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Bariatric and endo-bariatric interventions for diabetes:What is the current evidence?

World Journal of Diabetes 2024年第11期15卷 2255-2263页

作者： Sunetra mondal Vanessa Ambrose Fistus joseph m Pappachan Department of Endocrinology NRS Medical College and HospitalKolkata 700014West BengalIndia Department of medicine Royal Preston HospitalLancashire Teaching Hospitals NHS TrustPreston PR29HTLancashireUnited Kingdom Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTLancashireUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal UniversityManipal 576104India

Bariatric interventions have shown the best therapeutic benefits in individuals with *** can be classified into surgical procedures(bariatric/metabolic surgery)and endoscopic *** surgical procedures include sleeve gastrectomy,Roux-en-Y gastric bypass,bilio-pancreatic diversion with or without duodenal switch and Stomach Intestinal Pylorus Sparing *** procedures include intragastric balloons,transpyloric shuttle,endoscopic gastroplasties,aspiration therapy,duodenal mucosal resurfacing,duodeno-jejunal bypass liner,gastro-duodeno-jejunal bypass and incisionless magnetic anastomosis system among ***,these procedures are limited by lack of wide availability,high costs,immediate and long-term complications and poor acceptability in some *** re-gain is a common concern and revisional metabolic surgery is often *** pre-operative evaluation and correction of nutritional deficiencies post-surgery are very *** most appropriate procedure for a person would depend on multiple factors like the intended magnitude of weight-loss,comorbidities and surgical fitness,as well as choice of the ***,glucagon-like insulinotropic peptide-1 receptor agonists(GLP)and the GLP-1/gastric inhibitory polypeptide co-agonist-Tirzepatide have shown remarkable weight loss potential,which is at par with bariatric interventions in some *** far these can help in avoiding invasive bariatric procedures in near future remains to be *** updated and comprehensive clinical review by He et al in the recent issue of World Journal of Diabetes address has addressed the avenues and challenges of currently available bariatric surgeries which will enable clinicians to make better decisions in their practice,including their applicability in special populations like the elderly and pediatric age groups,type 1 diabetes mellitus,and non-diabetics.

关键词： Bariatric surgery Bariatric endoscopy Obesity Type 2 diabetes mellitus metabolic benefits

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Diabetic cardiomyopathy:Emerging therapeutic options

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World Journal of Diabetes 2024年第8期15卷 1677-1682页

作者： Cornelius James Fernandez Sahana Shetty joseph m Pappachan Department of Endocrinology&metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal Academy of Higher EducationManipal 576104KarnatakaIndia Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Diabetic cardiomyopathy(DbCm)is a common but underrecognized complication of patients with diabetes mellitus(Dm).Although the pathobiology of other cardiac complications of diabetes such as ischemic heart disease and cardiac autonomic neuropathy are mostly known with reasonable therapeutic options,the mechanisms and management options for DbCm are still not fully *** its early stages,DbCm presents with diastolic dysfunction followed by heart failure(HF)with preserved ejection fraction that can progress to systolic dysfunction and HF with reduced ejection fraction in its advanced stages unless appropriately *** from prompt control of Dm with lifestyle changes and antidiabetic medications,disease-modifying therapy for DbCm includes prompt control of hypertension and dyslipidemia inherent to patients with Dm as in other forms of heart diseases and the use of treatments with proven efficacy in HF.A basic study by Zhang et al,in a recent issue of the World Journal of Diabetes elaborates the potential pathophysiological alterations and the therapeutic role of teneligliptin in diabetic mouse models with *** this preliminary basic study might help to improve our understanding of DbCm and offer a potential new management option for patients with the disease,the positive results from such animal models might not always translate to clinical practice as the pathobiology of DbCm in humans could be ***,such experimental studies can encourage more scientific efforts to find a better solution to treat patients with this enigmatic disease.

关键词： Diabetic cardiomyopathy Diabetic cardiomyopathy Heart failure Pathobiology Teneligliptin

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management of diabesity:Current concepts

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World Journal of Diabetes 2023年第4期14卷 396-411页

作者： maria michaelidou joseph m Pappachan mohammad Sadiq Jeeyavudeen Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Endocrinology&metabolism University Hospitals of EdinburghEdinburgh EH164SAUnited Kingdom

The global prevalence of obesity is increasing rapidly with an exponential rise in incidence of type 2 diabetes mellitus in recent years.‘Diabesity’,the term coined to show the strong interlink between obesity and diabetes,is the direct cons-equence of the obesity pandemic,and poses significant challenges in the management of the *** addressing the clinical and mechanistic complications of obesity such as metabolic-associated fatty liver disease and obstructive sleep apnoea,a rational management algorithm for diabesity cannot be *** classes of anti-diabetic medications including insulins,sulphonylureas,thiazolidinediones and meglitinides are associated with the risk of weight gain and may potentially worsen ***,appropriate selection of antidiabetic drug regimen is crucial in the medical management of *** role of non-pharmacological measures such as dietary adjustments,exercise interventions and bariatric procedures should also be ***,the importance of appropriate and optimal management of diabesity is often overlooked by medical professionals when achieving adequate glycemic control which results in inappropriate management of the disease and its *** review provides a narrative clinical update on the evidence behind the management of diabesity.

关键词： Obesity Diabesity metabolic-associated fatty liver disease Antidiabetic medications Glycemic control metabolic surgery

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Functional attributes of two subtropical shrubs and implications for the distribution and management of endangered bird habitat

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Journal of Plant Ecology 2015年第6期8卷 578-592页

作者： Genie m.Fleming joseph m.Wunderle Jr David N.Ewert joseph J.O’Brien Eileen H.Helmer Puerto Rican Conservation Foundation PO Box 362495San JuanPR 00936USA International Institute of Tropical Forestry USDA Forest ServiceSabana Field Research StationHC 02 Box 6205LuquilloPR 00773-1377USA The Nature Conservancy 101 East Grand RiverLansingMI 48906USA Center for Forest Disturbance Science USDA Forest Service320 Green StAthensGA 30602USA

Aims The fruits of Erithalis fruticosa *** Lantana involucrata *** important in the diet of u federally endangered Kirtland’s Warblers(Setophaga kirtlandii)wintering in the bahamas *** two shrubs occur in tropical and subtropical dry forests,including forests that have been subjected to recent *** their importance to the endangered warbler,the disturbance ecology of these shrubs is poorly *** sought to determine,based on functional characteristics of the plants,whether their presence is favored by a particular type or regime of *** We used data from field experiments(seed broadcasting and shrub cutting)conducted on the island of Eleuthera,The bahamas to determine mechanisms of and conditions favoring establishment and persistence(‘vital attributes’)of *** and ***,which enabled categorization according to the plant functional types defined by Noble and slatyer(1980).We then compared hypothesized distributions of these plant functional types among different anthropogenic disturbance regimes to observed distribu-tions of *** and *** in order to identify distur-bance regimes most likely to produce habitat used by Kirtland’s *** Findings *** and *** were functionally categorized as widely dispersed but largely shade intolerant species capable of establishing or regenerating individuals after disturbance via both seeds and vegetative *** hypothesized and observed distribution patterns indicated the shrubs were favored by a regime of frequent disturbance producing open canopy and ground *** the anthropogenic disturbances we examined,areas of large-scale land clearing combined with subsequent goat graz-ing most often supported *** and ***,while the shrubs were relatively rare in burned *** the plant functional type framework in combination with field data to evaluate predictions of species occur

关键词： anthropogenic disturbance black torch plant functional type vital attributes wild sage

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Diabetes and tuberculosis:An emerging dual threat to healthcare

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World Journal of Diabetes 2024年第7期15卷 1409-1416页

作者： Sahana Shetty joseph m Pappachan Cornelius James Fernandez Department of Endocrinology Kasturba Medical CollegeManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Endocrinology&metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom

Tuberculosis(TB)remains a huge global healthcare challenge even in the 21^(st) century though the prevalence has dropped in developed countries in recent *** mellitus(Dm)is an important risk factor for the development and perpetuation of TB owing to the immune dysfunction in patients with *** coexistence of both diseases in the same individual also aggravates disease severity,complications,and chance of treatment failure because of gross immune alterations posed by Dm as well as *** complex cellular and humoral immunological factors are involved in the dangerous interaction between TB and Dm,some of which remain unknown even *** is highly important to identify the risk factors for TB in patients with Dm,and vice versa,to ensure early diagnosis and management to prevent complications from this ominous *** their research study published in the recent issue of the World Journal of Diabetes,Shi et al elaborate on the factors associated with the development of TB in a large cohort of Dm patients from *** such research output from different regions of the world is expected to improve our knowledge to fight the health devastation posed by TB in patients with diabetes.

关键词： Tuberculosis Diabetes mellitus Immune dysfunction Treatment failure multi-drug resistant tuberculosis

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Childhood Langerhans cell histiocytosis:a disease with many faces

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World Journal of Pediatrics 2019年第6期15卷 536-545页

作者： Alexander K.C.Leung joseph m.Lam Kin Fon Leong Department of Pediatrics The University of Calgaryand The Alberta Children's Hospital#20023316th Avenue NWCalgaryAB T2M 0H5Canada Department of Pediatrics University of British ColumbiaVancouverBCCanada Department of Dermatology and Skin Sciences University of British ColumbiaVancouverBCCanada Pediatric Institute Kuala Lumpur General HospitalKuala LumpurMalaysia

Background Langerhans cell histiocytosis(LCH)is a group of diseases characterized by the proliferation and accumulation of Langerhans *** presentations of LCH vary *** sources A Pubmed search was conducted using Clinical Queries with the key term "Langerhans cell histiocytosis".The search strategy included meta-analyses,randomized controlled trials,clinical trials,observational studies,and *** paper is based on,but not limited to,the search *** Generally,patients with LCH can be divided into two groups based on the extent of involvement at diagnosis,namely,single-system LCH and multisystem *** involvement may be unifocal or *** with isolated bone lesions typically present between 5 and 15 years of age,whereas those with multisystem LCH tend to present before 5 years of *** clinical spectrum is broad,ranging from an asymptomatic isolated skin or bone lesion to a life-threatening multisystem *** manifestations include,among others,"punched out" lytic bone lesion,seborrheic dermatitis-like erup-tion,erythematous/reddish-brown crusted/scaly papules/maculopapules/plaques/patches,and eczematous lesions,diabetes insipidus,hepatosplenomegaly,cytopenias,lymphadenopathy,and an acute fulminant disseminated multisystem condition presenting with fever,skin rash,anemia,thrombocytopenia,lymphadenopathy,and *** diagnosis is clinicopathologic,based on typical clinical findings and histologic/immunohistochemical examination of a biopsy of lesional *** CD1a,S100,and/or CD207(Langerin)immunohistochemical staining of lesional cells is required for a definitive *** waiting is recommended for patients with skin-only *** with symptomatic or refractory skin-only LCH may be treated with topical tacrolimus/corticosteroids,topical nitrogen mustard,oral methotrexate,or oral *** current recommended first-line therapy for patients with multisystem LCH i

关键词： Cytopenia Diabetes insipidus Eczematous lesions Hepatosplenomegaly Lymphadenopathy Seborrheic dermatitis-like eruption

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The emerging role and targetability of the TCA cycle in cancer metabolism

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Protein & Cell 2018年第2期9卷 216-237页

作者： Nicole m. Anderson Patrick mucka joseph G. Kern Hui Feng Abramson Family Cancer Research Institute University of Pennsylvania Philadelphia PA 19104-6160 USA Perelman School of medicine at the University of Pennsylvania Philadelphia PA 19104 USA Departments of Pharmacology and medicine The Center for Cancer Research Section of Hematology and Medical Oncology Boston University School of Medicine Boston MA 02118 USA Program in Biomedical Sciences Boston University School of Medicine Boston MA 02118 USA

The tricarboxylic acid （TCA） cycle is a central route for oxidative phosphorylation in cells, and fulfills their bioenergetic, biosynthetic, and redox balance require- ments. Despite early dogma that cancer cells bypass the TCA cycle and primarily utilize aerobic glycolysis, emerging evidence demonstrates that certain cancer cells, especially those with deregulated oncogene and tumor suppressor expression, rely heavily on the TCA cycle for energy production and macromolecule synthesis. As the field progresses, the importance of aberrant TCA cycle function in tumorigenesis and the potentials of applying small molecule inhibitors to perturb the enhanced cycle function for cancer treatment start to evolve. In this review, we summarize current knowledge about the fuels feeding the cycle, effects of oncogenes and tumor suppressors on fuel and cycle usage, common genetic alterations and deregulation of cycle enzymes, and potential therapeutic opportunities for targeting the TCA cycle in cancer cells. With the application of advanced technology and in vivo model organism studies, it is our hope that studies of this previously overlooked biochemical hub will provide fresh insights into cancer metabolism and tumorigenesis, subsequently revealing vulnerabilities for thera- peutic interventions in various cancer types.

关键词： glutaminolysis the TCA cycle cancer metabolism glycolysis

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Clinical implications of COVID-19 in patients with metabolicassociated fatty liver disease

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World Journal of Gastroenterology 2023年第3期29卷 487-502页

作者： mohammad Sadiq Jeeyavudeen Rahul Chaudhari joseph m Pappachan Sherouk Fouda Department of Endocrinology and metabolism University Hospitals of EdinburghEdinburgh EH42XUUnited Kingdom Department of Gastroenterology Hepatology and NutritionVirginia Commonwealth UniversityRichmondVA 23298United States Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom School of Health and Biomedical Sciences RMIT UniversityMelbourne VICAustralia

People across the world are affected by the"coronavirus disease 2019(COVID-19)",brought on by the"SARS-CoV type-2 coronavirus".Due to its high incidence in individuals with diabetes,metabolic syndrome,and metabolic-associated fatty liver disease(mAFLD),COVID-19 has gained much *** metabolic syndrome's hepatic manifestation,mAFLD,carries a significant risk of *** link between the above two conditions has also drawn increasing consideration since mAFLD is intricately linked to the obesity *** of the metabolic syndrome,mAFLD may impact the severity of the viral infections,including COVID-19 or may even be a risk *** important question is whether the present COVID-19 pandemic has been fueled by the obesity and mAFLD *** liver markers are seen elevated in *** patients with associated comorbid conditions like obesity,cardiovascular disease,renal disease,malignancy,hypertension,and old age are prone to develop severe *** is an urgent need for more studies to determine the link between the two conditions and whether it might account for racial differences in the mortality and morbidity rates linked to *** role of innate and adaptive immunity alterations in mAFLD patients may influence the severity of *** review investigates the implications of COVID-19 on liver injury and disease severity and *** also addressed the severity of COVID-19 in patients with prior mAFLD and its potential implications and therapeutic administration in the clinical setting.

关键词： metabolic-associated fatty liver disease COVID-19 metabolic syndrome Non-alcoholic steatohepatitis Angiotensin converting enzyme 2

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A cost-effective method to enhance adenoviral transduction of primary murine osteoblasts and bone marrow stromal cells

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Bone Research 2016年第2期4卷 91-100页

作者： Atum m Buo mark S Williams Jaclyn P Kerr joseph P Stains Department of Orthopaedics University of Maryland School of Medicine Department of microbiology and Immunology University of Maryland School of Medicine

We report here a method for the use of poly-L-lysine （PLL） to markedly improve the adenoviral transduction efficiency of primary murine osteoblasts and bone marrow stromal cells （BmSCs） in culture and in situ, which are typically difficult to transduce. We show by fluorescence microscopy and flow cytometry that the addition of PLL to the viral-containing medium significantly increases the number of green fluorescence protein （GFP）-positive osteoblasts and BmSCs transduced with an enhanced GFP-expressing adenovirus. We also demonstrate that PLL can greatly enhance the adenoviral transduction of osteoblasts and osteocytes in situ in ex vivo tibia and calvaria, as well as in long bone fragments. In addition, we validate that PLL can improve routine adenoviral transduction studies by permitting the use of low multiplicities of infection to obtain the desired biologic effect. Ultimately, the use of PLL to facilitate adenoviral gene transfer in osteogenic cells can provide a cost-effective means of performing efficient gene transfer studies in the context of bone research.

关键词： A cost-effective method to enhance adenoviral transduction of primary murine osteoblasts and bone marrow stromal cells PLL bone

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Advances in immuno-oncology biomarkers for gastroesophageal cancer:programmed death ligand 1,microsatellite instability,and beyond

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World Journal of Gastroenterology 2018年第25期24卷 2686-2697页

作者： Emily m Lin Jun Gong Samuel J Klempner joseph Chao Department of Internal medicine Harbor-UCLA Medical CenterTorranceCA 90509United States Department of medical Oncology and Developmental Therapeutics City of Hope Comprehensive Cancer CenterDuarteCA 91010United States The Angeles Clinic and Research Institute Los AngelesCA 90404United States Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical CenterLos AngelesCA 90048United States

Blockade of the programmed death ligand 1(PD-L1) and programmed cell death 1(PD-1) receptor axis represents an effective form of cancer immunotherapy. Preclinical evidence initially suggested that gastric and gastroesophageal junction(GEJ) cancers are potentially immunotherapy-sensitive tumors. Early phase clinical trials have demonstrated promising antitumor activity with PD-1/PD-L1 blockade in advanced or metastatic gastric/GEJ cancer. microsatellite instability(mSI) and PD-L1 expression have been shown to predict higher response to PD-1 inhibitors as highlighted by the recent approvals of pembrolizumab in treatmentrefractory solid tumors with mSI status and the thirdline or greater treatment of PD-L1 positive advanced gastric/GEJ cancers. However, predictive and prognostic biomarkers remain an ongoing need. In this review, we detail the preclinical evidence and early tissue biomarker analyses illustrating potential predictive biomarkers to PD-1/PD-L1 blockade in gastric/GEJ cancer. We also review the clinical development of PD-1/PD-L1 inhibitors in gastric/GEJ cancer and highlight several areas in need of future investigation in order to optimize the efficacy of PD-1/PD-L1 blockade in gastric/GEJ cancer.

关键词： Immunotherapy programmed cell death 1 programmed death ligand 1 microsatellite instablility Gastric cancer

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