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Epidemicity indices and reproduction numbers from infectious disease data in connected human populations

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Infectious Disease Modelling 2024年第3期9卷 875-891页

作者： Cristiano Trevisin Lorenzo Mari marino Gatto Andrea Rinaldo Laboratory of Ecohydrology École Polytechnique Fédérale de LausanneStation 2Lausanne1015Switzerland Dipartimento di Elettronica Informazione e BioingegneriaPolitecnico di MilanoVia Ponzio 34/5Milano20133Italy Dipartimento di Ingegneria Civile Edile e Ambientale(ICEA)Universitàdi PadovaStation 2Padova35131Italy

We focus on distinctive data-driven measures of the fate of ongoing *** relevance of our pursuit is suggested by recent results proving that the short-term temporal evolution of infection spread is described by an epidemicity index related to the maximum instantaneous growth rate of new infections,echoing concepts and tools developed to study the reactivity of *** epidemicity indices can showcase the dynamics of infections,together with commonly employed effective reproduction numbers,especially when the latter assume values less than *** particular,epidemicity evaluates the short-term reactivity to perturbations of a disease-free ***,we show that sufficient epidemicity thresholds to prevent transient epidemic outbreaks in a spatially connected setting can be estimated by generalizing existing analogues derived when spatial effects are *** specifically account for the discrete nature,in both space and time,of surveillance data of the type typically employed to estimate effective reproduction numbers that formed the bulk of the communication of the state of the COVID-19 pandemic and its *** analyzing the effects of spatial heterogeneity on the considered prognostic indicators,we perform a short-and long-term analysis on the COVID-19 pandemic in Italy,showing that endemic conditions were maintained throughout the duration of our simulation despite stringent control *** method provides a portfolio of prognostic indices that are essential to pinpoint the ongoing pandemic in both a qualitative and quantitative manner,as our results *** base our conclusions on extended investigations of the effects of spatial fragmentation of communities of different sizes owing to connectivity by human mobility and contact scenarios,within real geographic contexts and synthetic setups designed to test our framework.

关键词： COVID-19 Ecological reactivity Epidemicity Reproduction numbersLeslie matrix Metapopulation Mobility

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Ada marino 无形之韧

摄影之友 2024年第9期 58-65页

作者： Ada marino(图) 不详

艾达·马里诺面对令人窒息的传统父权制家庭,通过作品筑起了一座灯塔,用女性的韧性为那些深受压迫的群体编织了一轮新月。继《一家之父》(Paterfamilias)之后,意大利摄影师艾达·马里诺(Ada marino)再度把目光聚焦于女性领域,创作了超... 详细信息

艾达·马里诺面对令人窒息的传统父权制家庭,通过作品筑起了一座灯塔,用女性的韧性为那些深受压迫的群体编织了一轮新月。继《一家之父》(Paterfamilias)之后,意大利摄影师艾达·马里诺(Ada marino)再度把目光聚焦于女性领域,创作了超现实主义的作品《新月》(New Moons)。

关键词：马里诺《新月》父权制家庭超现实主义艾达 Ada 摄影师

Continuous Lumbar Plexus Catheter Removal in Postoperative Total Hip Replacement Patients Receiving Warfarin Thromboprophylaxis: A Retrospective Analysis

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Open Journal of Anesthesiology 2013年第6期3卷 293-297页

作者： joseph marino Jay Curtin Carol Patrick Kara Theal Cristina Sison George Koutsouras Scott Alpert W. Healy III Oonagh Dowling Renee Pekmezaris J. E. Chelly Biostatistics Unit The Feinstein Institute for Medical Research Manhasset USA Biostatistics Unit The Feinstein Institute for Medical Research Manhasset USA Department of Anesthesiology Franklin Hospital Medical Center Valley Stream USA Department of Anesthesiology Huntington Hospital Huntington USA Department of Cardiology Huntington Hospital Huntington USA Department of Information Services Huntington Hospital Huntington USA Department of Orthopedic Anesthesia and Acute Interventional Pain University of Pittsburgh School of Medicine Pittsburgh USA Department of Orthopedics Huntington Hospital Huntington USA Department of Population Health North Shore LIJ Health System Great Neck USA Department of Population Health North Shore LIJ Health System Great Neck USA

Background and Objectives: Based on the case reports of hemorrhagic complications, recommendations for the removal of lumbar plexus catheters in anticoagulated patients were created. These guidelines are controversial as they limit the use of lumbar plexus blocks in postoperative anticoagulated patients. This study was designed to evaluate the incidence of hemorrhagic complications and coagulation status using International Normalized Ratio (INR) at the time of lumbar plexus catheter removal in patients receiving warfarin after total hip replacement. Methods: A retrospective study of 371 patients on warfarin thromboprophylaxis who received continuous lumbar plexus catheters for postoperative analgesia after total hip surgery was performed. The primary outcome measure was the incidence of bleeding complications after catheter removal;secondary outcome measures included warfarin dose, bridge therapy, incidence of deep vein thrombosis, pulmonary embolism (DVT/PE) and INR values upon catheter removal. Results: Almost all lumbar plexus catheters (93%;344/371) were removed at 72 hours. At the time of catheter removal, mean INR was 1.99 [1.42-2.41] (p = 0.015);67% of patients had an INR > 1.5 and half of these patients had INRs between 2.0-3.0;5% had INR’s between 3.0-4.0. There were no adverse bleeding complications or nerve injury after the removal of catheters. Conclusions: We observed no incidence of bleeding after lumbar plexus catheter removal despite 67 % of patients demonstrating INR’s > 1.5. Our retrospective analysis illustrates the relative safety of catheter removal in anticoagulated patients and suggests that the removal of lumbar plexus catheters can be safely performed with an INR > 1.5 in patients receiving warfarin.

关键词： Lumbar Plexus Block Warfarin Prophylaxis Deep Vein Thrombosis Pulmonary Embolism

Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto La Rocca Giuseppe Celentano Claudio marino Massimiliano Creta Gianluigi Califano Celeste Manfredi Giorgio Ivan Russo Afonso Morgado Marco Falcone Marco Capece YAU Working Group Sexual and Reproductive Health Department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy Department of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella Salute edella Scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with P<0.001,compared to that before *** found improvement inall PDQ domains(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy

A new oxidative pathway of nitric oxide production from oximes in plants

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Molecular Plant 2024年第1期17卷 178-198页

作者： Pedro Lopez-Gomez Javier Buezo Marina Urra Alfonso Cornejo Raquel Esteban Jorge Fernandez de los Reyes Estibaliz Urarte Estefania Rodriguez-Dobreva Alejandro Chamizo-Ampudia Alejandro Eguaras Sebastian Wolf Daniel marino Victor Martinez-Merino Jose F.Moran Institute for Multidisciplinary Research in Applied Biology(IMAB) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for Advanced Materials and Mathematics(INAMAT2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Plant Molecular Biology(ZMBP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Natural Resources and Agrobiology of Salamanca(IRNASA) Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Department of Biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is an essential reactive oxygen species and a signal molecule in *** several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land ***,plants grown axenically with ammonium as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a metabolic pathway for oxidative production of *** hypothesized that oximes,such as indole-3-acetaldoxime(IAOx),a precursor to indole-3-acetic acid,are intermediate oxidation products in NO *** detected the production of NO from IAOx and other oximes catalyzed by peroxidase(POD)enzyme using both 4-amino-5-methylamino-2′,7′-difluorescein fluorescence and *** stimulated the reaction,while superoxide dismutase inhibited ***,mouse NO synthase can also use IAOx to produce NO at a lower rate than *** provided a full mechanism for POD-dependent NO production from IAOx consistent with the experimental data and supported by density functional theory *** showed that the addition of IAOx to extracts from Medicago truncatula increased the in vitro production of NO,while in vivo supplementation of IAOx and other oximes increased the number of lateral roots,as shown for NO donors,and a more than 10-fold increase in IAOx dehydratase ***,we found that in vivo supplementation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 mutant plants,defective in POD33-34,had reduced *** data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot ***,our study reveals that plants produce NO utilizing diverse molecules such as oximes,POD,and flavins,which are widely distributed in the plant kingdom,thus introducing a long-awaited oxidative pathway to NO production in plants.T

关键词： ammonium oxidation auxin nitric oxide oxime peroxidase root phenotype

Xenoestrogens challenge 17β-estradiol protective effects in colon cancer

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World Journal of Gastrointestinal Oncology 2014年第3期6卷 67-73页

作者： Maria marino Department of Science University Roma TreI-00146 RomaItaly

Several epidemiological,cellular,and molecular studies demonstrate the role of environmental chemicals with endocrine disrupting activities,typical of Westernized societies,in the pathogenesis of numerous diseases including *** this information,the design and execution of studies on endocrine disruptors are not yet cognizant that the specific actions of individual hormones often change with development and ageing,they may be different in males and females and may be mediated by different receptors isoforms expressed in different tissues or at different life *** statements are particularly true when assessing the hazard of endocrine disruptors against 17β-estradiol(E2)actions in that this hormone is crucial determinant of sexrelated differences in anatomical,physiological,and behavioral traits which characterize male and female ***,E2 is also involved in *** oncogenic effects of E2 have been investigated extensively in breast and ovarian cancers where hormone-receptor modulators are now an integral part of targeted *** is known about the E2preventive signalling in colorectal cancer,although this disease is more common in men than women,the difference being more striking amongst pre-menopausal women and age-matched *** review aims to dissect the role and action mechanisms of E2 in colorectal cancer evaluating the ability of estrogen disruptors(i.e.,xenoestrogens)in impair these E2 *** discussed here lead to define the possible role of xenoestrogens in the impairment and/or activation of E2signals important for colorectal cancer prevention.

关键词： 17β-Estradiol Estrogen receptors Xenoestrogens Bisphenol A Flavonoids Colorectal cancer

Minimal Free Resolutions of Zero-dimensional Schemes in P1 ×P1

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Algebra Colloquium 2015年第1期22卷 97-108页

作者： Paola Bonacini Lucia marino Universita degli Studi di Catania ViMe A. Doria 6 95125 Catania Italy

Let X be a zero-dimensional scheme in p1 × p1. Then X has a minimal free resolution of length 2 if and only if X is ACM. In this paper we determine a class of reduced schemes whose resolutions, similarly to the ACM case, can be obtained by their Hilbert functions and depend only on their distributions of points in a grid of lines. Moreover, a minimal set of generators of the ideal of these schemes is given by curves split into the union of lines.

关键词： resolution Hilbert function separators

Retinoprotective compounds,current efficacy,and future prospective

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Neural Regeneration Research 2023年第12期18卷 2619-2622页

作者： Rachele marino Rebecca Sappington Marco Feligioni Laboratory of Neuronal Cell Signaling EBRI Rita Levi-Montalcini FoundationRomeItaly Department of Neurobiology and Anatomy Wake Forest School of MedicineAtrium Health Wake Forest Baptist Medical CenterWinston-SalemNCUSA Department of Ophthalmology Wake Forest School of MedicineWinston-SalemNCUSA Department of Neurorehabilitation Sciences Casa di Cura IgeaMilanItaly

Retinal dysfunction is the most common cause of vision loss in several retinal *** has been estimated a great increase in these pathologies that are becoming more globally widespread and numerous over time,also supported by the life expectancy *** different types of retinopathies,we can account some that share causes,symptoms,and treatment including diabetic retinopathy,age-related macular degeneration,glaucoma,and retinitis *** changes,environmental factors,and genetic predisposition might be some of the main causes that drive retinal tissue to chronic inflammation and neurodegeneration in these *** treatments available on the market contain compounds that efficiently ameliorate some of the important clinical features of these pathologies like stabilization of the intraocular pressure,reduction of eye inflammation,control of eye oxidative stress which are considered the major molecular mechanisms related to retinal ***,the most commonly used drugs are antiinflammatories,such as corticosteroids,antioxidant,hypotonic molecules and natural neuroprotective ***,these drugs,which are fundamental to treating disease symptoms,are not capable to cure the pathologies and so they are not life-changing for *** review provided an overview of current treatments on the market,but more interestingly,wants to be a quick window on the new treatments that are now in clinical ***,it has been here highlighted that the recent technical enhancement of the investigation methods to identify the various retinopathies causes might be used as a sort of“precise medicine”approach to tailor the identification of molecular pathways involved and potentially study a dedicated treatment for each *** approach includes the use of cutting-edge technologies like gene therapy and metabolomics.

关键词： age-related macular degeneration anti-inflammatory drugs antioxidants diabetic retinopathy glaucoma neuroprotective compounds retinitis pigmentosa retinopathies vision loss

A Note on Weakly Isotone Maps and Common Solutions for Differential Systems

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Acta Mathematica Sinica,English Series 2006年第4期22卷 1171-1174页

作者： Giuseppe marino Vittorio COLAO Luigi MUGLIA Dipartimentodi Matematica Universitá degli Studi della Calabria87036Arcavacata di Rende(CS)Italy

In this short note we examine the connection between weakly isotone maps and common solutions for first order Cauchy problems in R^n and, as a rule, in Banach lattices.

关键词： Weakly isotone maps Differential equations Common solutions