and 80% of content of the striatal dopamine is reduced before the diagnosis can be established according to widely accepted clinical diagnostic criteria. This condition describes a stage of disease called ＂prodromal＂, where non-motor symptoms, such as olfactory dysfunction, constipation, rapid eye movement behaviour disorder, depression, precede motor sign of PD. Detection of prodromal phase of PD is becoming an important goal for determining the prognosis and choosing a suitable treatment strategy. In this review, we present some non-invasive instrumental approaches that could be useful to identify patients in the prodromal phase of PD or in an early clinical phase, when the first motor symptoms begin to be apparent. Conventional magnetic resonance imaging （MRI） and advanced MRI techniques, such as magnetic resonance spectroscopy imaging, diffusion-weighted and diffusion tensor imaging and functional MRI, are useful to differentiate early PD with initial motor symptoms from atypical parkinsonian disorders, thus, making easier early diagnosis. Functional MRI and diffusion tensor imaging techniques can show abnormalities in the olfactory system in prodromal PD.

关键词： Parkinson’s disease early diagnosis conventional magnetic resonance imaging magnetic resonance spectroscopy diffusion-weighted imaging diffusion tensor imaging functional magnetic resonance imaging olfactory dysfunction

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Is there a relationship between dopamine and rhegmatogenous retinal detachment?

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Neural Regeneration Research 2020年第2期15卷 311-314页

作者： Alessio Martucci Massimo Cesareo Maria Dolores Pinazo-Durán Michela Di Pierro Matteo Di marino Carlo Nucci Massimiliano Coletta Raffaele Mancino Ophthalmology Unit Department of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Ophthalmic Research Unit "Santiago Grisolia"/FISABIO and Cellular-Molecular Ophthalmobiology Group/University of Valencia ValenciaSpain Department of Clinical Sciences and Translational Medicine University of Rome Tor VergataRomeItaly

Dopamine and its receptors have been widely studied in the neurological conditions and in the retina. In this study, we evaluated the possible role of dopamine in rhegmatogenous retinal detachment(RRD) by comparing the amount of 3,4-dihydroxyphenylacetic acid(DOPAC), a surrogate index of retinal dopamin levels, in the vitreous sample of patients affected by RRD with those affected by macular pucker and vitre ous hemorrhage. Our results showed that significantly higher levels of DOPAC were found in the vitreou sample of patients affected by RRD compared with those affected by vitreous hemorrhage and macula pucker(P = 0.002). Specifically, no trace of the substance was found in vitreous hemorrhage and macula pucker samples. A slightly significant positive correlation was found among DOPAC and post-operativ best corrected visual acuity(r = 0.470, P = 0.049). No correlation was found between DOPAC and the day elapsed between diagnosis and surgery(P = 0.317). For the first time our findings suggest that DOPAC i released in RRD, but not in other retinal diseases such as vitreous hemorrhage and macular pucker. More over, we showed a correlation between visual acuity outcome and the amount of DOPAC in the vitreous This might have a potential, although still unknown, implication in the pathogenesis of the disease and/o in the associated photoreceptors loss. This study was approved by the Ethics Committee of Rome Tor Ver gata University Hospital(R.S.92.10) on September 24, 2010.

关键词： 3,4-dihydroxyphenylacetic acid DOPAC dopamine dopaminergic amacrine cells dopaminergic neurotoxicity macular pucker oxidative stress photoreceptor degeneration rhegmatogenous retinal detachment vitreous hemorrhage

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Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 598-603页

作者： Monia Deghrigue Carmen Festa Lotfi Ghribi Maria Valeria D’Auria Simona De marino Hichem Ben Jannet Abderrahman Bouraoui Laboratoire de développement chimique galénique et pharmacologique des médicaments (LR12ES09).Equipe de Pharmacologie marineFaculté de pharmacie de MonastirUniversité de Monastir Department of Pharmacy University of Naples "Federico II" Laboratoire de chimie hétérocyclique produits naturels et réactivité. Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir Laboratoire de chimie hétérocyclique produits naturels et réactivité.Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir

Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/Et OH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-Et OH showed an important antiinflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases.

关键词： Eunicella singularis Anti-inflammatory activity Analgesic activity Gastroprotective effect Diterpenoid Sterols

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Seismic Assessment of Asymmetric Structures Behaviour by Using Static Non-linear Analysis

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Journal of Civil Engineering and Architecture 2011年第5期5卷 402-411页

作者： Ivana marino Luigi Petti Department of Civil Engineering University of Salerno via Ponte don Melillo 84084 Fisciano Italy

The goal of this work is to investigate the seismic behaviour of plan-asymmetric structures by considering the least seismic-resistant directions and the spatial features of the seismic event. New tools for the analysis of the seismic behaviour of plan-asymmetric structures are herein presented and the concepts of ＂Polar Spectrum＂ and limit domains are discussed. In particular, the capacity of the structure is described by using the limit domains based on the Non Linear Static Procedures, while the seismic demand is analysed by introducing a new representation of the spectral response. This representation is based on the construction of a spectral surface obtained by the spectral seismic response for different in-plan directions and the in-plan projection of this surface is herein defined ＂Polar Spectrum＂. The obtained results for two benchmark structures, verified by means of non-linear incremental dynamic analyses, have pointed out that non-linear static analyses, carried out for different in-plan directions of the incoming seismic action, have allowed us to accurately evaluate the least seismic resistant directions.

关键词： Plan-asymmetric structures non-linear analyses polar spectrum.

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Understanding Changing in Traditional Agricultural Landscapes： Towards a Framework

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Journal of Agricultural Science and Technology(B) 2012年第9期2卷 971-987页

作者： Cavallo Aurora marino Davide Department of Bioscience and Territory University of Molise C. da Fonte Lappone snc Pesehe (IS) 86090 Italy

Since the second half of the 20th century in Italy, following farming conversion or abandonment, many traditional agricultural systems and the connected landscapes along with them have disappeared. We discuss a conceptual framework to understand and describe changing in agricultural landscapes. According to us, the traditionality of the agricultural landscape is an expression of the local coevolution between the social project of the farmer and the constraints made by the natural system. The paper focuses on defining a spatial-temporal analytical model based on both the morphological recognition of different typologies of elements which contribute to the environmental landscape mosaic and the dynamic observation of the transformations of the mosaic itself. We identify the natural, social and economic driving forces involved in defining the agricultural space using a transdisciplinary approach so that ecological, agronomics and socio-economical information must be integrated as a basis for land use planning and management. The research approach and the methodology are applied to a couple of case studies.

关键词： Rural landscape traditional agricultural landscapes landscape planning

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Targeting mTOR and eIF4E:a feasible scenario in ovarian cancer therapy

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Cancer Drug Resistance 2021年第3期4卷 596-606页

作者： Alice Romagnoli Cristina Maracci Mattia D’Agostino Anna La Teana Daniele Di marino Department of Life and Environmental Sciences Polytechnic University of MarcheAncona 60131Italy New York-Marche Structural Biology Center(NY-MaSBiC) Polytechnic University of MarcheAncona 60131Italy

Ovarian carcinoma is one of the most common causes for cancer death in women;lack of early diagnosis and acquired resistance to platinum-based chemotherapy account for its poor prognosis and high mortality *** with other cancer types,ovarian cancer is characterized by dysregulated signaling pathways and protein synthesis,which together contribute to rapid cellular growth and *** mechanistic/mammalian target of rapamycin(mTOR)pathway represents the core of different signaling pathways regulating a number of essential steps in the cell,among which protein synthesis and the eukaryotic initiation factor 4E(eIF4E),the mRNA cap binding protein,is one of its downstream ***4E is a limiting factor in translation initiation and its overexpression is a hallmark in many *** its action is regulated by a number of factors that compete for the same binding site,eIF4E is an ideal target for developing novel antineoplastic *** inhibitors targeting the mTOR signaling pathway have been designed thus far,however most of these molecules show poor stability and high toxicity in *** minireview explores the possibility of targeting mTOR and eIF4E proteins,thus impacting on translation initiation in ovarian cancer,describing the most promising experimental strategies and specific inhibitors that have been shown to have an effect on other kinds of cancers.

关键词： Ovarian cancer targeted therapy mTOR pathway eIF4E inhibitors

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Hepatitis B:Epidemiology and prevention in developing countries

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World Journal of Hepatology 2012年第3期4卷 74-80页

作者： Elisabetta Franco Barbara Bagnato Maria Giulia marino Cristina Meleleo Laura Serino Laura Zaratti Department of Public Health University Tor Vergata PhD Program for Methodologies in Preventive Medicine and Therapy University Tor Vergata Specialization School for Hygiene and Preventive Medicine University Tor Vergata

Hepatitis B virus(HBV)infection is a serious global public health *** infection may be transmitted through sexual intercourse,parenteral contact or from an infected mother to the baby at birth and,if contracted early in life,may lead to chronic liver disease,including cirrhosis and hepatocellular *** the basis of the HBV carrier rate,the world can be divided in 3 regions of high,medium and low *** major concern is about high endemicity countries,where the most common route of infection remains vertical transmission from mother to *** of all pregnant women and passive immunization with human hepatitis B immunoglobulin are not affordable for many developing *** infection rate can be reduced by modifying behavior,improving individual education,testing all blood donations,assuring asepsis in clinical practice and screening all pregnant ***,availability of a safe and efficacious vaccine and adoption of appropriate immunization strategies are the most effective means to prevent HBV infection and its *** unsolved problem for poorest countries,where the number of people currently infected is high,is the cost of the vaccine.A future challenge is to overcome the social and economic hurdles of maintaining and improving a prevention policy worldwide to reduce the global burden of the disease.

关键词： Hepatitis B Developing countries Endemicity Seroprevalence Vaccine

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Molecular regulations of circadian rhythm and implications for physiology and diseases

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Signal Transduction and Targeted Therapy 2022年第3期7卷 666-685页

作者： Francesca Fagiani Daniele Di marino Alice Romagnoli Cristina Travelli Davide Voltan Lorenzo Di Cesare Mannelli Marco Racchi Stefano Govoni Cristina Lanni Department of Drug Sciences(Pharmacology Section) University of PaviaV.le Taramelli 1427100 PaviaItaly Department of Life and Environmental Sciences Polytechnic University of Marchevia Brecce Blanche60131 AnconaItaly New York-Marche Structural Biology Center(NY-MaSBiC) Polytechnic University of Marchevia Brecce Bianche60131 AnconaItaly NEUROFARBA Department University of FlorenceFlorenceItaly

The term"circadian rhythms"describes endogenous oscillations with ca.24-h period associated with the earth’s daily rotation and light/dark *** rhythms reflect the existence of an intrinsic circadian clock that tempor... 详细信息

关键词： rotation earth Molecular

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Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy

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World Journal of Gastroenterology 2021年第28期27卷 4639-4652页

作者： Alberto E Muñoz Florencia D Pollarsky Mónica marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero Sección Hepatología Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoFacultad de MedicinaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina Instituto de Investigaciones en Salud Pública Facultad de OdontologíaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1122Argentina Unidad Clínica Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoInvestigador Asociado del Gobierno de la Ciudad Autónoma de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina

This review summarizes the safety and efficacy of statins in patients with *** to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in *** most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver *** is the most serious and potentially life-threatening *** has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle ***,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle *** to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something *** these effects,statins could prevent liver-related morbidity and mortality in cirrhotic *** studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and *** few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic *** large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival *** these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies ***,it is advisable to per

关键词： Cirrhosis Liver disease Statins Safety Efficiency

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Calabrian and Ionian： A proposal for the definition of Mediterranean stages for the Lower and Middle Pleistocene

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Episodes 2006年第2期29卷 107-114页

作者： Maria Bianca Cita Luca Capraro Neri Ciaranfi Enrico Di Stefano Maria marino Domenico Rio Rodolfo Sprovieri Gian Battista Vai Universita di Milano Dipartimento di Scienze della Terra ‘Ardito Desio＇ via Mangiagalli 34. 20133 Milano Italy Universita di Padova Dipartimento di Geologia Paleontologia e Geofisica via Giottol 35137 Padova Italy Universita di Bari Dipartimento di Geologia e Geofisica via Orabona 4 70125 Bari Italy Universita di Palermo Dipartimento di Geologia e Geodesia corso Tukory 131 90134 Palermo Italy Universita di Bologna Dipartimento di Scienze della Terra e Geologico-Ambientali Piazza di Porta San Donato 140126 Bologna Italy

The need to standardise stratigraphical subdivisions of continuous marine sedimentary successions that outcrop for hundreds metres, using clearly defined points fixed in the field is strongly felt. A proposal is presented here to formalize regional stages for the Lower Pleistocene （Calabrian） and for the Middle Pleistocene （Ionian） in Italy. The sections are well exposed, carefully investigated using multiple criteria （an integrated stratigraphical approach） and located in the central part of the Mediterranean. This area is recognized worldwide as a classical region for the Neogene and the Pleistocene sequences. The terrestrial record is directly correlated with the deep-sea record, as determined from ODP Sites 653 （Tyrrhenian Sea）, 963 （Sicily Channel） and 964 （Ionian Sea）from the central Mediterranean. The present formal proposal is consistent with the INQUA and ICS decision to define and correlate the Plio/Pleistocene boundary （GSSP at Vrica） within the Olduvai Subchron, at 1.81 My, the Lower/Middle Pleistocene boundary at the Matuyama/Brunhes reversal at 0. 78 My and the Middle/ Upper Pleistocene boundary with the base of MIS 5, approximately 0. 13My. The present proposal also is consistent with the call for stage unit stratotypes that emphasize both the physical content of a stage and its boundaries （Hilgen et al., 2006）.

关键词：卡拉布里亚爱奥尼亚地中海更新世

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